SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CO8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E
(Streptomyces
cinnabarigriseus) 		5 / 12 ALA A 163
LEU A 201
SER A  72
SER A  73
ILE A  74
 CO8  A1446 ( 3.7A)
CO8  A1446 ( 4.2A)
None
None
None
 1.13A 2bl9A-4a0sA:
undetectable		 2bl9A-4a0sA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 ALA A 145
ARG A 181
LYS A 150
 CO8  A 400 (-3.5A)
None
None
 0.84A 3kp5B-3mdeA:
1.4		 3kp5B-3mdeA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 ARG A 324
ASP A 253
ARG A 388
 CO8  A 400 (-4.2A)
CO8  A 400 (-3.6A)
CO8  A 400 ( 3.9A)
 1.00A 4mx0A-3mdeA:
undetectable		 4mx0A-3mdeA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		5 / 12 GLN A  95
GLU A  99
GLY A 265
ALA A 267
ILE A 339
 CO8  A 400 ( 4.7A)
None
None
None
None
 1.17A 4xe5A-3mdeA:
2.6		 4xe5A-3mdeA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE
(Sus
scrofa) 		3 / 3 THR A 168
ALA A 100
ASN A 169
 FAD  A 399 (-4.0A)
CO8  A 400 ( 4.2A)
None
 0.43A 5ersA-3mdeA:
undetectable		 5ersA-3mdeA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E
(Streptomyces
cinnabarigriseus) 		5 / 12 LEU A 390
GLY A 114
ALA A 174
PRO A 141
PHE A 166
 None
None
None
CO8  A1446 ( 4.4A)
CO8  A1446 (-4.2A)
 1.25A 5x6yC-4a0sA:
2.5		 5x6yC-4a0sA:
20.83