SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CJC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		6 / 9 ASN A  41
GLU A  45
ASP A  68
ARG A  71
ILE A  89
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-4.6A)
CJC  A 401 (-3.6A)
 0.49A 1aj6A-4hymA:
27.1		 1aj6A-4hymA:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		6 / 9 ASN A  41
GLU A  45
ASP A  68
ARG A  71
PRO A  74
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-3.6A)
 0.79A 1aj6A-4hymA:
27.1		 1aj6A-4hymA:
27.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 12 ASP A  44
GLU A  45
ASP A  68
ARG A  71
ASP A  76
ILE A  89
ARG A 131
THR A 162
 None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
None
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.96A 1kijA-4hymA:
37.0		 1kijA-4hymA:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 ASP A  44
GLU A  45
ASP A  68
PRO A  74
ASP A  76
ARG A 131
THR A 162
 None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 1.24A 1kijA-4hymA:
37.0		 1kijA-4hymA:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 12 ASN A  41
GLU A  45
ASP A  68
ARG A  71
ASP A  76
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
None
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.76A 1kijB-4hymA:
37.1		 1kijB-4hymA:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 ASN A  41
GLU A  45
ASP A  68
PRO A  74
ASP A  76
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 1.04A 1kijB-4hymA:
37.1		 1kijB-4hymA:
37.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		9 / 12 ASN A  41
SER A  42
ASP A  44
GLU A  45
ASP A  68
MET A  73
ASP A  76
ILE A  89
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
None
CJC  A 401 (-4.6A)
CJC  A 401 (-3.6A)
 0.88A 1s14A-4hymA:
27.0		 1s14A-4hymA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		10 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
ASP A  76
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
None
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.61A 1s14A-4hymA:
27.0		 1s14A-4hymA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		10 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
PRO A  74
ASP A  76
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.78A 1s14A-4hymA:
27.0		 1s14A-4hymA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 12 ASN A  41
SER A  42
ASP A  44
GLU A  45
ASP A  68
MET A  73
ASP A  76
ILE A  89
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
None
CJC  A 401 (-4.6A)
 1.00A 1s14B-4hymA:
29.1		 1s14B-4hymA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		10 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
PRO A  74
ASP A  76
ILE A  89
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
 0.84A 1s14B-4hymA:
29.1		 1s14B-4hymA:
29.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 12 ILE A  56
LEU A  58
ILE A  39
VAL A 118
VAL A 115
 None
None
None
None
CJC  A 401 (-4.6A)
 1.01A 2ygpA-4hymA:
undetectable		 2ygpA-4hymA:
19.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		9 / 12 ASN A  41
SER A  42
ASP A  44
GLU A  45
ASP A  68
MET A  73
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.70A 3lpsA-4hymA:
41.4		 3lpsA-4hymA:
48.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		9 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.40A 3lpsA-4hymA:
41.4		 3lpsA-4hymA:
48.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		9 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
PRO A  74
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.55A 3lpsA-4hymA:
41.4		 3lpsA-4hymA:
48.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 SER A  42
ASP A  44
GLU A  45
ASP A  68
ASP A  76
ARG A 131
THR A 162
 CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
None
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 1.01A 3lpsA-4hymA:
41.4		 3lpsA-4hymA:
48.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 12 SER A  42
GLU A  45
ASP A  68
ARG A  71
PRO A  74
ASP A  76
ARG A 131
THR A 162
 CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 1.03A 3lpsA-4hymA:
41.4		 3lpsA-4hymA:
48.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 12 ILE A  54
ALA A  51
LEU A 197
ALA A 196
ILE A  38
 None
None
None
None
CJC  A 401 (-4.5A)
 0.98A 3oapA-4hymA:
undetectable		 3oapA-4hymA:
18.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 11 ASN A  41
SER A  42
ASP A  44
ASP A  68
MET A  73
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.80A 4urnA-4hymA:
27.5		 4urnA-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 11 ASN A  41
SER A  42
ASP A  44
ASP A  68
MET A  73
PRO A  74
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.83A 4urnA-4hymA:
27.5		 4urnA-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		9 / 11 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.66A 4urnA-4hymA:
27.5		 4urnA-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		9 / 11 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
PRO A  74
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.66A 4urnA-4hymA:
27.5		 4urnA-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 11 SER A  42
GLU A  45
ASP A  68
ARG A  71
ILE A  86
 CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
None
 0.92A 4urnA-4hymA:
27.5		 4urnA-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 11 ASN A  41
SER A  42
ASP A  44
ASP A  68
MET A  73
PRO A  74
ILE A  89
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.6A)
CJC  A 401 (-3.6A)
 0.93A 4urnB-4hymA:
26.2		 4urnB-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		10 / 11 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
PRO A  74
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.65A 4urnB-4hymA:
26.2		 4urnB-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 11 SER A  42
GLU A  45
ASP A  68
ARG A  71
ILE A  86
 CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
None
 0.88A 4urnB-4hymA:
26.2		 4urnB-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 11 ASN A  41
SER A  42
ASP A  44
ASP A  68
MET A  73
PRO A  74
ILE A  89
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
None
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.6A)
CJC  A 401 (-3.6A)
 0.88A 4urnC-4hymA:
27.7		 4urnC-4hymA:
31.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		10 / 11 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
MET A  73
PRO A  74
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.63A 4urnC-4hymA:
27.7		 4urnC-4hymA:
31.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
ASP A  76
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
None
CJC  A 401 (-4.2A)
 0.83A 4uroA-4hymA:
27.5		 4uroA-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
ILE A  89
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
 0.50A 4uroA-4hymA:
27.5		 4uroA-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
PRO A  74
ASP A  76
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
 1.05A 4uroA-4hymA:
27.5		 4uroA-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		5 / 12 SER A  42
GLU A  45
ASP A  68
ARG A  71
ILE A  86
 CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
None
 0.83A 4uroA-4hymA:
27.5		 4uroA-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
PRO A  74
ILE A  89
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
 0.68A 4uroB-4hymA:
27.7		 4uroB-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 SER A  42
GLU A  45
ASP A  68
ARG A  71
PRO A  74
ASP A  76
ARG A 131
 CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
 0.99A 4uroB-4hymA:
27.7		 4uroB-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		6 / 12 ASN A  41
GLU A  45
ASP A  68
ARG A  71
ILE A  89
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
 0.52A 4uroC-4hymA:
27.8		 4uroC-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		6 / 12 ASN A  41
GLU A  45
ASP A  68
ARG A  71
PRO A  74
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.2A)
 0.79A 4uroC-4hymA:
27.8		 4uroC-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		6 / 12 GLU A  45
ASP A  68
ARG A  71
PRO A  74
ASP A  76
ARG A 131
 CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
 1.20A 4uroC-4hymA:
27.8		 4uroC-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
ILE A  89
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.50A 4uroD-4hymA:
27.0		 4uroD-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		8 / 12 ASN A  41
SER A  42
GLU A  45
ASP A  68
ARG A  71
PRO A  74
ARG A 131
THR A 162
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.73A 4uroD-4hymA:
27.0		 4uroD-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4hym TOPOISOMERASE IV,
SUBUNIT B
(Francisella
tularensis) 		7 / 12 SER A  42
GLU A  45
ASP A  68
ARG A  71
ASP A  76
ARG A 131
THR A 162
 CJC  A 401 (-3.1A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
None
CJC  A 401 (-4.2A)
CJC  A 401 (-3.6A)
 0.73A 4uroD-4hymA:
27.0		 4uroD-4hymA:
27.93