SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CM5'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 206
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.39A 1c4dA-6cxhA:
undetectable
1c4dB-6cxhA:
undetectable		 1c4dA-6cxhA:
undetectable
1c4dB-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 TRP A 202
VAL A 200
TRP B  87
 None
CM5  A 502 ( 4.9A)
None
 1.30A 1gmkC-6cxhA:
undetectable
1gmkD-6cxhA:
undetectable		 1gmkC-6cxhA:
undetectable
1gmkD-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		4 / 5 LEU A  86
ILE A  73
LEU A  70
SER A  69
 None
None
CM5  A 517 ( 4.6A)
None
 0.87A 2byoA-3k9yA:
undetectable		 2byoA-3k9yA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 202
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.35A 2xdcA-6cxhA:
undetectable
2xdcB-6cxhA:
undetectable		 2xdcA-6cxhA:
undetectable
2xdcB-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 206
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.23A 2xdcA-6cxhA:
undetectable
2xdcB-6cxhA:
undetectable		 2xdcA-6cxhA:
undetectable
2xdcB-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  87
VAL A 200
TRP A 202
 None
CM5  A 502 ( 4.9A)
None
 1.34A 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable		 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  87
VAL A 200
TRP A 206
 None
CM5  A 502 ( 4.9A)
None
 1.22A 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable		 2xdcA-6cxhB:
undetectable
2xdcB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 TRP A 202
VAL A 200
TRP A 206
 None
CM5  A 502 ( 4.9A)
None
 1.35A 2xdcE-6cxhA:
undetectable
2xdcF-6cxhA:
undetectable		 2xdcE-6cxhA:
undetectable
2xdcF-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 202
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.33A 2y5mA-6cxhA:
undetectable
2y5mB-6cxhA:
undetectable		 2y5mA-6cxhA:
undetectable
2y5mB-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 206
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.23A 2y5mA-6cxhA:
undetectable
2y5mB-6cxhA:
undetectable		 2y5mA-6cxhA:
undetectable
2y5mB-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 202
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.33A 2y6nA-6cxhA:
undetectable
2y6nB-6cxhA:
undetectable		 2y6nA-6cxhA:
undetectable
2y6nB-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 206
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.22A 2y6nA-6cxhA:
undetectable
2y6nB-6cxhA:
undetectable		 2y6nA-6cxhA:
undetectable
2y6nB-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  87
VAL A 200
TRP A 202
 None
CM5  A 502 ( 4.9A)
None
 1.32A 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable		 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 TRP B  87
VAL A 200
TRP A 206
 None
CM5  A 502 ( 4.9A)
None
 1.21A 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable		 2y6nA-6cxhB:
undetectable
2y6nB-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		3 / 3 VAL A 200
TRP A 206
TRP B  87
 CM5  A 502 ( 4.9A)
None
None
 1.32A 3zq8A-6cxhA:
undetectable
3zq8B-6cxhA:
undetectable		 3zq8A-6cxhA:
undetectable
3zq8B-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
(Methylomicrobium
alcaliphilum) 		3 / 3 TRP A 202
VAL A 200
TRP A 206
 None
CM5  A 502 ( 4.9A)
None
 1.10A 3zq8A-6cxhA:
undetectable
3zq8B-6cxhA:
undetectable		 3zq8A-6cxhA:
undetectable
3zq8B-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		5 / 12 LEU A  79
GLY A  78
GLY A  77
LEU A 101
MET A  99
 CM5  A 517 ( 4.8A)
None
None
CM5  A 517 ( 4.9A)
None
 1.17A 5uc1A-3k9yA:
undetectable		 5uc1A-3k9yA:
9.98