SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CO2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		6 / 8 CYH A  42
ASP A  44
HIS A  98
CYH A 101
GLY A 102
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 ( 4.5A)
CO2  A 302 (-3.7A)
 0.19A 1ekjA-5bq1A:
22.1
1ekjB-5bq1A:
21.8		 1ekjA-5bq1A:
28.63
1ekjB-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		5 / 8 CYH A  42
ASP A  44
HIS A  98
CYH A 101
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 (-3.7A)
 0.96A 1ekjA-5bq1A:
22.1
1ekjB-5bq1A:
21.8		 1ekjA-5bq1A:
28.63
1ekjB-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		6 / 8 CYH A  42
ASP A  44
VAL A  66
HIS A  98
CYH A 101
GLY A 102
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 ( 4.5A)
 0.26A 1ekjA-5bq1A:
22.1
1ekjB-5bq1A:
21.8		 1ekjA-5bq1A:
28.63
1ekjB-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		4 / 6 CYH A  42
ASP A  44
VAL A  66
GLY A 102
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
CO2  A 302 ( 4.5A)
 0.19A 1ekjC-5bq1A:
22.0
1ekjD-5bq1A:
22.2		 1ekjC-5bq1A:
28.63
1ekjD-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		4 / 6 CYH A  42
ASP A  44
VAL A  66
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
CO2  A 302 (-3.7A)
 0.98A 1ekjC-5bq1A:
22.0
1ekjD-5bq1A:
22.2		 1ekjC-5bq1A:
28.63
1ekjD-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		4 / 6 CYH A  42
ASP A  44
VAL A  66
GLY A 102
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
CO2  A 302 ( 4.5A)
 0.19A 1ekjC-5bq1A:
22.0
1ekjD-5bq1A:
22.2		 1ekjC-5bq1A:
28.63
1ekjD-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		4 / 6 CYH A  42
ASP A  44
VAL A  66
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
CO2  A 302 (-3.7A)
 1.00A 1ekjC-5bq1A:
22.0
1ekjD-5bq1A:
22.2		 1ekjC-5bq1A:
28.63
1ekjD-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		5 / 7 CYH A  42
ASP A  44
HIS A  98
GLY A 102
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
CO2  A 302 ( 4.5A)
CO2  A 302 (-3.7A)
 0.16A 1ekjE-5bq1A:
22.0
1ekjF-5bq1A:
21.9		 1ekjE-5bq1A:
28.63
1ekjF-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		4 / 7 CYH A  42
ASP A  44
HIS A  98
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
CO2  A 302 (-3.7A)
 0.86A 1ekjE-5bq1A:
22.0
1ekjF-5bq1A:
21.9		 1ekjE-5bq1A:
28.63
1ekjF-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		5 / 8 CYH A  42
ASP A  44
VAL A  66
GLY A 102
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
CO2  A 302 ( 4.5A)
CO2  A 302 (-3.7A)
 0.23A 1ekjE-5bq1A:
22.0
1ekjF-5bq1A:
21.9		 1ekjE-5bq1A:
28.63
1ekjF-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		5 / 8 CYH A  42
ASP A  44
HIS A  98
CYH A 101
GLY A 102
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 ( 4.5A)
 1.00A 1ekjG-5bq1A:
21.9
1ekjH-5bq1A:
22.3		 1ekjG-5bq1A:
28.63
1ekjH-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		6 / 8 CYH A  42
ASP A  44
HIS A  98
CYH A 101
GLY A 102
GLY A 103
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 ( 4.5A)
CO2  A 302 (-3.7A)
 0.16A 1ekjG-5bq1A:
21.9
1ekjH-5bq1A:
22.3		 1ekjG-5bq1A:
28.63
1ekjH-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		5 / 6 CYH A  42
ASP A  44
VAL A  66
HIS A  98
CYH A 101
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
 0.17A 1ekjG-5bq1A:
21.9
1ekjH-5bq1A:
22.3		 1ekjG-5bq1A:
28.63
1ekjH-5bq1A:
28.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Ruegeria
sp.
TM1040) 		5 / 12 LEU A 145
GLY A  85
ALA A 334
LEU A 337
PHE A 148
 None
CO2  A 505 ( 4.1A)
None
None
None
 0.91A 1gs4A-4ip4A:
undetectable		 1gs4A-4ip4A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN
(Ruegeria
sp.
TM1040) 		5 / 12 LEU A 145
GLY A  85
ALA A 334
LEU A 337
PHE A 148
 None
CO2  A 505 ( 4.1A)
None
None
None
 0.96A 2oz7A-4ip4A:
undetectable		 2oz7A-4ip4A:
19.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		7 / 10 CYH A  42
ASP A  44
VAL A  66
HIS A  98
CYH A 101
GLY A 102
ALA A 106
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 ( 4.5A)
None
 0.23A 3ucjA-5bq1A:
27.1		 3ucjA-5bq1A:
39.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		5 / 10 ASP A  44
HIS A  98
CYH A 101
GLY A 103
ALA A  67
 CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 (-3.7A)
CO2  A 302 ( 4.8A)
 1.19A 3ucjB-5bq1A:
27.3		 3ucjB-5bq1A:
39.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		6 / 10 CYH A  42
ASP A  44
HIS A  98
CYH A 101
GLY A 103
ALA A 106
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 (-3.7A)
None
 1.30A 3ucjB-5bq1A:
27.3		 3ucjB-5bq1A:
39.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 5bq1 CARBONIC ANHYDRASE
(Pseudomonas
aeruginosa) 		7 / 10 CYH A  42
ASP A  44
VAL A  66
HIS A  98
CYH A 101
GLY A 102
ALA A 106
 ZN  A 301 ( 2.2A)
CO2  A 302 ( 4.6A)
CO2  A 302 (-4.0A)
ZN  A 301 (-3.2A)
ZN  A 301 (-2.3A)
CO2  A 302 ( 4.5A)
None
 0.26A 3ucjB-5bq1A:
27.3		 3ucjB-5bq1A:
39.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2xvx CHELATASE, PUTATIVE
(Desulfovibrio
vulgaris) 		4 / 4 HIS A 216
GLU A  94
HIS A  88
LEU A  28
 CO2  A1286 ( 3.3A)
GOL  A1277 (-4.5A)
SO4  A1273 (-4.4A)
None
 1.33A 4m2rA-2xvxA:
undetectable		 4m2rA-2xvxA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5t13 CYANURIC ACID
AMIDOHYDROLASE
(Enterobacter
cloacae) 		5 / 12 ASN A 324
GLY A  83
GLY A  84
GLY A  52
ASN A  47
 None
CO2  A 401 (-4.5A)
None
CO2  A 402 ( 4.2A)
None
 0.98A 4obwB-5t13A:
undetectable		 4obwB-5t13A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_0
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4zaa FDC1
(Aspergillus
niger) 		5 / 12 PRO A 189
ILE A 227
GLU A 282
THR A 395
TYR A 394
 None
None
CO2  A 608 ( 4.8A)
4M4  A 606 (-4.3A)
4M4  A 606 (-3.4A)
 1.22A 4rfqA-4zaaA:
0.0		 4rfqA-4zaaA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5t13 CYANURIC ACID
AMIDOHYDROLASE
(Enterobacter
cloacae) 		3 / 3 LEU A 166
ARG A 195
ARG A  51
 None
None
CO2  A 402 (-4.3A)
 0.89A 4yiaB-5t13A:
undetectable		 4yiaB-5t13A:
6.91