SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CMP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
None
CMP  A 250 (-2.9A)
 1.20A 1cd2A-3ogjA:
undetectable		 1cd2A-3ogjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.33A 1cd2A-3shrA:
undetectable		 1cd2A-3shrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.86A 1cd2A-4qx5A:
undetectable		 1cd2A-4qx5A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		5 / 10 ALA A 179
PHE A 181
GLY A 245
GLU A 177
LEU A  72
 None
None
None
CMP  A 901 (-3.9A)
None
 1.35A 1cmcA-1lpcA:
undetectable
1cmcB-1lpcA:
undetectable		 1cmcA-1lpcA:
14.96
1cmcB-1lpcA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		5 / 10 GLU A 177
LEU A  72
ALA A 179
PHE A 181
GLY A 245
 CMP  A 901 (-3.9A)
None
None
None
None
 1.40A 1cmcA-1lpcA:
undetectable
1cmcB-1lpcA:
undetectable		 1cmcA-1lpcA:
14.96
1cmcB-1lpcA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY5_A_ACTA600_0
(RIBONUCLEASE A)		 5ahw UNIVERSAL STRESS
PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 4 HIS A 145
VAL A 116
ASN A 115
THR A 146
 None
CMP  A1148 (-3.6A)
None
CMP  A1148 (-2.9A)
 1.28A 1dy5A-5ahwA:
undetectable		 1dy5A-5ahwA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 11 ILE A 146
ALA A 194
PHE A 181
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
CMP  A 250 (-2.9A)
 1.02A 1dyrA-3ogjA:
undetectable		 1dyrA-3ogjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 11 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.90A 1dyrA-4qx5A:
undetectable		 1dyrA-4qx5A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 5w10 CGMP-SPECIFIC
PHOSPHODIESTERASE
(Leptospira
interrogans) 		4 / 7 GLU A 136
ARG A 104
VAL A  99
ALA A 122
 CMP  A 201 (-2.7A)
None
None
None
 0.93A 1fo4B-5w10A:
undetectable		 1fo4B-5w10A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		5 / 12 GLY A  96
LEU A  55
LEU A  54
VAL A  72
ALA A  93
 CMP  A 300 (-3.3A)
CMP  A 300 ( 4.5A)
None
None
None
 1.15A 1gseA-3gydA:
undetectable		 1gseA-3gydA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 1.04A 1j3jA-4qx5A:
undetectable		 1j3jA-4qx5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 11 ASN A 171
LEU A 201
GLU A 200
TYR A 229
ARG A 241
 None
CMP  A 401 (-3.4A)
CMP  A 401 (-2.9A)
None
None
 1.48A 1l5rA-4mx3A:
undetectable		 1l5rA-4mx3A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		6 / 9 PHE A  91
TYR A 121
ILE A 172
ALA A 176
GLU A 177
ARG A 180
 None
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 ( 4.0A)
CMP  A 901 (-3.9A)
CMP  A 901 (-3.0A)
 0.53A 1mrgA-1lpcA:
27.9		 1mrgA-1lpcA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		4 / 8 TYR A 121
ILE A 172
GLU A 177
ARG A 180
 CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 (-3.9A)
CMP  A 901 (-3.0A)
 0.20A 1mrjA-1lpcA:
27.6		 1mrjA-1lpcA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		5 / 11 ILE A  94
GLY A  92
GLU A  20
LYS A  24
GLU A  97
 None
None
None
None
CMP  A 300 (-2.8A)
 1.48A 1n6cA-3gydA:
undetectable		 1n6cA-3gydA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
None
CMP  A 250 (-2.9A)
 1.24A 1ra2A-3ogjA:
undetectable		 1ra2A-3ogjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.38A 1ra2A-3shrA:
undetectable		 1ra2A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.91A 1ra2A-4qx5A:
undetectable		 1ra2A-4qx5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
None
CMP  A 250 (-2.9A)
 1.22A 1ra8A-3ogjA:
undetectable		 1ra8A-3ogjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.37A 1ra8A-3shrA:
undetectable		 1ra8A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.92A 1ra8A-4qx5A:
undetectable		 1ra8A-4qx5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
None
CMP  A 250 (-2.9A)
 1.26A 1rb2A-3ogjA:
undetectable		 1rb2A-3ogjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.39A 1rb2A-3shrA:
undetectable		 1rb2A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.94A 1rb2A-4qx5A:
undetectable		 1rb2A-4qx5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3of1 CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 212
ALA A 260
PHE A 247
LEU A 270
ILE A 211
 CMP  A 501 (-4.5A)
CMP  A 501 (-3.5A)
None
None
None
 1.13A 1rb2B-3of1A:
undetectable		 1rb2B-3of1A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
None
CMP  A 250 (-2.9A)
 1.22A 1rb2B-3ogjA:
undetectable		 1rb2B-3ogjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 130
ALA A 178
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
CMP  A 401 (-2.8A)
 1.13A 1rb2B-3shrA:
undetectable		 1rb2B-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.96A 1rb2B-4qx5A:
undetectable		 1rb2B-4qx5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 264
ALA A 318
ILE A 276
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 1.24A 1rb3A-4qx5A:
undetectable		 1rb3A-4qx5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 1.00A 1rd7A-4qx5A:
undetectable		 1rd7A-4qx5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 194
PHE A 181
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
CMP  A 250 (-2.9A)
 1.06A 1re7A-3ogjA:
undetectable		 1re7A-3ogjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
ILE A 276
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 1.11A 1re7A-4qx5A:
undetectable		 1re7A-4qx5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.94A 1re7A-4qx5A:
undetectable		 1re7A-4qx5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
ILE A 276
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 1.14A 1re7B-4qx5A:
undetectable		 1re7B-4qx5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1o3t CATABOLITE GENE
ACTIVATOR PROTEIN
(Escherichia
coli) 		5 / 12 ILE A  70
GLY A  74
LEU A 116
LEU A  39
TYR A  40
 CMP  A 762 (-4.9A)
CMP  A 762 ( 4.9A)
None
None
None
 1.04A 1rjdA-1o3tA:
undetectable		 1rjdA-1o3tA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1o3t CATABOLITE GENE
ACTIVATOR PROTEIN
(Escherichia
coli) 		5 / 12 ILE A  70
GLY A  74
LEU A 116
LEU A  39
TYR A  40
 CMP  A 762 (-4.9A)
CMP  A 762 ( 4.9A)
None
None
None
 1.02A 1rjdB-1o3tA:
undetectable		 1rjdB-1o3tA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1o3t CATABOLITE GENE
ACTIVATOR PROTEIN
(Escherichia
coli) 		5 / 12 ILE A  70
GLY A  74
LEU A 116
LEU A  39
TYR A  40
 CMP  A 762 (-4.9A)
CMP  A 762 ( 4.9A)
None
None
None
 1.05A 1rjdC-1o3tA:
undetectable		 1rjdC-1o3tA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
None
CMP  A 250 (-2.9A)
 1.23A 1rx2A-3ogjA:
undetectable		 1rx2A-3ogjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.37A 1rx2A-3shrA:
undetectable		 1rx2A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.89A 1rx2A-4qx5A:
undetectable		 1rx2A-4qx5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.99A 1rx7A-4qx5A:
undetectable		 1rx7A-4qx5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		5 / 10 LEU A 251
ALA A 272
ILE A 236
ALA A 261
LEU A 263
 None
None
CMP  A 501 (-3.8A)
CMP  A 501 (-3.5A)
None
 1.20A 1xp0A-5kbfA:
undetectable		 1xp0A-5kbfA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 11 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 1.00A 2blaA-4qx5A:
undetectable		 2blaA-4qx5A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2ptm HYPERPOLARIZATION-AC
TIVATED (IH) CHANNEL
(Strongylocentrot
us
purpuratus) 		4 / 7 GLY A 610
SER A 634
ARG A 620
GLU A 564
 CMP  A 401 (-3.2A)
None
CMP  A 401 (-4.0A)
None
 0.93A 2c8aB-2ptmA:
undetectable		 2c8aB-2ptmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 194
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
CMP  A 250 (-2.9A)
 0.98A 2cd2A-3ogjA:
undetectable		 2cd2A-3ogjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
None
CMP  A 250 (-2.9A)
 1.21A 2d0kA-3ogjA:
undetectable		 2d0kA-3ogjA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.94A 2d0kA-4qx5A:
undetectable		 2d0kA-4qx5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
None
CMP  A 250 (-2.9A)
 1.19A 2d0kB-3ogjA:
undetectable		 2d0kB-3ogjA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.33A 2d0kB-3shrA:
undetectable		 2d0kB-3shrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.91A 2d0kB-4qx5A:
undetectable		 2d0kB-4qx5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Thermus
thermophilus) 		4 / 6 ALA A 130
ASP A 131
GLU A 133
MET A  77
 None
None
None
CMP  A 301 (-4.8A)
 0.85A 2ouzA-4ev0A:
undetectable		 2ouzA-4ev0A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 10 ILE A 146
ALA A 194
PHE A 181
LEU A 204
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
CMP  A 250 (-2.9A)
 1.25A 2w3aB-3ogjA:
undetectable		 2w3aB-3ogjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		4 / 6 GLU A 167
MET A 200
LYS A 104
ILE A 114
 CMP  A 401 (-2.8A)
None
None
None
 1.24A 2w98B-3shrA:
undetectable		 2w98B-3shrA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 2zmf CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens) 		3 / 3 TYR A 362
VAL A 385
THR A 363
 CMP  A2001 ( 4.3A)
None
None
 0.75A 2ygnA-2zmfA:
undetectable		 2ygnA-2zmfA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 3mzh PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
CRP/FNR-FAMILY)
(Mycobacterium
tuberculosis) 		4 / 5 ILE A  83
SER A  82
PRO A  86
PRO A  88
 None
CMP  A 623 (-2.7A)
None
None
 1.42A 3bjwC-3mzhA:
undetectable		 3bjwC-3mzhA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 2zmf CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens) 		5 / 12 ASN A 342
VAL A 385
ALA A 278
ILE A 343
THR A 364
 None
None
None
None
CMP  A2001 (-2.8A)
 1.24A 3dl9B-2zmfA:
undetectable		 3dl9B-2zmfA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		4 / 4 ILE A 146
PHE A 181
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
None
None
CMP  A 250 (-2.9A)
 1.04A 3ia4A-3ogjA:
undetectable		 3ia4A-3ogjA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		4 / 4 ILE A 130
PHE A 165
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
None
None
CMP  A 401 (-2.8A)
 1.14A 3ia4A-3shrA:
undetectable		 3ia4A-3shrA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		4 / 4 ILE A 264
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
None
None
CMP  A 401 (-2.9A)
 0.91A 3ia4A-4qx5A:
undetectable		 3ia4A-4qx5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1vp6 CYCLIC-NUCLEOTIDE
BINDING DOMAIN OF
MESORHIZOBIUM LOTI
CNG POTASSIUM
CHANNEL
(Mesorhizobium
loti) 		4 / 7 GLU A 289
VAL A 282
VAL A 275
ALA A 294
 None
CMP  A 368 (-4.4A)
None
None
 0.91A 3kp6B-1vp6A:
undetectable		 3kp6B-1vp6A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3kcc CATABOLITE GENE
ACTIVATOR
(Escherichia
coli) 		5 / 10 THR A 182
GLY A 184
GLU A 181
LEU A 187
ILE A 143
 None
None
CMP  A 303 ( 4.4A)
None
None
 1.11A 3kvrA-3kccA:
undetectable		 3kvrA-3kccA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3kcc CATABOLITE GENE
ACTIVATOR
(Escherichia
coli) 		5 / 10 THR A 182
GLY A 184
GLU A 181
LEU A 187
ILE A 143
 None
None
CMP  A 303 ( 4.4A)
None
None
 1.15A 3kvrB-3kccA:
undetectable		 3kvrB-3kccA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 2oz6 VIRULENCE FACTOR
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 10 VAL A  99
ILE A  44
ILE A  51
VAL A  91
VAL A  49
 None
None
CMP  A 301 ( 4.1A)
CMP  A 301 ( 4.9A)
None
 1.10A 3me6A-2oz6A:
undetectable		 3me6A-2oz6A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3pna CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 11 ILE A 163
ALA A 211
PHE A 198
LEU A 221
VAL A 162
 CMP  A 250 ( 4.3A)
CMP  A 250 (-3.8A)
None
None
None
 1.09A 3n0hA-3pnaA:
undetectable		 3n0hA-3pnaA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 11 ILE A 163
ALA A 211
PHE A 198
LEU A 221
VAL A 162
 CMP  A 401 ( 4.2A)
CMP  A 401 ( 3.8A)
None
None
None
 1.14A 3n0hA-4mx3A:
undetectable		 3n0hA-4mx3A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3kcc CATABOLITE GENE
ACTIVATOR
(Escherichia
coli) 		5 / 9 THR A 182
GLY A 184
GLU A 181
LEU A 187
ILE A 143
 None
None
CMP  A 303 ( 4.4A)
None
None
 1.13A 3nbqA-3kccA:
undetectable		 3nbqA-3kccA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 2oz6 VIRULENCE FACTOR
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 PHE A  71
ILE A  32
MET A 125
PHE A  42
 None
CMP  A 301 ( 4.3A)
None
None
 1.36A 3octA-2oz6A:
undetectable		 3octA-2oz6A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		3 / 3 ALA A 121
VAL A 120
GLN A  89
 CMP  A 501 ( 4.0A)
None
None
 0.58A 3of4B-1ykdA:
undetectable		 3of4B-1ykdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 1.01A 3qgtA-4qx5A:
undetectable		 3qgtA-4qx5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 1.01A 3qgtB-4qx5A:
undetectable		 3qgtB-4qx5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
ILE A 276
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 1.23A 3ql3A-4qx5A:
undetectable		 3ql3A-4qx5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3pna CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 12 ILE A 163
ALA A 211
PHE A 198
LEU A 221
VAL A 162
 CMP  A 250 ( 4.3A)
CMP  A 250 (-3.8A)
None
None
None
 1.08A 3s3vA-3pnaA:
undetectable		 3s3vA-3pnaA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		5 / 12 ILE A 163
ALA A 211
PHE A 198
LEU A 221
VAL A 162
 CMP  A 401 ( 4.2A)
CMP  A 401 ( 3.8A)
None
None
None
 1.11A 3s3vA-4mx3A:
undetectable		 3s3vA-4mx3A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		5 / 10 ALA A  93
VAL A  72
GLY A  96
ALA A  87
VAL A  89
 None
None
CMP  A 300 (-3.3A)
CMP  A 300 (-3.3A)
None
 0.88A 3t3cB-3gydA:
undetectable		 3t3cB-3gydA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 9 ILE A 146
ALA A 194
PHE A 181
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
CMP  A 250 (-2.9A)
 1.09A 3tq8A-3ogjA:
undetectable		 3tq8A-3ogjA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 9 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.98A 3tq8A-4qx5A:
undetectable		 3tq8A-4qx5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3pna CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		4 / 7 ILE A 163
PHE A 198
MET A 180
PHE A 156
 CMP  A 250 ( 4.3A)
None
None
None
 1.14A 3tvxB-3pnaA:
undetectable		 3tvxB-3pnaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		6 / 10 TYR A  73
TYR A 121
ILE A 172
ALA A 176
GLU A 177
ARG A 180
 CMP  A 901 (-4.1A)
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 ( 4.0A)
CMP  A 901 (-3.9A)
CMP  A 901 (-3.0A)
 0.56A 3u6tA-1lpcA:
27.6		 3u6tA-1lpcA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		4 / 4 LEU A 263
ILE A 217
TYR A 222
TYR A 319
 None
CMP  A 501 ( 4.9A)
None
CMP  A 501 (-3.6A)
 1.37A 3vt7A-5kbfA:
undetectable		 3vt7A-5kbfA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
CMP  A 250 (-2.9A)
 1.23A 4cd2A-3ogjA:
undetectable		 4cd2A-3ogjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 1.00A 4fhbA-4qx5A:
undetectable		 4fhbA-4qx5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 10 ILE A 146
ALA A 194
PHE A 181
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
CMP  A 250 (-2.9A)
 1.06A 4g8zX-3ogjA:
undetectable		 4g8zX-3ogjA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.94A 4g8zX-4qx5A:
undetectable		 4g8zX-4qx5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		5 / 12 ILE A  94
GLY A  92
GLU A  20
LYS A  24
GLU A  97
 None
None
None
None
CMP  A 300 (-2.8A)
 1.23A 4jlgA-3gydA:
undetectable		 4jlgA-3gydA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
None
CMP  A 250 (-2.9A)
 1.30A 4kjlA-3ogjA:
undetectable		 4kjlA-3ogjA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.44A 4kjlA-3shrA:
undetectable		 4kjlA-3shrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.91A 4kjlA-4qx5A:
undetectable		 4kjlA-4qx5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 10 ILE A 146
ALA A 194
PHE A 181
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
CMP  A 250 (-2.9A)
 1.06A 4km0A-3ogjA:
undetectable		 4km0A-3ogjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 10 ILE A 130
ALA A 178
PHE A 165
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
CMP  A 401 (-2.8A)
 1.16A 4km0A-3shrA:
undetectable		 4km0A-3shrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.93A 4km0A-4qx5A:
undetectable		 4km0A-4qx5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 194
PHE A 181
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
CMP  A 250 (-2.9A)
 1.06A 4km0B-3ogjA:
undetectable		 4km0B-3ogjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.94A 4km0B-4qx5A:
undetectable		 4km0B-4qx5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 130
ALA A 178
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
CMP  A 401 (-2.8A)
 1.00A 4km2A-3shrA:
undetectable		 4km2A-3shrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.89A 4km2A-4qx5A:
undetectable		 4km2A-4qx5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 130
ALA A 178
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
CMP  A 401 (-2.8A)
 1.09A 4km2B-3shrA:
undetectable		 4km2B-3shrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.88A 4km2B-4qx5A:
undetectable		 4km2B-4qx5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1ykd ADENYLATE CYCLASE
(Anabaena
sp.) 		4 / 5 ILE A 139
ASP A 136
GLU A 142
VAL A 194
 CMP  A 501 (-4.2A)
None
None
None
 1.16A 4nkxC-1ykdA:
undetectable		 4nkxC-1ykdA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		4 / 5 TYR A  73
TYR A 121
ILE A 172
ARG A 180
 CMP  A 901 (-4.1A)
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 (-3.0A)
 0.20A 4o0oA-1lpcA:
27.7		 4o0oA-1lpcA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 3of1 CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 MET A 300
ILE A 330
ILE A 329
VAL A 381
 None
CMP  A 601 (-4.8A)
None
None
 1.01A 4olmA-3of1A:
undetectable		 4olmA-3of1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 ILE A 340
ALA A 388
PHE A 375
LEU A 352
ILE A 339
 CMP  A 502 ( 4.1A)
CMP  A 502 (-3.5A)
None
None
None
 1.05A 4p3qA-5kbfA:
undetectable		 4p3qA-5kbfA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 11 ILE A 146
ALA A 194
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
CMP  A 250 (-2.9A)
 1.08A 4p66A-3ogjA:
undetectable		 4p66A-3ogjA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 11 ILE A 130
ALA A 178
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
CMP  A 401 (-2.8A)
 1.17A 4p66A-3shrA:
undetectable		 4p66A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 194
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
CMP  A 250 (-2.9A)
 1.10A 4pthA-3ogjA:
undetectable		 4pthA-3ogjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 194
PHE A 181
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
CMP  A 250 (-2.9A)
 0.98A 4ptjA-3ogjA:
undetectable		 4ptjA-3ogjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 130
ALA A 178
PHE A 165
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
CMP  A 401 (-2.8A)
 1.08A 4ptjA-3shrA:
undetectable		 4ptjA-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.88A 4ptjA-4qx5A:
undetectable		 4ptjA-4qx5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		5 / 9 ALA A 176
THR A 175
ALA A 179
VAL A  75
GLY A  66
 CMP  A 901 ( 4.0A)
None
None
None
None
 1.23A 4qvnK-1lpcA:
undetectable
4qvnL-1lpcA:
undetectable		 4qvnK-1lpcA:
23.62
4qvnL-1lpcA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		5 / 9 ALA A 176
THR A 175
ALA A 179
VAL A  75
GLY A  66
 CMP  A 901 ( 4.0A)
None
None
None
None
 1.23A 4qvnY-1lpcA:
undetectable
4qvnZ-1lpcA:
undetectable		 4qvnY-1lpcA:
23.62
4qvnZ-1lpcA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		3 / 3 GLU A 177
ALA A 178
PHE A 181
 CMP  A 901 (-3.9A)
None
None
 0.52A 4v1fA-1lpcA:
0.0		 4v1fA-1lpcA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		3 / 3 GLU A 177
ALA A 178
PHE A 181
 CMP  A 901 (-3.9A)
None
None
 0.49A 4v1fC-1lpcA:
0.0		 4v1fC-1lpcA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4cyd PROBABLE
TRANSCRIPTION
REGULATOR
(Corynebacterium
glutamicum) 		4 / 4 LEU A 126
VAL A 129
GLU A  83
ARG A 133
 None
None
CMP  A1228 (-2.6A)
CMP  A1228 (-4.4A)
 1.18A 4ww7A-4cydA:
undetectable		 4ww7A-4cydA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1o3t CATABOLITE GENE
ACTIVATOR PROTEIN
(Escherichia
coli) 		3 / 3 SER A  46
ALA A  48
VAL A  49
 None
None
CMP  A 762 (-4.5A)
 0.59A 4x20C-1o3tA:
undetectable		 4x20C-1o3tA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
None
CMP  A 250 (-2.9A)
 1.18A 4x5iA-3ogjA:
undetectable		 4x5iA-3ogjA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.32A 4x5iA-3shrA:
undetectable		 4x5iA-3shrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.94A 4x5iA-4qx5A:
undetectable		 4x5iA-4qx5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 194
PHE A 181
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
CMP  A 250 (-2.9A)
 1.08A 4x5jA-3ogjA:
undetectable		 4x5jA-3ogjA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.97A 4x5jA-4qx5A:
undetectable		 4x5jA-4qx5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		5 / 10 LEU A  64
GLY A  96
ASP A  62
SER A  99
ALA A 125
 None
CMP  A 300 (-3.3A)
None
CMP  A 300 (-3.3A)
None
 1.17A 4xj7C-3gydA:
undetectable
4xj7D-3gydA:
undetectable		 4xj7C-3gydA:
23.59
4xj7D-3gydA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 4mx3 CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Bos
taurus) 		4 / 5 ASP A 288
VAL A 281
PHE A 291
GLY A 323
 None
None
None
CMP  A 402 (-3.5A)
 0.98A 4xp6A-4mx3A:
undetectable		 4xp6A-4mx3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		7 / 9 TYR A  73
PHE A  91
TYR A 121
ILE A 172
ALA A 176
GLU A 177
ARG A 180
 CMP  A 901 (-4.1A)
None
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 ( 4.0A)
CMP  A 901 (-3.9A)
CMP  A 901 (-3.0A)
 0.58A 4yp2B-1lpcA:
27.7		 4yp2B-1lpcA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1o3t CATABOLITE GENE
ACTIVATOR PROTEIN
(Escherichia
coli) 		3 / 5 GLY A  74
GLY A  79
GLU A  78
 CMP  A 762 ( 4.9A)
None
None
 0.51A 4z2eA-1o3tA:
undetectable
4z2eD-1o3tA:
undetectable		 4z2eA-1o3tA:
17.25
4z2eD-1o3tA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		7 / 9 TYR A  73
PHE A  91
TYR A 121
ILE A 172
ALA A 176
GLU A 177
ARG A 180
 CMP  A 901 (-4.1A)
None
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 ( 4.0A)
CMP  A 901 (-3.9A)
CMP  A 901 (-3.0A)
 0.57A 5cf9B-1lpcA:
27.7		 5cf9B-1lpcA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 194
PHE A 181
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
CMP  A 250 (-2.9A)
 1.08A 5e8qA-3ogjA:
undetectable		 5e8qA-3ogjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.97A 5e8qA-4qx5A:
undetectable		 5e8qA-4qx5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
None
CMP  A 250 (-2.9A)
 1.27A 5eajA-3ogjA:
undetectable		 5eajA-3ogjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 146
PHE A 181
THR A 198
LEU A 204
ILE A 145
 CMP  A 250 ( 4.2A)
None
None
None
None
 0.95A 5eajA-3ogjA:
undetectable		 5eajA-3ogjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.96A 5eajA-4qx5A:
undetectable		 5eajA-4qx5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 GLU A 422
LEU A 428
LYS A 425
ASP A 439
ALA A 388
 None
CMP  A 502 (-4.3A)
None
None
CMP  A 502 (-3.5A)
 1.20A 5kbwA-5kbfA:
undetectable		 5kbwA-5kbfA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 182
VAL A 163
THR A 198
ALA A 206
LEU A 204
 CMP  A 250 (-3.2A)
None
None
None
None
 1.05A 5kocA-3ogjA:
undetectable		 5kocA-3ogjA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3mzh PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
CRP/FNR-FAMILY)
(Mycobacterium
tuberculosis) 		4 / 7 VAL A  55
ILE A  57
VAL A  37
ALA A  93
 None
CMP  A 623 ( 4.1A)
None
None
 0.68A 5ospA-3mzhA:
undetectable		 5ospA-3mzhA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3mzh PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
CRP/FNR-FAMILY)
(Mycobacterium
tuberculosis) 		4 / 7 VAL A  55
ILE A  57
VAL A  37
ALA A  93
 None
CMP  A 623 ( 4.1A)
None
None
 0.69A 5osrA-3mzhA:
undetectable		 5osrA-3mzhA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 146
PHE A 181
THR A 198
LEU A 204
ILE A 145
 CMP  A 250 ( 4.2A)
None
None
None
None
 0.95A 5ujxA-3ogjA:
undetectable		 5ujxA-3ogjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.41A 5ujxA-3shrA:
undetectable		 5ujxA-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.96A 5ujxA-4qx5A:
undetectable		 5ujxA-4qx5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 4avc LYSINE
ACETYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  79
GLU A 106
LEU A  82
ILE A  60
VAL A 102
 CMP  A 400 (-3.5A)
None
None
None
None
 1.04A 5vlmE-4avcA:
undetectable		 5vlmE-4avcA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		6 / 6 TYR A  73
VAL A  74
TYR A 121
ILE A 172
GLU A 177
ARG A 180
 CMP  A 901 (-4.1A)
CMP  A 901 (-4.0A)
CMP  A 901 (-4.3A)
CMP  A 901 (-4.1A)
CMP  A 901 (-3.9A)
CMP  A 901 (-3.0A)
 0.56A 5z3jA-1lpcA:
28.1		 5z3jA-1lpcA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
None
CMP  A 250 (-2.9A)
 1.25A 5z6jA-3ogjA:
undetectable		 5z6jA-3ogjA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.39A 5z6jA-3shrA:
undetectable		 5z6jA-3shrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.88A 5z6jA-4qx5A:
undetectable		 5z6jA-4qx5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
None
CMP  A 250 (-2.9A)
 1.24A 5z6kA-3ogjA:
undetectable		 5z6kA-3ogjA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.38A 5z6kA-3shrA:
undetectable		 5z6kA-3shrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.90A 5z6kA-4qx5A:
undetectable		 5z6kA-4qx5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3of1 CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 212
ALA A 260
PHE A 247
LEU A 270
ILE A 211
 CMP  A 501 (-4.5A)
CMP  A 501 (-3.5A)
None
None
None
 1.02A 5z6mA-3of1A:
undetectable		 5z6mA-3of1A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		6 / 11 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
None
CMP  A 250 (-2.9A)
 1.12A 5z6mA-3ogjA:
undetectable		 5z6mA-3ogjA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 11 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.25A 5z6mA-3shrA:
undetectable		 5z6mA-3shrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 11 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.97A 5z6mA-4qx5A:
undetectable		 5z6mA-4qx5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1lpc DIANTHIN 30
(Dianthus
caryophyllus) 		3 / 3 TYR A  73
ALA A 179
LEU A 246
 CMP  A 901 (-4.1A)
None
None
 0.59A 6ag0C-1lpcA:
undetectable		 6ag0C-1lpcA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5btx LPG1496
(Legionella
pneumophila) 		5 / 12 ILE A 102
HIS A 106
ASN A 107
SER A  71
TYR A  69
 None
CMP  A 201 (-3.9A)
CMP  A 201 ( 4.2A)
None
CMP  A 201 (-3.6A)
 1.48A 6chgC-5btxA:
undetectable		 6chgC-5btxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN
(Methylobacillus
flagellatus) 		3 / 3 GLU A  97
LEU A 144
ARG A 143
 CMP  A 300 (-2.8A)
None
None
 0.59A 6d8fA-3gydA:
undetectable		 6d8fA-3gydA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5btx LPG1496
(Legionella
pneumophila) 		6 / 12 PHE A  29
VAL A  33
VAL A  93
THR A 108
ALA A  77
TYR A  61
 None
None
None
CMP  A 201 (-3.2A)
None
CMP  A 201 (-3.6A)
 1.49A 6djzC-5btxA:
undetectable		 6djzC-5btxA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY
(Thermus
thermophilus) 		4 / 6 GLY A  49
THR A  95
ILE A  33
PHE A  34
 None
None
None
CMP  A 301 (-4.4A)
 0.88A 6f8cA-4ev0A:
undetectable		 6f8cA-4ev0A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ogj PRKG1 PROTEIN
(Homo
sapiens) 		6 / 12 ILE A 146
ALA A 194
PHE A 181
LEU A 204
ILE A 145
THR A 193
 CMP  A 250 ( 4.2A)
CMP  A 250 (-3.6A)
None
None
None
CMP  A 250 (-2.9A)
 1.24A 7dfrA-3ogjA:
undetectable		 7dfrA-3ogjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.36A 7dfrA-3shrA:
undetectable		 7dfrA-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4qx5 CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 264
ALA A 318
PHE A 305
ILE A 263
THR A 317
 CMP  A 401 (-4.0A)
CMP  A 401 (-3.7A)
None
None
CMP  A 401 (-2.9A)
 0.92A 7dfrA-4qx5A:
undetectable		 7dfrA-4qx5A:
20.48