SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CLF'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTN_T_TRPT81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	5n6y	NITROGENASE VANADIUM-IRON PROTEIN BETA CHAIN (Azotobacter vinelandii)	5 / 11	THR E 114 THR E 117 ILE E 124 GLY E 53 THR E 77	CLF E 501 (-4.2A) None None CLF E 501 (-3.5A) None	1.01A	1gtnT-5n6yE: undetectable 1gtnU-5n6yE: undetectable	1gtnT-5n6yE: 10.26 1gtnU-5n6yE: 10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X7H_A_PFNA1374_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	1qgu	PROTEIN (NITROGENASE MOLYBDENUM IRON PROTEIN) (Klebsiella pneumoniae)	4 / 6	SER A 81 LYS A 67 TYR A 63 CYH A 61	None None CLF A 505 (-4.8A) CLF A 505 (-2.4A)	1.40A	2x7hA-1qguA: 2.2	2x7hA-1qguA: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X7H_A_PFNA1374_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	4wzb	NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN (Azotobacter vinelandii)	4 / 6	SER A 82 LYS A 68 TYR A 64 CYH A 62	None None CLF A1498 (-4.7A) CLF A1498 (-2.5A)	1.42A	2x7hA-4wzbA: 2.2	2x7hA-4wzbA: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YVL_A_SAMA601_0 (HYPOTHETICAL PROTEIN)	5n6y	NITROGENASE VANADIUM-IRON PROTEIN BETA CHAIN (Azotobacter vinelandii)	5 / 12	THR E 114 ILE E 112 ILE E 111 GLY E 52 ALA E 84	CLF E 501 (-4.2A) None None None None	0.91A	2yvlA-5n6yE: 4.9	2yvlA-5n6yE: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YVL_B_SAMB602_0 (HYPOTHETICAL PROTEIN)	5n6y	NITROGENASE VANADIUM-IRON PROTEIN BETA CHAIN (Azotobacter vinelandii)	5 / 12	THR E 114 ILE E 112 GLY E 52 LEU E 49 ALA E 84	CLF E 501 (-4.2A) None None None None	1.15A	2yvlB-5n6yE: 5.0	2yvlB-5n6yE: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YVL_B_SAMB602_0 (HYPOTHETICAL PROTEIN)	5n6y	NITROGENASE VANADIUM-IRON PROTEIN BETA CHAIN (Azotobacter vinelandii)	5 / 12	THR E 114 ILE E 112 ILE E 111 GLY E 52 ALA E 84	CLF E 501 (-4.2A) None None None None	0.89A	2yvlB-5n6yE: 5.0	2yvlB-5n6yE: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YVL_C_SAMC604_0 (HYPOTHETICAL PROTEIN)	5n6y	NITROGENASE VANADIUM-IRON PROTEIN BETA CHAIN (Azotobacter vinelandii)	5 / 12	THR E 114 ILE E 112 ILE E 111 GLY E 52 ALA E 84	CLF E 501 (-4.2A) None None None None	0.92A	2yvlC-5n6yE: 4.7	2yvlC-5n6yE: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z2E_F_TR6F101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B SYMMETRIZED E-SITE DNA)	4wzb	NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN (Azotobacter vinelandii)	4 / 5	GLY A 188 ARG A 187 GLY A 185 GLU A 184	None None CLF A1498 (-3.5A) None	1.10A	4z2eB-4wzbA: undetectable 4z2eC-4wzbA: 2.9	4z2eB-4wzbA: 22.14 4z2eC-4wzbA: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ECM_A_LEUA602_0 (JASMONIC ACID-AMIDO SYNTHETASE JAR1)	4wn9	NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN (Clostridium pasteurianum)	4 / 5	ALA A 143 THR A 144 TYR A 55 HIS A 74	None CLF A 605 ( 4.6A) CLF A 605 (-4.9A) None	1.23A	5ecmA-4wn9A: undetectable	5ecmA-4wn9A: 23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AG0_C_ACRC607_0 (ALPHA-AMYLASE)	4wn9	NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN (Clostridium pasteurianum)	4 / 6	GLY A 119 ASP A 125 GLY A 75 PRO A 76	None None None CLF A 605 (-3.8A)	0.73A	6ag0C-4wn9A: undetectable	6ag0C-4wn9A: 11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CHG_C_SAMC1101_0 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC)	4wzb	NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN (Azotobacter vinelandii)	5 / 12	ILE A 79 ASN A 113 SER A 152 TYR A 64 LEU A 131	None None None CLF A1498 (-4.7A) None	1.33A	6chgC-4wzbA: undetectable	6chgC-4wzbA: 17.20

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GTN_T_TRPT81_0","TRP RNA-BINDING ATTENUATION PROTEIN","5n6y","NITROGENASE VANADIUM-IRON PROTEIN BETA CHAIN","Azotobacter vinelandii",5,"THR E 114;THR E 117;ILE E 124;GLY E  53;THR E  77","CLF E 501 (-4.2A);None;None;CLF E 501 (-3.5A);None","1.01A","1gtnT-5n6yE:undetectable;1gtnU-5n6yE:undetectable",null],["2X7H_A_PFNA1374_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","1qgu","PROTEIN (NITROGENASE MOLYBDENUM IRON PROTEIN)","Klebsiella pneumoniae",4,"SER A  81;LYS A  67;TYR A  63;CYH A  61","None;None;CLF A 505 (-4.8A);CLF A 505 (-2.4A)","1.40A","2x7hA-1qguA:2.2","1gtnT-5n6yE:10.26;1gtnU-5n6yE:10.26"],["2X7H_A_PFNA1374_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","4wzb","NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN","Azotobacter vinelandii",4,"SER A  82;LYS A  68;TYR A  64;CYH A  62","None;None;CLF A1498 (-4.7A);CLF A1498 (-2.5A)","1.42A","2x7hA-4wzbA:2.2","2x7hA-1qguA:21.84"],["2YVL_A_SAMA601_0","HYPOTHETICAL PROTEIN","5n6y","NITROGENASE VANADIUM-IRON PROTEIN BETA CHAIN","Azotobacter vinelandii",5,"THR E 114;ILE E 112;ILE E 111;GLY E  52;ALA E  84","CLF E 501 (-4.2A);None;None;None;None","0.91A","2yvlA-5n6yE:4.9","2x7hA-4wzbA:22.22"],["2YVL_B_SAMB602_0","HYPOTHETICAL PROTEIN","5n6y","NITROGENASE VANADIUM-IRON PROTEIN BETA CHAIN","Azotobacter vinelandii",5,"THR E 114;ILE E 112;GLY E  52;LEU E  49;ALA E  84","CLF E 501 (-4.2A);None;None;None;None","1.15A","2yvlB-5n6yE:5.0","2yvlA-5n6yE:20.83"],["2YVL_B_SAMB602_0","HYPOTHETICAL PROTEIN","5n6y","NITROGENASE VANADIUM-IRON PROTEIN BETA CHAIN","Azotobacter vinelandii",5,"THR E 114;ILE E 112;ILE E 111;GLY E  52;ALA E  84","CLF E 501 (-4.2A);None;None;None;None","0.89A","2yvlB-5n6yE:5.0","2yvlB-5n6yE:20.83"],["2YVL_C_SAMC604_0","HYPOTHETICAL PROTEIN","5n6y","NITROGENASE VANADIUM-IRON PROTEIN BETA CHAIN","Azotobacter vinelandii",5,"THR E 114;ILE E 112;ILE E 111;GLY E  52;ALA E  84","CLF E 501 (-4.2A);None;None;None;None","0.92A","2yvlC-5n6yE:4.7","2yvlB-5n6yE:20.83"],["4Z2E_F_TR6F101_1","DNA GYRASE SUBUNIT A;DNA GYRASE SUBUNIT B;SYMMETRIZED E-SITE DNA","4wzb","NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN","Azotobacter vinelandii",4,"GLY A 188;ARG A 187;GLY A 185;GLU A 184","None;None;CLF A1498 (-3.5A);None","1.10A","4z2eB-4wzbA:undetectable;4z2eC-4wzbA:2.9","2yvlC-5n6yE:20.83"],["5ECM_A_LEUA602_0","JASMONIC ACID-AMIDO SYNTHETASE JAR1","4wn9","NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN","Clostridium pasteurianum",4,"ALA A 143;THR A 144;TYR A  55;HIS A  74","None;CLF A 605 ( 4.6A);CLF A 605 (-4.9A);None","1.23A","5ecmA-4wn9A:undetectable","4z2eB-4wzbA:22.14;4z2eC-4wzbA:20.60"],["6AG0_C_ACRC607_0","ALPHA-AMYLASE","4wn9","NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN","Clostridium pasteurianum",4,"GLY A 119;ASP A 125;GLY A  75;PRO A  76","None;None;None;CLF A 605 (-3.8A)","0.73A","6ag0C-4wn9A:undetectable","5ecmA-4wn9A:23.70"],["6CHG_C_SAMC1101_0","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC","4wzb","NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN","Azotobacter vinelandii",5,"ILE A  79;ASN A 113;SER A 152;TYR A  64;LEU A 131","None;None;None;CLF A1498 (-4.7A);None","1.33A","6chgC-4wzbA:undetectable","6ag0C-4wn9A:11.34"]]