SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CEY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 LEU A 193
LEU A 196
ILE A 162
GLU A 154
LEU A 152
 None
None
None
CEY  A 400 (-3.1A)
None
 1.25A 1wopA-4gizA:
undetectable		 1wopA-4gizA:
23.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 GLU A 154
TYR A 156
MET A 331
TRP A 341
 CEY  A 400 (-3.1A)
CEY  A 400 (-3.7A)
CEY  A 400 ( 3.9A)
CEY  A 400 (-3.8A)
 0.83A 3jyrA-4gizA:
58.3		 3jyrA-4gizA:
91.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VFJ_A_ACTA410_0
(MALTOSE-BINDING
PERIPLASMIC PROTEIN,
C-TERMINAL FUSED BY
CYS-LYS-D-ALA-D-ALA)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 4 LYS A  16
ALA A  64
GLU A 112
LEU A 263
 CEY  A 400 (-2.9A)
CEY  A 400 (-3.6A)
CEY  A 400 (-3.0A)
None
 0.85A 3vfjA-4gizA:
56.3		 3vfjA-4gizA:
96.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
PROTEIN E6
(Alphapapillomavi
rus
9;
Escherichia
coli;
Homo
sapiens) 		3 / 3 TYR A 342
ARG C 129
SER A 338
 CEY  A 400 (-4.5A)
None
None
 1.04A 4khpI-4gizA:
undetectable
4khpJ-4gizA:
undetectable		 4khpI-4gizA:
15.18
4khpJ-4gizA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 MET A 337
TRP A 341
TYR A 172
GLU A 329
 None
CEY  A 400 (-3.8A)
None
None
 1.47A 4r87J-4gizA:
undetectable
4r87L-4gizA:
undetectable		 4r87J-4gizA:
18.23
4r87L-4gizA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 ALA A  64
GLY A 261
GLU A 112
ASN A  13
 CEY  A 400 (-3.6A)
None
CEY  A 400 (-3.0A)
CEY  A 400 (-3.7A)
 0.78A 5ybbB-4gizA:
undetectable		 5ybbB-4gizA:
21.83