SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CKK'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1IEP_A_STIA201_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | VAL A1092ALA A1108GLU A1127MET A1131GLY A1163ALA A1221ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 ( 4.5A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.92A | 1iepA-3c1xA:30.3 | 1iepA-3c1xA:32.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1IEP_B_STIB202_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | VAL A1092ALA A1108GLU A1127GLY A1163ALA A1221ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 ( 4.5A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.92A | 1iepB-3c1xA:26.1 | 1iepB-3c1xA:32.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1IEP_B_STIB202_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | VAL A1092ALA A1108GLU A1127MET A1131ALA A1221ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.94A | 1iepB-3c1xA:26.1 | 1iepB-3c1xA:32.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2HYY_A_STIA600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | VAL A1092ALA A1108GLU A1127MET A1131GLY A1163ALA A1221ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 ( 4.5A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.96A | 2hyyA-3c1xA:26.5 | 2hyyA-3c1xA:32.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2HYY_B_STIB600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | VAL A1092ALA A1108GLU A1127MET A1131GLY A1163ALA A1221ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 ( 4.5A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.93A | 2hyyB-3c1xA:26.4 | 2hyyB-3c1xA:32.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2OIQ_A_STIA1001_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | VAL A1092ALA A1108GLU A1127MET A1131TYR A1159GLY A1163ALA A1221ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-4.5A)CKK A1500 ( 4.5A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.98A | 2oiqA-3c1xA:26.6 | 2oiqA-3c1xA:32.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2PL0_A_STIA200_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | VAL A1092ALA A1108GLU A1127MET A1131TYR A1159ALA A1221ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-4.5A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.94A | 2pl0A-3c1xA:25.5 | 2pl0A-3c1xA:28.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2WGJ_A_VGHA2346_1 (HEPATOCYTE GROWTHFACTOR RECEPTOR) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 10 / 12 | GLY A1085VAL A1092ALA A1108LEU A1140LEU A1157TYR A1159MET A1160GLY A1163MET A1211ALA A1221 | NoneCKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-4.8A)CKK A1500 (-4.7A)CKK A1500 (-4.5A)NoneCKK A1500 ( 4.5A)CKK A1500 (-3.6A)CKK A1500 (-3.4A) | 0.50A | 2wgjA-3c1xA:28.5 | 2wgjA-3c1xA:80.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_B_NILB600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | ALA A1108GLY A1163HIS A1202ALA A1221ASP A1222 | CKK A1500 (-3.2A)CKK A1500 ( 4.5A)CKK A1500 (-4.2A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.49A | 3cs9B-3c1xA:30.9 | 3cs9B-3c1xA:33.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_B_NILB600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | GLU A1127GLY A1163HIS A1202ALA A1221ASP A1222 | CKK A1500 (-3.4A)CKK A1500 ( 4.5A)CKK A1500 (-4.2A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.66A | 3cs9B-3c1xA:30.9 | 3cs9B-3c1xA:33.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3CS9_C_NILC600_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | ALA A1108GLU A1127MET A1131PHE A1200HIS A1202ALA A1221ASP A1222 | CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 ( 4.8A)CKK A1500 (-4.2A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.83A | 3cs9C-3c1xA:26.7 | 3cs9C-3c1xA:33.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3GCS_A_BAXA401_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 14) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | VAL A1092ALA A1108GLU A1127HIS A1202ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-4.2A)CKK A1500 (-4.5A) | 0.79A | 3gcsA-3c1xA:20.2 | 3gcsA-3c1xA:22.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3K5V_B_STIB2_1 (TYROSINE-PROTEINKINASE ABL1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | VAL A1092ALA A1108GLU A1127MET A1131GLY A1163ALA A1221ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 ( 4.5A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.97A | 3k5vB-3c1xA:29.7 | 3k5vB-3c1xA:32.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MS9_A_STIA1_1 (TYROSINE-PROTEINKINASE ABL1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | VAL A1092ALA A1108GLU A1127MET A1131ALA A1221ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 1.02A | 3ms9A-3c1xA:29.9 | 3ms9A-3c1xA:32.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MS9_B_STIB1_1 (TYROSINE-PROTEINKINASE ABL1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | VAL A1092ALA A1108GLU A1127MET A1131GLY A1163ALA A1221ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 ( 4.5A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.99A | 3ms9B-3c1xA:26.2 | 3ms9B-3c1xA:32.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MSS_A_STIA1_1 (TYROSINE-PROTEINKINASE ABL1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | VAL A1092ALA A1108GLU A1127MET A1131ALA A1221ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 1.01A | 3mssA-3c1xA:26.5 | 3mssA-3c1xA:32.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MSS_C_STIC1_1 (TYROSINE-PROTEINKINASE ABL1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | VAL A1092ALA A1108GLU A1127MET A1131ALA A1221ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.98A | 3mssC-3c1xA:30.0 | 3mssC-3c1xA:32.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3MSS_D_STID1_1 (TYROSINE-PROTEINKINASE ABL1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | ALA A1108GLU A1127MET A1131GLY A1163ALA A1221ASP A1222 | CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 ( 4.5A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.91A | 3mssD-3c1xA:26.5 | 3mssD-3c1xA:32.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OEZ_B_STIB601_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | VAL A1092ALA A1108GLU A1127MET A1131TYR A1159ALA A1221ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-4.5A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.84A | 3oezB-3c1xA:26.8 | 3oezB-3c1xA:32.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3OXZ_A_0LIA1_1 (TYROSINE-PROTEINKINASE ABL1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | ALA A1108GLU A1127MET A1131GLY A1163HIS A1202ALA A1221ASP A1222 | CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 ( 4.5A)CKK A1500 (-4.2A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.81A | 3oxzA-3c1xA:30.3 | 3oxzA-3c1xA:34.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3V5W_A_8PRA701_2 (G-PROTEIN COUPLEDRECEPTOR KINASE 2) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 3 / 3 | LEU A1157MET A1160ASP A1164 | CKK A1500 (-4.7A)NoneCKK A1500 (-3.7A) | 0.61A | 3v5wA-3c1xA:20.1 | 3v5wA-3c1xA:18.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ZBF_A_VGHA3000_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | ALA A1108LEU A1140LEU A1157MET A1160GLY A1163ASP A1164 | CKK A1500 (-3.2A)CKK A1500 (-4.8A)CKK A1500 (-4.7A)NoneCKK A1500 ( 4.5A)CKK A1500 (-3.7A) | 0.53A | 3zbfA-3c1xA:30.6 | 3zbfA-3c1xA:35.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ANQ_A_VGHA9000_1 (ALK TYROSINE KINASERECEPTOR) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 9 | VAL A1092ALA A1108LEU A1157MET A1160GLY A1163ALA A1221 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-4.7A)NoneCKK A1500 ( 4.5A)CKK A1500 (-3.4A) | 0.75A | 4anqA-3c1xA:25.8 | 4anqA-3c1xA:33.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4BKJ_A_STIA1000_1 (EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | VAL A1092ALA A1108GLU A1127ILE A1130MET A1131TYR A1159ALA A1221ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)NoneCKK A1500 (-3.4A)CKK A1500 (-4.5A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 1.00A | 4bkjA-3c1xA:24.9 | 4bkjA-3c1xA:32.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4BKJ_B_STIB1000_1 (EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | ALA A1108GLU A1127ILE A1130MET A1131ALA A1221ASP A1222 | CKK A1500 (-3.2A)CKK A1500 (-3.4A)NoneCKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.96A | 4bkjB-3c1xA:25.0 | 4bkjB-3c1xA:32.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4BKJ_B_STIB1000_1 (EPITHELIAL DISCOIDINDOMAIN-CONTAININGRECEPTOR 1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | VAL A1092ALA A1108GLU A1127ILE A1130MET A1131ALA A1221 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)NoneCKK A1500 (-3.4A)CKK A1500 (-3.4A) | 1.05A | 4bkjB-3c1xA:25.0 | 4bkjB-3c1xA:32.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4CKI_A_ADNA2022_1 (PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 11 | GLY A1085GLY A1087VAL A1092ALA A1108TYR A1159GLY A1163 | NoneNoneCKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-4.5A)CKK A1500 ( 4.5A) | 0.90A | 4ckiA-3c1xA:26.5 | 4ckiA-3c1xA:31.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4CSV_A_STIA1265_1 (SRC-ABL TYROSINEKINASE ANCESTOR) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 8 / 12 | VAL A1092ALA A1108GLU A1127ILE A1130MET A1131TYR A1159ALA A1221ASP A1222 | CKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-3.4A)NoneCKK A1500 (-3.4A)CKK A1500 (-4.5A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.99A | 4csvA-3c1xA:27.1 | 4csvA-3c1xA:33.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4L9I_B_8PRB601_1 (RHODOPSIN KINASE) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 8 | GLY A1087VAL A1092ALA A1108MET A1160ASP A1164 | NoneCKK A1500 ( 4.3A)CKK A1500 (-3.2A)NoneCKK A1500 (-3.7A) | 0.92A | 4l9iB-3c1xA:17.0 | 4l9iB-3c1xA:24.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4QRC_A_0LIA802_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | GLU A1127MET A1131LEU A1195ALA A1221ASP A1222 | CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-4.4A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 1.16A | 4qrcA-3c1xA:24.4 | 4qrcA-3c1xA:32.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4TYJ_A_0LIA801_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | ALA A1108GLU A1127MET A1131HIS A1202ALA A1221ASP A1222 | CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-4.2A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.89A | 4tyjA-3c1xA:26.7 | 4tyjA-3c1xA:31.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4UXQ_A_0LIA1752_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 4) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | ALA A1108LEU A1195HIS A1202ALA A1221ASP A1222 | CKK A1500 (-3.2A)CKK A1500 (-4.4A)CKK A1500 (-4.2A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.53A | 4uxqA-3c1xA:25.6 | 4uxqA-3c1xA:30.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V01_A_0LIA1776_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | ALA A1108GLU A1127MET A1131LEU A1195HIS A1202ALA A1221ASP A1222 | CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-4.4A)CKK A1500 (-4.2A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.86A | 4v01A-3c1xA:27.5 | 4v01A-3c1xA:32.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V01_B_0LIB1770_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | ALA A1108GLU A1127MET A1131LEU A1195HIS A1202ALA A1221ASP A1222 | CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-3.4A)CKK A1500 (-4.4A)CKK A1500 (-4.2A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.81A | 4v01B-3c1xA:27.2 | 4v01B-3c1xA:32.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_A_0LIA1772_1 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | ALA A1108GLU A1127LEU A1195HIS A1202ALA A1221ASP A1222 | CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-4.4A)CKK A1500 (-4.2A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.85A | 4v04A-3c1xA:25.9 | 4v04A-3c1xA:32.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4V04_B_0LIB1771_2 (FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | ALA A1108GLU A1127LEU A1195HIS A1202ALA A1221ASP A1222 | CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-4.4A)CKK A1500 (-4.2A)CKK A1500 (-3.4A)CKK A1500 (-4.5A) | 0.89A | 4v04B-3c1xA:26.4 | 4v04B-3c1xA:32.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5LW1_B_ADNB401_1 (MITOGEN-ACTIVATEDPROTEIN KINASE 8) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 9 | ILE A1084GLY A1085VAL A1092ALA A1108MET A1160 | CKK A1500 ( 4.4A)NoneCKK A1500 ( 4.3A)CKK A1500 (-3.2A)None | 0.52A | 5lw1B-3c1xA:19.3 | 5lw1B-3c1xA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5MAF_A_XINA403_1 (MATERNAL EMBRYONICLEUCINE ZIPPERKINASE) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 7 / 12 | ILE A1084GLY A1085VAL A1092ALA A1108LEU A1157TYR A1159GLY A1163 | CKK A1500 ( 4.4A)NoneCKK A1500 ( 4.3A)CKK A1500 (-3.2A)CKK A1500 (-4.7A)CKK A1500 (-4.5A)CKK A1500 ( 4.5A) | 0.66A | 5mafA-3c1xA:22.4 | 5mafA-3c1xA:11.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5MO4_A_NILA601_2 (TYROSINE-PROTEINKINASE ABL1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 5 / 12 | ALA A1108MET A1131PHE A1200HIS A1202ASP A1222 | CKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 ( 4.8A)CKK A1500 (-4.2A)CKK A1500 (-4.5A) | 0.65A | 5mo4A-3c1xA:26.4 | 5mo4A-3c1xA:30.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VC3_A_DB8A601_1 (WEE1-LIKE PROTEINKINASE) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 6 / 12 | ILE A1084GLY A1085ALA A1108GLU A1127TYR A1159GLY A1163 | CKK A1500 ( 4.4A)NoneCKK A1500 (-3.2A)CKK A1500 (-3.4A)CKK A1500 (-4.5A)CKK A1500 ( 4.5A) | 0.96A | 5vc3A-3c1xA:21.7 | 5vc3A-3c1xA:25.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6HD6_B_STIB601_1 (TYROSINE-PROTEINKINASE ABL1) |
3c1x | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homosapiens) | 4 / 7 | MET A1160GLY A1163ARG A1203ALA A1221 | NoneCKK A1500 ( 4.5A)NoneCKK A1500 (-3.4A) | 0.57A | 6hd6B-3c1xA:29.6 | 6hd6B-3c1xA:13.54 |