SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CKK'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 VAL A1092
ALA A1108
GLU A1127
MET A1131
GLY A1163
ALA A1221
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.92A 1iepA-3c1xA:
30.3
1iepA-3c1xA:
32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 VAL A1092
ALA A1108
GLU A1127
GLY A1163
ALA A1221
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.92A 1iepB-3c1xA:
26.1
1iepB-3c1xA:
32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 VAL A1092
ALA A1108
GLU A1127
MET A1131
ALA A1221
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.94A 1iepB-3c1xA:
26.1
1iepB-3c1xA:
32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 VAL A1092
ALA A1108
GLU A1127
MET A1131
GLY A1163
ALA A1221
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.96A 2hyyA-3c1xA:
26.5
2hyyA-3c1xA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 VAL A1092
ALA A1108
GLU A1127
MET A1131
GLY A1163
ALA A1221
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.93A 2hyyB-3c1xA:
26.4
2hyyB-3c1xA:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 VAL A1092
ALA A1108
GLU A1127
MET A1131
TYR A1159
GLY A1163
ALA A1221
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.98A 2oiqA-3c1xA:
26.6
2oiqA-3c1xA:
32.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 VAL A1092
ALA A1108
GLU A1127
MET A1131
TYR A1159
ALA A1221
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.94A 2pl0A-3c1xA:
25.5
2pl0A-3c1xA:
28.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
10 / 12 GLY A1085
VAL A1092
ALA A1108
LEU A1140
LEU A1157
TYR A1159
MET A1160
GLY A1163
MET A1211
ALA A1221
None
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-4.8A)
CKK  A1500 (-4.7A)
CKK  A1500 (-4.5A)
None
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.6A)
CKK  A1500 (-3.4A)
0.50A 2wgjA-3c1xA:
28.5
2wgjA-3c1xA:
80.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 ALA A1108
GLY A1163
HIS A1202
ALA A1221
ASP A1222
CKK  A1500 (-3.2A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.49A 3cs9B-3c1xA:
30.9
3cs9B-3c1xA:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 GLU A1127
GLY A1163
HIS A1202
ALA A1221
ASP A1222
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.66A 3cs9B-3c1xA:
30.9
3cs9B-3c1xA:
33.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 ALA A1108
GLU A1127
MET A1131
PHE A1200
HIS A1202
ALA A1221
ASP A1222
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.8A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.83A 3cs9C-3c1xA:
26.7
3cs9C-3c1xA:
33.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 VAL A1092
ALA A1108
GLU A1127
HIS A1202
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.2A)
CKK  A1500 (-4.5A)
0.79A 3gcsA-3c1xA:
20.2
3gcsA-3c1xA:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 VAL A1092
ALA A1108
GLU A1127
MET A1131
GLY A1163
ALA A1221
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.97A 3k5vB-3c1xA:
29.7
3k5vB-3c1xA:
32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 VAL A1092
ALA A1108
GLU A1127
MET A1131
ALA A1221
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
1.02A 3ms9A-3c1xA:
29.9
3ms9A-3c1xA:
32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 VAL A1092
ALA A1108
GLU A1127
MET A1131
GLY A1163
ALA A1221
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.99A 3ms9B-3c1xA:
26.2
3ms9B-3c1xA:
32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 VAL A1092
ALA A1108
GLU A1127
MET A1131
ALA A1221
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
1.01A 3mssA-3c1xA:
26.5
3mssA-3c1xA:
32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 VAL A1092
ALA A1108
GLU A1127
MET A1131
ALA A1221
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.98A 3mssC-3c1xA:
30.0
3mssC-3c1xA:
32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 ALA A1108
GLU A1127
MET A1131
GLY A1163
ALA A1221
ASP A1222
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.91A 3mssD-3c1xA:
26.5
3mssD-3c1xA:
32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 VAL A1092
ALA A1108
GLU A1127
MET A1131
TYR A1159
ALA A1221
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.84A 3oezB-3c1xA:
26.8
3oezB-3c1xA:
32.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 ALA A1108
GLU A1127
MET A1131
GLY A1163
HIS A1202
ALA A1221
ASP A1222
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.81A 3oxzA-3c1xA:
30.3
3oxzA-3c1xA:
34.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
3 / 3 LEU A1157
MET A1160
ASP A1164
CKK  A1500 (-4.7A)
None
CKK  A1500 (-3.7A)
0.61A 3v5wA-3c1xA:
20.1
3v5wA-3c1xA:
18.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 ALA A1108
LEU A1140
LEU A1157
MET A1160
GLY A1163
ASP A1164
CKK  A1500 (-3.2A)
CKK  A1500 (-4.8A)
CKK  A1500 (-4.7A)
None
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.7A)
0.53A 3zbfA-3c1xA:
30.6
3zbfA-3c1xA:
35.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 9 VAL A1092
ALA A1108
LEU A1157
MET A1160
GLY A1163
ALA A1221
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-4.7A)
None
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.4A)
0.75A 4anqA-3c1xA:
25.8
4anqA-3c1xA:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 VAL A1092
ALA A1108
GLU A1127
ILE A1130
MET A1131
TYR A1159
ALA A1221
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
None
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
1.00A 4bkjA-3c1xA:
24.9
4bkjA-3c1xA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 ALA A1108
GLU A1127
ILE A1130
MET A1131
ALA A1221
ASP A1222
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
None
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.96A 4bkjB-3c1xA:
25.0
4bkjB-3c1xA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 VAL A1092
ALA A1108
GLU A1127
ILE A1130
MET A1131
ALA A1221
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
None
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
1.05A 4bkjB-3c1xA:
25.0
4bkjB-3c1xA:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 11 GLY A1085
GLY A1087
VAL A1092
ALA A1108
TYR A1159
GLY A1163
None
None
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-4.5A)
CKK  A1500 ( 4.5A)
0.90A 4ckiA-3c1xA:
26.5
4ckiA-3c1xA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
8 / 12 VAL A1092
ALA A1108
GLU A1127
ILE A1130
MET A1131
TYR A1159
ALA A1221
ASP A1222
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
None
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.99A 4csvA-3c1xA:
27.1
4csvA-3c1xA:
33.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 8 GLY A1087
VAL A1092
ALA A1108
MET A1160
ASP A1164
None
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
None
CKK  A1500 (-3.7A)
0.92A 4l9iB-3c1xA:
17.0
4l9iB-3c1xA:
24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 GLU A1127
MET A1131
LEU A1195
ALA A1221
ASP A1222
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
1.16A 4qrcA-3c1xA:
24.4
4qrcA-3c1xA:
32.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 ALA A1108
GLU A1127
MET A1131
HIS A1202
ALA A1221
ASP A1222
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.89A 4tyjA-3c1xA:
26.7
4tyjA-3c1xA:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 ALA A1108
LEU A1195
HIS A1202
ALA A1221
ASP A1222
CKK  A1500 (-3.2A)
CKK  A1500 (-4.4A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.53A 4uxqA-3c1xA:
25.6
4uxqA-3c1xA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 ALA A1108
GLU A1127
MET A1131
LEU A1195
HIS A1202
ALA A1221
ASP A1222
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.4A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.86A 4v01A-3c1xA:
27.5
4v01A-3c1xA:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 ALA A1108
GLU A1127
MET A1131
LEU A1195
HIS A1202
ALA A1221
ASP A1222
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.4A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.81A 4v01B-3c1xA:
27.2
4v01B-3c1xA:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 ALA A1108
GLU A1127
LEU A1195
HIS A1202
ALA A1221
ASP A1222
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.4A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.85A 4v04A-3c1xA:
25.9
4v04A-3c1xA:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 ALA A1108
GLU A1127
LEU A1195
HIS A1202
ALA A1221
ASP A1222
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.4A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
0.89A 4v04B-3c1xA:
26.4
4v04B-3c1xA:
32.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 9 ILE A1084
GLY A1085
VAL A1092
ALA A1108
MET A1160
CKK  A1500 ( 4.4A)
None
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
None
0.52A 5lw1B-3c1xA:
19.3
5lw1B-3c1xA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
7 / 12 ILE A1084
GLY A1085
VAL A1092
ALA A1108
LEU A1157
TYR A1159
GLY A1163
CKK  A1500 ( 4.4A)
None
CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-4.7A)
CKK  A1500 (-4.5A)
CKK  A1500 ( 4.5A)
0.66A 5mafA-3c1xA:
22.4
5mafA-3c1xA:
11.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
5 / 12 ALA A1108
MET A1131
PHE A1200
HIS A1202
ASP A1222
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 ( 4.8A)
CKK  A1500 (-4.2A)
CKK  A1500 (-4.5A)
0.65A 5mo4A-3c1xA:
26.4
5mo4A-3c1xA:
30.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
6 / 12 ILE A1084
GLY A1085
ALA A1108
GLU A1127
TYR A1159
GLY A1163
CKK  A1500 ( 4.4A)
None
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
CKK  A1500 ( 4.5A)
0.96A 5vc3A-3c1xA:
21.7
5vc3A-3c1xA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo
sapiens)
4 / 7 MET A1160
GLY A1163
ARG A1203
ALA A1221
None
CKK  A1500 ( 4.5A)
None
CKK  A1500 (-3.4A)
0.57A 6hd6B-3c1xA:
29.6
6hd6B-3c1xA:
13.54