SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CNA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 322
LEU A 315
LEU A 318
GLY A 319
 None
None
None
CNA  A1395 (-3.9A)
 0.80A 1n13D-4bn5A:
undetectable
1n13E-4bn5A:
undetectable		 1n13D-4bn5A:
17.02
1n13E-4bn5A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 347
ASN A 344
THR A 320
ILE A 317
MET A 143
 None
CNA  A1395 (-3.3A)
CNA  A1395 (-4.2A)
None
None
 1.45A 1xlxA-4bn5A:
undetectable		 1xlxA-4bn5A:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 6 ALA A 146
SER A 149
ASN A 229
ILE A 230
ASP A 231
 CNA  A1395 (-3.1A)
CNA  A1395 (-4.3A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
 0.40A 1yc2A-4bn5A:
20.9		 1yc2A-4bn5A:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 6 ALA A  59
SER A  62
PHE A  70
ASN A 141
ILE A 142
ASP A 143
 CNA  A 402 (-3.0A)
CNA  A 402 ( 4.1A)
CNA  A 402 (-3.2A)
CNA  A 402 (-4.1A)
CNA  A 402 (-4.7A)
CNA  A 402 (-3.7A)
 0.88A 1yc2A-4g1cA:
25.4		 1yc2A-4g1cA:
39.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ALA A 146
ASN A 229
ILE A 230
ASP A 231
 CNA  A1395 (-3.1A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
 0.34A 1yc2D-4bn5A:
20.6		 1yc2D-4bn5A:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ALA A  59
ASN A 141
ILE A 142
ASP A 143
 CNA  A 402 (-3.0A)
CNA  A 402 (-4.1A)
CNA  A 402 (-4.7A)
CNA  A 402 (-3.7A)
 0.38A 1yc2D-4g1cA:
25.2		 1yc2D-4g1cA:
39.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ALA A  59
PHE A  70
ILE A 142
ASP A 143
 CNA  A 402 (-3.0A)
CNA  A 402 (-3.2A)
CNA  A 402 (-4.7A)
CNA  A 402 (-3.7A)
 1.09A 1yc2D-4g1cA:
25.2		 1yc2D-4g1cA:
39.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 154
ASN A 229
ILE A 230
ASP A 231
 CNA  A1395 (-3.8A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
 0.40A 1yc2E-4bn5A:
20.8		 1yc2E-4bn5A:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 7 ALA A 146
SER A 149
ASN A 229
ILE A 230
ASP A 231
 CNA  A1395 (-3.1A)
CNA  A1395 (-4.3A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
 0.37A 1yc5A-4bn5A:
24.6		 1yc5A-4bn5A:
36.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 7 ALA A 146
SER A 149
ILE A 154
ASN A 229
ASP A 231
 CNA  A1395 (-3.1A)
CNA  A1395 (-4.3A)
CNA  A1395 (-3.8A)
CNA  A1395 (-3.7A)
CNA  A1395 (-3.5A)
 0.39A 1yc5A-4bn5A:
24.6		 1yc5A-4bn5A:
36.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 7 ALA A  59
SER A  62
ASN A 141
ILE A 142
ASP A 143
 CNA  A 402 (-3.0A)
CNA  A 402 ( 4.1A)
CNA  A 402 (-4.1A)
CNA  A 402 (-4.7A)
CNA  A 402 (-3.7A)
 0.27A 1yc5A-4g1cA:
24.9		 1yc5A-4g1cA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 5 ALA A 146
ILE A 154
ASN A 229
ILE A 230
ASP A 231
 CNA  A1395 (-3.1A)
CNA  A1395 (-3.8A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
 0.55A 2h4jA-4bn5A:
24.8		 2h4jA-4bn5A:
36.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ALA A  59
ASN A 141
ILE A 142
ASP A 143
 CNA  A 402 (-3.0A)
CNA  A 402 (-4.1A)
CNA  A 402 (-4.7A)
CNA  A 402 (-3.7A)
 0.20A 2h4jA-4g1cA:
24.4		 2h4jA-4g1cA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 ALA A  59
THR A  69
ALA A  86
PHE A 101
TYR A 102
ILE A 142
LEU A 227
 CNA  A 402 (-3.0A)
CNA  A 402 (-3.8A)
None
None
None
CNA  A 402 (-4.7A)
None
 0.88A 2nyrA-4g1cA:
37.7		 2nyrA-4g1cA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 THR A  69
ALA A  82
ALA A  86
TYR A 102
ILE A 142
LEU A 227
 CNA  A 402 (-3.8A)
None
None
None
CNA  A 402 (-4.7A)
None
 1.07A 2nyrA-4g1cA:
37.7		 2nyrA-4g1cA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 THR A  69
ALA A  86
PHE A 101
TYR A 102
ILE A 142
PHE A 223
LEU A 227
 CNA  A 402 (-3.8A)
None
None
None
CNA  A 402 (-4.7A)
None
None
 0.95A 2nyrA-4g1cA:
37.7		 2nyrA-4g1cA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		7 / 12 TYR A 102
ARG A 105
ILE A 142
HIS A 158
PHE A 223
GLY A 224
LEU A 232
 None
CNA  A 402 ( 4.8A)
CNA  A 402 (-4.7A)
CNA  A 402 (-4.3A)
None
None
None
 0.86A 2nyrB-4g1cA:
38.3		 2nyrB-4g1cA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 TYR A 102
ARG A 105
ILE A 142
PHE A 223
GLY A 224
ASN A 226
 None
CNA  A 402 ( 4.8A)
CNA  A 402 (-4.7A)
None
None
None
 0.91A 2nyrB-4g1cA:
38.3		 2nyrB-4g1cA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ALA A  59
ALA A  82
ALA A  86
VAL A 220
 CNA  A 402 (-3.0A)
None
None
None
 0.76A 2nyrB-4g1cA:
38.3		 2nyrB-4g1cA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ASP A 143
SER A  62
SER A  57
LEU A 155
 CNA  A 402 (-3.7A)
CNA  A 402 ( 4.1A)
None
None
 0.84A 3m0wE-4g1cA:
undetectable
3m0wF-4g1cA:
undetectable
3m0wG-4g1cA:
undetectable
3m0wH-4g1cA:
undetectable		 3m0wE-4g1cA:
20.95
3m0wF-4g1cA:
20.95
3m0wG-4g1cA:
20.95
3m0wH-4g1cA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP A 143
ILE A 142
SER A  57
HIS A 146
HIS A 118
 CNA  A 402 (-3.7A)
CNA  A 402 (-4.7A)
None
None
None
 1.16A 3o1cA-4g1cA:
undetectable		 3o1cA-4g1cA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ASP A 143
ILE A 142
SER A  57
HIS A 146
HIS A 118
 CNA  A 402 (-3.7A)
CNA  A 402 (-4.7A)
None
None
None
 1.18A 3o1xA-4g1cA:
undetectable		 3o1xA-4g1cA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 294
ILE A 154
ASP A 156
ARG A 158
PHE A 180
 SR7  A1396 (-3.5A)
CNA  A1395 (-3.8A)
SR7  A1396 ( 3.6A)
CNA  A1395 ( 3.6A)
SR7  A1396 (-3.7A)
 1.31A 3weoA-4bn5A:
undetectable		 3weoA-4bn5A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ASN A 229
ALA A 146
GLY A 145
THR A 320
 CNA  A1395 (-3.7A)
CNA  A1395 (-3.1A)
CNA  A1395 ( 3.7A)
CNA  A1395 (-4.2A)
 1.38A 4bboC-4bn5A:
undetectable		 4bboC-4bn5A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 ASN A 141
ALA A  59
GLY A  58
THR A 250
 CNA  A 402 (-4.1A)
CNA  A 402 (-3.0A)
CNA  A 402 ( 3.8A)
CNA  A 402 (-4.3A)
 1.29A 4bboC-4g1cA:
undetectable		 4bboC-4g1cA:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 154
ASN A 229
ILE A 230
ASP A 231
 CNA  A1395 (-3.8A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
 0.37A 4rmjA-4bn5A:
32.6		 4rmjA-4bn5A:
49.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PHE A 327
GLY A 145
LEU A 225
LEU A 244
 None
CNA  A1395 ( 3.7A)
None
None
 0.81A 5hs1A-4bn5A:
undetectable		 5hs1A-4bn5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4g1c NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 GLY A  60
ALA A  63
GLY A 249
GLU A 277
SER A 251
 CNA  A 402 (-3.0A)
CNA  A 402 (-3.5A)
CNA  A 402 (-3.2A)
CNA  A 402 (-3.4A)
CNA  A 402 (-2.7A)
 1.20A 5vw4A-4g1cA:
3.2		 5vw4A-4g1cA:
21.54