SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CEX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_1
(GLUCOAMYLASE-471)		 5d0f UNCHARACTERIZED
PROTEIN
([Candida]
glabrata) 		5 / 12 ALA A1062
ARG A1077
ASP A1078
TRP A1430
GLU A1492
 None
None
None
None
CEX  A2002 ( 4.9A)
 0.94A 1agmA-5d0fA:
17.6		 1agmA-5d0fA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_1
(GLUCOAMYLASE-471)		 5d0f UNCHARACTERIZED
PROTEIN
([Candida]
glabrata) 		5 / 12 ALA A1062
ARG A1077
ASP A1078
TRP A1430
GLU A1492
 None
None
None
None
CEX  A2002 ( 4.9A)
 0.94A 1agmA-5d0fA:
17.6		 1agmA-5d0fA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_1
(GLUCOAMYLASE GLU1)		 5d0f UNCHARACTERIZED
PROTEIN
([Candida]
glabrata) 		5 / 12 ALA A1062
ARG A1077
ASP A1078
TRP A1430
GLU A1492
 None
None
None
None
CEX  A2002 ( 4.9A)
 0.90A 2f6dA-5d0fA:
17.1		 2f6dA-5d0fA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 5d0f UNCHARACTERIZED
PROTEIN
([Candida]
glabrata) 		5 / 12 TRP A1075
ASP A1078
TRP A1510
TRP A1239
ASP A1241
 CEX  A2002 (-4.9A)
None
None
None
CEX  A2002 (-4.5A)
 1.08A 3pocB-5d0fA:
6.0		 3pocB-5d0fA:
18.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CLT_A_ACRA1000_1
(1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME)		 3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC
(Oryza
sativa) 		7 / 10 GLU A  45
TRP A  72
PRO A  74
GLY A 101
TRP A 319
GLU A 320
ARG A 323
 CEX  A 803 (-3.2A)
CEX  A 803 (-4.2A)
CEX  A 803 (-4.2A)
CEX  A 803 (-3.6A)
CEX  A 803 (-3.8A)
CEX  A 803 (-3.5A)
CEX  A 803 (-4.2A)
 0.49A 5cltA-3vu2A:
48.0		 5cltA-3vu2A:
52.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CLT_B_ACRB1000_1
(1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME)		 3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC
(Oryza
sativa) 		7 / 10 GLU A  45
TRP A  72
PRO A  74
GLY A 101
TRP A 319
GLU A 320
ARG A 323
 CEX  A 803 (-3.2A)
CEX  A 803 (-4.2A)
CEX  A 803 (-4.2A)
CEX  A 803 (-3.6A)
CEX  A 803 (-3.8A)
CEX  A 803 (-3.5A)
CEX  A 803 (-4.2A)
 0.47A 5cltB-3vu2A:
47.6		 5cltB-3vu2A:
52.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CLT_C_ACRC1000_1
(1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME)		 3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC
(Oryza
sativa) 		7 / 10 GLU A  45
TRP A  72
PRO A  74
GLY A 101
TRP A 319
GLU A 320
ARG A 323
 CEX  A 803 (-3.2A)
CEX  A 803 (-4.2A)
CEX  A 803 (-4.2A)
CEX  A 803 (-3.6A)
CEX  A 803 (-3.8A)
CEX  A 803 (-3.5A)
CEX  A 803 (-4.2A)
 0.50A 5cltC-3vu2A:
47.8		 5cltC-3vu2A:
52.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5d0f UNCHARACTERIZED
PROTEIN
([Candida]
glabrata) 		5 / 12 TRP A1075
ASP A1078
TRP A1510
TRP A1239
ASP A1241
 CEX  A2002 (-4.9A)
None
None
None
CEX  A2002 (-4.5A)
 1.08A 6ca1A-5d0fA:
4.5		 6ca1A-5d0fA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 5d0f UNCHARACTERIZED
PROTEIN
([Candida]
glabrata) 		5 / 12 TRP A1075
ASP A1078
TRP A1510
TRP A1239
ASP A1241
 CEX  A2002 (-4.9A)
None
None
None
CEX  A2002 (-4.5A)
 1.05A 6ca1B-5d0fA:
6.6		 6ca1B-5d0fA:
4.78