SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'COH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.56A 1cqeA-5ikrA:
59.0		 1cqeA-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.56A 1cqeB-5ikrA:
59.2		 1cqeB-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.61A 1eqhA-5ikrA:
59.4		 1eqhA-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.64A 1eqhB-5ikrA:
59.4		 1eqhB-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		9 / 12 PHE A 209
LEU A 352
PHE A 381
TYR A 385
TRP A 387
PHE A 518
GLY A 526
GLY A 533
LEU A 534
 None
ID8  A 601 (-4.1A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.5A)
None
None
 0.93A 1fe2A-5ikrA:
58.1		 1fe2A-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 PHE A 209
LEU A 352
TYR A 355
PHE A 381
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
GLY A 533
LEU A 534
 None
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
None
None
 0.76A 1fe2A-5ikrA:
58.1		 1fe2A-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 PHE A 205
PHE A 209
LEU A 352
TYR A 355
PHE A 381
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
GLY A 533
LEU A 534
 None
None
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
None
None
 0.59A 1igxA-5ikrA:
57.8		 1igxA-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		9 / 10 VAL A 349
LEU A 352
LEU A 384
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.49A 1pxxA-5ikrA:
34.5		 1pxxA-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		9 / 10 VAL A 349
LEU A 384
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 (-3.9A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.28A 1pxxA-5ikrA:
34.5		 1pxxA-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		9 / 9 VAL A 349
LEU A 352
LEU A 384
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.48A 1pxxB-5ikrA:
35.2		 1pxxB-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		10 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
LEU A 384
TYR A 385
TRP A 387
VAL A 523
GLY A 526
SER A 530
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.47A 1pxxC-5ikrA:
34.2		 1pxxC-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 VAL A 349
SER A 353
TYR A 355
LEU A 384
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 (-3.9A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.24A 1pxxC-5ikrA:
34.2		 1pxxC-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		9 / 10 VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
VAL A 523
GLY A 526
SER A 530
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.50A 1pxxD-5ikrA:
34.7		 1pxxD-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		9 / 10 VAL A 349
TYR A 355
LEU A 384
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
 ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.27A 1pxxD-5ikrA:
34.7		 1pxxD-5ikrA:
88.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.13A 1v54A-5ikrA:
undetectable
1v54C-5ikrA:
undetectable		 1v54A-5ikrA:
21.04
1v54C-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.13A 1v54N-5ikrA:
undetectable
1v54P-5ikrA:
undetectable		 1v54N-5ikrA:
21.04
1v54P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 1v55A-5ikrA:
undetectable
1v55C-5ikrA:
undetectable		 1v55A-5ikrA:
21.04
1v55C-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 1v55C-5ikrA:
undetectable
1v55N-5ikrA:
undetectable
1v55P-5ikrA:
undetectable		 1v55C-5ikrA:
20.62
1v55N-5ikrA:
21.04
1v55P-5ikrA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.39A 2aylA-5ikrA:
59.2		 2aylA-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		8 / 12 VAL A 349
LEU A 352
TYR A 385
TRP A 387
PHE A 518
GLY A 526
ALA A 527
SER A 530
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.80A 2aylA-5ikrA:
59.2		 2aylA-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.44A 2aylB-5ikrA:
59.4		 2aylB-5ikrA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.12A 2dyrA-5ikrA:
undetectable
2dyrC-5ikrA:
undetectable		 2dyrA-5ikrA:
21.04
2dyrC-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.13A 2dyrN-5ikrA:
undetectable
2dyrP-5ikrA:
undetectable		 2dyrN-5ikrA:
21.04
2dyrP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 6 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.17A 2dysA-5ikrA:
undetectable
2dysC-5ikrA:
undetectable		 2dysA-5ikrA:
21.04
2dysC-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 6 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.11A 2dysN-5ikrA:
undetectable
2dysP-5ikrA:
undetectable		 2dysN-5ikrA:
21.04
2dysP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 2eijA-5ikrA:
undetectable
2eijC-5ikrA:
undetectable		 2eijA-5ikrA:
21.04
2eijC-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 2eijN-5ikrA:
undetectable
2eijP-5ikrA:
undetectable		 2eijN-5ikrA:
21.04
2eijP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.18A 2eikA-5ikrA:
undetectable
2eikC-5ikrA:
undetectable		 2eikA-5ikrA:
21.04
2eikC-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 2eikN-5ikrA:
undetectable
2eikP-5ikrA:
undetectable		 2eikN-5ikrA:
21.04
2eikP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 2eilA-5ikrA:
undetectable
2eilC-5ikrA:
undetectable		 2eilA-5ikrA:
21.04
2eilC-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.13A 2eilN-5ikrA:
undetectable
2eilP-5ikrA:
undetectable		 2eilN-5ikrA:
21.04
2eilP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 6 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.17A 2eimA-5ikrA:
undetectable
2eimC-5ikrA:
undetectable		 2eimA-5ikrA:
21.04
2eimC-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 6 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.21A 2eimN-5ikrA:
undetectable
2eimP-5ikrA:
undetectable		 2eimN-5ikrA:
21.04
2eimP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 6 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.20A 2einA-5ikrA:
undetectable
2einC-5ikrA:
undetectable		 2einA-5ikrA:
21.04
2einC-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 6 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.22A 2einN-5ikrA:
undetectable
2einP-5ikrA:
undetectable		 2einN-5ikrA:
21.04
2einP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		5 / 12 ALA A 132
ARG A 150
TYR A 460
HIS A 386
THR A 212
 None
None
None
COH  A 602 (-3.7A)
COH  A 602 (-2.4A)
 1.12A 2xffA-5ikrA:
undetectable		 2xffA-5ikrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.11A 2y69A-5ikrA:
undetectable
2y69C-5ikrA:
undetectable		 2y69A-5ikrA:
21.04
2y69C-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.18A 2y69C-5ikrA:
undetectable
2y69N-5ikrA:
undetectable
2y69P-5ikrA:
undetectable		 2y69C-5ikrA:
20.62
2y69N-5ikrA:
21.04
2y69P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 6 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 2zxwA-5ikrA:
undetectable
2zxwC-5ikrA:
undetectable		 2zxwA-5ikrA:
21.04
2zxwC-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 6 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.14A 2zxwN-5ikrA:
undetectable
2zxwP-5ikrA:
undetectable		 2zxwN-5ikrA:
21.04
2zxwP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 3abkA-5ikrA:
undetectable
3abkC-5ikrA:
undetectable		 3abkA-5ikrA:
21.04
3abkC-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.14A 3abkN-5ikrA:
undetectable
3abkP-5ikrA:
undetectable		 3abkN-5ikrA:
21.04
3abkP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.11A 3ablA-5ikrA:
undetectable
3ablC-5ikrA:
undetectable
3ablP-5ikrA:
undetectable		 3ablA-5ikrA:
21.04
3ablC-5ikrA:
20.62
3ablP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.12A 3ablC-5ikrA:
undetectable
3ablN-5ikrA:
undetectable
3ablP-5ikrA:
undetectable		 3ablC-5ikrA:
20.62
3ablN-5ikrA:
21.04
3ablP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.12A 3abmA-5ikrA:
undetectable
3abmC-5ikrA:
undetectable
3abmP-5ikrA:
undetectable		 3abmA-5ikrA:
21.04
3abmC-5ikrA:
20.62
3abmP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.12A 3abmN-5ikrA:
undetectable
3abmP-5ikrA:
undetectable		 3abmN-5ikrA:
21.04
3abmP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 6 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 3ag1A-5ikrA:
undetectable
3ag1C-5ikrA:
undetectable		 3ag1A-5ikrA:
21.04
3ag1C-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 6 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.12A 3ag1N-5ikrA:
undetectable
3ag1P-5ikrA:
undetectable		 3ag1N-5ikrA:
21.04
3ag1P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 3ag2A-5ikrA:
undetectable
3ag2C-5ikrA:
undetectable		 3ag2A-5ikrA:
21.04
3ag2C-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.13A 3ag2N-5ikrA:
undetectable
3ag2P-5ikrA:
undetectable		 3ag2N-5ikrA:
21.04
3ag2P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.18A 3ag3A-5ikrA:
undetectable
3ag3C-5ikrA:
undetectable		 3ag3A-5ikrA:
21.04
3ag3C-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 3ag3N-5ikrA:
undetectable
3ag3P-5ikrA:
undetectable		 3ag3N-5ikrA:
21.04
3ag3P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.18A 3ag4A-5ikrA:
undetectable
3ag4C-5ikrA:
undetectable		 3ag4A-5ikrA:
21.04
3ag4C-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.17A 3ag4N-5ikrA:
undetectable
3ag4P-5ikrA:
undetectable		 3ag4N-5ikrA:
21.04
3ag4P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 6 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.18A 3asnA-5ikrA:
undetectable
3asnC-5ikrA:
undetectable		 3asnA-5ikrA:
21.04
3asnC-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.17A 3asnC-5ikrA:
undetectable
3asnN-5ikrA:
undetectable
3asnP-5ikrA:
undetectable		 3asnC-5ikrA:
20.62
3asnN-5ikrA:
21.04
3asnP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.18A 3asoA-5ikrA:
undetectable
3asoC-5ikrA:
undetectable
3asoP-5ikrA:
undetectable		 3asoA-5ikrA:
21.04
3asoC-5ikrA:
20.62
3asoP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.19A 3asoC-5ikrA:
undetectable
3asoN-5ikrA:
undetectable
3asoP-5ikrA:
undetectable		 3asoC-5ikrA:
20.62
3asoN-5ikrA:
21.04
3asoP-5ikrA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 VAL A 116
VAL A 349
SER A 353
TYR A 355
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 534
 None
ID8  A 601 (-3.9A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
None
 0.39A 3hs6A-5ikrA:
61.7		 3hs6A-5ikrA:
87.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		7 / 12 PHE A 210
TYR A 355
ILE A 377
PHE A 381
GLY A 526
ALA A 527
SER A 530
 COH  A 602 (-4.0A)
ID8  A 601 (-3.8A)
None
None
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 1.30A 3hs6B-5ikrA:
61.8		 3hs6B-5ikrA:
87.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		7 / 12 GLN A 192
VAL A 349
LEU A 352
TRP A 387
PHE A 518
GLY A 526
SER A 530
 None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.85A 3kk6A-5ikrA:
57.1		 3kk6A-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		9 / 12 GLN A 192
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
SER A 530
 None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.58A 3kk6A-5ikrA:
57.1		 3kk6A-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		8 / 12 HIS A  90
GLN A 192
VAL A 349
LEU A 352
TRP A 387
PHE A 518
GLY A 526
SER A 530
 None
None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.94A 3kk6B-5ikrA:
57.1		 3kk6B-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		9 / 12 HIS A  90
GLN A 192
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TRP A 387
GLY A 526
SER A 530
 None
None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.70A 3kk6B-5ikrA:
57.1		 3kk6B-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 HIS A  90
GLN A 192
VAL A 349
TYR A 355
LEU A 359
TRP A 387
ALA A 516
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
None
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.32A 3ln1A-5ikrA:
62.4		 3ln1A-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 HIS A  90
GLN A 192
VAL A 349
TYR A 355
LEU A 359
TRP A 387
ALA A 516
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
None
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.31A 3ln1B-5ikrA:
62.5		 3ln1B-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 HIS A  90
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
ALA A 516
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.33A 3ln1C-5ikrA:
62.5		 3ln1C-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 HIS A  90
GLN A 192
VAL A 349
SER A 353
TYR A 355
LEU A 359
TRP A 387
ALA A 516
VAL A 523
GLY A 526
ALA A 527
LEU A 531
 None
None
ID8  A 601 (-3.9A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.31A 3ln1D-5ikrA:
34.1		 3ln1D-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 VAL A 116
ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.42A 3n8wA-5ikrA:
58.7		 3n8wA-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		10 / 12 HIS A  90
ARG A 120
LEU A 352
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.63A 3n8xA-5ikrA:
58.1		 3n8xA-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		9 / 12 HIS A  90
ARG A 120
LEU A 352
TYR A 385
TRP A 387
PHE A 518
GLY A 526
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.82A 3n8xA-5ikrA:
58.1		 3n8xA-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		10 / 12 HIS A  90
ARG A 120
LEU A 352
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.62A 3n8xB-5ikrA:
58.3		 3n8xB-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		8 / 12 LEU A 352
TYR A 355
LEU A 359
TRP A 387
PHE A 518
GLY A 526
SER A 530
LEU A 531
 ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.80A 3n8xB-5ikrA:
58.3		 3n8xB-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		10 / 11 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.47A 3n8yA-5ikrA:
34.2		 3n8yA-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 VAL A 344
VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
LEU A 534
 None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
None
 0.48A 3n8yB-5ikrA:
33.4		 3n8yB-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 VAL A 116
ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.46A 3n8zA-5ikrA:
58.7		 3n8zA-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.61A 3n8zB-5ikrA:
58.7		 3n8zB-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.40A 3nt1A-5ikrA:
62.8		 3nt1A-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.42A 3nt1B-5ikrA:
63.0		 3nt1B-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 VAL A 116
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.48A 3pghA-5ikrA:
25.9		 3pghA-5ikrA:
87.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 11 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
MET A 522
VAL A 523
GLY A 526
ALA A 527
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-4.2A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.49A 3pghB-5ikrA:
24.0		 3pghB-5ikrA:
87.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.52A 3pghD-5ikrA:
26.0		 3pghD-5ikrA:
87.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.36A 3rr3A-5ikrA:
35.0		 3rr3A-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.36A 3rr3B-5ikrA:
34.4		 3rr3B-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 VAL A 116
ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.41A 3rr3C-5ikrA:
62.4		 3rr3C-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 VAL A 116
ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.42A 3rr3D-5ikrA:
34.2		 3rr3D-5ikrA:
88.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		5 / 9 PHE A 200
PHE A 395
ASN A 195
PHE A 426
LEU A 390
 COH  A 602 (-4.1A)
COH  A 602 ( 4.8A)
None
None
COH  A 602 ( 4.5A)
 1.35A 3t3sA-5ikrA:
undetectable		 3t3sA-5ikrA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		6 / 12 GLY A 297
LEU A 294
GLY A 293
TYR A 409
ASN A 411
PHE A 395
 None
COH  A 602 ( 4.4A)
None
None
None
COH  A 602 ( 4.8A)
 1.31A 3vywC-5ikrA:
undetectable		 3vywC-5ikrA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 3wg7A-5ikrA:
undetectable
3wg7C-5ikrA:
undetectable
3wg7P-5ikrA:
undetectable		 3wg7A-5ikrA:
21.04
3wg7C-5ikrA:
20.62
3wg7P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.14A 3wg7C-5ikrA:
undetectable
3wg7N-5ikrA:
undetectable
3wg7P-5ikrA:
undetectable		 3wg7C-5ikrA:
20.62
3wg7N-5ikrA:
21.04
3wg7P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.14A 3x2qA-5ikrA:
undetectable
3x2qC-5ikrA:
undetectable
3x2qP-5ikrA:
undetectable		 3x2qA-5ikrA:
21.04
3x2qC-5ikrA:
20.62
3x2qP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.14A 3x2qC-5ikrA:
undetectable
3x2qN-5ikrA:
undetectable
3x2qP-5ikrA:
undetectable		 3x2qC-5ikrA:
20.62
3x2qN-5ikrA:
21.04
3x2qP-5ikrA:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 ARG A 120
VAL A 349
SER A 353
TYR A 355
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.51A 4coxA-5ikrA:
24.3		 4coxA-5ikrA:
87.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 ARG A 120
VAL A 349
SER A 353
TYR A 355
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.50A 4coxB-5ikrA:
61.6		 4coxB-5ikrA:
87.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		10 / 12 ARG A 120
VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
VAL A 523
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.70A 4coxC-5ikrA:
16.7		 4coxC-5ikrA:
87.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 ARG A 120
VAL A 349
SER A 353
TYR A 355
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.49A 4coxC-5ikrA:
16.7		 4coxC-5ikrA:
87.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 ARG A 120
VAL A 349
SER A 353
TYR A 355
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.50A 4coxD-5ikrA:
33.8		 4coxD-5ikrA:
87.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		6 / 12 PHE A 210
TYR A 355
ILE A 377
PHE A 381
GLY A 526
ALA A 527
 COH  A 602 (-4.0A)
ID8  A 601 (-3.8A)
None
None
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 1.33A 4e1gA-5ikrA:
62.6		 4e1gA-5ikrA:
87.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		7 / 12 ARG A 120
PHE A 210
TYR A 355
ILE A 377
PHE A 381
GLY A 526
ALA A 527
 ID8  A 601 ( 4.4A)
COH  A 602 (-4.0A)
ID8  A 601 (-3.8A)
None
None
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 1.41A 4e1gB-5ikrA:
62.5		 4e1gB-5ikrA:
87.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 MET A 113
LEU A 117
ARG A 120
ILE A 345
VAL A 349
LEU A 352
LEU A 359
TRP A 387
MET A 522
ALA A 527
SER A 530
 None
None
ID8  A 601 ( 4.4A)
None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-4.2A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.55A 4m11A-5ikrA:
62.4		 4m11A-5ikrA:
88.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 MET A 113
VAL A 116
ARG A 120
ILE A 345
VAL A 349
LEU A 352
LEU A 359
TRP A 387
ALA A 527
SER A 530
LEU A 534
 None
None
ID8  A 601 ( 4.4A)
None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
None
 0.58A 4m11B-5ikrA:
62.4		 4m11B-5ikrA:
88.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		10 / 12 MET A 113
ILE A 345
VAL A 349
LEU A 352
LEU A 359
TRP A 387
VAL A 523
ALA A 527
SER A 530
LEU A 534
 None
None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
None
 0.42A 4m11C-5ikrA:
37.0		 4m11C-5ikrA:
88.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		10 / 12 MET A 113
VAL A 116
ILE A 345
VAL A 349
LEU A 359
TRP A 387
VAL A 523
ALA A 527
SER A 530
LEU A 534
 None
None
None
ID8  A 601 (-3.9A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
None
 0.49A 4m11C-5ikrA:
37.0		 4m11C-5ikrA:
88.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		10 / 12 MET A 113
ARG A 120
ILE A 345
VAL A 349
LEU A 352
LEU A 359
TRP A 387
VAL A 523
ALA A 527
SER A 530
 None
ID8  A 601 ( 4.4A)
None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.46A 4m11D-5ikrA:
62.4		 4m11D-5ikrA:
88.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		10 / 12 MET A 113
VAL A 116
ILE A 345
VAL A 349
LEU A 352
LEU A 359
TRP A 387
VAL A 523
ALA A 527
SER A 530
 None
None
None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.57A 4m11D-5ikrA:
62.4		 4m11D-5ikrA:
88.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 MET A 113
VAL A 116
LEU A 117
ARG A 120
ILE A 345
VAL A 349
LEU A 359
TRP A 387
PHE A 518
ALA A 527
SER A 530
 None
None
None
ID8  A 601 ( 4.4A)
None
ID8  A 601 (-3.9A)
None
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.73A 4o1zB-5ikrA:
58.8		 4o1zB-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		8 / 12 MET A 113
VAL A 116
LEU A 117
ARG A 120
TRP A 387
PHE A 518
ALA A 527
LEU A 531
 None
None
None
ID8  A 601 ( 4.4A)
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.97A 4o1zB-5ikrA:
58.8		 4o1zB-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.42A 4otyA-5ikrA:
34.1		 4otyA-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
LEU A 384
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.60A 4otyB-5ikrA:
34.1		 4otyB-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.40A 4otyB-5ikrA:
34.1		 4otyB-5ikrA:
88.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		9 / 10 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TRP A 387
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.62A 4ph9A-5ikrA:
63.0		 4ph9A-5ikrA:
88.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		9 / 10 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.32A 4ph9A-5ikrA:
63.0		 4ph9A-5ikrA:
88.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		9 / 10 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TRP A 387
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.60A 4ph9B-5ikrA:
62.9		 4ph9B-5ikrA:
88.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		9 / 10 VAL A 116
ARG A 120
VAL A 349
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.29A 4ph9B-5ikrA:
62.9		 4ph9B-5ikrA:
88.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
MET A 522
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-4.2A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.43A 4rrwA-5ikrA:
62.4		 4rrwA-5ikrA:
87.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
MET A 522
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-4.2A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.43A 4rrwB-5ikrA:
35.9		 4rrwB-5ikrA:
87.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.43A 4rrwC-5ikrA:
62.4		 4rrwC-5ikrA:
87.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.48A 4rrwD-5ikrA:
62.5		 4rrwD-5ikrA:
87.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 TYR A 348
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.48A 4rrxA-5ikrA:
61.8		 4rrxA-5ikrA:
87.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 TYR A 348
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.54A 4rrxB-5ikrA:
62.0		 4rrxB-5ikrA:
87.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
MET A 522
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-4.2A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.43A 4rrzA-5ikrA:
62.4		 4rrzA-5ikrA:
87.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
MET A 522
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-4.2A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.43A 4rrzB-5ikrA:
35.9		 4rrzB-5ikrA:
87.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.43A 4rrzC-5ikrA:
62.4		 4rrzC-5ikrA:
87.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.48A 4rrzD-5ikrA:
62.5		 4rrzD-5ikrA:
87.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.14A 5b1aA-5ikrA:
undetectable
5b1aC-5ikrA:
undetectable
5b1aP-5ikrA:
undetectable		 5b1aA-5ikrA:
21.04
5b1aC-5ikrA:
20.62
5b1aP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.14A 5b1aN-5ikrA:
undetectable
5b1aP-5ikrA:
undetectable		 5b1aN-5ikrA:
21.04
5b1aP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 5b1bA-5ikrA:
undetectable
5b1bC-5ikrA:
undetectable
5b1bP-5ikrA:
undetectable		 5b1bA-5ikrA:
21.04
5b1bC-5ikrA:
20.62
5b1bP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 5b1bN-5ikrA:
undetectable
5b1bP-5ikrA:
undetectable		 5b1bN-5ikrA:
21.04
5b1bP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 5b3sA-5ikrA:
undetectable
5b3sC-5ikrA:
undetectable
5b3sP-5ikrA:
undetectable		 5b3sA-5ikrA:
21.04
5b3sC-5ikrA:
20.62
5b3sP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 5b3sN-5ikrA:
undetectable
5b3sP-5ikrA:
undetectable		 5b3sN-5ikrA:
21.04
5b3sP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		5 / 12 GLY A 432
ASP A 190
PRO A 191
ILE A 188
LEU A 391
 None
None
None
None
COH  A 602 (-4.2A)
 1.17A 5bw4A-5ikrA:
undetectable		 5bw4A-5ikrA:
17.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		8 / 8 VAL A 349
LEU A 352
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.36A 5f1aA-5ikrA:
63.7		 5f1aA-5ikrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		7 / 7 VAL A 349
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
 ID8  A 601 (-3.9A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
 0.18A 5f1aB-5ikrA:
63.6		 5f1aB-5ikrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.40A 5ikqA-5ikrA:
63.6		 5ikqA-5ikrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.36A 5ikqB-5ikrA:
63.9		 5ikqB-5ikrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 VAL A 116
ARG A 120
VAL A 349
SER A 353
TYR A 355
LEU A 384
TRP A 387
MET A 522
VAL A 523
GLY A 526
ALA A 527
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
COH  A 602 (-4.5A)
ID8  A 601 (-4.2A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.32A 5iktA-5ikrA:
64.6		 5iktA-5ikrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 VAL A 116
ARG A 120
VAL A 349
LEU A 352
SER A 353
LEU A 384
TRP A 387
MET A 522
VAL A 523
GLY A 526
ALA A 527
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 ( 4.8A)
COH  A 602 (-4.5A)
ID8  A 601 (-4.2A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.20A 5iktB-5ikrA:
64.8		 5iktB-5ikrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 5iy5A-5ikrA:
undetectable
5iy5C-5ikrA:
undetectable		 5iy5A-5ikrA:
21.04
5iy5C-5ikrA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.14A 5iy5C-5ikrA:
undetectable
5iy5N-5ikrA:
undetectable
5iy5P-5ikrA:
undetectable		 5iy5C-5ikrA:
20.82
5iy5N-5ikrA:
21.04
5iy5P-5ikrA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.61A 5jvzA-5ikrA:
62.5		 5jvzA-5ikrA:
87.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 ARG A 120
VAL A 349
LEU A 352
SER A 353
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.60A 5jvzB-5ikrA:
62.2		 5jvzB-5ikrA:
87.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 HIS A  90
GLN A 192
VAL A 349
TYR A 355
LEU A 359
TRP A 387
ALA A 516
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
None
ID8  A 601 (-3.9A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.44A 5jw1A-5ikrA:
61.3		 5jw1A-5ikrA:
87.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		9 / 12 HIS A  90
ARG A 120
GLN A 192
TYR A 355
LEU A 359
TRP A 387
ALA A 516
GLY A 526
ALA A 527
 None
ID8  A 601 ( 4.4A)
None
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.82A 5jw1B-5ikrA:
61.1		 5jw1B-5ikrA:
87.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 HIS A  90
GLN A 192
LEU A 352
TYR A 355
LEU A 359
TRP A 387
ALA A 516
VAL A 523
GLY A 526
ALA A 527
LEU A 531
 None
None
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.49A 5jw1B-5ikrA:
61.1		 5jw1B-5ikrA:
87.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 HIS A  90
GLN A 192
VAL A 349
LEU A 352
TYR A 355
TRP A 387
ALA A 516
VAL A 523
ALA A 527
SER A 530
LEU A 531
 None
None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.68A 5kirA-5ikrA:
63.0		 5kirA-5ikrA:
99.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		11 / 12 HIS A  90
GLN A 192
VAL A 349
LEU A 352
TYR A 355
TRP A 387
ALA A 516
VAL A 523
GLY A 526
ALA A 527
LEU A 531
 None
None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.45A 5kirA-5ikrA:
63.0		 5kirA-5ikrA:
99.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		12 / 12 HIS A  90
GLN A 192
VAL A 349
SER A 353
TYR A 355
TRP A 387
ALA A 516
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
None
ID8  A 601 (-3.9A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.53A 5kirB-5ikrA:
63.8		 5kirB-5ikrA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.18A 5w97A-5ikrA:
undetectable
5w97C-5ikrA:
undetectable
5w97c-5ikrA:
undetectable		 5w97A-5ikrA:
21.04
5w97C-5ikrA:
20.62
5w97c-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 5w97C-5ikrA:
undetectable
5w97a-5ikrA:
undetectable
5w97c-5ikrA:
undetectable		 5w97C-5ikrA:
20.62
5w97a-5ikrA:
21.04
5w97c-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.17A 5wauA-5ikrA:
undetectable
5wauC-5ikrA:
undetectable
5wauc-5ikrA:
undetectable		 5wauA-5ikrA:
21.04
5wauC-5ikrA:
20.62
5wauc-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.13A 5wauC-5ikrA:
undetectable
5waua-5ikrA:
undetectable
5wauc-5ikrA:
undetectable		 5wauC-5ikrA:
20.62
5waua-5ikrA:
21.04
5wauc-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.17A 5x19A-5ikrA:
undetectable
5x19C-5ikrA:
undetectable
5x19P-5ikrA:
undetectable		 5x19A-5ikrA:
21.04
5x19C-5ikrA:
20.62
5x19P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 6 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 5x19N-5ikrA:
undetectable
5x19P-5ikrA:
undetectable		 5x19N-5ikrA:
21.04
5x19P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.14A 5x1bA-5ikrA:
undetectable
5x1bC-5ikrA:
undetectable
5x1bP-5ikrA:
undetectable		 5x1bA-5ikrA:
21.04
5x1bC-5ikrA:
20.62
5x1bP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 6 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 5x1bN-5ikrA:
undetectable
5x1bP-5ikrA:
undetectable		 5x1bN-5ikrA:
21.04
5x1bP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 5x1fA-5ikrA:
undetectable
5x1fC-5ikrA:
undetectable
5x1fP-5ikrA:
undetectable		 5x1fA-5ikrA:
21.04
5x1fC-5ikrA:
20.62
5x1fP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.19A 5x1fN-5ikrA:
undetectable
5x1fP-5ikrA:
undetectable		 5x1fN-5ikrA:
21.04
5x1fP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 5xdqA-5ikrA:
undetectable
5xdqC-5ikrA:
undetectable
5xdqP-5ikrA:
undetectable		 5xdqA-5ikrA:
21.04
5xdqC-5ikrA:
20.62
5xdqP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.14A 5xdqC-5ikrA:
undetectable
5xdqN-5ikrA:
undetectable
5xdqP-5ikrA:
undetectable		 5xdqC-5ikrA:
20.62
5xdqN-5ikrA:
21.04
5xdqP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 5xdxC-5ikrA:
undetectable
5xdxN-5ikrA:
undetectable
5xdxP-5ikrA:
undetectable		 5xdxC-5ikrA:
20.62
5xdxN-5ikrA:
21.04
5xdxP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 5z84A-5ikrA:
undetectable
5z84C-5ikrA:
undetectable
5z84P-5ikrA:
undetectable		 5z84A-5ikrA:
21.04
5z84C-5ikrA:
20.62
5z84P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 5z84C-5ikrA:
undetectable
5z84N-5ikrA:
undetectable
5z84P-5ikrA:
undetectable		 5z84C-5ikrA:
20.62
5z84N-5ikrA:
21.04
5z84P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 5z85A-5ikrA:
undetectable
5z85C-5ikrA:
undetectable
5z85P-5ikrA:
undetectable		 5z85A-5ikrA:
21.04
5z85C-5ikrA:
20.62
5z85P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 5z85C-5ikrA:
undetectable
5z85N-5ikrA:
undetectable
5z85P-5ikrA:
undetectable		 5z85C-5ikrA:
20.62
5z85N-5ikrA:
21.04
5z85P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.17A 5z86A-5ikrA:
undetectable
5z86C-5ikrA:
undetectable
5z86P-5ikrA:
undetectable		 5z86A-5ikrA:
21.04
5z86C-5ikrA:
20.62
5z86P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 5z86C-5ikrA:
undetectable
5z86N-5ikrA:
undetectable
5z86P-5ikrA:
undetectable		 5z86C-5ikrA:
20.62
5z86N-5ikrA:
21.04
5z86P-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.14A 5zcoA-5ikrA:
undetectable
5zcoC-5ikrA:
undetectable
5zcoP-5ikrA:
undetectable		 5zcoA-5ikrA:
21.04
5zcoC-5ikrA:
20.62
5zcoP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 5zcoC-5ikrA:
undetectable
5zcoN-5ikrA:
undetectable
5zcoP-5ikrA:
undetectable		 5zcoC-5ikrA:
20.62
5zcoN-5ikrA:
21.04
5zcoP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.17A 5zcpA-5ikrA:
undetectable
5zcpC-5ikrA:
undetectable
5zcpP-5ikrA:
undetectable		 5zcpA-5ikrA:
21.04
5zcpC-5ikrA:
20.62
5zcpP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 5zcpC-5ikrA:
undetectable
5zcpN-5ikrA:
undetectable
5zcpP-5ikrA:
undetectable		 5zcpC-5ikrA:
20.62
5zcpN-5ikrA:
21.04
5zcpP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 5zcqA-5ikrA:
undetectable
5zcqC-5ikrA:
undetectable
5zcqP-5ikrA:
undetectable		 5zcqA-5ikrA:
21.04
5zcqC-5ikrA:
20.62
5zcqP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 5zcqN-5ikrA:
undetectable
5zcqP-5ikrA:
undetectable		 5zcqN-5ikrA:
21.04
5zcqP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 6 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.12A 6nknA-5ikrA:
undetectable
6nknC-5ikrA:
undetectable		 6nknA-5ikrA:
21.04
6nknC-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 8 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 6nknC-5ikrA:
undetectable
6nknN-5ikrA:
undetectable
6nknP-5ikrA:
undetectable		 6nknC-5ikrA:
20.62
6nknN-5ikrA:
21.04
6nknP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 6nmfA-5ikrA:
undetectable
6nmfC-5ikrA:
undetectable
6nmfP-5ikrA:
undetectable		 6nmfA-5ikrA:
21.04
6nmfC-5ikrA:
20.62
6nmfP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.15A 6nmfN-5ikrA:
undetectable
6nmfP-5ikrA:
undetectable		 6nmfN-5ikrA:
21.04
6nmfP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 6 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 6nmpA-5ikrA:
undetectable
6nmpC-5ikrA:
undetectable		 6nmpA-5ikrA:
21.04
6nmpC-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		4 / 7 HIS A 386
ASP A 213
THR A 212
HIS A 388
 COH  A 602 (-3.7A)
None
COH  A 602 (-2.4A)
COH  A 602 (-3.3A)
 1.16A 6nmpN-5ikrA:
undetectable
6nmpP-5ikrA:
undetectable		 6nmpN-5ikrA:
21.04
6nmpP-5ikrA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		5 / 11 SER A 194
ALA A 202
PHE A 518
PHE A 198
HIS A 351
 None
COH  A 602 (-2.8A)
None
None
None
 1.34A 6qgbA-5ikrA:
undetectable		 6qgbA-5ikrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		5 / 11 SER A 194
LEU A 390
PHE A 518
PHE A 198
HIS A 351
 None
COH  A 602 ( 4.5A)
None
None
None
 1.37A 6qgbA-5ikrA:
undetectable		 6qgbA-5ikrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_B_BEZB802_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		5 / 10 SER A 194
ALA A 202
PHE A 518
PHE A 198
HIS A 351
 None
COH  A 602 (-2.8A)
None
None
None
 1.32A 6qgbB-5ikrA:
undetectable		 6qgbB-5ikrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_B_BEZB802_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		5 / 10 SER A 194
LEU A 390
PHE A 518
PHE A 198
HIS A 351
 None
COH  A 602 ( 4.5A)
None
None
None
 1.36A 6qgbB-5ikrA:
undetectable		 6qgbB-5ikrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_C_BEZC701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		5 / 9 SER A 194
LEU A 390
PHE A 518
PHE A 198
HIS A 351
 None
COH  A 602 ( 4.5A)
None
None
None
 1.37A 6qgbC-5ikrA:
0.3		 6qgbC-5ikrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		5 / 10 SER A 194
ALA A 202
PHE A 518
PHE A 198
HIS A 351
 None
COH  A 602 (-2.8A)
None
None
None
 1.30A 6qgbD-5ikrA:
undetectable		 6qgbD-5ikrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		5 / 10 SER A 194
LEU A 390
PHE A 518
PHE A 198
HIS A 351
 None
COH  A 602 ( 4.5A)
None
None
None
 1.34A 6qgbD-5ikrA:
undetectable		 6qgbD-5ikrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		5 / 11 SER A 194
ALA A 202
PHE A 518
PHE A 198
HIS A 351
 None
COH  A 602 (-2.8A)
None
None
None
 1.32A 6qgbE-5ikrA:
undetectable		 6qgbE-5ikrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		5 / 11 SER A 194
LEU A 390
PHE A 518
PHE A 198
HIS A 351
 None
COH  A 602 ( 4.5A)
None
None
None
 1.35A 6qgbE-5ikrA:
undetectable		 6qgbE-5ikrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		5 / 10 SER A 194
ALA A 202
PHE A 518
PHE A 198
HIS A 351
 None
COH  A 602 (-2.8A)
None
None
None
 1.36A 6qgbF-5ikrA:
undetectable		 6qgbF-5ikrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens) 		5 / 10 SER A 194
LEU A 390
PHE A 518
PHE A 198
HIS A 351
 None
COH  A 602 ( 4.5A)
None
None
None
 1.40A 6qgbF-5ikrA:
undetectable		 6qgbF-5ikrA:
20.21