SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'COD'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Burkholderia
pseudomallei)
5 / 11 LEU A  58
VAL A  35
TYR A   6
PRO A  12
LEU A  13
None
None
COD  A 201 (-4.7A)
None
None
1.23A 1klmA-3pxuA:
undetectable
1klmA-3pxuA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)
3uf6 LMO1369 PROTEIN
(Listeria
monocytogenes)
4 / 6 LEU A 285
MET A 136
MET A  98
LEU A 114
None
COD  A 289 (-4.7A)
None
None
1.32A 2oz7A-3uf6A:
undetectable
2oz7A-3uf6A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)
2grj DEPHOSPHO-COA KINASE
(Thermotoga
maritima)
4 / 6 HIS A  84
GLN A 145
ALA A 106
THR A   6
COD  A 201 (-3.7A)
COD  A 201 (-3.5A)
COD  A 201 ( 3.8A)
None
1.04A 2xfhA-2grjA:
undetectable
2xfhA-2grjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)
3uf6 LMO1369 PROTEIN
(Listeria
monocytogenes)
3 / 3 ASP A 270
ASN A 269
SER A 254
COD  A 289 ( 3.8A)
COD  A 289 ( 4.4A)
COD  A 289 (-3.5A)
0.96A 3lslA-3uf6A:
2.2
3lslD-3uf6A:
undetectable
3lslA-3uf6A:
21.22
3lslD-3uf6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)
3uf6 LMO1369 PROTEIN
(Listeria
monocytogenes)
3 / 3 SER A 254
ASP A 270
ASN A 269
COD  A 289 (-3.5A)
COD  A 289 ( 3.8A)
COD  A 289 ( 4.4A)
0.98A 3lslA-3uf6A:
2.2
3lslD-3uf6A:
undetectable
3lslA-3uf6A:
21.22
3lslD-3uf6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)
2grj DEPHOSPHO-COA KINASE
(Thermotoga
maritima)
4 / 7 GLY A   7
ILE A   9
GLY A  10
ILE A 131
None
COD  A 201 (-3.8A)
ADP  A 200 (-3.5A)
None
0.67A 4eatA-2grjA:
undetectable
4eatA-2grjA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)
2grj DEPHOSPHO-COA KINASE
(Thermotoga
maritima)
3 / 3 THR A  98
HIS A  84
LEU A 114
None
COD  A 201 (-3.7A)
None
0.88A 5axdC-2grjA:
undetectable
5axdC-2grjA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)
3uf6 LMO1369 PROTEIN
(Listeria
monocytogenes)
4 / 6 TYR A 241
ILE A 122
VAL A 245
ALA A 250
COD  A 289 (-4.1A)
None
None
None
0.78A 5cu6A-3uf6A:
undetectable
5cu6A-3uf6A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)
3uf6 LMO1369 PROTEIN
(Listeria
monocytogenes)
4 / 7 TYR A 241
ILE A 122
VAL A 245
ALA A 250
COD  A 289 (-4.1A)
None
None
None
0.78A 5osrA-3uf6A:
undetectable
5osrA-3uf6A:
21.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)
3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Burkholderia
pseudomallei)
4 / 5 GLY A   8
THR A   9
HIS A  17
SER A 127
COD  A 201 (-3.1A)
COD  A 201 (-3.6A)
COD  A 201 (-4.3A)
SO4  A 205 (-3.0A)
0.74A 6jmjA-3pxuA:
25.4
6jmjA-3pxuA:
52.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)
3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Burkholderia
pseudomallei)
5 / 7 GLY A   8
THR A   9
PHE A  10
HIS A  17
SER A 127
COD  A 201 (-3.1A)
COD  A 201 (-3.6A)
COD  A 201 (-4.5A)
COD  A 201 (-4.3A)
SO4  A 205 (-3.0A)
0.75A 6jnhA-3pxuA:
25.6
6jnhA-3pxuA:
52.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)
3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Burkholderia
pseudomallei)
4 / 6 GLY A   8
THR A   9
HIS A  17
SER A 127
COD  A 201 (-3.1A)
COD  A 201 (-3.6A)
COD  A 201 (-4.3A)
SO4  A 205 (-3.0A)
0.79A 6jogA-3pxuA:
25.4
6jogA-3pxuA:
52.98