SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'COI'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfohalobium
retbaense) 		4 / 7 ILE A 216
GLY A 170
PRO A 242
ASN A 167
 None
None
COI  A 601 ( 4.4A)
None
 0.76A 1oniG-5ereA:
undetectable
1oniI-5ereA:
undetectable		 1oniG-5ereA:
14.47
1oniI-5ereA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfohalobium
retbaense) 		4 / 7 GLU A 146
ILE A 243
TRP A 173
LEU A 169
 None
None
None
COI  A 601 (-3.7A)
 1.36A 1q0yH-5ereA:
undetectable
1q0yL-5ereA:
undetectable		 1q0yH-5ereA:
18.02
1q0yL-5ereA:
18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		5 / 8 TYR A 143
ARG A 145
GLY A 303
THR A 304
ALA A 305
 COI  A1517 (-4.8A)
None
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
 0.43A 2a1hA-3uzbA:
38.8
2a1hB-3uzbA:
38.7		 2a1hA-3uzbA:
31.84
2a1hB-3uzbA:
31.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfohalobium
retbaense) 		4 / 7 PHE A 285
PRO A 242
TYR A 339
THR A 140
 None
COI  A 601 ( 4.4A)
None
None
 1.13A 2aouB-5ereA:
5.0		 2aouB-5ereA:
18.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		6 / 10 TYR A 143
ARG A 145
TYR A 175
GLY A 303
THR A 304
ALA A 305
 COI  A1517 (-4.8A)
None
COI  A1517 ( 4.8A)
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
 0.69A 2coiA-3uzbA:
39.5
2coiB-3uzbA:
39.7		 2coiA-3uzbA:
32.66
2coiB-3uzbA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		6 / 10 TYR A 143
ARG A 145
TYR A 175
GLY A 303
THR A 304
ALA A 305
 COI  A1517 (-4.8A)
None
COI  A1517 ( 4.8A)
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
 0.68A 2coiA-3uzbA:
39.5
2coiB-3uzbA:
39.7		 2coiA-3uzbA:
32.66
2coiB-3uzbA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		5 / 10 TYR A 207
TYR A 175
GLY A 303
THR A 304
ALA A 305
 COI  A1517 (-4.7A)
COI  A1517 ( 4.8A)
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
 1.23A 2coiA-3uzbA:
39.5
2coiB-3uzbA:
39.7		 2coiA-3uzbA:
32.66
2coiB-3uzbA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		7 / 11 PHE A  76
TYR A 143
ARG A 145
TYR A 175
GLY A 303
THR A 304
ALA A 305
 COI  A1517 (-4.9A)
COI  A1517 (-4.8A)
None
COI  A1517 ( 4.8A)
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
 0.49A 2cojA-3uzbA:
39.7
2cojB-3uzbA:
39.9		 2cojA-3uzbA:
32.66
2cojB-3uzbA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		5 / 9 TYR A 143
ARG A 145
GLY A 303
THR A 304
ALA A 305
 COI  A1517 (-4.8A)
None
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
 0.40A 2cojA-3uzbA:
39.7
2cojB-3uzbA:
39.9		 2cojA-3uzbA:
32.66
2cojB-3uzbA:
32.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		6 / 8 TYR A 143
ARG A 145
GLY A 303
THR A 304
ALA A 305
ALA A 306
 COI  A1517 (-4.8A)
None
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
COI  A1517 (-4.1A)
 0.43A 2ej3A-3uzbA:
33.2		 2ej3A-3uzbA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		8 / 10 PHE A  76
TYR A 143
ARG A 145
TYR A 207
GLY A 303
THR A 304
ALA A 305
ALA A 306
 COI  A1517 (-4.9A)
COI  A1517 (-4.8A)
None
COI  A1517 (-4.7A)
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
COI  A1517 (-4.1A)
 0.53A 2ej3B-3uzbA:
33.3		 2ej3B-3uzbA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfohalobium
retbaense) 		5 / 11 GLY A 124
SER A 106
ILE A  38
SER A 100
ALA A  84
 COI  A 601 (-4.1A)
None
None
None
None
 0.94A 2nnhA-5ereA:
undetectable		 2nnhA-5ereA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE
(Deinococcus
radiodurans) 		4 / 7 ARG A 100
TYR A 207
ARG A 192
GLU A 238
 PLP  A 371 (-3.0A)
COI  A1517 (-4.7A)
PLP  A 371 ( 3.7A)
PLP  A 371 (-3.7A)
 0.98A 2zt7A-3uzbA:
undetectable		 2zt7A-3uzbA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3hps 2-ISOPROPYLMALATE
SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 250
SER A 173
ALA A 253
GLU A 111
GLU A 309
 COI  A 702 (-4.5A)
None
None
None
None
 1.34A 4zjoA-3hpsA:
undetectable		 4zjoA-3hpsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfohalobium
retbaense) 		4 / 8 SER A 103
THR A 240
ILE A 243
ALA A 218
 COI  A 601 (-2.4A)
None
None
COI  A 601 ( 4.3A)
 0.81A 5te8B-5ereA:
undetectable		 5te8B-5ereA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Desulfohalobium
retbaense) 		4 / 7 SER A 103
THR A 240
ILE A 243
ALA A 218
 COI  A 601 (-2.4A)
None
None
COI  A 601 ( 4.3A)
 0.81A 6ma7A-5ereA:
undetectable		 6ma7A-5ereA:
8.45