SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CLA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4xk8 CHLOROPHYLL A-B
BINDING PROTEIN 3,
CHLOROPLASTIC
(Pisum
sativum) 		5 / 11 ARG 3 226
LEU 3  62
LEU 3  51
ALA 3  54
PHE 3  72
 CLA  3 302 ( 3.4A)
CLA  3 302 (-4.0A)
None
None
XAT  3 317 ( 4.3A)
 1.37A 1cmaA-4xk83:
undetectable
1cmaB-4xk83:
undetectable		 1cmaA-4xk83:
14.35
1cmaB-4xk83:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 4xk8 CHLOROPHYLL A-B
BINDING PROTEIN 3,
CHLOROPLASTIC
(Pisum
sativum) 		5 / 10 ARG 3 226
LEU 3  62
LEU 3  51
ALA 3  54
PHE 3  72
 CLA  3 302 ( 3.4A)
CLA  3 302 (-4.0A)
None
None
XAT  3 317 ( 4.3A)
 1.43A 1cmcA-4xk83:
undetectable
1cmcB-4xk83:
undetectable		 1cmcA-4xk83:
14.35
1cmcB-4xk83:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		4 / 8 MET b 129
PHE b 124
THR b  61
LEU b 142
 ECH  b1847 (-3.7A)
ECH  b1847 (-4.5A)
CLA  b1831 ( 3.3A)
ECH  b1847 ( 4.4A)
 1.21A 1ea1A-5oy0b:
undetectable		 1ea1A-5oy0b:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 8 PHE B 250
SER D 155
ILE D 159
LEU B 460
LEU D 291
 CLA  B1010 ( 3.7A)
CLA  D1004 ( 4.7A)
DGD  B1058 (-4.5A)
DGD  B1058 (-3.6A)
DGD  B1058 ( 4.6A)
 1.24A 1eupA-3a0hB:
undetectable		 1eupA-3a0hB:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT VI,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 7 THR H  66
LEU H  64
GLY H  61
LEU H  59
 None
CLA  H1079 ( 3.9A)
None
None
 1.05A 1gtiD-2wscH:
undetectable		 1gtiD-2wscH:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT VI,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 7 THR H  66
LEU H  64
GLY H  61
LEU H  59
 None
CLA  H1079 ( 3.9A)
None
None
 0.95A 1gtiE-2wscH:
undetectable		 1gtiE-2wscH:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1ppr PERIDININ-CHLOROPHYL
L PROTEIN
(Amphidinium
carterae) 		4 / 8 GLY M  71
ILE M  73
ILE M 207
ILE M 211
 None
PID  M 614 (-4.4A)
PID  M 612 (-4.1A)
CLA  M 601 (-4.1A)
 0.72A 1hshD-1pprM:
undetectable		 1hshD-1pprM:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 TRP B 582
ASN B 585
LEU B 434
GLY B 430
TYR B 437
 CLA  A9012 ( 3.5A)
CLA  A9012 (-3.7A)
CLA  A9012 ( 3.9A)
CLA  A9013 (-3.4A)
CLA  B9010 (-4.6A)
 0.97A 1hvyA-4rkuB:
undetectable		 1hvyA-4rkuB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 12 TRP b 579
ASN b 582
LEU b 432
GLY b 428
TYR b 435
 None
None
CLA  b1806 (-4.3A)
None
CLA  b1806 ( 4.4A)
 1.05A 1hvyA-5oy0b:
undetectable		 1hvyA-5oy0b:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 TRP B 582
ASN B 585
LEU B 434
GLY B 430
TYR B 437
 CLA  A9012 ( 3.5A)
CLA  A9012 (-3.7A)
CLA  A9012 ( 3.9A)
CLA  A9013 (-3.4A)
CLA  B9010 (-4.6A)
 1.00A 1hvyB-4rkuB:
undetectable		 1hvyB-4rkuB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 12 TRP b 579
ASN b 582
LEU b 432
GLY b 428
TYR b 435
 None
None
CLA  b1806 (-4.3A)
None
CLA  b1806 ( 4.4A)
 1.08A 1hvyB-5oy0b:
undetectable		 1hvyB-5oy0b:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 11 TRP B 582
ASN B 585
LEU B 434
GLY B 430
TYR B 437
 CLA  A9012 ( 3.5A)
CLA  A9012 (-3.7A)
CLA  A9012 ( 3.9A)
CLA  A9013 (-3.4A)
CLA  B9010 (-4.6A)
 1.01A 1hvyC-4rkuB:
undetectable		 1hvyC-4rkuB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 11 TRP b 579
ASN b 582
LEU b 432
GLY b 428
TYR b 435
 None
None
CLA  b1806 (-4.3A)
None
CLA  b1806 ( 4.4A)
 1.08A 1hvyC-5oy0b:
undetectable		 1hvyC-5oy0b:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 TRP B 582
ASN B 585
LEU B 434
GLY B 430
TYR B 437
 CLA  A9012 ( 3.5A)
CLA  A9012 (-3.7A)
CLA  A9012 ( 3.9A)
CLA  A9013 (-3.4A)
CLA  B9010 (-4.6A)
 0.89A 1hvyD-4rkuB:
undetectable		 1hvyD-4rkuB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 12 TRP b 579
ASN b 582
LEU b 432
GLY b 428
TYR b 435
 None
None
CLA  b1806 (-4.3A)
None
CLA  b1806 ( 4.4A)
 0.98A 1hvyD-5oy0b:
undetectable		 1hvyD-5oy0b:
15.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		9 / 9 MET A 691
PHE A 692
SER A 695
GLY A 696
ARG A 697
TRP A 700
ALA A 724
LEU A 725
GLY A 730
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
PQN  A5001 ( 4.1A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 0.31A 1jb0A-4rkuA:
46.3		 1jb0A-4rkuA:
83.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		7 / 9 MET B 662
PHE B 663
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.48A 1jb0A-4rkuB:
35.5		 1jb0A-4rkuB:
42.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		9 / 9 MET 1 684
PHE 1 685
SER 1 688
GLY 1 689
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
GLY 1 723
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
PQN  1 842 ( 4.3A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 0.32A 1jb0A-5oy01:
47.1		 1jb0A-5oy01:
85.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		7 / 9 MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.60A 1jb0A-5oy0b:
34.8		 1jb0A-5oy0b:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.84A 1jb0A-6fosB:
27.3		 1jb0A-6fosB:
6.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		9 / 11 TRP A  55
MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ILE A 704
ALA A 724
LEU A 725
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
CLA  A1139 ( 4.5A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.59A 1jb0B-4rkuA:
33.6		 1jb0B-4rkuA:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		11 / 11 TRP B  22
MET B 662
PHE B 663
SER B 666
TRP B 667
ARG B 668
TRP B 671
ILE B 675
ALA B 699
LEU B 700
ALA B 705
 CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
CLA  B1238 (-3.9A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.26A 1jb0B-4rkuB:
43.5		 1jb0B-4rkuB:
78.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		9 / 11 TRP 1  49
MET 1 684
PHE 1 685
SER 1 688
ARG 1 690
TRP 1 693
ILE 1 697
ALA 1 717
LEU 1 718
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
None
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.44A 1jb0B-5oy01:
33.9		 1jb0B-5oy01:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		11 / 11 TRP b  22
MET b 659
PHE b 660
SER b 663
TRP b 664
ARG b 665
TRP b 668
ILE b 672
ALA b 696
LEU b 697
ALA b 702
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
None
PQN  b1844 ( 3.4A)
CLA  b1841 (-4.6A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.36A 1jb0B-5oy0b:
44.4		 1jb0B-5oy0b:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		9 / 11 TRP B  22
MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
 None
PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.76A 1jb0B-6fosB:
32.3		 1jb0B-6fosB:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		9 / 11 TRP B  22
MET B 660
PHE B 661
SER B 664
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 None
PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.65A 1jb0B-6fosB:
32.3		 1jb0B-6fosB:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.87A 1jnoA-5zgb3:
undetectable		 1jnoA-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.86A 1jnoB-5zgb3:
undetectable		 1jnoB-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2o01 PSI LIGHT-HARVESTING
ANTENNA CHLOROPHYLL
A/B-BINDING PROTEIN
(Pisum
sativum) 		5 / 11 GLY 4 177
PRO 4 178
GLY 4 166
GLN 4 170
LEU 4 162
 None
None
CLA  44003 ( 3.8A)
CLA  44003 (-3.1A)
CLA  44003 (-4.7A)
 1.24A 1jzsA-2o014:
undetectable		 1jzsA-2o014:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		3 / 3 ALA b 708
HIS b 709
VAL b 712
 CLA  b1842 ( 3.9A)
CLA  b1842 (-3.9A)
LMG  b1851 (-4.5A)
 0.37A 1lqtB-5oy0b:
undetectable		 1lqtB-5oy0b:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		3 / 3 ALA b 708
HIS b 709
VAL b 712
 CLA  b1842 ( 3.9A)
CLA  b1842 (-3.9A)
LMG  b1851 (-4.5A)
 0.38A 1lquB-5oy0b:
undetectable		 1lquB-5oy0b:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.92A 1magA-5zgb3:
undetectable		 1magA-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.92A 1magB-5zgb3:
undetectable		 1magB-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 4 HIS B 389
ALA B 388
PHE B 387
GLY B 335
 CLA  B1226 (-4.0A)
CLA  B1226 ( 4.2A)
BCR  B6010 ( 3.2A)
BCR  B6010 ( 4.3A)
 1.11A 1mj2B-4rkuB:
undetectable		 1mj2B-4rkuB:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 4 HIS B 389
ALA B 388
PHE B 387
GLY B 335
 CLA  B1226 (-4.0A)
CLA  B1226 ( 4.2A)
BCR  B6010 ( 3.2A)
BCR  B6010 ( 4.3A)
 1.06A 1mj2D-4rkuB:
undetectable		 1mj2D-4rkuB:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		4 / 4 HIS b 387
ALA b 386
PHE b 385
GLY b 333
 CLA  b1832 (-3.9A)
CLA  b1832 ( 3.9A)
BCR  b1848 ( 3.3A)
BCR  b1848 ( 4.4A)
 1.11A 1mj2D-5oy0b:
undetectable		 1mj2D-5oy0b:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		4 / 4 HIS B 387
ALA B 386
PHE B 385
GLY B 333
 CLA  B1226 (-4.1A)
CLA  B1226 ( 4.4A)
BCR  B4008 (-4.8A)
BCR  B4008 ( 4.6A)
 1.39A 1mj2D-6fosB:
undetectable		 1mj2D-6fosB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 4 HIS B 389
ALA B 388
PHE B 387
GLY B 335
 CLA  B1226 (-4.0A)
CLA  B1226 ( 4.2A)
BCR  B6010 ( 3.2A)
BCR  B6010 ( 4.3A)
 1.09A 1mjoB-4rkuB:
undetectable		 1mjoB-4rkuB:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 4 HIS B 389
ALA B 388
PHE B 387
GLY B 335
 CLA  B1226 (-4.0A)
CLA  B1226 ( 4.2A)
BCR  B6010 ( 3.2A)
BCR  B6010 ( 4.3A)
 1.09A 1mjoA-4rkuB:
undetectable		 1mjoA-4rkuB:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		4 / 4 HIS b 387
ALA b 386
PHE b 385
GLY b 333
 CLA  b1832 (-3.9A)
CLA  b1832 ( 3.9A)
BCR  b1848 ( 3.3A)
BCR  b1848 ( 4.4A)
 1.14A 1mjoA-5oy0b:
undetectable		 1mjoA-5oy0b:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 4 HIS B 389
ALA B 388
PHE B 387
GLY B 335
 CLA  B1226 (-4.0A)
CLA  B1226 ( 4.2A)
BCR  B6010 ( 3.2A)
BCR  B6010 ( 4.3A)
 1.09A 1mjoD-4rkuB:
undetectable		 1mjoD-4rkuB:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.91A 1ng8A-5zgb3:
undetectable		 1ng8A-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.90A 1ng8B-5zgb3:
undetectable		 1ng8B-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.93A 1nrmA-5zgb3:
undetectable		 1nrmA-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.92A 1nrmB-5zgb3:
undetectable		 1nrmB-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.85A 1nruA-5zgb3:
undetectable		 1nruA-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		3 / 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.85A 1nruB-5zgb3:
undetectable		 1nruB-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		5 / 12 LEU A 346
PHE A 417
ILE A 349
TYR A 428
TYR A 422
 CLA  A1122 ( 4.7A)
BCR  A6007 ( 4.3A)
None
None
None
 1.46A 1osvB-4rkuA:
undetectable		 1osvB-4rkuA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		5 / 12 LEU A 346
PHE A 417
ILE A 349
TYR A 428
TYR A 422
 CLA  A1122 ( 4.7A)
BCR  A6007 ( 4.3A)
None
None
None
 1.50A 1ot7B-4rkuA:
undetectable		 1ot7B-4rkuA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 5 LEU B 518
TRP B 596
LEU B 616
GLN B 452
 None
None
CLA  A9012 (-4.1A)
None
 1.32A 1p93D-4rkuB:
undetectable		 1p93D-4rkuB:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		4 / 5 LEU b 515
TRP b 593
LEU b 613
GLN b 450
 None
None
CLA  b1806 (-4.7A)
None
 1.29A 1p93D-5oy0b:
undetectable		 1p93D-5oy0b:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 ALA B 204
VAL B 208
ALA B 205
HIS B 202
 CLA  B1010 ( 3.7A)
CLA  B1010 (-4.4A)
CLA  B1010 (-3.6A)
CLA  B1011 (-3.7A)
 1.18A 1q23A-3a0hB:
undetectable		 1q23A-3a0hB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 ALA B 204
VAL B 208
ALA B 205
HIS B 202
 CLA  B1010 ( 3.7A)
CLA  B1010 (-4.4A)
CLA  B1010 (-3.6A)
CLA  B1011 (-3.7A)
 1.10A 1q23F-3a0hB:
undetectable		 1q23F-3a0hB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		4 / 4 ALA A 414
VAL A 560
ALA A 415
HIS A 355
 BCR  A6007 ( 3.8A)
None
None
CLA  A1103 (-3.6A)
 1.23A 1q23F-4rkuA:
undetectable		 1q23F-4rkuA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		3 / 3 VAL B 280
ALA B 277
HIS B 274
 None
CLA  B1214 (-3.4A)
CLA  B1215 (-3.4A)
 0.74A 1q23G-6fosB:
undetectable		 1q23G-6fosB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 4 ALA B 204
VAL B 208
ALA B 205
HIS B 202
 CLA  B1010 ( 3.7A)
CLA  B1010 (-4.4A)
CLA  B1010 (-3.6A)
CLA  B1011 (-3.7A)
 1.12A 1q23K-3a0hB:
undetectable		 1q23K-3a0hB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		3 / 3 VAL B 280
ALA B 277
HIS B 274
 None
CLA  B1214 (-3.4A)
CLA  B1215 (-3.4A)
 0.77A 1q23L-6fosB:
undetectable		 1q23L-6fosB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5zgb LHCR3
(Cyanidioschyzon
merolae) 		4 / 6 PRO 3  17
LYS 3  13
GLU 3  31
GLU 3  33
 None
None
None
CLA  3 203 (-3.2A)
 1.16A 1qhyA-5zgb3:
undetectable		 1qhyA-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY 1 408
HIS 1 407
SER 1  69
ASP 1 415
VAL 1 553
 BCR  1 847 (-3.6A)
CLA  1 830 (-3.9A)
CLA  1 825 ( 4.1A)
None
BCR  1 848 (-4.8A)
 1.29A 1qu3A-5oy01:
undetectable		 1qu3A-5oy01:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 TYR C 297
LEU C  95
VAL C 185
VAL C 176
LEU C 202
 CLA  C 503 ( 4.7A)
CLA  C 503 (-4.1A)
None
None
None
 1.22A 1rk3A-5mdxC:
undetectable		 1rk3A-5mdxC:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 3jcu CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 8 PHE G  58
TYR G  35
LEU G  36
GLY G  42
 CLA  G 602 ( 4.9A)
None
CLA  G 602 (-4.1A)
CLA  G 602 (-4.4A)
 1.01A 1rmtC-3jcuG:
undetectable		 1rmtC-3jcuG:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 PHE G  92
TYR G  69
LEU G  70
GLY G  76
 CLA  G 602 (-4.5A)
None
CLA  G 602 (-4.1A)
CLA  G 602 (-4.8A)
 0.93A 1rmtC-5mdxG:
undetectable		 1rmtC-5mdxG:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Zea
mays) 		4 / 8 PHE Y  54
TYR Y  31
LEU Y  32
GLY Y  38
 CLA  Y 602 (-4.7A)
None
CLA  Y 602 (-4.0A)
CLA  Y 602 (-4.5A)
 1.00A 1rmtC-5zjiY:
undetectable		 1rmtC-5zjiY:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		3 / 3 LEU A 359
HIS A 390
ILE A 393
 CLA  A1117 ( 4.7A)
CLA  A1127 (-4.0A)
CLA  A1127 (-4.3A)
 0.72A 1s9pB-6fosA:
undetectable		 1s9pB-6fosA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		3 / 3 LEU B 180
HIS B 275
ILE B 278
 CLA  B1210 (-3.6A)
CLA  B1215 (-4.0A)
CLA  B1215 ( 4.9A)
 0.69A 1s9pB-6fosB:
undetectable		 1s9pB-6fosB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 LEU C 437
ALA C 278
LEU C 276
SER C 273
 CLA  C 501 ( 4.6A)
CLA  C 507 ( 3.7A)
CLA  C 508 (-4.9A)
CLA  C 505 ( 4.2A)
 1.14A 1tt6B-5mdxC:
undetectable		 1tt6B-5mdxC:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 7 LEU B 371
HIS B  89
TYR B 117
HIS B  67
 CLA  B1225 ( 4.4A)
CLA  B1205 ( 3.9A)
None
CLA  B1204 (-4.1A)
 1.18A 1v55C-4rkuB:
2.9
1v55N-4rkuB:
undetectable
1v55P-4rkuB:
2.9		 1v55C-4rkuB:
16.14
1v55N-4rkuB:
22.74
1v55P-4rkuB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 LEU B  69
THR B 262
LEU B 158
GLY B 154
HIS B 202
 CLA  B1014 (-3.6A)
CLA  B1011 (-3.7A)
None
None
CLA  B1011 (-3.7A)
 1.37A 1v8bA-3a0hB:
undetectable		 1v8bA-3a0hB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 LEU B  69
THR B 262
LEU B 158
GLY B 154
HIS B 202
 CLA  B1014 (-3.6A)
CLA  B1011 (-3.7A)
None
None
CLA  B1011 (-3.7A)
 1.42A 1v8bB-3a0hB:
undetectable		 1v8bB-3a0hB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 LEU B  69
THR B 262
LEU B 158
GLY B 154
HIS B 202
 CLA  B1014 (-3.6A)
CLA  B1011 (-3.7A)
None
None
CLA  B1011 (-3.7A)
 1.38A 1v8bD-3a0hB:
undetectable		 1v8bD-3a0hB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 6 VAL A 551
LEU A 554
MET B 662
SER B 666
 None
CLA  B9023 (-4.5A)
CLA  B9023 ( 3.3A)
PQN  B5002 (-3.2A)
 1.04A 1wrlB-4rkuA:
undetectable		 1wrlB-4rkuA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		5 / 11 VAL A 553
THR A 552
ALA A 363
ILE A 360
ALA A 414
 BCR  A6008 (-3.9A)
CLA  A1124 (-3.5A)
BCR  A6008 (-3.7A)
BCR  A6007 ( 4.5A)
BCR  A6007 ( 3.8A)
 1.15A 2admB-4rkuA:
undetectable		 2admB-4rkuA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2o01 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLAST
(Spinacia
oleracea) 		4 / 8 PHE L 143
LEU L  95
LEU L  64
LEU L  63
 None
None
None
CLA  L1502 (-4.2A)
 1.01A 2bfpB-2o01L:
undetectable		 2bfpB-2o01L:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 4 VAL A 408
LEU B 674
ILE A 443
LEU A 446
 CLA  A1128 ( 4.6A)
None
None
CLA  A1137 ( 3.6A)
 0.99A 2byoA-4rkuA:
undetectable		 2byoA-4rkuA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Zea
mays;
Zea
mays) 		4 / 6 SER 2  95
SER 2  72
GLN 3 166
ASP 2  89
 None
None
None
CLA  2 602 ( 3.4A)
 1.17A 2cl5B-5zji2:
undetectable		 2cl5B-5zji2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA602_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		4 / 5 ILE A 136
LYS A 108
PRO A 381
ASP A 379
 CLA  A1106 (-3.4A)
None
None
None
 0.97A 2f7fA-6fosA:
undetectable		 2f7fA-6fosA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		5 / 12 GLN A 634
PHE A 529
VAL A 531
HIS A 532
ALA A 633
 None
None
None
CLA  A1135 (-4.3A)
None
 1.16A 2g70B-6fosA:
undetectable		 2g70B-6fosA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		6 / 12 THR A 480
GLN A 644
PHE A 539
LEU A 484
VAL A 541
HIS A 542
 None
None
CLA  A1136 (-4.7A)
None
None
CLA  A1136 ( 3.3A)
 1.48A 2g72B-4rkuA:
undetectable		 2g72B-4rkuA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		5 / 12 GLN A 634
PHE A 529
VAL A 531
HIS A 532
ALA A 633
 None
None
None
CLA  A1135 (-4.3A)
None
 1.23A 2g72B-6fosA:
undetectable		 2g72B-6fosA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		5 / 12 MET A 418
ALA A 356
SER A 359
LEU A 432
ILE A 349
 None
BCR  A6007 ( 3.8A)
BCR  A6008 ( 3.7A)
CLA  A1122 ( 4.8A)
None
 1.15A 2h77A-4rkuA:
undetectable		 2h77A-4rkuA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H9T_H_SVRH301_1
(THROMBIN)		 5zgb LHCR1
(Cyanidioschyzon
merolae) 		5 / 11 PRO 1  13
ARG 1  29
VAL 1  36
GLN 1  40
GLU 1 113
 None
None
None
CLA  1 602 (-4.0A)
None
 1.30A 2h9tH-5zgb1:
undetectable		 2h9tH-5zgb1:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 TYR C 297
LEU C  95
VAL C 185
VAL C 176
LEU C 202
 CLA  C 503 ( 4.7A)
CLA  C 503 (-4.1A)
None
None
None
 1.30A 2hc4A-5mdxC:
undetectable		 2hc4A-5mdxC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5zgb LHCR1
PSAF
(Cyanidioschyzon
merolae;
Cyanidioschyzon
merolae) 		4 / 5 SER F 156
VAL F 124
VAL 1 107
SER F 127
 None
CLA  F 302 ( 4.8A)
None
None
 1.34A 2j9cA-5zgbF:
undetectable
2j9cB-5zgbF:
undetectable
2j9cC-5zgbF:
undetectable		 2j9cA-5zgbF:
undetectable
2j9cB-5zgbF:
undetectable
2j9cC-5zgbF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 3jcu CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 GLU G  65
LEU G 155
TYR G 156
MET G 188
ARG G 185
 CLA  G 602 (-2.7A)
None
CLA  G 610 (-3.9A)
CLA  G 602 ( 3.3A)
CLA  G 602 (-3.2A)
 1.43A 2jj8B-3jcuG:
undetectable		 2jj8B-3jcuG:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		6 / 8 MET A 691
PHE A 692
SER A 695
TRP A 700
ALA A 724
LEU A 725
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 1.08A 2o01A-4rkuA:
41.5		 2o01A-4rkuA:
99.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 8 MET B 662
PHE B 663
SER B 666
TRP B 671
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.7A)
 1.25A 2o01A-4rkuB:
29.2		 2o01A-4rkuB:
44.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 8 MET B 662
SER B 666
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 1.15A 2o01A-4rkuB:
29.2		 2o01A-4rkuB:
44.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		6 / 8 MET 1 684
PHE 1 685
SER 1 688
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 1.00A 2o01A-5oy01:
35.0		 2o01A-5oy01:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		5 / 8 TRP 1  49
MET 1 684
PHE 1 685
SER 1 688
LEU 1 718
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
PQN  1 842 ( 3.6A)
 1.15A 2o01A-5oy01:
35.0		 2o01A-5oy01:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 8 MET b 659
PHE b 660
SER b 663
TRP b 668
LEU b 697
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
PQN  b1844 ( 3.4A)
PQN  b1844 ( 3.8A)
 1.15A 2o01A-5oy0b:
29.0		 2o01A-5oy0b:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 8 MET b 659
SER b 663
TRP b 668
ALA b 696
LEU b 697
 CLA  b1807 ( 3.2A)
PQN  b1844 (-3.7A)
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 1.08A 2o01A-5oy0b:
29.0		 2o01A-5oy0b:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		6 / 8 TRP B  22
MET B 660
PHE B 661
SER B 664
TRP B 669
ALA B 697
 None
PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
 1.11A 2o01A-6fosB:
24.5		 2o01A-6fosB:
7.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O01_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		7 / 9 MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.86A 2o01B-4rkuA:
26.4		 2o01B-4rkuA:
45.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O01_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		9 / 9 MET B 662
PHE B 663
SER B 666
TRP B 667
ARG B 668
TRP B 671
ALA B 699
LEU B 700
ALA B 705
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.82A 2o01B-4rkuB:
28.9		 2o01B-4rkuB:
98.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		6 / 9 MET 1 684
PHE 1 685
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
 0.77A 2o01B-5oy01:
23.4		 2o01B-5oy01:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		6 / 9 MET 1 684
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.83A 2o01B-5oy01:
23.4		 2o01B-5oy01:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		8 / 9 MET b 659
PHE b 660
SER b 663
TRP b 664
ARG b 665
TRP b 668
ALA b 696
ALA b 702
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 (-3.1A)
 0.80A 2o01B-5oy0b:
29.9		 2o01B-5oy0b:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ALA B 697
ALA B 703
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.4A)
 1.01A 2o01B-6fosB:
23.4		 2o01B-6fosB:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 9 PHE B 661
SER B 664
TRP B 665
ARG B 666
TRP B 669
ALA B 697
LEU B 698
ALA B 703
 PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 1.32A 2o01B-6fosB:
23.4		 2o01B-6fosB:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3iiu PERIDININ-CHLOROPHYL
L A-BINDING PROTEIN
1, CHLOROPLASTIC
(Amphidinium
carterae) 		4 / 5 LEU M  58
ALA M  91
LEU M  92
MET M  50
 None
None
CLA  M 601 ( 4.3A)
PID  M 613 ( 3.8A)
 1.25A 2oaxA-3iiuM:
undetectable		 2oaxA-3iiuM:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Zea
mays) 		4 / 5 PRO 1  64
ILE 1 193
GLY 1  65
LYS 1  85
 None
None
CLA  1 602 (-4.6A)
None
 1.18A 2qeuA-5zji1:
undetectable
2qeuC-5zji1:
undetectable		 2qeuA-5zji1:
undetectable
2qeuC-5zji1:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSC_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		8 / 9 MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
GLY A 730
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 0.69A 2wscA-4rkuA:
20.1		 2wscA-4rkuA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSC_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 9 MET B 662
PHE B 663
SER B 666
TRP B 671
ALA B 699
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
 0.95A 2wscA-4rkuB:
32.3		 2wscA-4rkuB:
43.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSC_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		6 / 9 MET B 662
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.78A 2wscA-4rkuB:
32.3		 2wscA-4rkuB:
43.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		8 / 9 MET 1 684
PHE 1 685
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
GLY 1 723
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 0.71A 2wscA-5oy01:
14.7		 2wscA-5oy01:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		6 / 9 TRP 1  49
MET 1 684
PHE 1 685
SER 1 688
LEU 1 718
GLY 1 723
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 1.46A 2wscA-5oy01:
14.7		 2wscA-5oy01:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		7 / 9 MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.80A 2wscA-5oy0b:
28.8		 2wscA-5oy0b:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		5 / 9 MET B 660
SER B 664
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.73A 2wscA-6fosB:
13.7		 2wscA-6fosB:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		5 / 9 PHE B 661
SER B 664
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.77A 2wscA-6fosB:
13.7		 2wscA-6fosB:
7.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSC_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		8 / 10 TRP A  55
MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.82A 2wscB-4rkuA:
12.6		 2wscB-4rkuA:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSC_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		9 / 10 TRP B  22
MET B 662
PHE B 663
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
ALA B 705
 CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.62A 2wscB-4rkuB:
36.7		 2wscB-4rkuB:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		8 / 10 TRP 1  49
MET 1 684
PHE 1 685
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.73A 2wscB-5oy01:
11.4		 2wscB-5oy01:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		9 / 10 TRP b  22
MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
ALA b 702
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.83A 2wscB-5oy0b:
19.7		 2wscB-5oy0b:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 10 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 1.00A 2wscB-6fosB:
12.2		 2wscB-6fosB:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		6 / 10 SER B 664
TRP B 665
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 CLA  B1023 (-4.5A)
None
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 1.34A 2wscB-6fosB:
12.2		 2wscB-6fosB:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 10 TRP B  22
MET B 660
PHE B 661
SER B 664
TRP B 669
ALA B 697
LEU B 698
ALA B 703
 None
PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.87A 2wscB-6fosB:
12.2		 2wscB-6fosB:
11.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		8 / 9 MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
GLY A 730
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 0.69A 2wseA-4rkuA:
20.2		 2wseA-4rkuA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 9 MET B 662
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.43A 2wseA-4rkuB:
32.4		 2wseA-4rkuB:
43.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 9 MET B 662
PHE B 663
SER B 666
TRP B 671
ALA B 699
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
 0.94A 2wseA-4rkuB:
32.4		 2wseA-4rkuB:
43.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 9 MET B 662
SER B 666
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.75A 2wseA-4rkuB:
32.4		 2wseA-4rkuB:
43.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		8 / 9 MET 1 684
PHE 1 685
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
GLY 1 723
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 0.70A 2wseA-5oy01:
14.8		 2wseA-5oy01:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		6 / 9 TRP 1  49
MET 1 684
PHE 1 685
SER 1 688
LEU 1 718
GLY 1 723
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 1.45A 2wseA-5oy01:
14.8		 2wseA-5oy01:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		7 / 9 MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.80A 2wseA-5oy0b:
13.2		 2wseA-5oy0b:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		6 / 9 TRP b  22
MET b 659
PHE b 660
SER b 663
TRP b 668
LEU b 697
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
PQN  b1844 ( 3.4A)
PQN  b1844 ( 3.8A)
 1.49A 2wseA-5oy0b:
13.2		 2wseA-5oy0b:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		6 / 9 MET B 660
PHE B 661
SER B 664
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.81A 2wseA-6fosB:
11.4		 2wseA-6fosB:
7.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		8 / 10 TRP A  55
MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.82A 2wseB-4rkuA:
12.7		 2wseB-4rkuA:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		9 / 10 TRP B  22
MET B 662
PHE B 663
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
ALA B 705
 CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.62A 2wseB-4rkuB:
36.3		 2wseB-4rkuB:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		8 / 10 TRP 1  49
MET 1 684
PHE 1 685
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.72A 2wseB-5oy01:
11.6		 2wseB-5oy01:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		9 / 10 TRP b  22
MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
ALA b 702
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.82A 2wseB-5oy0b:
19.7		 2wseB-5oy0b:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 10 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 1.00A 2wseB-6fosB:
12.1		 2wseB-6fosB:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		6 / 10 SER B 664
TRP B 665
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 CLA  B1023 (-4.5A)
None
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 1.33A 2wseB-6fosB:
12.1		 2wseB-6fosB:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 10 TRP B  22
MET B 660
PHE B 661
SER B 664
TRP B 669
ALA B 697
LEU B 698
ALA B 703
 None
PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.87A 2wseB-6fosB:
12.1		 2wseB-6fosB:
11.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		8 / 9 MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
GLY A 730
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 0.65A 2wsfA-4rkuA:
9.9		 2wsfA-4rkuA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 9 MET B 662
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.40A 2wsfA-4rkuB:
30.3		 2wsfA-4rkuB:
43.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		6 / 9 MET B 662
PHE B 663
SER B 666
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.89A 2wsfA-4rkuB:
30.3		 2wsfA-4rkuB:
43.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		8 / 9 MET 1 684
PHE 1 685
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
GLY 1 723
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 0.67A 2wsfA-5oy01:
7.6		 2wsfA-5oy01:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		6 / 9 TRP 1  49
MET 1 684
PHE 1 685
SER 1 688
LEU 1 718
GLY 1 723
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 1.44A 2wsfA-5oy01:
7.6		 2wsfA-5oy01:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		7 / 9 MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.78A 2wsfA-5oy0b:
29.8		 2wsfA-5oy0b:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		6 / 9 TRP b  22
MET b 659
PHE b 660
SER b 663
TRP b 668
LEU b 697
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
PQN  b1844 ( 3.4A)
PQN  b1844 ( 3.8A)
 1.48A 2wsfA-5oy0b:
29.8		 2wsfA-5oy0b:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		5 / 9 MET B 660
SER B 664
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.77A 2wsfA-6fosB:
27.7		 2wsfA-6fosB:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		5 / 9 PHE B 661
SER B 664
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.77A 2wsfA-6fosB:
27.7		 2wsfA-6fosB:
7.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSF_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		7 / 9 MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.79A 2wsfB-4rkuA:
18.0		 2wsfB-4rkuA:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WSF_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		8 / 9 MET B 662
PHE B 663
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
ALA B 705
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.61A 2wsfB-4rkuB:
36.2		 2wsfB-4rkuB:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		7 / 9 MET 1 684
PHE 1 685
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.66A 2wsfB-5oy01:
12.3		 2wsfB-5oy01:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		8 / 9 MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
ALA b 702
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.82A 2wsfB-5oy0b:
12.1		 2wsfB-5oy0b:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.99A 2wsfB-6fosB:
11.7		 2wsfB-6fosB:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 MET B 660
PHE B 661
SER B 664
TRP B 669
ALA B 697
LEU B 698
ALA B 703
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.88A 2wsfB-6fosB:
11.7		 2wsfB-6fosB:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		6 / 9 SER B 664
TRP B 665
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 CLA  B1023 (-4.5A)
None
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 1.34A 2wsfB-6fosB:
11.7		 2wsfB-6fosB:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		4 / 8 HIS A 605
ILE A 522
HIS A 532
ASP A 528
 CLA  A1135 (-4.3A)
CLA  A1135 ( 4.9A)
CLA  A1135 (-4.3A)
None
 0.98A 2xadA-6fosA:
undetectable		 2xadA-6fosA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		4 / 8 HIS A 605
ILE A 522
HIS A 532
ASP A 528
 CLA  A1135 (-4.3A)
CLA  A1135 ( 4.9A)
CLA  A1135 (-4.3A)
None
 1.00A 2xadB-6fosA:
undetectable		 2xadB-6fosA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		4 / 8 HIS A 605
ILE A 522
HIS A 532
ASP A 528
 CLA  A1135 (-4.3A)
CLA  A1135 ( 4.9A)
CLA  A1135 (-4.3A)
None
 1.00A 2xadC-6fosA:
undetectable		 2xadC-6fosA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		4 / 8 HIS A 605
ILE A 522
HIS A 532
ASP A 528
 CLA  A1135 (-4.3A)
CLA  A1135 ( 4.9A)
CLA  A1135 (-4.3A)
None
 0.97A 2xadD-6fosA:
undetectable		 2xadD-6fosA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		4 / 8 THR B  27
GLN B 702
ASP B  30
SER B  33
 None
None
CLA  B1226 (-3.4A)
None
 1.13A 2xytE-6fosB:
undetectable		 2xytE-6fosB:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		4 / 7 THR B  27
GLN B 702
ASP B  30
SER B  33
 None
None
CLA  B1226 (-3.4A)
None
 1.11A 2xytI-6fosB:
undetectable		 2xytI-6fosB:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		4 / 8 THR B  27
GLN B 702
ASP B  30
SER B  33
 None
None
CLA  B1226 (-3.4A)
None
 1.09A 2xz5C-6fosB:
undetectable
2xz5D-6fosB:
undetectable		 2xz5C-6fosB:
undetectable
2xz5D-6fosB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		5 / 12 VAL 1 678
PHE 1 742
SER 1 610
VAL 1 737
TYR 1 599
 BCR  1 856 (-4.9A)
CLA  1 801 (-3.4A)
None
BCR  1 856 (-3.7A)
CLA  1 801 (-4.5A)
 1.25A 2y01A-5oy01:
undetectable		 2y01A-5oy01:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 8 LEU B 371
HIS B  89
TYR B 117
HIS B  67
 CLA  B1225 ( 4.4A)
CLA  B1205 ( 3.9A)
None
CLA  B1204 (-4.1A)
 1.17A 2y69C-4rkuB:
2.9
2y69N-4rkuB:
undetectable
2y69P-4rkuB:
2.9		 2y69C-4rkuB:
16.14
2y69N-4rkuB:
22.74
2y69P-4rkuB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 SER 4 232
ARG 4 233
PRO 4  78
GLY 4  79
 None
CLA  4 302 (-3.3A)
None
CLA  4 302 (-4.4A)
 1.46A 2y7kB-5mdx4:
undetectable		 2y7kB-5mdx4:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5xnl LIGHT HARVESTING
CHLOROPHYLL
A/B-BINDING PROTEIN
LHCB5, CP26
(Pisum
sativum) 		4 / 5 ARG S 194
PRO S  54
GLY S  55
TRP S  26
 CLA  S 602 (-4.2A)
None
CLA  S 602 (-4.7A)
CLA  S 611 ( 4.1A)
 0.80A 2y7kB-5xnlS:
undetectable		 2y7kB-5xnlS:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Zea
mays) 		4 / 5 ARG Y 181
PRO Y  37
GLY Y  38
TRP Y  12
 CLA  Y 602 (-3.3A)
None
CLA  Y 602 (-4.5A)
CLA  Y 611 ( 4.6A)
 0.94A 2y7kB-5zjiY:
undetectable		 2y7kB-5zjiY:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3jcu CHLOROPHYLL A-B
BINDING PROTEIN 26
KD (CP26)
(Spinacia
oleracea) 		4 / 6 ARG S 194
PRO S  54
GLY S  55
TRP S  26
 CLA  S 602 (-3.1A)
None
None
CLA  S 611 ( 3.9A)
 0.74A 2y7pA-3jcuS:
undetectable		 2y7pA-3jcuS:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3jcu CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 ARG G 185
PRO G  41
GLY G  42
TRP G  16
 CLA  G 602 (-3.2A)
None
CLA  G 602 (-4.4A)
CLA  G 611 ( 3.7A)
 0.82A 2y7pA-3jcuG:
undetectable		 2y7pA-3jcuG:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5xnl LIGHT HARVESTING
CHLOROPHYLL
A/B-BINDING PROTEIN
LHCB5, CP26
(Pisum
sativum) 		4 / 6 ARG S 194
PRO S  54
GLY S  55
TRP S  26
 CLA  S 602 (-4.2A)
None
CLA  S 602 (-4.7A)
CLA  S 611 ( 4.1A)
 0.84A 2y7pA-5xnlS:
undetectable		 2y7pA-5xnlS:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Zea
mays) 		4 / 6 ARG Y 181
PRO Y  37
GLY Y  38
TRP Y  12
 CLA  Y 602 (-3.3A)
None
CLA  Y 602 (-4.5A)
CLA  Y 611 ( 4.6A)
 0.81A 2y7pA-5zjiY:
undetectable		 2y7pA-5zjiY:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2wse LHCA3
(Glycine
max) 		5 / 9 GLY 3  62
TYR 3  64
GLY 3  57
ARG 3 188
ILE 3  60
 None
CLA  31222 ( 2.6A)
None
CLA  31223 ( 4.0A)
None
 1.40A 2y7wA-2wse3:
undetectable		 2y7wA-2wse3:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YK1_H_NCTH300_1
(FAB FRAGMENT, HEAVY
CHAIN
FAB FRAGMENT, LIGHT
CHAIN)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		5 / 10 ILE A 143
GLY A 134
SER A 671
VAL A 136
ALA A 390
 CLA  A1106 ( 4.7A)
None
None
None
None
 1.28A 2yk1H-4rkuA:
undetectable
2yk1L-4rkuA:
undetectable		 2yk1H-4rkuA:
13.57
2yk1L-4rkuA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 6fos PSAM
(Cyanidioschyzon
merolae) 		3 / 3 ASP O 118
PHE O 121
LEU O 125
 None
None
CLA  O1602 (-3.9A)
 0.30A 2zi9A-6fosO:
undetectable		 2zi9A-6fosO:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 SER B 666
GLY B 660
THR B 659
LEU B 710
VAL B 711
 PQN  B5002 (-3.2A)
None
CLA  B9023 ( 3.7A)
None
CLA  B1239 ( 4.0A)
 1.13A 2zifA-4rkuB:
undetectable		 2zifA-4rkuB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		5 / 12 SER B 664
GLY B 658
THR B 657
LEU B 708
VAL B 709
 CLA  B1023 (-4.5A)
None
CLA  B1239 ( 4.4A)
None
CLA  B1226 (-4.4A)
 1.13A 2zifA-6fosB:
undetectable		 2zifA-6fosB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 SER B 666
GLY B 660
THR B 659
LEU B 710
VAL B 711
 PQN  B5002 (-3.2A)
None
CLA  B9023 ( 3.7A)
None
CLA  B1239 ( 4.0A)
 1.09A 2zifB-4rkuB:
undetectable		 2zifB-4rkuB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		5 / 12 SER B 664
GLY B 658
THR B 657
LEU B 708
VAL B 709
 CLA  B1023 (-4.5A)
None
CLA  B1239 ( 4.4A)
None
CLA  B1226 (-4.4A)
 1.12A 2zifB-6fosB:
undetectable		 2zifB-6fosB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 TYR C 297
LEU C  95
VAL C 185
VAL C 176
LEU C 202
 CLA  C 503 ( 4.7A)
CLA  C 503 (-4.1A)
None
None
None
 1.25A 2zlcA-5mdxC:
undetectable		 2zlcA-5mdxC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 8 LEU B 371
HIS B  89
TYR B 117
HIS B  67
 CLA  B1225 ( 4.4A)
CLA  B1205 ( 3.9A)
None
CLA  B1204 (-4.1A)
 1.16A 3ablC-4rkuB:
2.9
3ablN-4rkuB:
undetectable
3ablP-4rkuB:
2.8		 3ablC-4rkuB:
16.14
3ablN-4rkuB:
22.74
3ablP-4rkuB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 8 LEU B 371
HIS B  89
TYR B 117
HIS B  67
 CLA  B1225 ( 4.4A)
CLA  B1205 ( 3.9A)
None
CLA  B1204 (-4.1A)
 1.14A 3asnC-4rkuB:
2.9
3asnN-4rkuB:
undetectable
3asnP-4rkuB:
3.0		 3asnC-4rkuB:
16.14
3asnN-4rkuB:
22.74
3asnP-4rkuB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 8 HIS B  89
TYR B 117
HIS B  67
LEU B 371
 CLA  B1205 ( 3.9A)
None
CLA  B1204 (-4.1A)
CLA  B1225 ( 4.4A)
 1.15A 3asoA-4rkuB:
undetectable
3asoC-4rkuB:
2.9
3asoP-4rkuB:
2.9		 3asoA-4rkuB:
22.74
3asoC-4rkuB:
16.14
3asoP-4rkuB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 8 LEU B 371
HIS B  89
TYR B 117
HIS B  67
 CLA  B1225 ( 4.4A)
CLA  B1205 ( 3.9A)
None
CLA  B1204 (-4.1A)
 1.16A 3asoC-4rkuB:
2.9
3asoN-4rkuB:
undetectable
3asoP-4rkuB:
2.9		 3asoC-4rkuB:
16.14
3asoN-4rkuB:
22.74
3asoP-4rkuB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 5oy0 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU 0 141
LEU 0 142
GLN 0  77
LEU 0  67
TYR 0  59
 CLA  0 203 ( 4.2A)
CLA  0 203 (-4.6A)
None
CLA  0 203 (-4.1A)
BCR  0 205 (-4.0A)
 1.29A 3d90B-5oy00:
undetectable		 3d90B-5oy00:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		5 / 12 GLN A 490
GLY A 640
SER A 646
ASP A 623
HIS A 615
 None
None
None
None
CLA  A1135 (-3.7A)
 1.28A 3d91A-4rkuA:
undetectable		 3d91A-4rkuA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		3 / 3 MET B 583
MET A 691
PHE B 576
 None
CLA  A9013 ( 3.6A)
CLA  B1226 (-3.7A)
 1.28A 3gn8A-4rkuB:
undetectable		 3gn8A-4rkuB:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 11 LEU B 631
LEU B 643
GLY B 653
HIS B 654
LEU B 651
 None
None
None
CLA  B9022 ( 4.0A)
CLA  B9022 (-3.5A)
 1.11A 3hm1B-4rkuB:
undetectable		 3hm1B-4rkuB:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU b 628
LEU b 640
GLY b 650
HIS b 651
LEU b 648
 None
None
None
CLA  b1806 ( 4.0A)
None
 1.05A 3hm1B-5oy0b:
undetectable		 3hm1B-5oy0b:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3jcu CHLOROPHYLL A-B
BINDING PROTEIN 29
KD (CP29)
(Spinacia
oleracea) 		5 / 12 PHE R 211
GLY R 207
ALA R 204
GLY R 109
LEU R 108
 LUT  R 620 (-3.8A)
LUT  R 620 (-3.9A)
LUT  R 620 (-3.5A)
CLA  R 604 (-3.2A)
CLA  R 604 (-4.4A)
 1.01A 3hs6B-3jcuR:
undetectable		 3hs6B-3jcuR:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4rku CHLOROPHYLL A-B
BINDING PROTEIN 3,
CHLOROPLASTIC
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum;
Pisum
sativum) 		3 / 3 LYS 3 148
ILE A 249
PHE A 248
 None
CLA  A1114 ( 4.6A)
None
 0.99A 3j7zS-4rku3:
undetectable
3j7za-4rku3:
undetectable		 3j7zS-4rku3:
19.77
3j7za-4rku3:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 8 GLY A  90
CYH C 287
PHE C 289
PHE C 292
 None
None
CLA  C 503 (-3.5A)
None
 1.06A 3ko0D-5mdxA:
0.1
3ko0E-5mdxA:
undetectable		 3ko0D-5mdxA:
16.93
3ko0E-5mdxA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 8 PHE C 292
GLY A  90
CYH C 287
PHE C 289
 None
None
None
CLA  C 503 (-3.5A)
 1.03A 3ko0B-5mdxC:
undetectable
3ko0J-5mdxC:
undetectable		 3ko0B-5mdxC:
12.11
3ko0J-5mdxC:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 7 PHE C 292
GLY A  90
CYH C 287
PHE C 289
 None
None
None
CLA  C 503 (-3.5A)
 1.03A 3ko0K-5mdxC:
undetectable
3ko0S-5mdxC:
undetectable		 3ko0K-5mdxC:
12.11
3ko0S-5mdxC:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 6 PHE B  61
VAL B 252
THR B 263
PHE B  65
 CLA  B1015 ( 3.4A)
CLA  B1012 (-4.5A)
None
CLA  B1012 ( 3.2A)
 1.39A 3ltwA-3a0hB:
undetectable		 3ltwA-3a0hB:
20.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		8 / 9 MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
GLY A 730
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 0.65A 3lw5A-4rkuA:
42.7		 3lw5A-4rkuA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		6 / 9 TRP A  55
MET A 691
PHE A 692
SER A 695
LEU A 725
GLY A 730
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 1.38A 3lw5A-4rkuA:
42.7		 3lw5A-4rkuA:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		6 / 9 MET B 662
PHE B 663
SER B 666
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.86A 3lw5A-4rkuB:
32.4		 3lw5A-4rkuB:
44.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		6 / 9 MET B 662
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.75A 3lw5A-4rkuB:
32.4		 3lw5A-4rkuB:
44.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		6 / 9 TRP B  22
MET B 662
PHE B 663
SER B 666
TRP B 671
LEU B 700
 CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.7A)
 1.45A 3lw5A-4rkuB:
32.4		 3lw5A-4rkuB:
44.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		8 / 9 MET 1 684
PHE 1 685
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
GLY 1 723
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 0.67A 3lw5A-5oy01:
38.1		 3lw5A-5oy01:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		6 / 9 TRP 1  49
MET 1 684
PHE 1 685
SER 1 688
LEU 1 718
GLY 1 723
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 1.34A 3lw5A-5oy01:
38.1		 3lw5A-5oy01:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		7 / 9 MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.76A 3lw5A-5oy0b:
11.7		 3lw5A-5oy0b:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		6 / 9 TRP b  22
MET b 659
PHE b 660
SER b 663
TRP b 668
LEU b 697
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
PQN  b1844 ( 3.4A)
PQN  b1844 ( 3.8A)
 1.38A 3lw5A-5oy0b:
11.7		 3lw5A-5oy0b:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		6 / 9 MET B 660
PHE B 661
SER B 664
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.79A 3lw5A-6fosB:
28.5		 3lw5A-6fosB:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		6 / 9 TRP B  22
MET B 660
PHE B 661
SER B 664
TRP B 669
LEU B 698
 None
PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.6A)
 1.41A 3lw5A-6fosB:
28.5		 3lw5A-6fosB:
7.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		7 / 10 MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.77A 3lw5B-4rkuA:
12.2		 3lw5B-4rkuA:
45.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		6 / 10 ILE B  21
MET B 662
PHE B 663
SER B 666
LEU B 700
ALA B 705
 CLA  A1131 ( 4.4A)
CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 1.48A 3lw5B-4rkuB:
15.5		 3lw5B-4rkuB:
98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		9 / 10 ILE B  25
MET B 662
PHE B 663
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
ALA B 705
 CLA  B1201 ( 4.7A)
CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.59A 3lw5B-4rkuB:
15.5		 3lw5B-4rkuB:
98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		7 / 10 ILE B  25
TRP B 667
ARG B 668
TRP B 671
ALA B 699
LEU B 700
ALA B 705
 CLA  B1201 ( 4.7A)
None
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 1.27A 3lw5B-4rkuB:
15.5		 3lw5B-4rkuB:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		7 / 10 MET 1 684
PHE 1 685
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.64A 3lw5B-5oy01:
11.2		 3lw5B-5oy01:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 10 ILE b  21
MET b 659
PHE b 660
SER b 663
ALA b 702
 None
CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
PQN  b1844 (-3.1A)
 1.33A 3lw5B-5oy0b:
12.1		 3lw5B-5oy0b:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		9 / 10 ILE b  25
MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
ALA b 702
 LMG  b1851 ( 4.9A)
CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.81A 3lw5B-5oy0b:
12.1		 3lw5B-5oy0b:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		5 / 10 ILE B  21
MET B 660
PHE B 661
SER B 664
ALA B 703
 None
PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.4A)
 1.34A 3lw5B-6fosB:
11.5		 3lw5B-6fosB:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 10 ILE B  25
MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 CLA  B1201 ( 4.6A)
PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.96A 3lw5B-6fosB:
11.5		 3lw5B-6fosB:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 10 ILE B  25
MET B 660
PHE B 661
SER B 664
TRP B 669
ALA B 697
LEU B 698
ALA B 703
 CLA  B1201 ( 4.6A)
PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.86A 3lw5B-6fosB:
11.5		 3lw5B-6fosB:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		5 / 10 SER B 664
TRP B 665
ARG B 666
TRP B 669
ALA B 697
 CLA  B1023 (-4.5A)
None
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
 1.40A 3lw5B-6fosB:
11.5		 3lw5B-6fosB:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 GLY B 260
GLU B 503
ASN B 506
ASN B 502
HIS B 467
 None
None
None
None
CLA  B1231 (-3.9A)
 1.38A 3mekA-4rkuB:
2.3		 3mekA-4rkuB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 GLY B 260
GLU B 503
ASN B 506
HIS B 467
PHE B 509
 None
None
None
CLA  B1231 (-3.9A)
CLA  B1223 (-4.4A)
 1.36A 3mekA-4rkuB:
2.3		 3mekA-4rkuB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 TRP B 582
ASN B 585
LEU B 434
GLY B 430
TYR B 437
 CLA  A9012 ( 3.5A)
CLA  A9012 (-3.7A)
CLA  A9012 ( 3.9A)
CLA  A9013 (-3.4A)
CLA  B9010 (-4.6A)
 0.98A 3nrrA-4rkuB:
undetectable		 3nrrA-4rkuB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 12 TRP b 579
ASN b 582
LEU b 432
GLY b 428
TYR b 435
 None
None
CLA  b1806 (-4.3A)
None
CLA  b1806 ( 4.4A)
 1.06A 3nrrA-5oy0b:
undetectable		 3nrrA-5oy0b:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 TRP B 582
ASN B 585
LEU B 434
GLY B 430
TYR B 437
 CLA  A9012 ( 3.5A)
CLA  A9012 (-3.7A)
CLA  A9012 ( 3.9A)
CLA  A9013 (-3.4A)
CLA  B9010 (-4.6A)
 0.98A 3nrrB-4rkuB:
undetectable		 3nrrB-4rkuB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 12 TRP b 579
ASN b 582
LEU b 432
GLY b 428
TYR b 435
 None
None
CLA  b1806 (-4.3A)
None
CLA  b1806 ( 4.4A)
 1.06A 3nrrB-5oy0b:
undetectable		 3nrrB-5oy0b:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 SER B 202
ILE B 199
ALA B 274
ALA B 357
GLY B 260
 None
None
None
CLA  B1215 (-3.5A)
None
 1.06A 3nxuA-4rkuB:
undetectable		 3nxuA-4rkuB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 11 PHE b 647
HIS b 651
LEU b 628
ILE b 629
SER b 625
 CLA  b1806 (-4.7A)
CLA  b1806 ( 4.0A)
None
CLA  b1806 ( 4.7A)
CLA  b1806 (-3.6A)
 1.47A 3o94C-5oy0b:
undetectable		 3o94C-5oy0b:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		9 / 9 MET A 691
PHE A 692
SER A 695
GLY A 696
ARG A 697
TRP A 700
ALA A 724
LEU A 725
GLY A 730
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
PQN  A5001 ( 4.1A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 0.33A 3pcqA-4rkuA:
46.3		 3pcqA-4rkuA:
83.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		7 / 9 MET B 662
PHE B 663
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.49A 3pcqA-4rkuB:
35.6		 3pcqA-4rkuB:
42.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		9 / 9 MET 1 684
PHE 1 685
SER 1 688
GLY 1 689
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
GLY 1 723
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
PQN  1 842 ( 4.3A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 0.34A 3pcqA-5oy01:
47.1		 3pcqA-5oy01:
85.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		7 / 9 MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.61A 3pcqA-5oy0b:
34.8		 3pcqA-5oy0b:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.84A 3pcqA-6fosB:
27.3		 3pcqA-6fosB:
6.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		9 / 11 TRP A  55
MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ILE A 704
ALA A 724
LEU A 725
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
CLA  A1139 ( 4.5A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.59A 3pcqB-4rkuA:
33.5		 3pcqB-4rkuA:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		11 / 11 TRP B  22
MET B 662
PHE B 663
SER B 666
TRP B 667
ARG B 668
TRP B 671
ILE B 675
ALA B 699
LEU B 700
ALA B 705
 CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
CLA  B1238 (-3.9A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.26A 3pcqB-4rkuB:
43.6		 3pcqB-4rkuB:
78.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		9 / 11 TRP 1  49
MET 1 684
PHE 1 685
SER 1 688
ARG 1 690
TRP 1 693
ILE 1 697
ALA 1 717
LEU 1 718
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
None
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.44A 3pcqB-5oy01:
33.9		 3pcqB-5oy01:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		11 / 11 TRP b  22
MET b 659
PHE b 660
SER b 663
TRP b 664
ARG b 665
TRP b 668
ILE b 672
ALA b 696
LEU b 697
ALA b 702
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
None
PQN  b1844 ( 3.4A)
CLA  b1841 (-4.6A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.36A 3pcqB-5oy0b:
44.5		 3pcqB-5oy0b:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		9 / 11 TRP B  22
MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
 None
PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.76A 3pcqB-6fosB:
32.3		 3pcqB-6fosB:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		9 / 11 TRP B  22
MET B 660
PHE B 661
SER B 664
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 None
PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.64A 3pcqB-6fosB:
32.3		 3pcqB-6fosB:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		4 / 6 THR A 158
TYR A  88
GLN A 154
ILE A 149
 CLA  A1112 (-3.7A)
None
CLA  A1114 (-4.4A)
None
 1.17A 3peoG-6fosA:
undetectable		 3peoG-6fosA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5zgb PSAF
(Cyanidioschyzon
merolae) 		4 / 6 TYR F 131
THR F 132
LEU F 129
GLU F 134
 None
None
CLA  F 301 (-3.9A)
None
 1.00A 3ps9A-5zgbF:
undetectable		 3ps9A-5zgbF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 LEU B 631
LEU B 643
GLY B 653
HIS B 654
LEU B 651
 None
None
None
CLA  B9022 ( 4.0A)
CLA  B9022 (-3.5A)
 1.07A 3q95B-4rkuB:
undetectable		 3q95B-4rkuB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU b 628
LEU b 640
GLY b 650
HIS b 651
LEU b 648
 None
None
None
CLA  b1806 ( 4.0A)
None
 0.99A 3q95B-5oy0b:
undetectable		 3q95B-5oy0b:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 5 HIS B 389
ILE B 392
HIS B 331
LEU B 334
 CLA  B1226 (-4.0A)
CLA  B1226 (-4.4A)
CLA  B1202 ( 3.8A)
CLA  B1202 ( 3.8A)
 1.50A 3qpkA-4rkuB:
undetectable		 3qpkA-4rkuB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		4 / 5 HIS A 404
ILE A 407
HIS A 346
LEU A 349
 CLA  A1128 (-4.1A)
None
CLA  A1103 (-3.2A)
CLA  A1103 ( 3.6A)
 1.32A 3qpkA-6fosA:
undetectable		 3qpkA-6fosA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 GLY B 260
GLU B 503
ASN B 506
HIS B 467
PHE B 509
 None
None
None
CLA  B1231 (-3.9A)
CLA  B1223 (-4.4A)
 1.38A 3qwpA-4rkuB:
undetectable		 3qwpA-4rkuB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus;
Thermosynechococ
cus
vulcanus) 		4 / 4 VAL D 287
PHE B 453
PHE B 451
VAL B 252
 DGD  B1058 (-4.2A)
None
CLA  B1012 (-3.6A)
CLA  B1012 (-4.5A)
 1.41A 3rv5C-3a0hD:
1.5
3rv5D-3a0hD:
undetectable		 3rv5C-3a0hD:
13.82
3rv5D-3a0hD:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Zea
mays) 		4 / 8 ASP 1  60
ASP 1  66
GLY 1  68
PRO 1  64
 None
CLA  1 602 (-3.2A)
CLA  1 602 (-3.9A)
None
 0.99A 3s3mA-5zji1:
undetectable		 3s3mA-5zji1:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 7 PHE B 244
PHE B 360
THR B 126
LEU B 270
 None
None
CLA  B1215 ( 4.7A)
None
 1.02A 3t3sC-4rkuB:
1.9		 3t3sC-4rkuB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		4 / 7 PHE b 244
PHE b 358
THR b 126
LEU b 270
 None
None
CLA  b1821 ( 4.7A)
None
 0.92A 3t3sC-5oy0b:
undetectable		 3t3sC-5oy0b:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		5 / 12 PHE B 293
LEU B 173
GLY B 179
LEU B 180
ALA B 285
 None
None
CLA  B1210 ( 4.7A)
CLA  B1210 (-3.6A)
None
 1.13A 3tbgD-6fosB:
undetectable		 3tbgD-6fosB:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 8 HIS B 469
TRP B 468
PHE B 479
PRO B   4
 CLA  B1019 (-3.8A)
CLA  B1019 ( 3.4A)
None
None
 1.29A 3v35A-3a0hB:
undetectable		 3v35A-3a0hB:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT V,
CHLOROPLASTIC
(Pisum
sativum) 		5 / 11 GLN G  94
ARG G 107
GLY G  98
GLY B 298
ASN B 176
 None
None
None
CLA  B1218 (-3.8A)
None
 1.49A 3v3nA-4rkuG:
undetectable		 3v3nA-4rkuG:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT V,
CHLOROPLASTIC
(Pisum
sativum) 		5 / 11 GLN G  94
ARG G 107
GLY G  98
GLY B 298
ASN B 176
 None
None
None
CLA  B1218 (-3.8A)
None
 1.49A 3v3nD-4rkuG:
undetectable		 3v3nD-4rkuG:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 TYR C 297
LEU C  95
VAL C 185
VAL C 176
LEU C 202
 CLA  C 503 ( 4.7A)
CLA  C 503 (-4.1A)
None
None
None
 1.21A 3vt3A-5mdxC:
undetectable		 3vt3A-5mdxC:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 TYR C 297
LEU C  95
VAL C 185
VAL C 176
LEU C 202
 CLA  C 503 ( 4.7A)
CLA  C 503 (-4.1A)
None
None
None
 1.23A 3vt7A-5mdxC:
undetectable		 3vt7A-5mdxC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 8 LEU B 371
HIS B  89
TYR B 117
HIS B  67
 CLA  B1225 ( 4.4A)
CLA  B1205 ( 3.9A)
None
CLA  B1204 (-4.1A)
 1.14A 3x2qC-4rkuB:
2.9
3x2qN-4rkuB:
2.3
3x2qP-4rkuB:
2.9		 3x2qC-4rkuB:
16.14
3x2qN-4rkuB:
22.74
3x2qP-4rkuB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		4 / 8 LEU b 369
HIS b  89
TYR b 117
HIS b  67
 CLA  b1831 ( 4.4A)
CLA  b1811 ( 3.9A)
CLA  b1811 ( 4.5A)
CLA  b1810 (-3.9A)
 1.14A 3x2qC-5oy0b:
1.9
3x2qN-5oy0b:
undetectable
3x2qP-5oy0b:
1.9		 3x2qC-5oy0b:
undetectable
3x2qN-5oy0b:
undetectable
3x2qP-5oy0b:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT V,
CHLOROPLASTIC
(Pisum
sativum) 		5 / 11 GLN G  94
ARG G 107
GLY G  98
GLY B 298
ASN B 176
 None
None
None
CLA  B1218 (-3.8A)
None
 1.45A 4a99D-4rkuG:
undetectable		 4a99D-4rkuG:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		4 / 6 VAL 1 443
LEU 1 440
ILE 1 445
CYH 1 444
 CLA  1 838 (-4.9A)
CLA  1 838 (-3.5A)
CLA  1 832 (-4.1A)
None
 0.93A 4asdA-5oy01:
undetectable		 4asdA-5oy01:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 5zgb PSAF
(Cyanidioschyzon
merolae) 		4 / 6 ARG F 102
GLU F 106
LEU F  86
ASP F 100
 None
None
None
CLA  F 303 (-4.1A)
 1.45A 4cevE-5zgbF:
undetectable
4cevF-5zgbF:
undetectable		 4cevE-5zgbF:
undetectable
4cevF-5zgbF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 ALA L  83
GLY L  72
PRO L  73
LEU L  86
 None
None
CLA  H1079 ( 4.0A)
None
 0.74A 4dubA-2wscL:
undetectable		 4dubA-2wscL:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 ALA L  82
GLY L  66
PRO L  67
VAL L  65
 None
CLA  L1168 (-2.8A)
CLA  L1168 ( 4.0A)
None
 0.94A 4dubB-2wscL:
undetectable		 4dubB-2wscL:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 ALA L  83
GLY L  72
PRO L  73
LEU L  86
 None
None
CLA  H1079 ( 4.0A)
None
 0.76A 4dubB-2wscL:
undetectable		 4dubB-2wscL:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Zea
mays) 		3 / 3 LYS 1 166
LYS 1 165
PRO 1 169
 None
None
CLA  1 610 (-3.3A)
 1.08A 4dv1L-5zji1:
undetectable		 4dv1L-5zji1:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		5 / 11 ILE B 278
GLY B 182
GLY B 190
HIS B 274
TRP B 188
 CLA  B1215 ( 4.9A)
None
None
CLA  B1215 (-3.4A)
CLA  B1215 (-4.0A)
 1.26A 4e47C-6fosB:
undetectable		 4e47C-6fosB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 7 PHE A 599
GLY A 730
ILE B 665
PHE A 603
 None
PQN  A5001 ( 4.0A)
CLA  B9023 ( 3.9A)
CLA  B9023 ( 4.5A)
 0.86A 4ejjA-4rkuA:
undetectable		 4ejjA-4rkuA:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		8 / 10 MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
GLY A 730
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 0.36A 4fe1A-4rkuA:
45.6
4fe1J-4rkuA:
undetectable		 4fe1A-4rkuA:
83.31
4fe1J-4rkuA:
4.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		7 / 10 MET B 662
PHE B 663
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.53A 4fe1A-4rkuB:
35.5
4fe1J-4rkuB:
undetectable		 4fe1A-4rkuB:
42.88
4fe1J-4rkuB:
4.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT VIII
(Pisum
sativum) 		5 / 10 MET B 662
PHE B 663
SER B 666
TRP B 671
MET I  21
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
PQN  B5002 ( 3.3A)
CLA  B1206 (-3.7A)
 1.11A 4fe1A-4rkuB:
35.5
4fe1J-4rkuB:
undetectable		 4fe1A-4rkuB:
42.88
4fe1J-4rkuB:
4.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		8 / 10 MET 1 684
PHE 1 685
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
GLY 1 723
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 0.40A 4fe1A-5oy01:
46.5
4fe1J-5oy01:
undetectable		 4fe1A-5oy01:
85.00
4fe1J-5oy01:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		7 / 10 MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.62A 4fe1A-5oy0b:
34.6
4fe1J-5oy0b:
undetectable		 4fe1A-5oy0b:
7.11
4fe1J-5oy0b:
23.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX
(Cyanidioschyzon
merolae) 		6 / 10 MET A 681
PHE A 682
TRP A 690
LEU A 715
GLY A 720
ALA J  10
 PQN  A2001 ( 3.3A)
PQN  A2001 (-4.3A)
PQN  A2001 ( 3.2A)
PQN  A2001 (-3.7A)
None
CLA  A1101 ( 4.6A)
 1.06A 4fe1A-6fosA:
47.0
4fe1J-6fosA:
undetectable		 4fe1A-6fosA:
81.25
4fe1J-6fosA:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX
(Cyanidioschyzon
merolae) 		5 / 10 MET A 681
SER A 685
TRP A 690
LEU A 715
ALA J  10
 PQN  A2001 ( 3.3A)
PQN  A2001 (-4.4A)
PQN  A2001 ( 3.2A)
PQN  A2001 (-3.7A)
CLA  A1101 ( 4.6A)
 1.34A 4fe1A-6fosA:
47.0
4fe1J-6fosA:
undetectable		 4fe1A-6fosA:
81.25
4fe1J-6fosA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 10 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.87A 4fe1A-6fosB:
27.2
4fe1J-6fosB:
undetectable		 4fe1A-6fosB:
6.81
4fe1J-6fosB:
22.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		7 / 9 MET A 691
SER A 695
ARG A 697
TRP A 700
ILE A 704
ALA A 724
LEU A 725
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
CLA  A1139 ( 4.5A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.66A 4fe1B-4rkuA:
33.4		 4fe1B-4rkuA:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		9 / 9 MET B 662
SER B 666
TRP B 667
ARG B 668
TRP B 671
ILE B 675
ALA B 699
LEU B 700
ALA B 705
 CLA  B9023 ( 3.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
CLA  B1238 (-3.9A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.30A 4fe1B-4rkuB:
42.4		 4fe1B-4rkuB:
78.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		7 / 9 MET 1 684
SER 1 688
ARG 1 690
TRP 1 693
ILE 1 697
ALA 1 717
LEU 1 718
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
None
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.44A 4fe1B-5oy01:
33.7		 4fe1B-5oy01:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		9 / 9 MET b 659
SER b 663
TRP b 664
ARG b 665
TRP b 668
ILE b 672
ALA b 696
LEU b 697
ALA b 702
 CLA  b1807 ( 3.2A)
PQN  b1844 (-3.7A)
None
None
PQN  b1844 ( 3.4A)
CLA  b1841 (-4.6A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.38A 4fe1B-5oy0b:
43.9		 4fe1B-5oy0b:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 9 MET B 660
SER B 664
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.87A 4fe1B-6fosB:
32.3		 4fe1B-6fosB:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 TRP D 191
LEU D 279
GLY D 278
VAL D 152
ALA D 151
 CLA  D1004 (-4.8A)
PHO  D1039 ( 4.0A)
PQ9  D1042 ( 4.9A)
CLA  D1004 (-3.9A)
None
 1.05A 4fqsA-3a0hD:
undetectable		 4fqsA-3a0hD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 TRP D 191
LEU D 279
GLY D 278
VAL D 152
ALA D 151
 CLA  D1004 (-4.8A)
PHO  D1039 ( 4.0A)
PQ9  D1042 ( 4.9A)
CLA  D1004 (-3.9A)
None
 1.07A 4fqsB-3a0hD:
undetectable		 4fqsB-3a0hD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU b 476
ASP b 272
ALA b 488
TRP b 494
GLY b 259
 CLA  b1836 (-4.3A)
None
CLA  b1837 ( 4.1A)
CLA  b1836 ( 4.1A)
CLA  b1820 ( 4.0A)
 1.14A 4hfpD-5oy0b:
undetectable		 4hfpD-5oy0b:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 5 VAL B 407
ARG B 410
MET B 411
GLU B 413
 CLA  B1220 (-4.1A)
CLA  B1227 (-3.9A)
CLA  B1227 (-3.9A)
CLA  B1227 (-3.9A)
 1.07A 4hojA-4rkuB:
undetectable		 4hojA-4rkuB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 4fe1 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI
(Thermosynechococ
cus
elongatus) 		5 / 12 LEU L  79
ALA L 132
PHE L 136
LEU L 138
LEU L 139
 None
None
None
CLA  L1004 ( 4.6A)
CLA  L1004 (-4.3A)
 0.97A 4i1rA-4fe1L:
undetectable		 4i1rA-4fe1L:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		4 / 6 ILE A 743
THR A 746
VAL A 735
SER A 610
 CLA  A1126 (-3.9A)
CL0  A9011 (-3.4A)
None
CL0  A9011 ( 4.3A)
 1.14A 4iaqA-4rkuA:
2.8		 4iaqA-4rkuA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		4 / 6 ILE A 733
THR A 736
VAL A 725
SER A 600
 CLA  A1126 ( 3.8A)
CLA  A1011 (-3.1A)
None
CLA  A1011 ( 4.3A)
 1.09A 4iaqA-6fosA:
2.9		 4iaqA-6fosA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4xk8 CHLOROPHYLL A-B
BINDING PROTEIN P4,
CHLOROPLASTIC
(Pisum
sativum) 		5 / 12 LEU 4 177
VAL 4 166
SER 4 165
LEU 4  96
VAL 4  97
 CHL  4 615 ( 4.4A)
None
None
None
CLA  4 608 (-4.4A)
 1.28A 4ib4A-4xk84:
undetectable		 4ib4A-4xk84:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE b 520
TYR b 620
PHE b 721
TYR b 718
TRP b 599
 CLA  b1838 (-4.1A)
None
CLA  b1806 (-3.2A)
CLA  b1806 (-4.6A)
None
 1.24A 4j03A-5oy0b:
undetectable		 4j03A-5oy0b:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		5 / 11 ILE B 278
GLY B 182
GLY B 190
HIS B 274
TRP B 188
 CLA  B1215 ( 4.9A)
None
None
CLA  B1215 (-3.4A)
CLA  B1215 (-4.0A)
 1.25A 4jdsC-6fosB:
undetectable		 4jdsC-6fosB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		5 / 12 ILE B 278
GLY B 182
GLY B 190
HIS B 274
TRP B 188
 CLA  B1215 ( 4.9A)
None
None
CLA  B1215 (-3.4A)
CLA  B1215 (-4.0A)
 1.20A 4jlgA-6fosB:
undetectable		 4jlgA-6fosB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4rku CHLOROPHYLL A-B
BINDING PROTEIN 6A,
CHLOROPLASTIC
(Pisum
sativum) 		3 / 3 HIS 1 178
GLY 1  57
ILE 1 182
 None
CLA  11004 (-4.5A)
CLA  11007 (-4.4A)
 0.63A 4k50A-4rku1:
undetectable		 4k50A-4rku1:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4rku CHLOROPHYLL A-B
BINDING PROTEIN 6A,
CHLOROPLASTIC
(Pisum
sativum) 		3 / 3 HIS 1 178
GLY 1  57
ILE 1 182
 None
CLA  11004 (-4.5A)
CLA  11007 (-4.4A)
 0.64A 4k50I-4rku1:
undetectable		 4k50I-4rku1:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Zea
mays) 		3 / 3 ARG 2 219
ASP 2  85
ASP 2  89
 None
None
CLA  2 602 ( 3.4A)
 0.81A 4kicB-5zji2:
undetectable		 4kicB-5zji2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		3 / 3 TYR B 593
GLN B 376
TRP B 589
 CLA  B1234 (-3.4A)
CLA  B1222 (-3.4A)
CLA  B9010 ( 3.4A)
 1.18A 4kn2C-4rkuB:
undetectable		 4kn2C-4rkuB:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		3 / 3 TYR b 590
GLN b 374
TRP b 586
 CLA  b1838 (-3.8A)
CLA  b1828 (-3.2A)
CLA  b1806 ( 3.6A)
 1.13A 4kn2C-5oy0b:
undetectable		 4kn2C-5oy0b:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5mdx PHOTOSYSTEM II
PROTEIN D1
PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		5 / 12 PHE C 435
PHE A 206
GLY A 201
LEU A 288
ALA A 156
 None
CLA  A 402 (-4.4A)
CLA  A 402 ( 4.4A)
None
None
 1.03A 4krhB-5mdxC:
undetectable		 4krhB-5mdxC:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		9 / 11 MET A 691
PHE A 692
SER A 695
GLY A 696
ARG A 697
TRP A 700
ALA A 724
LEU A 725
GLY A 730
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
PQN  A5001 ( 4.1A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 0.27A 4kt0A-4rkuA:
45.6
4kt0J-4rkuA:
undetectable		 4kt0A-4rkuA:
81.00
4kt0J-4rkuA:
6.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		7 / 11 MET B 662
PHE B 663
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.54A 4kt0A-4rkuB:
34.9
4kt0J-4rkuB:
undetectable		 4kt0A-4rkuB:
42.75
4kt0J-4rkuB:
4.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		9 / 11 MET 1 684
PHE 1 685
SER 1 688
GLY 1 689
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
GLY 1 723
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
PQN  1 842 ( 4.3A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 0.40A 4kt0A-5oy01:
46.6
4kt0J-5oy01:
undetectable		 4kt0A-5oy01:
100.00
4kt0J-5oy01:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		7 / 11 MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.61A 4kt0A-5oy0b:
34.4
4kt0J-5oy0b:
undetectable		 4kt0A-5oy0b:
7.36
4kt0J-5oy0b:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 11 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.89A 4kt0A-6fosB:
27.3
4kt0J-6fosB:
undetectable		 4kt0A-6fosB:
19.42
4kt0J-6fosB:
14.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KT0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		7 / 9 TRP A  55
MET A 691
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.50A 4kt0B-4rkuA:
37.8		 4kt0B-4rkuA:
46.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KT0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		9 / 9 TRP B  22
MET B 662
SER B 666
TRP B 667
ARG B 668
TRP B 671
ALA B 699
LEU B 700
ALA B 705
 CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.29A 4kt0B-4rkuB:
48.5		 4kt0B-4rkuB:
78.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		7 / 9 TRP 1  49
MET 1 684
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.50A 4kt0B-5oy01:
35.6		 4kt0B-5oy01:
7.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KT0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		9 / 9 TRP b  22
MET b 659
SER b 663
TRP b 664
ARG b 665
TRP b 668
ALA b 696
LEU b 697
ALA b 702
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 (-3.7A)
None
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.34A 4kt0B-5oy0b:
44.9		 4kt0B-5oy0b:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 9 TRP B  22
MET B 660
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
ALA B 703
 None
PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.82A 4kt0B-6fosB:
32.8		 4kt0B-6fosB:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 9 TRP B  22
SER B 664
TRP B 665
ARG B 666
TRP B 669
ALA B 697
LEU B 698
ALA B 703
 None
CLA  B1023 (-4.5A)
None
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 1.05A 4kt0B-6fosB:
32.8		 4kt0B-6fosB:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2o01 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLAST
(Spinacia
oleracea) 		5 / 11 PHE L 143
GLY L  53
ALA L  59
GLY L 146
ALA L  71
 None
None
CLA  L1502 ( 3.3A)
None
None
 1.21A 4l6v1-2o01L:
undetectable
4l6v6-2o01L:
undetectable		 4l6v1-2o01L:
14.98
4l6v6-2o01L:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		10 / 11 TRP A  55
MET A 691
PHE A 692
SER A 695
GLY A 696
ARG A 697
TRP A 700
ALA A 724
LEU A 725
GLY A 730
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
PQN  A5001 ( 4.1A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 0.32A 4l6v1-4rkuA:
43.3
4l6v6-4rkuA:
2.0		 4l6v1-4rkuA:
81.00
4l6v6-4rkuA:
11.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		8 / 11 TRP B  22
MET B 662
PHE B 663
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.57A 4l6v1-4rkuB:
34.0
4l6v6-4rkuB:
2.1		 4l6v1-4rkuB:
42.75
4l6v6-4rkuB:
11.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		10 / 11 TRP 1  49
MET 1 684
PHE 1 685
SER 1 688
GLY 1 689
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
GLY 1 723
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
PQN  1 842 ( 4.3A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 0.43A 4l6v1-5oy01:
45.9
4l6v6-5oy01:
1.9		 4l6v1-5oy01:
100.00
4l6v6-5oy01:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		8 / 11 TRP b  22
MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.60A 4l6v1-5oy0b:
34.5
4l6v6-5oy0b:
undetectable		 4l6v1-5oy0b:
7.36
4l6v6-5oy0b:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX
(Cyanidioschyzon
merolae) 		8 / 11 MET A 681
PHE A 682
GLY A 686
TRP A 690
ALA A 714
LEU A 715
GLY A 720
ALA J  10
 PQN  A2001 ( 3.3A)
PQN  A2001 (-4.3A)
PQN  A2001 ( 3.9A)
PQN  A2001 ( 3.2A)
PQN  A2001 (-3.2A)
PQN  A2001 (-3.7A)
None
CLA  A1101 ( 4.6A)
 1.41A 4l6v1-6fosA:
40.0
4l6v6-6fosA:
2.3		 4l6v1-6fosA:
69.23
4l6v6-6fosA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 11 TRP B  22
MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 None
PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.90A 4l6v1-6fosB:
27.2
4l6v6-6fosB:
1.4		 4l6v1-6fosB:
19.42
4l6v6-6fosB:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6V_2_PQN22002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		7 / 9 TRP A  55
MET A 691
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.59A 4l6v2-4rkuA:
39.9		 4l6v2-4rkuA:
46.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6V_2_PQN22002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		9 / 9 TRP B  22
MET B 662
SER B 666
TRP B 667
ARG B 668
TRP B 671
ALA B 699
LEU B 700
ALA B 705
 CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.33A 4l6v2-4rkuB:
43.4		 4l6v2-4rkuB:
78.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_2_PQN22002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		7 / 9 TRP 1  49
MET 1 684
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.52A 4l6v2-5oy01:
40.2		 4l6v2-5oy01:
7.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6V_2_PQN22002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		9 / 9 TRP b  22
MET b 659
SER b 663
TRP b 664
ARG b 665
TRP b 668
ALA b 696
LEU b 697
ALA b 702
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 (-3.7A)
None
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.52A 4l6v2-5oy0b:
44.9		 4l6v2-5oy0b:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_2_PQN22002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		6 / 9 MET B 660
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.88A 4l6v2-6fosB:
32.7		 4l6v2-6fosB:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_2_PQN22002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		6 / 9 MET B 660
SER B 664
TRP B 669
ALA B 697
LEU B 698
ALA B 703
 PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.73A 4l6v2-6fosB:
32.7		 4l6v2-6fosB:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_2_PQN22002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 TRP B  22
SER B 664
TRP B 665
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 None
CLA  B1023 (-4.5A)
None
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 1.00A 4l6v2-6fosB:
32.7		 4l6v2-6fosB:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_2_PQN22002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 TRP B  22
SER B 664
TRP B 665
TRP B 669
ALA B 697
LEU B 698
ALA B 703
 None
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.82A 4l6v2-6fosB:
32.7		 4l6v2-6fosB:
10.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		8 / 9 TRP A  55
MET A 691
PHE A 692
SER A 695
TRP A 700
ALA A 724
LEU A 725
GLY A 730
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 0.28A 4l6va-4rkuA:
43.3
4l6vf-4rkuA:
undetectable		 4l6va-4rkuA:
81.00
4l6vf-4rkuA:
11.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		7 / 9 TRP B  22
MET B 662
PHE B 663
SER B 666
TRP B 671
ALA B 699
LEU B 700
 CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.57A 4l6va-4rkuB:
34.0
4l6vf-4rkuB:
0.4		 4l6va-4rkuB:
42.75
4l6vf-4rkuB:
11.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		8 / 9 TRP 1  49
MET 1 684
PHE 1 685
SER 1 688
TRP 1 693
ALA 1 717
LEU 1 718
GLY 1 723
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 0.33A 4l6va-5oy01:
45.4
4l6vf-5oy01:
0.1		 4l6va-5oy01:
100.00
4l6vf-5oy01:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		7 / 9 TRP b  22
MET b 659
PHE b 660
SER b 663
TRP b 668
ALA b 696
LEU b 697
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.51A 4l6va-5oy0b:
34.4
4l6vf-5oy0b:
undetectable		 4l6va-5oy0b:
7.36
4l6vf-5oy0b:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 TRP B  22
MET B 660
PHE B 661
SER B 664
TRP B 669
ALA B 697
LEU B 698
 None
PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.67A 4l6va-6fosB:
27.2
4l6vf-6fosB:
undetectable		 4l6va-6fosB:
19.42
4l6vf-6fosB:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6V_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		7 / 9 TRP A  55
MET A 691
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.56A 4l6vB-4rkuA:
34.0		 4l6vB-4rkuA:
46.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6V_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		9 / 9 TRP B  22
MET B 662
SER B 666
TRP B 667
ARG B 668
TRP B 671
ALA B 699
LEU B 700
ALA B 705
 CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.32A 4l6vB-4rkuB:
43.3		 4l6vB-4rkuB:
78.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		7 / 9 TRP 1  49
MET 1 684
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.47A 4l6vB-5oy01:
34.1		 4l6vB-5oy01:
7.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4L6V_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		9 / 9 TRP b  22
MET b 659
SER b 663
TRP b 664
ARG b 665
TRP b 668
ALA b 696
LEU b 697
ALA b 702
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 (-3.7A)
None
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.51A 4l6vB-5oy0b:
44.7		 4l6vB-5oy0b:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		6 / 9 MET B 660
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.84A 4l6vB-6fosB:
32.7		 4l6vB-6fosB:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		6 / 9 MET B 660
SER B 664
TRP B 669
ALA B 697
LEU B 698
ALA B 703
 PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.70A 4l6vB-6fosB:
32.7		 4l6vB-6fosB:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 TRP B  22
SER B 664
TRP B 665
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 None
CLA  B1023 (-4.5A)
None
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.99A 4l6vB-6fosB:
32.7		 4l6vB-6fosB:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 TRP B  22
SER B 664
TRP B 665
TRP B 669
ALA B 697
LEU B 698
ALA B 703
 None
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.84A 4l6vB-6fosB:
32.7		 4l6vB-6fosB:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT III
(Zea
mays) 		4 / 8 ASN 4  88
GLU F 209
GLU 4  84
TYR F 170
 None
None
None
CLA  F 301 (-4.8A)
 1.14A 4mj8A-5zji4:
undetectable
4mj8C-5zji4:
undetectable		 4mj8A-5zji4:
16.76
4mj8C-5zji4:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		5 / 12 HIS A 545
GLY A 366
THR A 552
MET A 400
THR A 369
 CLA  A1135 (-3.9A)
None
CLA  A1124 (-3.5A)
CLA  A1124 (-3.6A)
CLA  A1127 (-3.3A)
 1.33A 4mubA-4rkuA:
undetectable		 4mubA-4rkuA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 5xnl LIGHT HARVESTING
CHLOROPHYLL
A/B-BINDING PROTEIN
LHCB5, CP26
(Pisum
sativum) 		4 / 6 VAL S  53
ASP S  56
SER S  65
ALA S  47
 None
CLA  S 602 (-4.0A)
CLA  S 602 ( 4.0A)
None
 1.14A 4nedA-5xnlS:
undetectable		 4nedA-5xnlS:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 5 TYR B 437
LEU B 444
ASP B 622
VAL A 664
 CLA  B9010 (-4.6A)
None
None
None
 1.17A 4nkvA-4rkuB:
1.6		 4nkvA-4rkuB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 5oy0 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY 0 133
GLY 0 131
GLY 0 130
LEU 0  51
GLY 0  58
 BCR  0 205 (-3.5A)
None
None
CLA  0 201 ( 4.8A)
None
 0.90A 4o33A-5oy00:
undetectable		 4o33A-5oy00:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 5oy0 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY 0 133
GLY 0 131
GLY 0 130
LEU 0  51
GLY 0  58
 BCR  0 205 (-3.5A)
None
None
CLA  0 201 ( 4.8A)
None
 0.75A 4o3fA-5oy00:
undetectable		 4o3fA-5oy00:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1ppr PERIDININ-CHLOROPHYL
L PROTEIN
(Amphidinium
carterae) 		4 / 4 ALA M 221
ALA M 224
ALA M 225
ALA M 228
 None
None
CLA  M 602 (-3.5A)
None
 0.09A 4oadA-1pprM:
0.0		 4oadA-1pprM:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 4 ALA A 149
ALA A 152
ALA A 153
ALA A 156
 PHO  A 404 ( 3.8A)
None
CLA  A 402 ( 3.7A)
None
 0.00A 4oadA-5mdxA:
undetectable		 4oadA-5mdxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1ppr PERIDININ-CHLOROPHYL
L PROTEIN
(Amphidinium
carterae) 		4 / 4 ALA M 221
ALA M 224
ALA M 225
ALA M 228
 None
None
CLA  M 602 (-3.5A)
None
 0.11A 4oaeA-1pprM:
0.0		 4oaeA-1pprM:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 4 ALA A 149
ALA A 152
ALA A 153
ALA A 156
 PHO  A 404 ( 3.8A)
None
CLA  A 402 ( 3.7A)
None
 0.00A 4oaeA-5mdxA:
undetectable		 4oaeA-5mdxA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		4 / 5 ASN A 455
LEU A 451
HIS A 454
THR A 471
 None
CLA  A1132 (-4.5A)
CLA  A1132 (-3.6A)
None
 1.42A 4p6sA-6fosA:
undetectable		 4p6sA-6fosA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 LEU B 631
LEU B 643
GLY B 653
HIS B 654
LEU B 651
 None
None
None
CLA  B9022 ( 4.0A)
CLA  B9022 (-3.5A)
 1.09A 4pxmA-4rkuB:
undetectable		 4pxmA-4rkuB:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU b 628
LEU b 640
GLY b 650
HIS b 651
LEU b 648
 None
None
None
CLA  b1806 ( 4.0A)
None
 1.01A 4pxmA-5oy0b:
undetectable		 4pxmA-5oy0b:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		5 / 12 PHE A 740
SER A 600
PHE A 604
TYR A 728
GLY A 732
 None
CLA  A1011 ( 4.3A)
CLA  A1011 (-4.6A)
None
CLA  A1011 (-3.9A)
 1.31A 4qb9E-6fosA:
undetectable		 4qb9E-6fosA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		5 / 12 GLY B 383
GLY B 333
ILE B 381
ILE B 390
ALA B 386
 CLA  B1226 (-3.4A)
BCR  B4008 ( 4.6A)
CLA  B1222 (-3.7A)
CLA  B1226 (-4.3A)
CLA  B1226 ( 4.4A)
 1.07A 4qtuD-6fosB:
undetectable		 4qtuD-6fosB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		7 / 9 TRP 1  49
MET 1 684
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.50A 4rkuB-5oy01:
34.0		 4rkuB-5oy01:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		9 / 9 TRP b  22
MET b 659
SER b 663
TRP b 664
ARG b 665
TRP b 668
ALA b 696
LEU b 697
ALA b 702
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 (-3.7A)
None
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.46A 4rkuB-5oy0b:
43.5		 4rkuB-5oy0b:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 TRP B  22
MET B 660
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 None
PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.82A 4rkuB-6fosB:
32.8		 4rkuB-6fosB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 TRP B  22
MET B 660
SER B 664
TRP B 669
ALA B 697
LEU B 698
ALA B 703
 None
PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.68A 4rkuB-6fosB:
32.8		 4rkuB-6fosB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 TRP B  22
SER B 664
TRP B 665
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 None
CLA  B1023 (-4.5A)
None
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 1.08A 4rkuB-6fosB:
32.8		 4rkuB-6fosB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 TRP B  22
SER B 664
TRP B 665
TRP B 669
ALA B 697
LEU B 698
ALA B 703
 None
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.95A 4rkuB-6fosB:
32.8		 4rkuB-6fosB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 1q90 CYTOCHROME B6
(Chlamydomonas
reinhardtii) 		4 / 4 ALA B 125
VAL B 101
GLY B  37
THR B  40
 CLA  D 910 ( 3.1A)
HEM  B 901 ( 4.1A)
HEM  B 901 (-3.1A)
HEM  B 901 (-4.0A)
 1.12A 4ubeA-1q90B:
undetectable		 4ubeA-1q90B:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		5 / 12 GLY A 516
GLY A 517
SER A 510
ALA A 507
ALA A 499
 None
None
None
CLA  A1133 ( 4.6A)
CLA  A1133 ( 3.7A)
 1.10A 4uckB-4rkuA:
undetectable		 4uckB-4rkuA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 GLY C 235
PHE C 181
ILE C 199
ALA C 179
HIS C 237
 None
None
None
None
CLA  C1025 (-3.7A)
 1.42A 4wh5A-3a0hC:
undetectable		 4wh5A-3a0hC:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 4il6 PHOTOSYSTEM Q(B)
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 11 GLY A 171
PHE A 158
LEU A 120
ALA A 154
PHE A 186
 None
PHO  A1007 ( 4.9A)
LMG  A1012 ( 4.1A)
CLA  A1005 ( 4.3A)
CLA  A1005 (-4.0A)
 1.17A 4wnuA-4il6A:
undetectable		 4wnuA-4il6A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 5zgb LHCR1
LHCR2
(Cyanidioschyzon
merolae) 		5 / 11 LEU 1   6
PHE 1  30
GLY 2 121
LEU 2 122
PHE 2 118
 CLA  1 601 (-4.0A)
CLA  1 602 ( 3.7A)
None
CLA  2 607 ( 4.8A)
None
 1.09A 4wnuA-5zgb1:
undetectable		 4wnuA-5zgb1:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5zgb LHCR1
LHCR2
(Cyanidioschyzon
merolae) 		5 / 11 LEU 1   6
PHE 1  30
GLY 2 121
LEU 2 122
PHE 2 118
 CLA  1 601 (-4.0A)
CLA  1 602 ( 3.7A)
None
CLA  2 607 ( 4.8A)
None
 1.07A 4wnuC-5zgb1:
undetectable		 4wnuC-5zgb1:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 5zgb LHCR1
LHCR2
(Cyanidioschyzon
merolae) 		5 / 11 PHE 1  30
GLY 2 121
LEU 2 122
ASP 1  26
PHE 2 118
 CLA  1 602 ( 3.7A)
None
CLA  2 607 ( 4.8A)
CLA  1 602 ( 3.2A)
None
 1.35A 4wnuC-5zgb1:
undetectable		 4wnuC-5zgb1:
10.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		7 / 7 MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.32A 4xk8A-4rkuA:
45.4		 4xk8A-4rkuA:
99.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		7 / 7 MET B 662
PHE B 663
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.48A 4xk8A-4rkuB:
34.4		 4xk8A-4rkuB:
44.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		7 / 7 MET 1 684
PHE 1 685
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.31A 4xk8A-5oy01:
45.1		 4xk8A-5oy01:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		7 / 7 MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.60A 4xk8A-5oy0b:
34.6		 4xk8A-5oy0b:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 7 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.83A 4xk8A-6fosB:
27.3		 4xk8A-6fosB:
7.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		8 / 8 MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
GLY A 730
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 0.30A 4xk8a-4rkuA:
45.4		 4xk8a-4rkuA:
99.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		7 / 8 MET B 662
PHE B 663
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.49A 4xk8a-4rkuB:
34.5		 4xk8a-4rkuB:
44.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		8 / 8 MET 1 684
PHE 1 685
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
GLY 1 723
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 0.27A 4xk8a-5oy01:
45.1		 4xk8a-5oy01:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		7 / 8 MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.59A 4xk8a-5oy0b:
34.6		 4xk8a-5oy0b:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 8 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.82A 4xk8a-6fosB:
27.3		 4xk8a-6fosB:
7.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		8 / 10 TRP A  55
MET A 691
SER A 695
ARG A 697
TRP A 700
ILE A 704
ALA A 724
LEU A 725
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
CLA  A1139 ( 4.5A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.63A 4xk8B-4rkuA:
38.7		 4xk8B-4rkuA:
45.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		10 / 10 TRP B  22
MET B 662
SER B 666
TRP B 667
ARG B 668
TRP B 671
ILE B 675
ALA B 699
LEU B 700
ALA B 705
 CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
CLA  B1238 (-3.9A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.29A 4xk8B-4rkuB:
48.3		 4xk8B-4rkuB:
98.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		8 / 10 TRP 1  49
MET 1 684
SER 1 688
ARG 1 690
TRP 1 693
ILE 1 697
ALA 1 717
LEU 1 718
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
None
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.50A 4xk8B-5oy01:
37.3		 4xk8B-5oy01:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		10 / 10 TRP b  22
MET b 659
SER b 663
TRP b 664
ARG b 665
TRP b 668
ILE b 672
ALA b 696
LEU b 697
ALA b 702
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 (-3.7A)
None
None
PQN  b1844 ( 3.4A)
CLA  b1841 (-4.6A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.40A 4xk8B-5oy0b:
44.7		 4xk8B-5oy0b:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 10 MET B 660
SER B 664
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.87A 4xk8B-6fosB:
32.7		 4xk8B-6fosB:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 10 TRP B  22
SER B 664
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 None
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.80A 4xk8B-6fosB:
32.7		 4xk8B-6fosB:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 GLY G 194
TYR G 191
GLU G 187
ASP G 197
 None
CLA  G 610 (-4.3A)
None
CLA  G 610 (-3.3A)
 1.24A 4xueA-5mdxG:
undetectable		 4xueA-5mdxG:
18.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		8 / 9 MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
GLY A 730
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 0.32A 4y28A-4rkuA:
53.5
4y28J-4rkuA:
undetectable		 4y28A-4rkuA:
99.58
4y28J-4rkuA:
5.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		7 / 9 MET B 662
PHE B 663
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.49A 4y28A-4rkuB:
34.8
4y28J-4rkuB:
undetectable		 4y28A-4rkuB:
43.95
4y28J-4rkuB:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		8 / 9 MET 1 684
PHE 1 685
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
GLY 1 723
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 0.29A 4y28A-5oy01:
44.1
4y28J-5oy01:
undetectable		 4y28A-5oy01:
8.88
4y28J-5oy01:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		7 / 9 MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.62A 4y28A-5oy0b:
34.1
4y28J-5oy0b:
undetectable		 4y28A-5oy0b:
8.28
4y28J-5oy0b:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.83A 4y28A-6fosB:
28.0
4y28J-6fosB:
undetectable		 4y28A-6fosB:
7.16
4y28J-6fosB:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y28_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		7 / 9 TRP A  55
MET A 691
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.54A 4y28B-4rkuA:
34.0		 4y28B-4rkuA:
45.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y28_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		9 / 9 TRP B  22
MET B 662
SER B 666
TRP B 667
ARG B 668
TRP B 671
ALA B 699
LEU B 700
ALA B 705
 CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.27A 4y28B-4rkuB:
45.0		 4y28B-4rkuB:
99.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		7 / 9 TRP 1  49
MET 1 684
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.45A 4y28B-5oy01:
34.3		 4y28B-5oy01:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		9 / 9 TRP b  22
MET b 659
SER b 663
TRP b 664
ARG b 665
TRP b 668
ALA b 696
LEU b 697
ALA b 702
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 (-3.7A)
None
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.36A 4y28B-5oy0b:
44.2		 4y28B-5oy0b:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 9 TRP B  22
MET B 660
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
ALA B 703
 None
PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.83A 4y28B-6fosB:
32.7		 4y28B-6fosB:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		5 / 11 LEU A 117
VAL A 116
LEU A  91
GLY A 171
LEU A 159
 CLA  A 405 ( 4.7A)
None
None
None
None
 1.30A 4zbqA-5mdxA:
undetectable		 4zbqA-5mdxA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 5 ALA A 153
HIS A 332
PRO A 162
PHE A 186
 CLA  A 402 ( 3.7A)
None
None
CLA  A 402 (-4.4A)
 1.35A 4ze2A-5mdxA:
undetectable		 4ze2A-5mdxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		5 / 11 ALA A 347
LEU A 337
LEU A 341
LEU A 423
MET A 426
 BCR  A4007 ( 4.9A)
CLA  A1122 ( 4.4A)
CLA  A1123 (-3.8A)
BCR  A4007 ( 4.7A)
CLA  A1129 (-3.4A)
 1.36A 4zn7B-6fosA:
1.9		 4zn7B-6fosA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2o01 PSI LIGHT-HARVESTING
ANTENNA CHLOROPHYLL
A/B-BINDING PROTEIN
(Pisum
sativum) 		5 / 12 GLU 4 102
ILE 4 103
GLN 4  42
ILE 4 109
PHE 4  40
 CLA  44012 (-2.9A)
CLA  41304 (-4.1A)
CLA  44011 (-2.9A)
None
None
 1.00A 4zvmA-2o014:
undetectable
4zvmB-2o014:
undetectable		 4zvmA-2o014:
22.73
4zvmB-2o014:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 2dre WATER-SOLUBLE
CHLOROPHYLL PROTEIN
(Lepidium
virginicum) 		4 / 6 ALA A  37
LEU A 153
SER A 152
VAL A  35
 CLA  A1001 (-3.5A)
None
None
CLA  A1001 (-4.1A)
 1.03A 5a6iA-2dreA:
undetectable		 5a6iA-2dreA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY 1 405
GLY 1 408
ILE 1 401
LEU 1 549
ALA 1 556
 BCR  1 848 ( 3.9A)
BCR  1 847 (-3.6A)
CLA  1 826 ( 3.7A)
BCR  1 848 (-3.9A)
None
 1.16A 5bw4B-5oy01:
undetectable		 5bw4B-5oy01:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCL_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 GLY B 260
GLU B 503
ASN B 506
HIS B 467
PHE B 509
 None
None
None
CLA  B1231 (-3.9A)
CLA  B1223 (-4.4A)
 1.36A 5cclA-4rkuB:
undetectable		 5cclA-4rkuB:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 GLY B 260
GLU B 503
ASN B 506
ASN B 502
HIS B 467
 None
None
None
None
CLA  B1231 (-3.9A)
 1.39A 5ccmA-4rkuB:
1.0		 5ccmA-4rkuB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 GLY B 260
GLU B 503
ASN B 506
HIS B 467
PHE B 509
 None
None
None
CLA  B1231 (-3.9A)
CLA  B1223 (-4.4A)
 1.39A 5ccmA-4rkuB:
1.0		 5ccmA-4rkuB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		4 / 5 HIS A 343
ILE A 327
ILE A 330
TYR A 317
 LHG  A7003 ( 4.0A)
CLA  A1119 ( 4.5A)
CLA  A1119 (-4.3A)
CLA  A1119 (-4.6A)
 1.17A 5dnuA-4rkuA:
undetectable		 5dnuA-4rkuA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		4 / 6 PHE b 141
SER b 147
ALA b 146
LEU b 143
 CLA  b1817 (-4.0A)
None
None
None
 1.13A 5dzkB-5oy0b:
undetectable
5dzkP-5oy0b:
undetectable		 5dzkB-5oy0b:
undetectable
5dzkP-5oy0b:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		4 / 7 PHE b 141
SER b 147
ALA b 146
LEU b 143
 CLA  b1817 (-4.0A)
None
None
None
 1.15A 5dzkD-5oy0b:
undetectable
5dzkR-5oy0b:
undetectable		 5dzkD-5oy0b:
undetectable
5dzkR-5oy0b:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		4 / 6 PHE A 679
SER A 667
LEU A 677
LEU A 680
 None
None
CLA  A9012 ( 4.0A)
CLA  A9012 (-4.1A)
 1.22A 5dzke-4rkuA:
undetectable
5dzks-4rkuA:
undetectable		 5dzke-4rkuA:
14.06
5dzks-4rkuA:
1.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 6 ALA A 153
THR A 155
VAL A 157
VAL A 123
 CLA  A 402 ( 3.7A)
None
None
PHO  A 404 ( 4.7A)
 1.04A 5eckA-5mdxA:
undetectable		 5eckA-5mdxA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5mdx PHOTOSYSTEM II
PROTEIN D1
(Arabidopsis
thaliana) 		4 / 6 ALA A 153
THR A 155
VAL A 157
VAL A 123
 CLA  A 402 ( 3.7A)
None
None
PHO  A 404 ( 4.7A)
 1.02A 5eckD-5mdxA:
undetectable		 5eckD-5mdxA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT V,
CHLOROPLASTIC
(Pisum
sativum;
Pisum
sativum) 		4 / 6 TYR B 323
GLY G  98
GLU G  93
ASP G 102
 CLA  B1221 (-4.0A)
None
None
None
 1.24A 5emlA-4rkuB:
undetectable		 5emlA-4rkuB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Zea
mays;
Zea
mays) 		4 / 5 SER 2  95
SER 2  72
GLN 3 166
ASP 2  89
 None
None
None
CLA  2 602 ( 3.4A)
 1.20A 5fhrB-5zji2:
undetectable		 5fhrB-5zji2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5oy0 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE 0  62
ALA 0 135
GLY 0  69
GLY 0  84
LEU 0  86
 None
None
CLA  1 833 ( 4.2A)
None
None
 1.26A 5i71A-5oy00:
undetectable		 5i71A-5oy00:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		3 / 3 VAL B 588
SER B 344
MET B 350
 None
CLA  B1222 (-3.3A)
None
 0.80A 5ikqA-6fosB:
0.0		 5ikqA-6fosB:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		3 / 3 VAL B  96
LEU B 158
MET B 166
 CLA  B1013 (-4.9A)
None
None
 0.90A 5ikrA-3a0hB:
undetectable		 5ikrA-3a0hB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		3 / 3 TYR 1 145
TYR 1 668
SER 1 747
 None
CLA  1 808 (-4.0A)
None
 0.95A 5iktB-5oy01:
undetectable		 5iktB-5oy01:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		4 / 8 LEU b 369
HIS b  89
TYR b 117
HIS b  67
 CLA  b1831 ( 4.4A)
CLA  b1811 ( 3.9A)
CLA  b1811 ( 4.5A)
CLA  b1810 (-3.9A)
 1.14A 5iy5C-5oy0b:
1.9
5iy5N-5oy0b:
undetectable
5iy5P-5oy0b:
1.9		 5iy5C-5oy0b:
undetectable
5iy5N-5oy0b:
undetectable
5iy5P-5oy0b:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 4xk8 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Pisum
sativum) 		5 / 7 GLY L  49
GLY L 142
SER L 145
GLY L 143
VAL L  52
 None
None
BCR  L 206 (-3.2A)
None
CLA  L 203 (-3.3A)
 1.32A 5izjB-4xk8L:
undetectable		 5izjB-4xk8L:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 1q90 CYTOCHROME B6
(Chlamydomonas
reinhardtii) 		5 / 12 PHE B 203
ILE B 123
ALA B 125
THR B 128
LEU B  45
 HEM  B 903 (-3.6A)
None
CLA  D 910 ( 3.1A)
HEM  B 901 ( 4.6A)
None
 1.05A 5jkvA-1q90B:
undetectable		 5jkvA-1q90B:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN
CP26, CHLOROPLASTIC
PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana) 		4 / 5 TYR C 131
GLY C 136
GLY S  87
LEU S  76
 CLA  S 301 (-4.0A)
None
None
None
 0.88A 5jlcA-5mdxC:
undetectable		 5jlcA-5mdxC:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 6 HIS D 197
VAL D 286
TYR D 160
HIS D 189
 CLA  D1004 ( 4.3A)
CLA  D1004 (-4.1A)
IOD  D1068 (-3.7A)
None
 1.35A 5kkzA-3a0hD:
undetectable
5kkzG-3a0hD:
undetectable		 5kkzA-3a0hD:
23.06
5kkzG-3a0hD:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3a0h PHOTOSYSTEM II D2
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 7 HIS D 189
HIS D 197
VAL D 286
TYR D 160
 None
CLA  D1004 ( 4.3A)
CLA  D1004 (-4.1A)
IOD  D1068 (-3.7A)
 1.32A 5kkzM-3a0hD:
undetectable
5kkzO-3a0hD:
undetectable		 5kkzM-3a0hD:
19.76
5kkzO-3a0hD:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 6 THR B 720
GLY B 653
PHE B 652
ILE A 462
 CLA  B9010 (-3.5A)
None
BCR  A6017 ( 4.5A)
CLA  A1132 ( 4.1A)
 0.94A 5kmfA-4rkuB:
undetectable
5kmfC-4rkuB:
2.9		 5kmfA-4rkuB:
17.30
5kmfC-4rkuB:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 8 TYR B 670
THR A 552
CYH A 450
LEU A 446
 CLA  B9023 (-4.2A)
CLA  A1124 (-3.5A)
CLA  B9023 (-4.2A)
CLA  A1137 ( 3.6A)
 1.44A 5kxiA-4rkuB:
2.6
5kxiB-4rkuB:
4.3		 5kxiA-4rkuB:
19.84
5kxiB-4rkuB:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 8 TYR B 670
THR A 552
CYH A 450
LEU A 446
 CLA  B9023 (-4.2A)
CLA  A1124 (-3.5A)
CLA  B9023 (-4.2A)
CLA  A1137 ( 3.6A)
 1.41A 5kxiD-4rkuB:
2.7
5kxiE-4rkuB:
4.3		 5kxiD-4rkuB:
19.84
5kxiE-4rkuB:
18.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		9 / 9 MET A 691
PHE A 692
SER A 695
GLY A 696
ARG A 697
TRP A 700
ALA A 724
LEU A 725
GLY A 730
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
PQN  A5001 ( 4.1A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 0.33A 5l8rA-4rkuA:
44.4		 5l8rA-4rkuA:
98.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		7 / 9 MET B 662
PHE B 663
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.52A 5l8rA-4rkuB:
33.9		 5l8rA-4rkuB:
43.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		9 / 9 MET 1 684
PHE 1 685
SER 1 688
GLY 1 689
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
GLY 1 723
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
PQN  1 842 ( 4.3A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 0.34A 5l8rA-5oy01:
44.7		 5l8rA-5oy01:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		7 / 9 MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.63A 5l8rA-5oy0b:
34.5		 5l8rA-5oy0b:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.85A 5l8rA-6fosB:
28.3		 5l8rA-6fosB:
7.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L8R_B_PQNB841_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		7 / 9 TRP A  55
MET A 691
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.73A 5l8rB-4rkuA:
34.1		 5l8rB-4rkuA:
46.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L8R_B_PQNB841_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		9 / 9 TRP B  22
MET B 662
SER B 666
TRP B 667
ARG B 668
TRP B 671
ALA B 699
LEU B 700
ALA B 705
 CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.49A 5l8rB-4rkuB:
44.6		 5l8rB-4rkuB:
97.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_B_PQNB841_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		5 / 9 MET 1 684
SER 1 688
ARG 1 690
TRP 1 693
ALA 1 717
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
 0.83A 5l8rB-5oy01:
34.7		 5l8rB-5oy01:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_B_PQNB841_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		6 / 9 TRP 1  49
MET 1 684
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.39A 5l8rB-5oy01:
34.7		 5l8rB-5oy01:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_B_PQNB841_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		9 / 9 TRP b  22
MET b 659
SER b 663
TRP b 664
ARG b 665
TRP b 668
ALA b 696
LEU b 697
ALA b 702
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 (-3.7A)
None
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.52A 5l8rB-5oy0b:
44.9		 5l8rB-5oy0b:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_B_PQNB841_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 TRP B  22
MET B 660
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 None
PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.82A 5l8rB-6fosB:
32.7		 5l8rB-6fosB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_B_PQNB841_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 9 TRP B  22
MET B 660
SER B 664
TRP B 669
ALA B 697
LEU B 698
ALA B 703
 None
PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.67A 5l8rB-6fosB:
32.7		 5l8rB-6fosB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 LEU B  69
THR B 262
LEU B 158
GLY B 154
HIS B 202
 CLA  B1014 (-3.6A)
CLA  B1011 (-3.7A)
None
None
CLA  B1011 (-3.7A)
 1.41A 5m66A-3a0hB:
undetectable		 5m66A-3a0hB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5mdx PHOTOSYSTEM II
PROTEIN D1
PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		4 / 5 ILE A 283
PHE C 435
SER A 148
ALA A 153
 PHO  A 404 (-4.1A)
None
None
CLA  A 402 ( 3.7A)
 1.20A 5msdA-5mdxA:
undetectable		 5msdA-5mdxA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		3 / 3 SER B 340
SER B 344
PHE B 385
 None
CLA  B1222 (-3.3A)
BCR  B4008 (-4.8A)
 0.93A 5mugA-6fosB:
undetectable		 5mugA-6fosB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Zea
mays) 		5 / 10 ILE 4 246
THR 2 152
ILE 2 155
ILE 2 156
ILE 2 159
 CLA  4 613 (-3.8A)
None
CLA  4 614 ( 4.3A)
CLA  4 614 (-4.0A)
CLA  4 601 (-4.8A)
 0.70A 5murE-5zji4:
undetectable		 5murE-5zji4:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Zea
mays) 		4 / 6 PHE 4 190
ASN 4 191
ARG 4 157
GLY 4 184
 CHL  4 608 (-4.1A)
LUT  4 619 (-3.1A)
CLA  4 609 ( 2.3A)
CHL  4 608 (-3.8A)
 1.06A 5o4yA-5zji4:
undetectable		 5o4yA-5zji4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		4 / 6 TYR b 351
TYR b 370
HIS b 363
TYR b 590
 CLA  b1838 (-4.4A)
None
None
CLA  b1838 (-3.8A)
 1.04A 5ov9A-5oy0b:
undetectable		 5ov9A-5oy0b:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		4 / 7 TYR b 351
TYR b 370
HIS b 363
TYR b 590
 CLA  b1838 (-4.4A)
None
None
CLA  b1838 (-3.8A)
 1.10A 5ov9B-5oy0b:
undetectable		 5ov9B-5oy0b:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		8 / 10 MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ALA A 724
LEU A 725
GLY A 730
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 0.39A 5oy01-4rkuA:
44.6
5oy07-4rkuA:
undetectable		 5oy01-4rkuA:
7.20
5oy07-4rkuA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		7 / 10 MET B 662
PHE B 663
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.45A 5oy01-4rkuB:
34.1
5oy07-4rkuB:
undetectable		 5oy01-4rkuB:
6.72
5oy07-4rkuB:
4.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 10 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.76A 5oy01-6fosB:
27.7
5oy07-6fosB:
undetectable		 5oy01-6fosB:
33.33
5oy07-6fosB:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		9 / 12 TRP A  55
MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ILE A 704
ALA A 724
LEU A 725
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
CLA  A1139 ( 4.5A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.57A 5oy02-4rkuA:
34.1		 5oy02-4rkuA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		9 / 12 ILE B  21
MET B 662
PHE B 663
SER B 666
TRP B 667
ARG B 668
TRP B 671
LEU B 700
ALA B 705
 CLA  A1131 ( 4.4A)
CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 1.48A 5oy02-4rkuB:
43.3		 5oy02-4rkuB:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		12 / 12 TRP B  22
ILE B  25
MET B 662
PHE B 663
SER B 666
TRP B 667
ARG B 668
TRP B 671
ILE B 675
ALA B 699
LEU B 700
ALA B 705
 CLA  B1238 ( 4.0A)
CLA  B1201 ( 4.7A)
CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
CLA  B1238 (-3.9A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.42A 5oy02-4rkuB:
43.3		 5oy02-4rkuB:
11.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		11 / 12 TRP B  22
ILE B  25
MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 None
CLA  B1201 ( 4.6A)
PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.74A 5oy02-6fosB:
32.6		 5oy02-6fosB:
85.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		10 / 12 TRP B  22
ILE B  25
PHE B 661
TRP B 665
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 None
CLA  B1201 ( 4.6A)
PQN  B2002 ( 4.3A)
None
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 1.04A 5oy02-6fosB:
32.6		 5oy02-6fosB:
85.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		8 / 10 MET A 691
PHE A 692
SER A 695
ARG A 697
TRP A 700
ILE A 704
ALA A 724
LEU A 725
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
CLA  A1139 ( 4.5A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.65A 5oy0b-4rkuA:
34.2		 5oy0b-4rkuA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		10 / 10 MET B 662
PHE B 663
SER B 666
TRP B 667
ARG B 668
TRP B 671
ILE B 675
ALA B 699
LEU B 700
ALA B 705
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
CLA  B1238 (-3.9A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.45A 5oy0b-4rkuB:
43.5		 5oy0b-4rkuB:
10.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		9 / 10 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.66A 5oy0b-6fosB:
32.7		 5oy0b-6fosB:
85.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		9 / 10 PHE B 661
SER B 664
TRP B 665
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.96A 5oy0b-6fosB:
32.7		 5oy0b-6fosB:
85.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 1q90 CYTOCHROME B6
CYTOCHROME B6-F
COMPLEX SUBUNIT 4
(Chlamydomonas
reinhardtii) 		4 / 8 VAL B 126
GLY D 107
LEU D 108
THR D 110
 CLA  D 910 ( 4.3A)
None
CLA  D 910 ( 4.9A)
None
 1.10A 5syjA-1q90B:
undetectable		 5syjA-1q90B:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5oy0 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI
(Synechocystis
sp.
PCC
6803) 		4 / 8 VAL 0  53
LEU 0  96
THR 0  93
ALA 0  92
 CLA  0 202 (-3.1A)
BCR  0 204 (-4.0A)
None
BCR  0 204 ( 3.5A)
 0.90A 5tt3H-5oy00:
undetectable		 5tt3H-5oy00:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 12 LEU B  69
THR B 262
LEU B 158
GLY B 154
HIS B 202
 CLA  B1014 (-3.6A)
CLA  B1011 (-3.7A)
None
None
CLA  B1011 (-3.7A)
 1.38A 5utuF-3a0hB:
undetectable		 5utuF-3a0hB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 GLY B 260
GLU B 503
ASN B 506
HIS B 467
PHE B 509
 None
None
None
CLA  B1231 (-3.9A)
CLA  B1223 (-4.4A)
 1.37A 5v37A-4rkuB:
undetectable		 5v37A-4rkuB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 5mdx PHOTOSYSTEM II
PROTEIN D1
PHOTOSYSTEM II
REACTION CENTER
PROTEIN I
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		4 / 8 HIS A 118
PHE A  93
PRO A  95
TYR I   9
 CLA  A 405 (-3.5A)
CLA  A 405 (-3.9A)
CLA  A 405 (-3.9A)
None
 1.33A 5v4vA-5mdxA:
undetectable		 5v4vA-5mdxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 5mdx PHOTOSYSTEM II
PROTEIN D1
PHOTOSYSTEM II
REACTION CENTER
PROTEIN I
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		4 / 8 HIS A 118
PHE A  93
PRO A  95
TYR I   9
 CLA  A 405 (-3.5A)
CLA  A 405 (-3.9A)
CLA  A 405 (-3.9A)
None
 1.31A 5v4vB-5mdxA:
undetectable		 5v4vB-5mdxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		4 / 9 LYS A  40
ILE A 710
ILE A  45
LEU A  48
 None
None
CLA  A1101 ( 4.3A)
CLA  A1101 ( 4.4A)
 0.79A 5vkqB-6fosA:
2.6
5vkqC-6fosA:
2.6		 5vkqB-6fosA:
undetectable
5vkqC-6fosA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		5 / 8 GLY A 285
GLN A 231
TYR A 259
ASP A 288
ASP A 519
 CLA  A1116 (-3.4A)
None
None
None
None
 1.24A 5vlmB-4rkuA:
undetectable		 5vlmB-4rkuA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		5 / 7 GLY A 285
GLN A 231
TYR A 259
ASP A 288
ASP A 519
 CLA  A1116 (-3.4A)
None
None
None
None
 1.33A 5vlmE-4rkuA:
undetectable		 5vlmE-4rkuA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		4 / 7 GLY A 285
GLN A 231
TYR A 259
ASP A 288
 CLA  A1116 (-3.4A)
None
None
None
 1.12A 5vlmG-4rkuA:
undetectable		 5vlmG-4rkuA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum;
Pisum
sativum) 		4 / 8 GLY A 698
ILE A 704
GLN A 721
ASP B 540
 None
CLA  A1139 ( 4.5A)
None
None
 1.01A 5vlmH-4rkuA:
undetectable		 5vlmH-4rkuA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 7 HIS B  89
TYR B 117
HIS B  67
LEU B 371
 CLA  B1205 ( 3.9A)
None
CLA  B1204 (-4.1A)
CLA  B1225 ( 4.4A)
 1.21A 5x1fA-4rkuB:
undetectable
5x1fC-4rkuB:
3.0
5x1fP-4rkuB:
2.9		 5x1fA-4rkuB:
22.74
5x1fC-4rkuB:
16.14
5x1fP-4rkuB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 8 LEU B 371
HIS B  89
TYR B 117
HIS B  67
 CLA  B1225 ( 4.4A)
CLA  B1205 ( 3.9A)
None
CLA  B1204 (-4.1A)
 1.15A 5xdqC-4rkuB:
2.9
5xdqN-4rkuB:
undetectable
5xdqP-4rkuB:
2.9		 5xdqC-4rkuB:
16.14
5xdqN-4rkuB:
22.74
5xdqP-4rkuB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 8 LEU B 371
HIS B  89
TYR B 117
HIS B  67
 CLA  B1225 ( 4.4A)
CLA  B1205 ( 3.9A)
None
CLA  B1204 (-4.1A)
 1.15A 5xdxC-4rkuB:
3.1
5xdxN-4rkuB:
undetectable
5xdxP-4rkuB:
2.9		 5xdxC-4rkuB:
16.14
5xdxN-4rkuB:
22.74
5xdxP-4rkuB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5xnl LIGHT HARVESTING
CHLOROPHYLL
A/B-BINDING PROTEIN
LHCB4, CP29
(Pisum
sativum) 		4 / 8 GLY R 211
LEU R 210
ALA R 103
PHE R 209
 CLA  R 613 (-3.3A)
XAT  R 622 ( 4.0A)
XAT  R 622 ( 3.9A)
XAT  R 622 (-4.0A)
 0.92A 5xu8A-5xnlR:
undetectable		 5xu8A-5xnlR:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 GLY B 260
GLU B 503
ASN B 506
ASN B 502
HIS B 467
 None
None
None
None
CLA  B1231 (-3.9A)
 1.35A 5xxgA-4rkuB:
undetectable		 5xxgA-4rkuB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 GLY B 260
GLU B 503
ASN B 506
HIS B 467
PHE B 509
 None
None
None
CLA  B1231 (-3.9A)
CLA  B1223 (-4.4A)
 1.37A 5xxgA-4rkuB:
undetectable		 5xxgA-4rkuB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 GLY B 260
GLU B 503
ASN B 506
ASN B 502
HIS B 467
 None
None
None
None
CLA  B1231 (-3.9A)
 1.36A 5xxjA-4rkuB:
undetectable		 5xxjA-4rkuB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 12 GLY B 260
GLU B 503
ASN B 506
HIS B 467
PHE B 509
 None
None
None
CLA  B1231 (-3.9A)
CLA  B1223 (-4.4A)
 1.35A 5xxjA-4rkuB:
undetectable		 5xxjA-4rkuB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 7 LEU B 371
HIS B  89
TYR B 117
HIS B  67
 CLA  B1225 ( 4.4A)
CLA  B1205 ( 3.9A)
None
CLA  B1204 (-4.1A)
 1.15A 5z84C-4rkuB:
2.9
5z84N-4rkuB:
undetectable
5z84P-4rkuB:
2.9		 5z84C-4rkuB:
16.14
5z84N-4rkuB:
22.74
5z84P-4rkuB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 8 LEU B 371
HIS B  89
TYR B 117
HIS B  67
 CLA  B1225 ( 4.4A)
CLA  B1205 ( 3.9A)
None
CLA  B1204 (-4.1A)
 1.16A 5z86C-4rkuB:
2.9
5z86N-4rkuB:
4.8
5z86P-4rkuB:
2.9		 5z86C-4rkuB:
16.14
5z86N-4rkuB:
22.74
5z86P-4rkuB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGB_B_PQNB844_1
(PSAB)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		7 / 9 ILE A  54
TRP A  55
MET A 691
ARG A 697
TRP A 700
ALA A 724
LEU A 725
 CLA  A1101 ( 3.9A)
CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 1.13A 5zgbB-4rkuA:
39.3		 5zgbB-4rkuA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGB_B_PQNB844_1
(PSAB)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		8 / 9 ILE B  21
TRP B  22
MET B 662
ARG B 668
TRP B 671
ALA B 699
LEU B 700
ALA B 705
 CLA  A1131 ( 4.4A)
CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 1.13A 5zgbB-4rkuB:
44.1		 5zgbB-4rkuB:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGB_B_PQNB844_1
(PSAB)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		8 / 9 ILE B  21
TRP B  22
MET B 662
TRP B 667
ARG B 668
ALA B 699
LEU B 700
ALA B 705
 CLA  A1131 ( 4.4A)
CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
None
None
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.57A 5zgbB-4rkuB:
44.1		 5zgbB-4rkuB:
9.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZGB_B_PQNB844_1
(PSAB)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		7 / 9 ILE 1  48
TRP 1  49
MET 1 684
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 None
CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 1.16A 5zgbB-5oy01:
37.4		 5zgbB-5oy01:
36.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZGB_B_PQNB844_1
(PSAB)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		8 / 9 ILE b  21
TRP b  22
MET b 659
TRP b 664
ARG b 665
ALA b 696
LEU b 697
ALA b 702
 None
CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
None
None
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.57A 5zgbB-5oy0b:
42.3		 5zgbB-5oy0b:
89.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZGB_B_PQNB844_1
(PSAB)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		7 / 9 ILE b  21
TRP b  22
MET b 659
TRP b 668
ALA b 696
LEU b 697
ALA b 702
 None
CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 1.18A 5zgbB-5oy0b:
42.3		 5zgbB-5oy0b:
89.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZGB_B_PQNB844_1
(PSAB)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 9 ILE b  25
MET b 659
TRP b 664
LEU b 697
ALA b 702
 LMG  b1851 ( 4.9A)
CLA  b1807 ( 3.2A)
None
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 1.43A 5zgbB-5oy0b:
42.3		 5zgbB-5oy0b:
89.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZGB_B_PQNB844_1
(PSAB)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		7 / 9 ILE A  45
TRP A  46
MET A 681
ARG A 687
TRP A 690
ALA A 714
LEU A 715
 CLA  A1101 ( 4.3A)
None
PQN  A2001 ( 3.3A)
None
PQN  A2001 ( 3.2A)
PQN  A2001 (-3.2A)
PQN  A2001 (-3.7A)
 1.41A 5zgbB-6fosA:
34.9		 5zgbB-6fosA:
36.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGH_B_PQNB843_1
(PSAB)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		7 / 9 ILE A  54
TRP A  55
MET A 691
ARG A 697
TRP A 700
ALA A 724
LEU A 725
 CLA  A1101 ( 3.9A)
CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 1.13A 5zghB-4rkuA:
33.3		 5zghB-4rkuA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGH_B_PQNB843_1
(PSAB)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		7 / 9 ILE B  21
TRP B  22
MET B 662
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  A1131 ( 4.4A)
CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 1.22A 5zghB-4rkuB:
41.1		 5zghB-4rkuB:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGH_B_PQNB843_1
(PSAB)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		8 / 9 ILE B  21
TRP B  22
MET B 662
TRP B 667
ARG B 668
ALA B 699
LEU B 700
ALA B 705
 CLA  A1131 ( 4.4A)
CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
None
None
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.61A 5zghB-4rkuB:
41.1		 5zghB-4rkuB:
9.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZGH_B_PQNB843_1
(PSAB)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		7 / 9 ILE 1  48
TRP 1  49
MET 1 684
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 None
CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 1.17A 5zghB-5oy01:
33.9		 5zghB-5oy01:
36.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZGH_B_PQNB843_1
(PSAB)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		8 / 9 ILE b  21
TRP b  22
MET b 659
TRP b 664
ARG b 665
ALA b 696
LEU b 697
ALA b 702
 None
CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
None
None
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.60A 5zghB-5oy0b:
42.0		 5zghB-5oy0b:
89.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZGH_B_PQNB843_1
(PSAB)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		6 / 9 ILE b  21
TRP b  22
MET b 659
TRP b 668
ALA b 696
LEU b 697
 None
CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 1.26A 5zghB-5oy0b:
42.0		 5zghB-5oy0b:
89.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZGH_B_PQNB843_1
(PSAB)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		7 / 9 ILE A  45
TRP A  46
MET A 681
ARG A 687
TRP A 690
ALA A 714
LEU A 715
 CLA  A1101 ( 4.3A)
None
PQN  A2001 ( 3.3A)
None
PQN  A2001 ( 3.2A)
PQN  A2001 (-3.2A)
PQN  A2001 (-3.7A)
 1.41A 5zghB-6fosA:
31.6		 5zghB-6fosA:
36.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
(Thermosynechococ
cus
vulcanus) 		5 / 10 MET B 166
GLY B 160
ILE B 203
ALA B 155
PHE B 247
 None
None
None
None
CLA  B1010 ( 3.6A)
 1.42A 5zjiA-3a0hB:
3.0
5zjiJ-3a0hB:
undetectable		 5zjiA-3a0hB:
9.03
5zjiJ-3a0hB:
7.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		9 / 10 MET A 691
PHE A 692
SER A 695
GLY A 696
ARG A 697
TRP A 700
ILE A 704
ALA A 724
LEU A 725
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.6A)
PQN  A5001 (-3.5A)
PQN  A5001 ( 4.1A)
None
PQN  A5001 ( 3.4A)
CLA  A1139 ( 4.5A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.49A 5zjiA-4rkuA:
51.6
5zjiJ-4rkuA:
undetectable		 5zjiA-4rkuA:
98.04
5zjiJ-4rkuA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		8 / 10 MET B 662
PHE B 663
SER B 666
ARG B 668
TRP B 671
ILE B 675
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 4.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
CLA  B1238 (-3.9A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.51A 5zjiA-4rkuB:
35.3
5zjiJ-4rkuB:
undetectable		 5zjiA-4rkuB:
6.88
5zjiJ-4rkuB:
5.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		9 / 10 MET 1 684
PHE 1 685
SER 1 688
GLY 1 689
ARG 1 690
TRP 1 693
ILE 1 697
ALA 1 717
LEU 1 718
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.8A)
PQN  1 842 (-3.4A)
PQN  1 842 ( 4.3A)
None
PQN  1 842 ( 3.3A)
None
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.30A 5zjiA-5oy01:
46.7
5zjiJ-5oy01:
undetectable		 5zjiA-5oy01:
64.94
5zjiJ-5oy01:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		8 / 10 MET b 659
PHE b 660
SER b 663
ARG b 665
TRP b 668
ILE b 672
ALA b 696
LEU b 697
 CLA  b1807 ( 3.2A)
PQN  b1844 ( 4.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
CLA  b1841 (-4.6A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.56A 5zjiA-5oy0b:
34.5
5zjiJ-5oy0b:
undetectable		 5zjiA-5oy0b:
42.62
5zjiJ-5oy0b:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 10 MET B 660
PHE B 661
SER B 664
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
 PQN  B2002 ( 3.2A)
PQN  B2002 ( 4.3A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.82A 5zjiA-6fosB:
28.3
5zjiJ-6fosB:
undetectable		 5zjiA-6fosB:
50.00
5zjiJ-6fosB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		7 / 10 TRP A  55
MET A 691
ARG A 697
TRP A 700
ILE A 704
ALA A 724
LEU A 725
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
None
PQN  A5001 ( 3.4A)
CLA  A1139 ( 4.5A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.66A 5zjiB-4rkuA:
40.2		 5zjiB-4rkuA:
7.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		10 / 10 TRP B  22
ILE B  25
MET B 662
TRP B 667
ARG B 668
TRP B 671
ILE B 675
ALA B 699
LEU B 700
ALA B 705
 CLA  B1238 ( 4.0A)
CLA  B1201 ( 4.7A)
CLA  B9023 ( 3.3A)
None
None
PQN  B5002 ( 3.3A)
CLA  B1238 (-3.9A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.56A 5zjiB-4rkuB:
46.0		 5zjiB-4rkuB:
94.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		7 / 10 TRP 1  49
MET 1 684
ARG 1 690
TRP 1 693
ILE 1 697
ALA 1 717
LEU 1 718
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
None
PQN  1 842 ( 3.3A)
None
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.57A 5zjiB-5oy01:
37.4		 5zjiB-5oy01:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		6 / 10 ILE b  21
MET b 659
TRP b 664
TRP b 668
LEU b 697
ALA b 702
 None
CLA  b1807 ( 3.2A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 1.44A 5zjiB-5oy0b:
44.3		 5zjiB-5oy0b:
78.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		10 / 10 TRP b  22
ILE b  25
MET b 659
TRP b 664
ARG b 665
TRP b 668
ILE b 672
ALA b 696
LEU b 697
ALA b 702
 CLA  b1841 ( 4.0A)
LMG  b1851 ( 4.9A)
CLA  b1807 ( 3.2A)
None
None
PQN  b1844 ( 3.4A)
CLA  b1841 (-4.6A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.37A 5zjiB-5oy0b:
44.3		 5zjiB-5oy0b:
78.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 10 ILE B  25
MET B 660
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 CLA  B1201 ( 4.6A)
PQN  B2002 ( 3.2A)
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.68A 5zjiB-6fosB:
32.7		 5zjiB-6fosB:
83.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		9 / 10 TRP B  22
ILE B  25
TRP B 665
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 None
CLA  B1201 ( 4.6A)
None
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.94A 5zjiB-6fosB:
32.7		 5zjiB-6fosB:
83.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLY 1 142
THR 1 385
GLN 1 386
TYR 1 145
 CLA  1 829 (-4.6A)
None
None
None
 1.08A 6ag0A-5oy01:
undetectable		 6ag0A-5oy01:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLY 1 142
THR 1 385
GLN 1 386
TYR 1 145
 CLA  1 829 (-4.6A)
None
None
None
 1.14A 6ag0C-5oy01:
undetectable		 6ag0C-5oy01:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1q90 CYTOCHROME B6
(Chlamydomonas
reinhardtii) 		5 / 12 VAL B 151
PHE B 183
VAL B 190
SER B 130
VAL B 133
 TDS  D 920 (-4.1A)
None
None
CLA  D 910 (-3.6A)
CLA  D 910 (-4.0A)
 0.88A 6ap6A-1q90B:
undetectable		 6ap6A-1q90B:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1q90 CYTOCHROME B6
(Chlamydomonas
reinhardtii) 		5 / 12 VAL B 151
PHE B 183
VAL B 190
SER B 130
VAL B 133
 TDS  D 920 (-4.1A)
None
None
CLA  D 910 (-3.6A)
CLA  D 910 (-4.0A)
 0.90A 6ap6B-1q90B:
undetectable		 6ap6B-1q90B:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 5xno CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Pisum
sativum) 		3 / 3 TYR 3  33
PRO 3  42
LEU 3  45
 CHL  3 601 (-4.6A)
None
CLA  3 602 (-4.0A)
 0.95A 6beoA-5xno3:
undetectable		 6beoA-5xno3:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		5 / 12 ASP 1 589
SER 1 586
VAL 1 402
GLY 1 405
ALA 1 409
 None
None
CLA  1 830 ( 4.7A)
BCR  1 848 ( 3.9A)
None
 1.12A 6bqgA-5oy01:
1.7		 6bqgA-5oy01:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 1ppr PERIDININ-CHLOROPHYL
L PROTEIN
(Amphidinium
carterae) 		4 / 7 ASP M  86
ASN M  89
ALA M  90
LEU M  10
 None
PID  M 614 (-4.0A)
None
CLA  M 601 ( 4.9A)
 0.96A 6ci6A-1pprM:
1.7		 6ci6A-1pprM:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Cyanidioschyzon
merolae) 		4 / 5 TYR A 368
GLN A 383
GLY A 507
ILE A 522
 None
None
None
CLA  A1135 ( 4.9A)
 1.45A 6debB-6fosA:
undetectable		 6debB-6fosA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 2o01 PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLAST
(Spinacia
oleracea) 		5 / 12 LEU L  58
GLY L 142
GLY L 146
GLU L  55
LEU L  51
 CLA  H1501 (-3.8A)
None
None
CLA  L1502 ( 3.4A)
None
 0.96A 6ectA-2o01L:
undetectable		 6ectA-2o01L:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 5zji CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Zea
mays) 		5 / 11 TYR 3 194
ASP 3 191
LEU 3  64
GLY 3 223
PRO 3 192
 CLA  3 610 (-4.3A)
None
CLA  3 602 ( 4.8A)
None
None
 1.45A 6euqA-5zji3:
undetectable		 6euqA-5zji3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 3jcu CHLOROPHYLL A-B
BINDING PROTEIN 26
KD (CP26)
(Spinacia
oleracea) 		3 / 3 HIS S 221
ASN S 229
LEU S 230
 CLA  S 614 ( 3.4A)
CLA  S 614 ( 3.7A)
CLA  S 613 (-3.7A)
 0.89A 6f7lB-3jcuS:
undetectable		 6f7lB-3jcuS:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		6 / 6 TRP A  55
MET A 691
GLY A 696
TRP A 700
ALA A 724
LEU A 725
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 ( 4.1A)
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.65A 6fosA-4rkuA:
43.0		 6fosA-4rkuA:
86.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 6 TRP B  22
MET B 662
TRP B 671
ALA B 699
LEU B 700
 CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.51A 6fosA-4rkuB:
32.7		 6fosA-4rkuB:
7.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		6 / 6 TRP 1  49
MET 1 684
GLY 1 689
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 ( 4.3A)
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.62A 6fosA-5oy01:
41.0		 6fosA-5oy01:
73.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		5 / 6 TRP b  22
MET b 659
TRP b 668
ALA b 696
LEU b 697
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.56A 6fosA-5oy0b:
32.2		 6fosA-5oy0b:
33.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		5 / 6 MET A 691
ARG A 697
TRP A 700
ALA A 724
LEU A 725
 CLA  A9013 ( 3.6A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.79A 6fosB-4rkuA:
28.2		 6fosB-4rkuA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 6 MET B 662
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.73A 6fosB-4rkuB:
32.8		 6fosB-4rkuB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		5 / 6 MET B 662
TRP B 671
ALA B 699
LEU B 700
ALA B 705
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.55A 6fosB-4rkuB:
32.8		 6fosB-4rkuB:
11.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		5 / 6 MET 1 684
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 802 ( 3.2A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.76A 6fosB-5oy01:
27.7		 6fosB-5oy01:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		6 / 6 MET b 659
ARG b 665
TRP b 668
ALA b 696
LEU b 697
ALA b 702
 CLA  b1807 ( 3.2A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.60A 6fosB-5oy0b:
32.7		 6fosB-5oy0b:
85.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 3a0h PHOTOSYSTEM II CP43
PROTEIN
(Thermosynechococ
cus
vulcanus) 		4 / 5 ASN C 294
TYR C 297
ARG C 423
PHE C 289
 None
None
None
CLA  C1025 ( 4.3A)
 1.45A 6h3dA-3a0hC:
undetectable		 6h3dA-3a0hC:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		9 / 10 TRP A  55
MET A 691
SER A 695
GLY A 696
ARG A 697
TRP A 700
ALA A 724
LEU A 725
GLY A 730
 CLA  A1139 (-4.1A)
CLA  A9013 ( 3.6A)
PQN  A5001 (-3.5A)
PQN  A5001 ( 4.1A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
PQN  A5001 ( 4.0A)
 0.30A 6hqbA-4rkuA:
50.2
6hqbJ-4rkuA:
undetectable		 6hqbA-4rkuA:
23.53
6hqbJ-4rkuA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		7 / 10 TRP B  22
MET B 662
SER B 666
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B1238 ( 4.0A)
CLA  B9023 ( 3.3A)
PQN  B5002 (-3.2A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.63A 6hqbA-4rkuB:
34.8
6hqbJ-4rkuB:
undetectable		 6hqbA-4rkuB:
7.02
6hqbJ-4rkuB:
4.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		9 / 10 TRP 1  49
MET 1 684
SER 1 688
GLY 1 689
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
GLY 1 723
 CLA  1 840 (-4.7A)
CLA  1 802 ( 3.2A)
PQN  1 842 (-3.4A)
PQN  1 842 ( 4.3A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
PQN  1 842 ( 3.9A)
 0.37A 6hqbA-5oy01:
44.9
6hqbJ-5oy01:
undetectable		 6hqbA-5oy01:
100.00
6hqbJ-5oy01:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		7 / 10 TRP b  22
MET b 659
SER b 663
ARG b 665
TRP b 668
ALA b 696
LEU b 697
 CLA  b1841 ( 4.0A)
CLA  b1807 ( 3.2A)
PQN  b1844 (-3.7A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
 0.64A 6hqbA-5oy0b:
34.0
6hqbJ-5oy0b:
undetectable		 6hqbA-5oy0b:
25.45
6hqbJ-5oy0b:
16.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		7 / 10 TRP B  22
MET B 660
SER B 664
ARG B 666
TRP B 669
ALA B 697
LEU B 698
 None
PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
 0.84A 6hqbA-6fosB:
28.4
6hqbJ-6fosB:
undetectable		 6hqbA-6fosB:
47.92
6hqbJ-6fosB:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Pisum
sativum) 		7 / 9 MET A 691
SER A 695
ARG A 697
TRP A 700
ILE A 704
ALA A 724
LEU A 725
 CLA  A9013 ( 3.6A)
PQN  A5001 (-3.5A)
None
PQN  A5001 ( 3.4A)
CLA  A1139 ( 4.5A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.65A 6hqbB-4rkuA:
33.8		 6hqbB-4rkuA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		9 / 9 MET B 662
SER B 666
TRP B 667
ARG B 668
TRP B 671
ILE B 675
ALA B 699
LEU B 700
ALA B 705
 CLA  B9023 ( 3.3A)
PQN  B5002 (-3.2A)
None
None
PQN  B5002 ( 3.3A)
CLA  B1238 (-3.9A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.33A 6hqbB-4rkuB:
42.5		 6hqbB-4rkuB:
11.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
(Synechocystis
sp.
PCC
6803) 		7 / 9 MET 1 684
SER 1 688
ARG 1 690
TRP 1 693
ILE 1 697
ALA 1 717
LEU 1 718
 CLA  1 802 ( 3.2A)
PQN  1 842 (-3.4A)
None
PQN  1 842 ( 3.3A)
None
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.40A 6hqbB-5oy01:
34.1		 6hqbB-5oy01:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Synechocystis
sp.
PCC
6803) 		9 / 9 MET b 659
SER b 663
TRP b 664
ARG b 665
TRP b 668
ILE b 672
ALA b 696
LEU b 697
ALA b 702
 CLA  b1807 ( 3.2A)
PQN  b1844 (-3.7A)
None
None
PQN  b1844 ( 3.4A)
CLA  b1841 (-4.6A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.37A 6hqbB-5oy0b:
44.1		 6hqbB-5oy0b:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 9 MET B 660
SER B 664
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 PQN  B2002 ( 3.2A)
CLA  B1023 (-4.5A)
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 0.85A 6hqbB-6fosB:
32.7		 6hqbB-6fosB:
85.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		8 / 9 SER B 664
TRP B 665
ARG B 666
TRP B 669
ILE B 673
ALA B 697
LEU B 698
ALA B 703
 CLA  B1023 (-4.5A)
None
None
PQN  B2002 (-3.3A)
None
PQN  B2002 (-3.1A)
PQN  B2002 (-3.6A)
PQN  B2002 (-3.4A)
 1.09A 6hqbB-6fosB:
32.7		 6hqbB-6fosB:
85.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Cyanidioschyzon
merolae) 		4 / 7 GLY B 658
PHE B 711
HIS B 710
VAL B 713
 None
None
CLA  B1239 (-4.1A)
None
 0.98A 6hu9S-6fosB:
undetectable
6hu9q-6fosB:
undetectable		 6hu9S-6fosB:
undetectable
6hu9q-6fosB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5zji 16KDA MEMBRANE
PROTEIN
(Zea
mays) 		4 / 8 HIS O 103
LEU O  53
GLY O  52
LEU O 110
 CLA  O2001 (-3.3A)
None
CLA  O2002 ( 4.1A)
None
 0.85A 6mdqA-5zjiO:
undetectable		 6mdqA-5zjiO:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2
(Pisum
sativum) 		4 / 7 HIS B  89
TYR B 117
HIS B  67
LEU B 371
 CLA  B1205 ( 3.9A)
None
CLA  B1204 (-4.1A)
CLA  B1225 ( 4.4A)
 1.18A 6nmfA-4rkuB:
1.3
6nmfC-4rkuB:
2.8
6nmfP-4rkuB:
2.8		 6nmfA-4rkuB:
22.74
6nmfC-4rkuB:
16.14
6nmfP-4rkuB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 5mdx CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 LEU 4  77
ASP 4  84
LEU 4  88
GLY 4  89
PHE 4  94
 CLA  4 302 (-4.1A)
CLA  4 302 (-3.6A)
None
CLA  4 302 ( 4.7A)
None
 1.31A 6r2eG-5mdx4:
undetectable		 6r2eG-5mdx4:
21.43