SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CIR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 1lxy ARGININE DEIMINASE
(Mycoplasma
arginini) 		5 / 12 LEU A  78
LEU A  75
LEU A 156
ARG A 180
LEU A 403
 None
None
None
CIR  A 500 (-4.0A)
None
 1.39A 1a28B-1lxyA:
undetectable		 1a28B-1lxyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4jqo ORNITHINE
CARBAMOYLTRANSFERASE
(Vibrio
vulnificus) 		4 / 5 ALA A 161
TYR A 162
TYR A 231
GLN A 138
 None
None
None
CIR  A 402 (-3.6A)
 1.15A 1xl6A-4jqoA:
undetectable
1xl6B-4jqoA:
undetectable		 1xl6A-4jqoA:
20.88
1xl6B-4jqoA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4jqo ORNITHINE
CARBAMOYLTRANSFERASE
(Vibrio
vulnificus) 		4 / 4 LEU A  13
SER A  28
ASP A 142
ASP A 233
 CL  A 403 (-3.9A)
None
None
CIR  A 402 (-3.2A)
 1.37A 2br4B-4jqoA:
5.1		 2br4B-4jqoA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1lxy ARGININE DEIMINASE
(Mycoplasma
arginini) 		3 / 3 SER A 285
ASP A 349
CYH A 398
 None
None
CIR  A 500 (-1.7A)
 1.14A 2br4E-1lxyA:
undetectable		 2br4E-1lxyA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		4 / 6 SER A  92
LEU A  89
ASP A 124
GLU A 270
 None
None
ASP  A 501 ( 3.6A)
CIR  A 502 (-2.6A)
 1.07A 2j2pE-2nz2A:
undetectable
2j2pF-2nz2A:
undetectable		 2j2pE-2nz2A:
19.47
2j2pF-2nz2A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 1lxy ARGININE DEIMINASE
(Mycoplasma
arginini) 		5 / 12 LEU A  78
LEU A  75
LEU A 156
ARG A 180
LEU A 403
 None
None
None
CIR  A 500 (-4.0A)
None
 1.44A 2w8yB-1lxyA:
undetectable		 2w8yB-1lxyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 1lxy ARGININE DEIMINASE
(Mycoplasma
arginini) 		3 / 3 PHE A 158
ASN A 155
PHE A  45
 CIR  A 500 ( 3.8A)
CIR  A 500 (-3.6A)
CIR  A 500 ( 4.9A)
 1.07A 2zbuD-1lxyA:
undetectable		 2zbuD-1lxyA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1lxy ARGININE DEIMINASE
(Mycoplasma
arginini) 		5 / 11 GLY A 228
THR A 275
ARG A 176
ARG A 232
GLY A 214
 None
None
None
CIR  A 500 (-2.9A)
None
 1.50A 3abmA-1lxyA:
0.0
3abmB-1lxyA:
0.0
3abmT-1lxyA:
0.0		 3abmA-1lxyA:
20.50
3abmB-1lxyA:
19.56
3abmT-1lxyA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 1lxy ARGININE DEIMINASE
(Mycoplasma
arginini) 		5 / 11 GLY A 228
THR A 275
ARG A 176
ARG A 232
GLY A 214
 None
None
None
CIR  A 500 (-2.9A)
None
 1.50A 3ag1A-1lxyA:
0.0
3ag1B-1lxyA:
0.0
3ag1T-1lxyA:
0.0		 3ag1A-1lxyA:
20.50
3ag1B-1lxyA:
19.56
3ag1T-1lxyA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 1lxy ARGININE DEIMINASE
(Mycoplasma
arginini) 		3 / 3 TRP A 264
TRP A 273
THR A 272
 None
None
CIR  A 500 (-4.5A)
 1.36A 4bboB-1lxyA:
0.0		 4bboB-1lxyA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 1lxy ARGININE DEIMINASE
(Mycoplasma
arginini) 		4 / 5 GLU A 183
ARG A 180
PRO A 162
SER A 187
 None
CIR  A 500 (-4.0A)
None
None
 1.19A 4k17B-1lxyA:
undetectable		 4k17B-1lxyA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 2nz2 ARGININOSUCCINATE
SYNTHASE
(Homo
sapiens) 		5 / 12 HIS A 187
THR A  91
SER A  92
GLY A 280
GLY A 264
 None
CIR  A 502 (-3.7A)
None
None
None
 1.50A 4uinH-2nz2A:
undetectable
4uinL-2nz2A:
undetectable		 4uinH-2nz2A:
18.20
4uinL-2nz2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 1lxy ARGININE DEIMINASE
(Mycoplasma
arginini) 		5 / 11 PHE A  45
ILE A  48
LEU A  49
LEU A  44
PRO A 154
 CIR  A 500 ( 4.9A)
None
None
CIR  A 500 (-3.5A)
None
 1.25A 6fgcA-1lxyA:
0.0		 6fgcA-1lxyA:
11.47