SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CLM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		5 / 12 GLY A 354
LEU A 233
LEU A 236
THR A 362
LEU A  62
 None
None
CLM  A 500 (-4.9A)
None
None
 0.96A 2egvA-4zowA:
undetectable		 2egvA-4zowA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		5 / 12 GLY A 354
LEU A 233
LEU A 236
THR A 362
LEU A  62
 None
None
CLM  A 500 (-4.9A)
None
None
 0.99A 2egvB-4zowA:
undetectable		 2egvB-4zowA:
19.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		8 / 10 TYR A  30
ASN A  33
ASP A  34
LEU A  62
PRO A 154
GLY A 354
GLN A 357
MET A 358
 CLM  A 500 (-4.2A)
CLM  A 500 (-3.5A)
CLM  A 500 (-2.7A)
None
CLM  A 500 ( 4.4A)
None
None
None
 0.61A 4zp0A-4zowA:
68.7		 4zp0A-4zowA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		9 / 10 TYR A  30
ASN A  33
ASP A  34
MET A  58
LEU A  62
PRO A 154
LEU A 236
GLY A 354
GLN A 357
 CLM  A 500 (-4.2A)
CLM  A 500 (-3.5A)
CLM  A 500 (-2.7A)
CLM  A 500 (-4.7A)
None
CLM  A 500 ( 4.4A)
CLM  A 500 (-4.9A)
None
None
 0.30A 4zp0A-4zowA:
68.7		 4zp0A-4zowA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		11 / 11 TYR A  30
ASN A  33
ASP A  34
MET A  58
LEU A  62
GLN A  69
GLY A 123
PRO A 154
LEU A 236
GLN A 357
MET A 358
 CLM  A 500 (-4.2A)
CLM  A 500 (-3.5A)
CLM  A 500 (-2.7A)
CLM  A 500 (-4.7A)
None
None
None
CLM  A 500 ( 4.4A)
CLM  A 500 (-4.9A)
None
None
 0.56A 6euqA-4zowA:
67.8		 6euqA-4zowA:
99.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 4zow MULTIDRUG
TRANSPORTER MDFA
(Escherichia
coli) 		5 / 12 GLY A  64
GLY A 116
LEU A 119
GLY A 364
ASN A  33
 None
None
CLM  A 500 ( 4.7A)
None
CLM  A 500 (-3.5A)
 0.99A 6gngB-4zowA:
undetectable		 6gngB-4zowA:
20.80