SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CH6'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1xqm KINDLING FLUORESCENT
PROTEIN
(Anemonia
sulcata) 		4 / 7 TYR A  72
SER A  83
TYR A 178
GLN A  39
 None
None
None
CH6  A  63 ( 3.5A)
 1.22A 1eiiA-1xqmA:
undetectable		 1eiiA-1xqmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 1xqm KINDLING FLUORESCENT
PROTEIN
(Anemonia
sulcata) 		5 / 12 MET A  41
CYH A  26
ILE A 121
PHE A  24
LEU A  51
 CH6  A  63 ( 3.8A)
None
None
None
None
 1.48A 1m2zD-1xqmA:
undetectable		 1m2zD-1xqmA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1xqm KINDLING FLUORESCENT
PROTEIN
(Anemonia
sulcata) 		5 / 11 GLY A 219
HIS A 193
GLU A 145
HIS A 197
VAL A 218
 None
None
CH6  A  63 ( 3.3A)
CH6  A  63 ( 3.5A)
None
 1.14A 1pg2A-1xqmA:
undetectable		 1pg2A-1xqmA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1xqm KINDLING FLUORESCENT
PROTEIN
(Anemonia
sulcata) 		4 / 6 GLU A 215
THR A  13
TYR A 117
TYR A 178
 CH6  A  63 ( 3.0A)
None
CH6  A  63 ( 4.6A)
None
 1.23A 1qvuA-1xqmA:
undetectable		 1qvuA-1xqmA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 4ohs FAR-RED FLUORESCENT
PROTEIN AQ143
(Actinia
equina) 		4 / 6 ARG A 181
GLY A  87
LYS A  67
THR A  68
 None
None
CH6  A  63 ( 4.0A)
None
 1.10A 2m2oB-4ohsA:
undetectable		 2m2oB-4ohsA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1xqm KINDLING FLUORESCENT
PROTEIN
(Anemonia
sulcata) 		4 / 6 THR A  14
GLY A  28
ILE A  43
LYS A  66
 None
None
None
CH6  A  63 ( 3.5A)
 1.01A 4acbC-1xqmA:
undetectable		 4acbC-1xqmA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4ohs FAR-RED FLUORESCENT
PROTEIN AQ143
(Actinia
equina) 		4 / 6 THR A  14
GLY A  28
ILE A  43
LYS A  66
 None
None
None
CH6  A  63 ( 3.6A)
 1.07A 4acbC-4ohsA:
undetectable		 4acbC-4ohsA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11
(synthetic
construct) 		5 / 12 PHE C  56
GLN C 253
LEU C  46
VAL C  48
ILE C  29
 None
CH6  C  66 ( 4.7A)
None
None
None
 1.09A 4k38B-4kf5C:
undetectable		 4k38B-4kf5C:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11
(synthetic
construct) 		5 / 12 PHE C  56
GLN C 253
LEU C  46
VAL C  48
ILE C  29
 None
CH6  C  66 ( 4.7A)
None
None
None
 1.16A 4k39A-4kf5C:
undetectable		 4k39A-4kf5C:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 1xqm KINDLING FLUORESCENT
PROTEIN
(Anemonia
sulcata) 		4 / 5 GLY A  37
ALA A 217
PHE A  69
GLU A 215
 None
None
None
CH6  A  63 ( 3.0A)
 0.93A 4m93B-1xqmA:
undetectable
4m93C-1xqmA:
undetectable		 4m93B-1xqmA:
22.27
4m93C-1xqmA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 4ohs FAR-RED FLUORESCENT
PROTEIN AQ143
(Actinia
equina) 		4 / 5 GLY A  37
ALA A 216
PHE A  69
GLU A 214
 None
None
None
CH6  A  63 ( 2.8A)
 0.89A 4m93B-4ohsA:
undetectable
4m93C-4ohsA:
undetectable		 4m93B-4ohsA:
22.00
4m93C-4ohsA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11
(synthetic
construct) 		4 / 8 TRP C 143
ILE C 161
GLU C 148
GLN C 163
 CH6  C  66 ( 4.7A)
CH6  C  66 ( 4.9A)
None
CH6  C  66 ( 3.5A)
 0.93A 4mj8A-4kf5C:
undetectable		 4mj8A-4kf5C:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11
(synthetic
construct) 		3 / 3 LYS C 222
ARG C  95
VAL C  96
 None
CH6  C  66 ( 2.5A)
None
 0.77A 4x3uA-4kf5C:
undetectable
4x3uB-4kf5C:
undetectable		 4x3uA-4kf5C:
16.81
4x3uB-4kf5C:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4kf5 FLUORESCENT PROTEIN
SFCHERRY+GFP10-11
(synthetic
construct) 		3 / 3 TYR C 120
TYR C  82
SER C  86
 CH6  C  66 ( 4.3A)
None
None
 1.01A 5iktB-4kf5C:
undetectable		 5iktB-4kf5C:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1xqm KINDLING FLUORESCENT
PROTEIN
(Anemonia
sulcata) 		5 / 12 GLU A 149
VAL A 150
HIS A 197
PHE A  80
GLY A 219
 None
None
CH6  A  63 ( 3.5A)
None
None
 1.14A 5xioA-1xqmA:
undetectable		 5xioA-1xqmA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1xqm KINDLING FLUORESCENT
PROTEIN
(Anemonia
sulcata) 		5 / 11 ILE A  70
TYR A 178
LEU A 154
GLY A 156
SER A 158
 None
None
None
None
CH6  A  63 ( 2.4A)
 1.19A 6ieyA-1xqmA:
undetectable
6ieyB-1xqmA:
undetectable		 6ieyA-1xqmA:
17.55
6ieyB-1xqmA:
17.55