SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'COS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 5ol2 ACYL-COA
DEHYDROGENASE
(Clostridioides
difficile) 		4 / 8 ILE C 245
ASN C 158
GLY C 241
LEU C 238
 None
None
None
COS  C 402 (-4.4A)
 0.87A 1dzmA-5ol2C:
undetectable		 1dzmA-5ol2C:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 LEU A  55
ILE A  86
ALA A 375
ILE A 332
 None
None
COS  A 400 (-4.8A)
None
 0.71A 2xkwA-1ivhA:
0.0		 2xkwA-1ivhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 SER A 101
GLY A  94
LEU A 253
ASN A 106
ASP A 252
 None
None
None
None
COS  A 400 (-3.6A)
 1.40A 3r24A-1ivhA:
undetectable		 3r24A-1ivhA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 TYR A 372
LEU A 357
ARG A 294
 None
None
COS  A1434 (-3.3A)
 0.81A 3sufB-2jifA:
undetectable		 3sufB-2jifA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		4 / 7 THR A 238
GLY A 241
GLY A 364
THR A 365
 None
None
COS  A 402 (-3.1A)
FAD  A 401 (-2.7A)
 0.80A 3tajA-4l1fA:
undetectable		 3tajA-4l1fA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 5ol2 ACYL-COA
DEHYDROGENASE
(Clostridioides
difficile) 		4 / 7 SER C 134
GLY C 130
THR C 131
PHE C 231
 COS  C 402 (-3.2A)
FAD  C 401 (-3.3A)
FAD  C 401 ( 3.2A)
COS  C 402 (-4.6A)
 0.95A 4ac9C-5ol2C:
undetectable		 4ac9C-5ol2C:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN
(Acidaminococcus
fermentans) 		4 / 6 ALA A 302
LEU A 305
ASP A 240
GLU A 237
 None
None
COS  A 402 (-2.9A)
COS  A 402 (-4.5A)
 0.88A 4g24A-4l1fA:
undetectable		 4g24A-4l1fA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 1ivh ISOVALERYL-COA
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 LYS A 164
ILE A 193
LYS A 181
VAL A 244
 None
None
None
COS  A 400 (-4.4A)
 1.13A 4tvtA-1ivhA:
0.0		 4tvtA-1ivhA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		6 / 12 GLU A 292
ASN A 291
GLY A 288
GLY A 296
PHE A 174
ILE A 295
 None
COS  A1434 (-3.0A)
None
None
None
None
 1.22A 5vooD-2jifA:
undetectable		 5vooD-2jifA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 ASN A 291
GLY A 288
GLY A 296
PHE A 174
ILE A 295
 COS  A1434 (-3.0A)
None
None
None
None
 1.16A 5vooF-2jifA:
undetectable		 5vooF-2jifA:
22.11