SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CKI'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1M17_A_AQ4A999_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2csn	CASEIN KINASE-1 (Schizosaccharomy ces pombe)	8 / 12	ALA A 39 LYS A 41 GLU A 55 LEU A 83 LEU A 87 GLY A 89 LEU A 138 ASP A 154	CKI A 300 (-3.6A) None None None None None CKI A 300 (-4.4A) CKI A 300 (-4.4A)	1.30A	1m17A-2csnA: 22.7	1m17A-2csnA: 24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LFA_A_1N1A361_1 (MITOGEN-ACTIVATED PROTEIN KINASE 14)	2csn	CASEIN KINASE-1 (Schizosaccharomy ces pombe)	5 / 8	ALA A 39 LYS A 41 GLU A 55 LEU A 83 LEU A 87	CKI A 300 (-3.6A) None None None None	0.76A	3lfaA-2csnA: 18.4	3lfaA-2csnA: 22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V5W_A_8PRA701_1 (G-PROTEIN COUPLED RECEPTOR KINASE 2)	2csn	CASEIN KINASE-1 (Schizosaccharomy ces pombe)	7 / 12	ILE A 18 GLY A 21 GLY A 24 ALA A 39 LYS A 41 LEU A 138 ASP A 154	CKI A 300 (-4.1A) None None CKI A 300 (-3.6A) None CKI A 300 (-4.4A) CKI A 300 (-4.4A)	0.77A	3v5wA-2csnA: 24.3	3v5wA-2csnA: 17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KS8_A_B49A701_1 (SERINE/THREONINE-PRO TEIN KINASE PAK 6)	2csn	CASEIN KINASE-1 (Schizosaccharomy ces pombe)	6 / 10	ILE A 18 ALA A 39 LEU A 88 GLY A 89 LEU A 138 ASP A 154	CKI A 300 (-4.1A) CKI A 300 (-3.6A) CKI A 300 (-4.0A) None CKI A 300 (-4.4A) CKI A 300 (-4.4A)	1.36A	4ks8A-2csnA: 24.5	4ks8A-2csnA: 25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KS8_A_B49A701_1 (SERINE/THREONINE-PRO TEIN KINASE PAK 6)	2csn	CASEIN KINASE-1 (Schizosaccharomy ces pombe)	6 / 10	ILE A 18 ALA A 39 VAL A 153 LEU A 88 GLY A 89 LEU A 138	CKI A 300 (-4.1A) CKI A 300 (-3.6A) CKI A 300 (-4.1A) CKI A 300 (-4.0A) None CKI A 300 (-4.4A)	1.30A	4ks8A-2csnA: 24.5	4ks8A-2csnA: 25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OTI_A_MI1A1001_1 (SERINE/THREONINE-PRO TEIN KINASE N1)	2csn	CASEIN KINASE-1 (Schizosaccharomy ces pombe)	7 / 12	GLY A 19 GLY A 21 GLY A 24 ALA A 39 LYS A 41 LEU A 138 ASP A 154	CKI A 300 ( 3.8A) None None CKI A 300 (-3.6A) None CKI A 300 (-4.4A) CKI A 300 (-4.4A)	0.62A	4otiA-2csnA: 12.6	4otiA-2csnA: 24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QMS_A_1N1A401_1 (SERINE/THREONINE-PRO TEIN KINASE 24)	2csn	CASEIN KINASE-1 (Schizosaccharomy ces pombe)	6 / 11	ILE A 18 ALA A 39 LYS A 41 GLU A 55 LEU A 138 ASP A 154	CKI A 300 (-4.1A) CKI A 300 (-3.6A) None None CKI A 300 (-4.4A) CKI A 300 (-4.4A)	0.86A	4qmsA-2csnA: 25.6	4qmsA-2csnA: 24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZ7_A_1E8A901_1 (CGMP-DEPENDENT PROTEIN KINASE, PUTATIVE)	2csn	CASEIN KINASE-1 (Schizosaccharomy ces pombe)	5 / 10	ILE A 18 ALA A 39 LYS A 41 LEU A 87 LEU A 138	CKI A 300 (-4.1A) CKI A 300 (-3.6A) None None CKI A 300 (-4.4A)	0.41A	4rz7A-2csnA: 23.3	4rz7A-2csnA: 16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U8Y_B_MIYB1102_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	4xhl	CASEIN KINASE I HOMOLOG HRR25 (Saccharomyces cerevisiae)	5 / 12	GLU A 40 ILE A 37 ALA A 36 VAL A 35 PHE A 9	None None CKI A 401 (-3.3A) None None	0.95A	4u8yB-4xhlA: undetectable	4u8yB-4xhlA: 17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U95_B_MIYB1102_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	4xhl	CASEIN KINASE I HOMOLOG HRR25 (Saccharomyces cerevisiae)	5 / 12	GLU A 40 ILE A 37 ALA A 36 VAL A 35 PHE A 9	None None CKI A 401 (-3.3A) None None	0.93A	4u95B-4xhlA: undetectable	4u95B-4xhlA: 17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WKQ_A_IREA1101_1 (EPIDERMAL GROWTH FACTOR RECEPTOR)	2csn	CASEIN KINASE-1 (Schizosaccharomy ces pombe)	7 / 12	ALA A 39 LYS A 41 GLU A 55 LEU A 83 LEU A 87 GLY A 89 LEU A 138	CKI A 300 (-3.6A) None None None None None CKI A 300 (-4.4A)	1.27A	4wkqA-2csnA: 22.3	4wkqA-2csnA: 23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AJQ_B_DB8B800_1 (SERINE/THREONINE-PRO TEIN KINASE 10)	2csn	CASEIN KINASE-1 (Schizosaccharomy ces pombe)	5 / 10	ALA A 39 ILE A 85 GLY A 89 LEU A 138 ASP A 154	CKI A 300 (-3.6A) CKI A 300 ( 4.5A) None CKI A 300 (-4.4A) CKI A 300 (-4.4A)	1.13A	5ajqB-2csnA: 21.9	5ajqB-2csnA: 20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IZF_E_AZ1E2_1 (CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA 6J9-ZEU-DAR-ACA-DAR- NH2)	2csn	CASEIN KINASE-1 (Schizosaccharomy ces pombe)	5 / 7	GLY A 19 GLY A 21 SER A 22 PHE A 23 LYS A 41	CKI A 300 ( 3.8A) None None None None	1.25A	5izfA-2csnA: 23.6	5izfA-2csnA: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5J5X_B_AZ1B2_1 (CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA 47P-AZ1-DAL-DAR-DAR- DAR-DAR)	2csn	CASEIN KINASE-1 (Schizosaccharomy ces pombe)	4 / 7	GLY A 19 GLY A 21 SER A 22 LYS A 41	CKI A 300 ( 3.8A) None None None	0.43A	5j5xA-2csnA: 23.7	5j5xA-2csnA: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OWR_A_1N1A401_1 (SERINE/THREONINE-PRO TEIN KINASE 10)	2csn	CASEIN KINASE-1 (Schizosaccharomy ces pombe)	5 / 8	ALA A 39 GLU A 55 ILE A 85 LEU A 138 ASP A 154	CKI A 300 (-3.6A) None CKI A 300 ( 4.5A) CKI A 300 (-4.4A) CKI A 300 (-4.4A)	0.85A	5owrA-2csnA: 20.4	5owrA-2csnA: 20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OWR_A_1N1A401_1 (SERINE/THREONINE-PRO TEIN KINASE 10)	4xhl	CASEIN KINASE I HOMOLOG HRR25 (Saccharomyces cerevisiae)	5 / 8	ALA A 36 GLU A 52 ILE A 82 LEU A 135 ASP A 149	CKI A 401 (-3.3A) None CKI A 401 ( 4.1A) None None	0.78A	5owrA-4xhlA: 19.4	5owrA-4xhlA: 23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VCV_A_1N1A404_1 (MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE)	2csn	CASEIN KINASE-1 (Schizosaccharomy ces pombe)	6 / 12	ALA A 39 LYS A 41 GLU A 55 LEU A 83 GLY A 89 PRO A 90	CKI A 300 (-3.6A) None None None None None	0.84A	5vcvA-2csnA: 21.8	5vcvA-2csnA: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y7Z_B_IREB401_0 (CYCLIN-G-ASSOCIATED KINASE)	2csn	CASEIN KINASE-1 (Schizosaccharomy ces pombe)	8 / 12	ALA A 39 LYS A 41 GLU A 55 LEU A 83 LEU A 87 GLY A 89 LEU A 138 ASP A 154	CKI A 300 (-3.6A) None None None None None CKI A 300 (-4.4A) CKI A 300 (-4.4A)	1.02A	5y7zB-2csnA: 23.9	5y7zB-2csnA: 16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FZB_B_SRYB301_1 (STREPTOMYCIN 3''-ADENYLYLTRANSFER ASE)	4xhl	CASEIN KINASE I HOMOLOG HRR25 (Saccharomyces cerevisiae)	5 / 12	GLN A 190 ASP A 195 ASP A 132 ASP A 149 ILE A 148	None None None None CKI A 401 ( 3.7A)	1.39A	6fzbB-4xhlA: 0.8	6fzbB-4xhlA: 12.95

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1M17_A_AQ4A999_1","EPIDERMAL GROWTH FACTOR RECEPTOR","2csn","CASEIN KINASE-1","Schizosaccharomyces pombe",8,"ALA A  39;LYS A  41;GLU A  55;LEU A  83;LEU A  87;GLY A  89;LEU A 138;ASP A 154","CKI A 300 (-3.6A);None;None;None;None;None;CKI A 300 (-4.4A);CKI A 300 (-4.4A)","1.30A","1m17A-2csnA:22.7",null],["3LFA_A_1N1A361_1","MITOGEN-ACTIVATED PROTEIN KINASE 14","2csn","CASEIN KINASE-1","Schizosaccharomyces pombe",5,"ALA A  39;LYS A  41;GLU A  55;LEU A  83;LEU A  87","CKI A 300 (-3.6A);None;None;None;None","0.76A","3lfaA-2csnA:18.4","1m17A-2csnA:24.15"],["3V5W_A_8PRA701_1","G-PROTEIN COUPLED RECEPTOR KINASE 2","2csn","CASEIN KINASE-1","Schizosaccharomyces pombe",7,"ILE A  18;GLY A  21;GLY A  24;ALA A  39;LYS A  41;LEU A 138;ASP A 154","CKI A 300 (-4.1A);None;None;CKI A 300 (-3.6A);None;CKI A 300 (-4.4A);CKI A 300 (-4.4A)","0.77A","3v5wA-2csnA:24.3","3lfaA-2csnA:22.44"],["4KS8_A_B49A701_1","SERINE\/THREONINE-PROTEIN KINASE PAK 6","2csn","CASEIN KINASE-1","Schizosaccharomyces pombe",6,"ILE A  18;ALA A  39;LEU A  88;GLY A  89;LEU A 138;ASP A 154","CKI A 300 (-4.1A);CKI A 300 (-3.6A);CKI A 300 (-4.0A);None;CKI A 300 (-4.4A);CKI A 300 (-4.4A)","1.36A","4ks8A-2csnA:24.5","3v5wA-2csnA:17.42"],["4KS8_A_B49A701_1","SERINE\/THREONINE-PROTEIN KINASE PAK 6","2csn","CASEIN KINASE-1","Schizosaccharomyces pombe",6,"ILE A  18;ALA A  39;VAL A 153;LEU A  88;GLY A  89;LEU A 138","CKI A 300 (-4.1A);CKI A 300 (-3.6A);CKI A 300 (-4.1A);CKI A 300 (-4.0A);None;CKI A 300 (-4.4A)","1.30A","4ks8A-2csnA:24.5","4ks8A-2csnA:25.29"],["4OTI_A_MI1A1001_1","SERINE\/THREONINE-PROTEIN KINASE N1","2csn","CASEIN KINASE-1","Schizosaccharomyces pombe",7,"GLY A  19;GLY A  21;GLY A  24;ALA A  39;LYS A  41;LEU A 138;ASP A 154","CKI A 300 ( 3.8A);None;None;CKI A 300 (-3.6A);None;CKI A 300 (-4.4A);CKI A 300 (-4.4A)","0.62A","4otiA-2csnA:12.6","4ks8A-2csnA:25.29"],["4QMS_A_1N1A401_1","SERINE\/THREONINE-PROTEIN KINASE 24","2csn","CASEIN KINASE-1","Schizosaccharomyces pombe",6,"ILE A  18;ALA A  39;LYS A  41;GLU A  55;LEU A 138;ASP A 154","CKI A 300 (-4.1A);CKI A 300 (-3.6A);None;None;CKI A 300 (-4.4A);CKI A 300 (-4.4A)","0.86A","4qmsA-2csnA:25.6","4otiA-2csnA:24.66"],["4RZ7_A_1E8A901_1","CGMP-DEPENDENT PROTEIN KINASE, PUTATIVE","2csn","CASEIN KINASE-1","Schizosaccharomyces pombe",5,"ILE A  18;ALA A  39;LYS A  41;LEU A  87;LEU A 138","CKI A 300 (-4.1A);CKI A 300 (-3.6A);None;None;CKI A 300 (-4.4A)","0.41A","4rz7A-2csnA:23.3","4qmsA-2csnA:24.20"],["4U8Y_B_MIYB1102_1","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","4xhl","CASEIN KINASE I HOMOLOG HRR25","Saccharomyces cerevisiae",5,"GLU A  40;ILE A  37;ALA A  36;VAL A  35;PHE A   9","None;None;CKI A 401 (-3.3A);None;None","0.95A","4u8yB-4xhlA:undetectable","4rz7A-2csnA:16.12"],["4U95_B_MIYB1102_1","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","4xhl","CASEIN KINASE I HOMOLOG HRR25","Saccharomyces cerevisiae",5,"GLU A  40;ILE A  37;ALA A  36;VAL A  35;PHE A   9","None;None;CKI A 401 (-3.3A);None;None","0.93A","4u95B-4xhlA:undetectable","4u8yB-4xhlA:17.90"],["4WKQ_A_IREA1101_1","EPIDERMAL GROWTH FACTOR RECEPTOR","2csn","CASEIN KINASE-1","Schizosaccharomyces pombe",7,"ALA A  39;LYS A  41;GLU A  55;LEU A  83;LEU A  87;GLY A  89;LEU A 138","CKI A 300 (-3.6A);None;None;None;None;None;CKI A 300 (-4.4A)","1.27A","4wkqA-2csnA:22.3","4u95B-4xhlA:17.13"],["5AJQ_B_DB8B800_1","SERINE\/THREONINE-PROTEIN KINASE 10","2csn","CASEIN KINASE-1","Schizosaccharomyces pombe",5,"ALA A  39;ILE A  85;GLY A  89;LEU A 138;ASP A 154","CKI A 300 (-3.6A);CKI A 300 ( 4.5A);None;CKI A 300 (-4.4A);CKI A 300 (-4.4A)","1.13A","5ajqB-2csnA:21.9","4wkqA-2csnA:23.73"],["5IZF_E_AZ1E2_1","CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA;6J9-ZEU-DAR-ACA-DAR-NH2","2csn","CASEIN KINASE-1","Schizosaccharomyces pombe",5,"GLY A  19;GLY A  21;SER A  22;PHE A  23;LYS A  41","CKI A 300 ( 3.8A);None;None;None;None","1.25A","5izfA-2csnA:23.6","5ajqB-2csnA:20.57"],["5J5X_B_AZ1B2_1","CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA;47P-AZ1-DAL-DAR-DAR-DAR-DAR","2csn","CASEIN KINASE-1","Schizosaccharomyces pombe",4,"GLY A  19;GLY A  21;SER A  22;LYS A  41","CKI A 300 ( 3.8A);None;None;None","0.43A","5j5xA-2csnA:23.7","5izfA-2csnA:21.84"],["5OWR_A_1N1A401_1","SERINE\/THREONINE-PROTEIN KINASE 10","2csn","CASEIN KINASE-1","Schizosaccharomyces pombe",5,"ALA A  39;GLU A  55;ILE A  85;LEU A 138;ASP A 154","CKI A 300 (-3.6A);None;CKI A 300 ( 4.5A);CKI A 300 (-4.4A);CKI A 300 (-4.4A)","0.85A","5owrA-2csnA:20.4","5j5xA-2csnA:21.84"],["5OWR_A_1N1A401_1","SERINE\/THREONINE-PROTEIN KINASE 10","4xhl","CASEIN KINASE I HOMOLOG HRR25","Saccharomyces cerevisiae",5,"ALA A  36;GLU A  52;ILE A  82;LEU A 135;ASP A 149","CKI A 401 (-3.3A);None;CKI A 401 ( 4.1A);None;None","0.78A","5owrA-4xhlA:19.4","5owrA-2csnA:20.25"],["5VCV_A_1N1A404_1","MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE","2csn","CASEIN KINASE-1","Schizosaccharomyces pombe",6,"ALA A  39;LYS A  41;GLU A  55;LEU A  83;GLY A  89;PRO A  90","CKI A 300 (-3.6A);None;None;None;None;None","0.84A","5vcvA-2csnA:21.8","5owrA-4xhlA:23.40"],["5Y7Z_B_IREB401_0","CYCLIN-G-ASSOCIATED KINASE","2csn","CASEIN KINASE-1","Schizosaccharomyces pombe",8,"ALA A  39;LYS A  41;GLU A  55;LEU A  83;LEU A  87;GLY A  89;LEU A 138;ASP A 154","CKI A 300 (-3.6A);None;None;None;None;None;CKI A 300 (-4.4A);CKI A 300 (-4.4A)","1.02A","5y7zB-2csnA:23.9","5vcvA-2csnA:22.47"],["6FZB_B_SRYB301_1","STREPTOMYCIN 3''-ADENYLYLTRANSFERASE","4xhl","CASEIN KINASE I HOMOLOG HRR25","Saccharomyces cerevisiae",5,"GLN A 190;ASP A 195;ASP A 132;ASP A 149;ILE A 148","None;None;None;None;CKI A 401 ( 3.7A)","1.39A","6fzbB-4xhlA:0.8","5y7zB-2csnA:16.33"]]