SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CLU'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IVV_A_DAHA382_1 (AMINE OXIDASE)	2pnc	COPPER AMINE OXIDASE, LIVER ISOZYME (Bos taurus)	7 / 10	TYR A 371 THR A 466 ASP A 471 TYR A 472 HIS A 519 HIS A 521 HIS A 683	None TPQ A 470 ( 4.0A) TPQ A 470 (-3.6A) CLU A 808 (-3.4A) CU A 804 (-3.3A) CU A 804 ( 3.3A) CU A 804 (-3.2A)	0.65A	1ivvA-2pncA: 35.8	1ivvA-2pncA: 24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IVV_B_DAHB382_1 (AMINE OXIDASE)	2pnc	COPPER AMINE OXIDASE, LIVER ISOZYME (Bos taurus)	7 / 10	TYR A 371 THR A 466 ASP A 471 TYR A 472 HIS A 519 HIS A 521 HIS A 683	None TPQ A 470 ( 4.0A) TPQ A 470 (-3.6A) CLU A 808 (-3.4A) CU A 804 (-3.3A) CU A 804 ( 3.3A) CU A 804 (-3.2A)	0.68A	1ivvB-2pncA: 36.8	1ivvB-2pncA: 24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XVA_A_SAMA293_0 (GLYCINE N-METHYLTRANSFERASE)	2pnc	COPPER AMINE OXIDASE, LIVER ISOZYME (Bos taurus)	5 / 12	TYR A 371 THR A 381 SER A 522 ILE A 494 TYR A 472	None None None TPQ A 470 ( 4.8A) CLU A 808 (-3.4A)	1.48A	1xvaA-2pncA: undetectable	1xvaA-2pncA: 16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U15_A_0HKA2001_1 (MUSCARINIC ACETYLCHOLINE RECEPTOR M3,LYSOZYME,MUSCARIN IC ACETYLCHOLINE RECEPTOR M3)	2pnc	COPPER AMINE OXIDASE, LIVER ISOZYME (Bos taurus)	5 / 12	ASP A 385 TRP A 626 THR A 678 ALA A 679 TRP A 474	CLU A 808 (-3.1A) None None None None	1.40A	4u15A-2pncA: undetectable	4u15A-2pncA: 20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BMV_C_VLBC507_1 (TUBULIN BETA CHAIN TUBULIN ALPHA-1B CHAIN)	2pnc	COPPER AMINE OXIDASE, LIVER ISOZYME (Bos taurus)	4 / 6	LYS A 471 TYR A 472 TYR A 525 LEU A 364	CLU A 808 (-3.7A) CLU A 808 (-3.4A) None None	1.27A	5bmvB-2pncA: undetectable	5bmvB-2pncA: 20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_H_PCFH604_0 (CYTOCHROME B-C1 COMPLEX SUBUNIT 8 CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL)	2pnc	COPPER AMINE OXIDASE, LIVER ISOZYME (Bos taurus)	5 / 8	PHE A 624 HIS A 524 GLY A 680 SER A 522 ALA A 369	None None None None CLU A 808 (-3.4A)	1.14A	6hu9H-2pncA: undetectable 6hu9e-2pncA: undetectable	6hu9H-2pncA: 9.17 6hu9e-2pncA: 12.52

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IVV_A_DAHA382_1","AMINE OXIDASE","2pnc","COPPER AMINE OXIDASE, LIVER ISOZYME","Bos taurus",7,"TYR A 371;THR A 466;ASP A 471;TYR A 472;HIS A 519;HIS A 521;HIS A 683","None;TPQ A 470 ( 4.0A);TPQ A 470 (-3.6A);CLU A 808 (-3.4A); CU A 804 (-3.3A); CU A 804 ( 3.3A); CU A 804 (-3.2A)","0.65A","1ivvA-2pncA:35.8",null],["1IVV_B_DAHB382_1","AMINE OXIDASE","2pnc","COPPER AMINE OXIDASE, LIVER ISOZYME","Bos taurus",7,"TYR A 371;THR A 466;ASP A 471;TYR A 472;HIS A 519;HIS A 521;HIS A 683","None;TPQ A 470 ( 4.0A);TPQ A 470 (-3.6A);CLU A 808 (-3.4A); CU A 804 (-3.3A); CU A 804 ( 3.3A); CU A 804 (-3.2A)","0.68A","1ivvB-2pncA:36.8","1ivvA-2pncA:24.29"],["1XVA_A_SAMA293_0","GLYCINE N-METHYLTRANSFERASE","2pnc","COPPER AMINE OXIDASE, LIVER ISOZYME","Bos taurus",5,"TYR A 371;THR A 381;SER A 522;ILE A 494;TYR A 472","None;None;None;TPQ A 470 ( 4.8A);CLU A 808 (-3.4A)","1.48A","1xvaA-2pncA:undetectable","1ivvB-2pncA:24.29"],["4U15_A_0HKA2001_1","MUSCARINIC ACETYLCHOLINE RECEPTOR M3,LYSOZYME,MUSCARINIC ACETYLCHOLINE RECEPTOR M3","2pnc","COPPER AMINE OXIDASE, LIVER ISOZYME","Bos taurus",5,"ASP A 385;TRP A 626;THR A 678;ALA A 679;TRP A 474","CLU A 808 (-3.1A);None;None;None;None","1.40A","4u15A-2pncA:undetectable","1xvaA-2pncA:16.58"],["5BMV_C_VLBC507_1","TUBULIN BETA CHAIN;TUBULIN ALPHA-1B CHAIN","2pnc","COPPER AMINE OXIDASE, LIVER ISOZYME","Bos taurus",4,"LYS A 471;TYR A 472;TYR A 525;LEU A 364","CLU A 808 (-3.7A);CLU A 808 (-3.4A);None;None","1.27A","5bmvB-2pncA:undetectable","4u15A-2pncA:20.05"],["6HU9_H_PCFH604_0","CYTOCHROME B-C1 COMPLEX SUBUNIT 8;CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL","2pnc","COPPER AMINE OXIDASE, LIVER ISOZYME","Bos taurus",5,"PHE A 624;HIS A 524;GLY A 680;SER A 522;ALA A 369","None;None;None;None;CLU A 808 (-3.4A)","1.14A","6hu9H-2pncA:undetectable;6hu9e-2pncA:undetectable","5bmvB-2pncA:20.41"]]