SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CMU'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)
1uou THYMIDINE
PHOSPHORYLASE

(Homo
sapiens)
5 / 12 GLY A 405
GLY A 149
GLY A 147
VAL A 208
THR A 207
None
None
CMU  A1481 ( 4.9A)
None
None
0.98A 2wa2A-1uouA:
undetectable
2wa2A-1uouA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)
1uou THYMIDINE
PHOSPHORYLASE

(Homo
sapiens)
4 / 4 LEU A 155
GLY A 153
MET A 142
PHE A 164
None
CMU  A1481 ( 4.1A)
None
None
1.21A 3vaqB-1uouA:
1.9
3vaqB-1uouA:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)
1uou THYMIDINE
PHOSPHORYLASE

(Homo
sapiens)
6 / 11 ARG A 202
VAL A 208
ILE A 214
SER A 217
LYS A 221
LEU A 251
CMU  A1481 (-2.8A)
None
CMU  A1481 (-3.9A)
CMU  A1481 (-2.7A)
CMU  A1481 (-2.6A)
None
0.32A 4lhmA-1uouA:
49.0
4lhmA-1uouA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)
1uou THYMIDINE
PHOSPHORYLASE

(Homo
sapiens)
5 / 11 THR A 118
TYR A 199
SER A 217
LYS A 221
LEU A 251
None
CMU  A1481 (-4.7A)
CMU  A1481 (-2.7A)
CMU  A1481 (-2.6A)
None
1.07A 4lhmA-1uouA:
49.0
4lhmA-1uouA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)
1uou THYMIDINE
PHOSPHORYLASE

(Homo
sapiens)
6 / 11 TYR A 199
ARG A 202
ILE A 214
SER A 217
LYS A 221
LEU A 251
CMU  A1481 (-4.7A)
CMU  A1481 (-2.8A)
CMU  A1481 (-3.9A)
CMU  A1481 (-2.7A)
CMU  A1481 (-2.6A)
None
0.66A 4lhmA-1uouA:
49.0
4lhmA-1uouA:
38.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)
1uou THYMIDINE
PHOSPHORYLASE

(Homo
sapiens)
4 / 5 HIS A 116
SER A 144
GLY A 145
TYR A 199
CMU  A1481 (-4.3A)
None
None
CMU  A1481 (-4.7A)
1.45A 5yodH-1uouA:
undetectable
5yodH-1uouA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
1uou THYMIDINE
PHOSPHORYLASE

(Homo
sapiens)
5 / 12 GLY A 147
GLY A 149
SER A 117
VAL A 121
GLY A 153
CMU  A1481 ( 4.9A)
None
CMU  A1481 (-4.3A)
None
CMU  A1481 ( 4.1A)
0.86A 5zhmB-1uouA:
2.2
5zhmB-1uouA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)
1uou THYMIDINE
PHOSPHORYLASE

(Homo
sapiens)
5 / 10 LEU A 395
LEU A 423
GLY A 119
GLY A 278
VAL A 281
None
None
CMU  A1481 ( 3.8A)
None
None
1.21A 6eu9B-1uouA:
0.0
6eu9B-1uouA:
8.86