SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CHW'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RNR_A_DAHA208_1 (RIBONUCLEOTIDE REDUCTASE R1 PROTEIN)	3vva	ALTERNATIVE OXIDASE, MITOCHONDRIAL (Trypanosoma brucei)	6 / 11	GLU A 162 HIS A 165 LEU A 212 GLU A 213 ILE A 262 GLU A 266	FE A 501 (-2.4A) FE A 501 (-3.3A) CHW A 504 (-4.1A) FE A 502 (-2.1A) None OH A 503 (-2.3A)	0.95A	1rnrA-3vvaA: 8.1	1rnrA-3vvaA: 21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RNR_B_DAHB208_1 (RIBONUCLEOTIDE REDUCTASE R1 PROTEIN)	3vva	ALTERNATIVE OXIDASE, MITOCHONDRIAL (Trypanosoma brucei)	5 / 12	GLU A 162 HIS A 165 LEU A 212 GLU A 213 GLU A 266	FE A 501 (-2.4A) FE A 501 (-3.3A) CHW A 504 (-4.1A) FE A 502 (-2.1A) OH A 503 (-2.3A)	0.92A	1rnrB-3vvaA: 6.6	1rnrB-3vvaA: 21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TUD_D_ERMD1201_1 (5-HYDROXYTRYPTAMINE RECEPTOR 2B,SOLUBLE CYTOCHROME B562 CHIMERA)	3vva	ALTERNATIVE OXIDASE, MITOCHONDRIAL (Trypanosoma brucei)	5 / 12	MET A 190 PHE A 208 VAL A 128 LEU A 212 VAL A 92	CHW A 504 ( 4.8A) None None CHW A 504 (-4.1A) None	1.15A	5tudD-3vvaA: 3.3	5tudD-3vvaA: 19.57

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1RNR_A_DAHA208_1","RIBONUCLEOTIDE REDUCTASE R1 PROTEIN","3vva","ALTERNATIVE OXIDASE, MITOCHONDRIAL","Trypanosoma brucei",6,"GLU A 162;HIS A 165;LEU A 212;GLU A 213;ILE A 262;GLU A 266"," FE A 501 (-2.4A); FE A 501 (-3.3A);CHW A 504 (-4.1A); FE A 502 (-2.1A);None; OH A 503 (-2.3A)","0.95A","1rnrA-3vvaA:8.1",null],["1RNR_B_DAHB208_1","RIBONUCLEOTIDE REDUCTASE R1 PROTEIN","3vva","ALTERNATIVE OXIDASE, MITOCHONDRIAL","Trypanosoma brucei",5,"GLU A 162;HIS A 165;LEU A 212;GLU A 213;GLU A 266"," FE A 501 (-2.4A); FE A 501 (-3.3A);CHW A 504 (-4.1A); FE A 502 (-2.1A); OH A 503 (-2.3A)","0.92A","1rnrB-3vvaA:6.6","1rnrA-3vvaA:21.61"],["5TUD_D_ERMD1201_1","5-HYDROXYTRYPTAMINE RECEPTOR 2B,SOLUBLE CYTOCHROME B562 CHIMERA","3vva","ALTERNATIVE OXIDASE, MITOCHONDRIAL","Trypanosoma brucei",5,"MET A 190;PHE A 208;VAL A 128;LEU A 212;VAL A  92","CHW A 504 ( 4.8A);None;None;CHW A 504 (-4.1A);None","1.15A","5tudD-3vvaA:3.3","1rnrB-3vvaA:21.61"]]