SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CMO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT
(Hydrogenovibrio
marinus) 		4 / 8 GLY B  20
GLY B  83
HIS A  83
VAL A  78
 None
None
CMO  A 603 (-4.0A)
O  A 609 ( 4.7A)
 0.93A 1dbbH-3ayxB:
undetectable
1dbbL-3ayxB:
undetectable		 1dbbH-3ayxB:
18.56
1dbbL-3ayxB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT
(Hydrogenovibrio
marinus) 		4 / 6 CYH A  79
VAL A  78
HIS A  83
CYH A 593
 O  A 609 (-1.8A)
O  A 609 ( 4.7A)
CMO  A 603 (-4.0A)
FE2  A 601 (-2.2A)
 1.38A 1ekjG-3ayxA:
undetectable
1ekjH-3ayxA:
undetectable		 1ekjG-3ayxA:
16.69
1ekjH-3ayxA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		5 / 11 ALA A 137
LEU A 138
LEU A 134
ILE A  64
ALA A  67
 None
HEM  A 144 ( 4.9A)
None
CMO  A 145 ( 4.0A)
HEM  A 144 (-3.4A)
 0.98A 1ha2A-1spgA:
undetectable		 1ha2A-1spgA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 12 GLY L 300
MET L 376
THR L 152
ILE L 153
PHE L 296
 None
PDT  L 425 (-3.6A)
None
None
CMO  L 431 ( 4.5A)
 1.34A 1p93D-1hfeL:
undetectable		 1p93D-1hfeL:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		5 / 12 HIS B  63
ALA B  27
ILE B 109
VAL B  67
LEU B 142
 CMO  B 149 ( 3.9A)
None
None
HEM  B 148 (-3.9A)
HEM  B 148 (-4.9A)
 1.29A 1udtA-1spgB:
undetectable		 1udtA-1spgB:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 6 ILE A  64
GLY A  61
ALA A  26
HIS A  60
 CMO  A 145 ( 4.0A)
None
None
CMO  A 145 ( 3.9A)
 0.98A 1wmqA-1spgA:
undetectable		 1wmqA-1spgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		4 / 6 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 CMO  A 144 (-4.7A)
None
None
CMO  A 144 ( 3.5A)
 1.00A 1wmqB-1ouuA:
1.1		 1wmqB-1ouuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 6 ILE A  64
GLY A  61
ALA A  26
HIS A  60
 CMO  A 145 ( 4.0A)
None
None
CMO  A 145 ( 3.9A)
 0.98A 1wmqB-1spgA:
undetectable		 1wmqB-1spgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 6 ILE A  64
GLY A  61
ALA A  26
HIS A  60
 CMO  A 145 ( 4.0A)
None
None
CMO  A 145 ( 3.9A)
 1.00A 1wpuA-1spgA:
undetectable		 1wpuA-1spgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 6 ILE A  64
GLY A  61
ALA A  26
HIS A  60
 CMO  A 145 ( 4.0A)
None
None
CMO  A 145 ( 3.9A)
 0.99A 1wpuB-1spgA:
2.2		 1wpuB-1spgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		4 / 6 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 CMO  A 144 (-4.7A)
None
None
CMO  A 144 ( 3.5A)
 0.97A 1wrqA-1ouuA:
1.1		 1wrqA-1ouuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 6 ILE A  64
GLY A  61
ALA A  26
HIS A  60
 CMO  A 145 ( 4.0A)
None
None
CMO  A 145 ( 3.9A)
 0.97A 1wrqA-1spgA:
1.2		 1wrqA-1spgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1ouu HEMOGLOBIN I
(Oncorhynchus
mykiss) 		4 / 6 ILE A  63
GLY A  60
ALA A  26
HIS A  59
 CMO  A 144 (-4.7A)
None
None
CMO  A 144 ( 3.5A)
 0.97A 1wrqB-1ouuA:
1.1		 1wrqB-1ouuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1spg HEMOGLOBIN
(Leiostomus
xanthurus) 		4 / 6 ILE A  64
GLY A  61
ALA A  26
HIS A  60
 CMO  A 145 ( 4.0A)
None
None
CMO  A 145 ( 3.9A)
 0.97A 1wrqB-1spgA:
undetectable		 1wrqB-1spgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		5 / 12 GLN A 388
ALA A 113
ILE A 295
GLU A 304
VAL A 298
 None
None
CMO  A  10 (-4.4A)
None
None
 1.09A 4azsA-1e08A:
undetectable		 4azsA-1e08A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		5 / 12 GLN A 388
ALA A 113
ILE A 295
GLU A 304
VAL A 298
 None
None
CMO  A  10 (-4.4A)
None
None
 1.11A 4azwA-1e08A:
undetectable		 4azwA-1e08A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 8 ASP L 255
SER L 230
THR L 145
GLY L 205
 None
None
CMO  L 431 ( 4.9A)
None
 0.97A 4fo4A-1hfeL:
undetectable		 4fo4A-1hfeL:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 2vv8 SENSOR PROTEIN FIXL
(Bradyrhizobium
japonicum) 		5 / 12 ILE A 165
ILE A 204
LEU A 236
VAL A 222
ILE A 157
 None
HEM  A1258 ( 4.6A)
CMO  A1259 ( 3.7A)
HEM  A1258 (-4.2A)
HEM  A1258 (-3.8A)
 0.92A 4km2A-2vv8A:
undetectable		 4km2A-2vv8A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 2vv8 SENSOR PROTEIN FIXL
(Bradyrhizobium
japonicum) 		5 / 12 ILE A 165
ILE A 204
LEU A 236
VAL A 222
ILE A 157
 None
HEM  A1258 ( 4.6A)
CMO  A1259 ( 3.7A)
HEM  A1258 (-4.2A)
HEM  A1258 (-3.8A)
 0.77A 4km2B-2vv8A:
undetectable		 4km2B-2vv8A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 5 HIS A 117
ALA A 638
SER A 640
GLY A 113
 CMO  A 812 (-4.5A)
None
None
None
 1.10A 5yodB-3cf4A:
undetectable		 5yodB-3cf4A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT
(Methanosarcina
barkeri) 		4 / 5 HIS A 117
ALA A 638
SER A 640
GLY A 113
 CMO  A 812 (-4.5A)
None
None
None
 1.10A 5yodD-3cf4A:
undetectable		 5yodD-3cf4A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 5 LEU A 258
THR A 228
PRO A 108
ARG A 282
 None
None
CMO  A   9 ( 3.8A)
None
 1.37A 6ew0B-1e08A:
0.0		 6ew0B-1e08A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 5 LEU A 258
THR A 228
PRO A 108
ARG A 282
 None
None
CMO  A   9 ( 3.8A)
None
 1.37A 6ew0D-1e08A:
0.0		 6ew0D-1e08A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 5 LEU A 258
THR A 228
PRO A 108
ARG A 282
 None
None
CMO  A   9 ( 3.8A)
None
 1.37A 6ew0H-1e08A:
0.0		 6ew0H-1e08A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
(Desulfovibrio
desulfuricans) 		4 / 5 LEU A 258
THR A 228
PRO A 108
ARG A 282
 None
None
CMO  A   9 ( 3.8A)
None
 1.37A 6ew0I-1e08A:
0.0		 6ew0I-1e08A:
14.29