SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CF5'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		7 / 12 HIS A 391
HIS A 393
HIS A 659
GLU A 662
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.77A 1a4lA-2a3lA:
20.7		 1a4lA-2a3lA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		6 / 12 HIS A 393
HIS A 659
GLU A 662
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.70A 1a4lB-2a3lA:
20.8		 1a4lB-2a3lA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		7 / 12 HIS A 391
HIS A 393
HIS A 659
GLU A 662
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.72A 1a4lC-2a3lA:
20.8		 1a4lC-2a3lA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		6 / 12 HIS A 393
HIS A 659
GLU A 662
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.65A 1a4lD-2a3lA:
20.5		 1a4lD-2a3lA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 11 TYR A 517
HIS A 391
HIS A 659
ASP A 736
ASP A 737
 None
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 1.20A 1c3sA-2a3lA:
undetectable		 1c3sA-2a3lA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 ASP A 601
HIS A 391
HIS A 659
ASP A 736
ASP A 737
 None
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 1.46A 1t69A-2a3lA:
undetectable		 1t69A-2a3lA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 712
TYR A 467
HIS A 393
HIS A 659
HIS A 391
 None
CF5  A 841 (-2.7A)
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
ZN  A 840 ( 3.2A)
 1.36A 1tmxB-2a3lA:
undetectable		 1tmxB-2a3lA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		6 / 12 ASP A 601
HIS A 659
HIS A 681
SER A 708
ASP A 736
ASP A 737
 None
ZN  A 840 ( 3.1A)
CF5  A 841 (-4.2A)
CF5  A 841 (-3.6A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 1.47A 2pgfA-2a3lA:
20.8		 2pgfA-2a3lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		7 / 12 HIS A 393
HIS A 659
GLU A 662
HIS A 681
SER A 708
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 (-3.6A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.74A 2pgfA-2a3lA:
20.8		 2pgfA-2a3lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		6 / 12 HIS A 391
ASP A 601
HIS A 659
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
None
ZN  A 840 ( 3.1A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 1.46A 2pgrA-2a3lA:
20.8		 2pgrA-2a3lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		7 / 12 HIS A 391
HIS A 393
HIS A 659
GLU A 662
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.72A 2pgrA-2a3lA:
20.8		 2pgrA-2a3lA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 5 HIS A 391
HIS A 659
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 1.17A 3c0zA-2a3lA:
undetectable		 3c0zA-2a3lA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 6 ASP A 601
HIS A 391
HIS A 659
ASP A 736
ASP A 737
 None
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 1.46A 3c0zC-2a3lA:
undetectable		 3c0zC-2a3lA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 6 HIS A 681
HIS A 659
HIS A 391
ASP A 737
 CF5  A 841 (-4.2A)
ZN  A 840 ( 3.1A)
ZN  A 840 ( 3.2A)
CF5  A 841 (-2.5A)
 0.78A 3nvcA-2a3lA:
undetectable		 3nvcA-2a3lA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 8 ASP A 736
SER A 705
HIS A 391
ASP A 737
 CF5  A 841 ( 2.5A)
None
ZN  A 840 ( 3.2A)
CF5  A 841 (-2.5A)
 1.04A 3sg9B-2a3lA:
undetectable		 3sg9B-2a3lA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 8 ASP A 736
SER A 734
HIS A 391
ASP A 737
 CF5  A 841 ( 2.5A)
None
ZN  A 840 ( 3.2A)
CF5  A 841 (-2.5A)
 0.94A 3sg9B-2a3lA:
undetectable		 3sg9B-2a3lA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		6 / 12 HIS A 659
GLU A 662
GLU A 603
HIS A 681
SER A 708
ASP A 736
 ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
None
CF5  A 841 (-4.2A)
CF5  A 841 (-3.6A)
CF5  A 841 ( 2.5A)
 0.94A 4aqlA-2a3lA:
11.4		 4aqlA-2a3lA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 ASP A 602
HIS A 391
HIS A 681
ASP A 736
TYR A 467
 None
ZN  A 840 ( 3.2A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.7A)
 1.41A 4bz6A-2a3lA:
undetectable
4bz6B-2a3lA:
undetectable		 4bz6A-2a3lA:
20.57
4bz6B-2a3lA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 4 HIS A 391
HIS A 393
HIS A 681
HIS A 659
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.2A)
CF5  A 841 (-4.2A)
ZN  A 840 ( 3.1A)
 1.13A 4ef3A-2a3lA:
undetectable		 4ef3A-2a3lA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 4 HIS A 659
HIS A 681
HIS A 393
HIS A 391
 ZN  A 840 ( 3.1A)
CF5  A 841 (-4.2A)
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.2A)
 1.04A 4ef3A-2a3lA:
undetectable		 4ef3A-2a3lA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 5 HIS A 393
ALA A 396
GLN A 546
TYR A 467
 ZN  A 840 ( 3.2A)
CF5  A 841 ( 4.7A)
None
CF5  A 841 (-2.7A)
 1.30A 4gboA-2a3lA:
undetectable		 4gboA-2a3lA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 5 HIS A 393
ALA A 396
GLN A 546
TYR A 467
 ZN  A 840 ( 3.2A)
CF5  A 841 ( 4.7A)
None
CF5  A 841 (-2.7A)
 1.40A 4gboB-2a3lA:
undetectable		 4gboB-2a3lA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 11 ASP A 601
HIS A 391
HIS A 659
ASP A 736
ASP A 737
 None
ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 1.41A 4lxzB-2a3lA:
undetectable		 4lxzB-2a3lA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		5 / 12 HIS A 681
HIS A 659
HIS A 393
ASP A 736
SER A 705
 CF5  A 841 (-4.2A)
ZN  A 840 ( 3.1A)
ZN  A 840 ( 3.2A)
CF5  A 841 ( 2.5A)
None
 1.44A 4r88A-2a3lA:
14.3		 4r88A-2a3lA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 4 ASP A 737
HIS A 391
SER A 705
GLU A 662
 CF5  A 841 (-2.5A)
ZN  A 840 ( 3.2A)
None
CF5  A 841 (-2.6A)
 1.05A 5hfjC-2a3lA:
0.0		 5hfjC-2a3lA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 5 HIS A 393
ALA A 396
GLN A 546
TYR A 467
 ZN  A 840 ( 3.2A)
CF5  A 841 ( 4.7A)
None
CF5  A 841 (-2.7A)
 1.31A 5uizA-2a3lA:
undetectable		 5uizA-2a3lA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 7 ASP A 737
ASP A 736
LYS A 466
GLN A 546
 CF5  A 841 (-2.5A)
CF5  A 841 ( 2.5A)
None
None
 1.31A 6g31A-2a3lA:
undetectable		 6g31A-2a3lA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_I_ZOLI401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		4 / 4 ASP A 737
ASP A 736
LYS A 466
GLN A 546
 CF5  A 841 (-2.5A)
CF5  A 841 ( 2.5A)
None
None
 1.34A 6g31I-2a3lA:
undetectable		 6g31I-2a3lA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		6 / 12 HIS A 393
HIS A 659
GLU A 662
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.63A 6n91A-2a3lA:
20.5		 6n91A-2a3lA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 2a3l AMP DEAMINASE
(Arabidopsis
thaliana) 		6 / 12 HIS A 393
HIS A 659
GLU A 662
HIS A 681
ASP A 736
ASP A 737
 ZN  A 840 ( 3.2A)
ZN  A 840 ( 3.1A)
CF5  A 841 (-2.6A)
CF5  A 841 (-4.2A)
CF5  A 841 ( 2.5A)
CF5  A 841 (-2.5A)
 0.64A 6n91B-2a3lA:
20.8		 6n91B-2a3lA:
7.94