SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CNP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.06A 1a4gA-4sliA:
24.8		 1a4gA-4sliA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.58A 1a4gA-4sliA:
24.8		 1a4gA-4sliA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.06A 1a4gB-4sliA:
24.6		 1a4gB-4sliA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.61A 1a4gB-4sliA:
24.6		 1a4gB-4sliA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.96A 1nncA-4sliA:
21.1		 1nncA-4sliA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.65A 1nncA-4sliA:
21.1		 1nncA-4sliA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 10 ARG A 293
TYR A 561
GLU A 595
ARG A 611
ARG A 673
 CNP  A 760 (-3.0A)
None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
 0.82A 1v3eA-4sliA:
25.4		 1v3eA-4sliA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 10 ARG A 293
TYR A 561
GLU A 595
ARG A 611
TYR A 713
 CNP  A 760 (-3.0A)
None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.92A 1v3eA-4sliA:
25.4		 1v3eA-4sliA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 10 ARG A 293
TYR A 561
GLU A 595
ARG A 611
TYR A 713
 CNP  A 760 (-3.0A)
None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.78A 1v3eB-4sliA:
25.2		 1v3eB-4sliA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.03A 2cmlA-4sliA:
4.8		 2cmlA-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.59A 2cmlA-4sliA:
4.8		 2cmlA-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.04A 2cmlB-4sliA:
5.8		 2cmlB-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.59A 2cmlB-4sliA:
5.8		 2cmlB-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.01A 2cmlC-4sliA:
4.0		 2cmlC-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.63A 2cmlC-4sliA:
4.0		 2cmlC-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.07A 2cmlD-4sliA:
21.3		 2cmlD-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.62A 2cmlD-4sliA:
21.3		 2cmlD-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
TYR A 561
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.45A 2f0zA-4sliA:
39.6		 2f0zA-4sliA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		8 / 12 ARG A 293
ILE A 294
ARG A 312
TYR A 561
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
CNP  A 760 (-3.6A)
None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.64A 2f10A-4sliA:
38.4		 2f10A-4sliA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.22A 2htqA-4sliA:
10.9		 2htqA-4sliA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.76A 2htqA-4sliA:
10.9		 2htqA-4sliA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ASN A 737
ASP A 310
ILE A 323
ILE A 374
ASP A 318
 None
None
None
CNP  A 760 ( 4.4A)
CNP  A 760 (-2.6A)
 1.33A 2qmjA-4sliA:
undetectable		 2qmjA-4sliA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 323
ARG A 673
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
None
CNP  A 760 (-3.0A)
 1.28A 2ya7A-4sliA:
46.1		 2ya7A-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		10 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 374
ASP A 375
ASP A 392
TYR A 561
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
CNP  A 760 ( 4.4A)
CNP  A 760 (-2.8A)
CNP  A 760 (-4.4A)
None
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.42A 2ya7A-4sliA:
46.1		 2ya7A-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 323
ARG A 673
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
None
CNP  A 760 (-3.0A)
 1.25A 2ya7B-4sliA:
45.8		 2ya7B-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		10 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 374
ASP A 375
ASP A 392
TYR A 561
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
CNP  A 760 ( 4.4A)
CNP  A 760 (-2.8A)
CNP  A 760 (-4.4A)
None
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.41A 2ya7B-4sliA:
45.8		 2ya7B-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 323
ARG A 673
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
None
CNP  A 760 (-3.0A)
 1.25A 2ya7C-4sliA:
41.1		 2ya7C-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		10 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 374
ASP A 375
ASP A 392
TYR A 561
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
CNP  A 760 ( 4.4A)
CNP  A 760 (-2.8A)
CNP  A 760 (-4.4A)
None
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.41A 2ya7C-4sliA:
41.1		 2ya7C-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 323
ARG A 673
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
None
CNP  A 760 (-3.0A)
 1.24A 2ya7D-4sliA:
45.1		 2ya7D-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		10 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 374
ASP A 375
ASP A 392
TYR A 561
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
CNP  A 760 ( 4.4A)
CNP  A 760 (-2.8A)
CNP  A 760 (-4.4A)
None
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.41A 2ya7D-4sliA:
45.1		 2ya7D-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.67A 3b7eA-4sliA:
21.6		 3b7eA-4sliA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.66A 3b7eB-4sliA:
12.7		 3b7eB-4sliA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.63A 3ckzA-4sliA:
12.6		 3ckzA-4sliA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
 0.61A 3k37B-4sliA:
24.7		 3k37B-4sliA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.53A 3k39B-4sliA:
24.6		 3k39B-4sliA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.14A 3k39N-4sliA:
24.6		 3k39N-4sliA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.14A 3k39P-4sliA:
24.7		 3k39P-4sliA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.02A 3sanA-4sliA:
2.5		 3sanA-4sliA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.65A 3sanA-4sliA:
2.5		 3sanA-4sliA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.02A 3sanB-4sliA:
10.9		 3sanB-4sliA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.64A 3sanB-4sliA:
10.9		 3sanB-4sliA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.63A 3ti5A-4sliA:
12.2		 3ti5A-4sliA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.62A 3ti5B-4sliA:
21.5		 3ti5B-4sliA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.04A 3ticA-4sliA:
8.3		 3ticA-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.57A 3ticA-4sliA:
8.3		 3ticA-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.03A 3ticB-4sliA:
21.6		 3ticB-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.60A 3ticB-4sliA:
21.6		 3ticB-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.04A 3ticC-4sliA:
8.0		 3ticC-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.58A 3ticC-4sliA:
8.0		 3ticC-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.03A 3ticD-4sliA:
21.4		 3ticD-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.58A 3ticD-4sliA:
21.4		 3ticD-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.67A 4b7nA-4sliA:
12.3		 4b7nA-4sliA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.64A 4b7qA-4sliA:
10.9		 4b7qA-4sliA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.69A 4b7qB-4sliA:
21.4		 4b7qB-4sliA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.64A 4b7qC-4sliA:
12.1		 4b7qC-4sliA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.69A 4b7qD-4sliA:
21.7		 4b7qD-4sliA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.12A 4cpnA-4sliA:
24.6		 4cpnA-4sliA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.67A 4cpnA-4sliA:
24.6		 4cpnA-4sliA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.08A 4cpnB-4sliA:
4.0		 4cpnB-4sliA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.62A 4cpnB-4sliA:
4.0		 4cpnB-4sliA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.16A 4cpzA-4sliA:
4.1		 4cpzA-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.60A 4cpzA-4sliA:
4.1		 4cpzA-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.10A 4cpzB-4sliA:
24.8		 4cpzB-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.58A 4cpzB-4sliA:
24.8		 4cpzB-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.12A 4cpzC-4sliA:
24.8		 4cpzC-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.62A 4cpzC-4sliA:
24.8		 4cpzC-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.08A 4cpzD-4sliA:
25.0		 4cpzD-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.53A 4cpzD-4sliA:
25.0		 4cpzD-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.13A 4cpzE-4sliA:
24.8		 4cpzE-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.62A 4cpzE-4sliA:
24.8		 4cpzE-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.17A 4cpzF-4sliA:
24.8		 4cpzF-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.65A 4cpzF-4sliA:
24.8		 4cpzF-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.15A 4cpzG-4sliA:
24.9		 4cpzG-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.58A 4cpzG-4sliA:
24.9		 4cpzG-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.15A 4cpzH-4sliA:
24.7		 4cpzH-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.67A 4cpzH-4sliA:
24.7		 4cpzH-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.02A 4i00A-4sliA:
21.6		 4i00A-4sliA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.57A 4i00A-4sliA:
21.6		 4i00A-4sliA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.95A 4mwrA-4sliA:
7.9		 4mwrA-4sliA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.61A 4mwrA-4sliA:
7.9		 4mwrA-4sliA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.61A 4mwxA-4sliA:
7.8		 4mwxA-4sliA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		3 / 3 ARG A 293
ASP A 318
ARG A 673
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 (-3.0A)
 0.45A 4mx0A-4sliA:
7.2		 4mx0A-4sliA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.07A 4wa5A-4sliA:
13.1		 4wa5A-4sliA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.72A 4wa5A-4sliA:
13.1		 4wa5A-4sliA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		3 / 3 ASP A 732
ARG A 673
TYR A 731
 None
CNP  A 760 (-3.0A)
None
 0.96A 5a7mA-4sliA:
undetectable		 5a7mA-4sliA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		3 / 3 ASP A 732
ARG A 673
TYR A 731
 None
CNP  A 760 (-3.0A)
None
 0.95A 5a7mB-4sliA:
undetectable		 5a7mB-4sliA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 9 ALA A 391
ILE A 294
GLY A 542
ILE A 543
ILE A 325
 None
CNP  A 760 (-4.5A)
None
None
None
 1.12A 5kr0A-4sliA:
undetectable		 5kr0A-4sliA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.96A 5l17A-4sliA:
21.3		 5l17A-4sliA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.57A 5l17A-4sliA:
21.3		 5l17A-4sliA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 SER A 714
ARG A 293
GLU A 729
TYR A 713
 None
CNP  A 760 (-3.0A)
None
CNP  A 760 (-4.0A)
 1.14A 5x7pA-4sliA:
4.1		 5x7pA-4sliA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 SER A 714
ARG A 293
GLU A 729
TYR A 713
 None
CNP  A 760 (-3.0A)
None
CNP  A 760 (-4.0A)
 1.18A 5x7pB-4sliA:
3.1		 5x7pB-4sliA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 SER A 714
ARG A 293
GLU A 729
TYR A 713
 None
CNP  A 760 (-3.0A)
None
CNP  A 760 (-4.0A)
 1.18A 5x7qA-4sliA:
4.0		 5x7qA-4sliA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 SER A 714
ARG A 293
GLU A 729
TYR A 713
 None
CNP  A 760 (-3.0A)
None
CNP  A 760 (-4.0A)
 1.16A 5x7qB-4sliA:
3.0		 5x7qB-4sliA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 SER A 714
ARG A 293
GLU A 729
TYR A 713
 None
CNP  A 760 (-3.0A)
None
CNP  A 760 (-4.0A)
 1.19A 5x7rB-4sliA:
3.0		 5x7rB-4sliA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 SER A 666
GLU A 729
ARG A 312
ASP A 310
 None
None
CNP  A 760 (-3.6A)
None
 1.24A 5zw4A-4sliA:
undetectable		 5zw4A-4sliA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		7 / 12 ARG A 293
ILE A 294
ARG A 312
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
CNP  A 760 (-3.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.58A 6ekuA-4sliA:
39.7		 6ekuA-4sliA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ILE A 294
ASP A 375
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-4.5A)
CNP  A 760 (-2.8A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.77A 6ekuA-4sliA:
39.7		 6ekuA-4sliA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ASP A 318
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.60A 6hcxA-4sliA:
11.5		 6hcxA-4sliA:
9.17