SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CNC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 8 TYR A 226
GLY A 235
LEU B 148
VAL B 113
 None
CNC  B2601 ( 3.7A)
CNC  B2601 (-4.1A)
CNC  B2601 (-4.9A)
 1.02A 1gsfC-1uc4A:
undetectable		 1gsfC-1uc4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 11 GLY B  68
PRO B  69
HIS B  84
GLN B 133
LEU B 160
 None
None
None
CNC  B2601 ( 4.7A)
None
 1.06A 1jzsA-1uc4B:
undetectable		 1jzsA-1uc4B:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 12 ILE B 130
ALA B 117
LEU B 153
LEU B 160
ILE B 132
 None
None
CNC  B2601 (-4.0A)
None
None
 1.03A 1rd7B-1uc4B:
undetectable		 1rd7B-1uc4B:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 8 ASP A 278
TYR A 229
THR A 289
TYR A 277
 None
CNC  A 701 ( 3.5A)
CNC  A 701 (-3.4A)
None
 1.04A 1rmtD-2gskA:
undetectable		 1rmtD-2gskA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 8 LEU B 203
ALA B 157
GLY B  81
HIS B  84
 None
CNC  B2601 (-3.2A)
None
None
 0.71A 1sv9A-1uc4B:
undetectable		 1sv9A-1uc4B:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		5 / 10 GLY B 131
GLN B 133
VAL B 113
ILE B 168
VAL B  91
 None
CNC  B2601 ( 4.7A)
CNC  B2601 (-4.9A)
None
None
 1.23A 3fhjA-1uc4B:
undetectable		 3fhjA-1uc4B:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		4 / 5 PRO A 229
SER A 227
LEU A 260
SER A 259
 None
CNC  A 501 (-3.2A)
None
None
 1.39A 3iluH-4zrqA:
undetectable		 3iluH-4zrqA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		6 / 12 GLY B 120
VAL B 113
ILE B 100
GLY B 125
ALA B 172
ALA B 173
 None
CNC  B2601 (-4.9A)
None
None
None
None
 1.42A 3sufD-1uc4B:
undetectable		 3sufD-1uc4B:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		5 / 12 GLY A 142
GLY A 140
LEU A 183
SER A 135
ALA A  88
 None
None
None
CNC  A 501 ( 4.0A)
None
 1.09A 4qtuB-4zrqA:
undetectable		 4qtuB-4zrqA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4zrq TRANSCOBALAMIN-2
(Homo
sapiens) 		3 / 3 LEU A 358
TYR A  62
SER A  83
 CNC  A 501 (-3.6A)
None
CNC  A 501 ( 4.3A)
 0.89A 5iktA-4zrqA:
0.7		 5iktA-4zrqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		3 / 3 HIS B 204
SER B 200
LYS B 135
 None
CNC  B2601 (-2.7A)
CNC  B2601 (-2.8A)
 1.26A 5os7A-1uc4B:
undetectable		 5os7A-1uc4B:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		4 / 8 ILE B 130
ALA B 117
LEU B 153
ILE B 132
 None
None
CNC  B2601 (-4.0A)
None
 0.83A 5uihA-1uc4B:
undetectable		 5uihA-1uc4B:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca;
Klebsiella
oxytoca) 		5 / 12 GLN B 197
GLY A 261
SER A 307
ILE A 313
GLY A 298
 CNC  B2601 ( 4.6A)
NH4  A2604 (-4.1A)
None
None
None
 1.03A 5wyqA-1uc4B:
undetectable		 5wyqA-1uc4B:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca;
Klebsiella
oxytoca) 		5 / 12 GLN B 197
GLY A 261
SER A 307
ILE A 313
GLY A 298
 CNC  B2601 ( 4.6A)
NH4  A2604 (-4.1A)
None
None
None
 0.97A 5wyqB-1uc4B:
undetectable		 5wyqB-1uc4B:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 5np4 TRANSCOBALAMIN-2
(Homo
sapiens) 		4 / 5 PHE A 376
VAL A 337
PRO A 386
VAL A 407
 CNC  A 502 ( 4.2A)
None
None
None
 1.42A 6ekzA-5np4A:
undetectable		 6ekzA-5np4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1uc4 DIOL DEHYDRASE BETA
SUBUNIT
(Klebsiella
oxytoca) 		3 / 3 HIS B 204
SER B 200
LYS B 135
 None
CNC  B2601 (-2.7A)
CNC  B2601 (-2.8A)
 1.26A 6gmdB-1uc4B:
undetectable		 6gmdB-1uc4B:
19.61