SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CDU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		5 / 12 PHE A 403
SER A 271
HIS A 263
PHE A 406
TYR A 294
 None
None
None
CDU  A1100 (-4.6A)
None
 1.32A 3adsA-1ek2A:
0.0		 3adsA-1ek2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		5 / 12 PHE A 403
SER A 271
HIS A 263
PHE A 406
TYR A 294
 None
None
None
CDU  A1100 (-4.6A)
None
 1.32A 3adxA-1ek2A:
undetectable		 3adxA-1ek2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		3 / 3 PHE A 458
GLN A 382
PHE A 403
 None
CDU  A1100 (-3.5A)
None
 0.84A 3rv5A-1ek2A:
undetectable		 3rv5A-1ek2A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		5 / 11 PHE A 406
ILE A 427
THR A 402
LEU A 462
PHE A 265
 CDU  A1100 (-4.6A)
None
None
None
None
 0.93A 3t3rA-1ek2A:
undetectable		 3t3rA-1ek2A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		4 / 7 PHE A 385
PHE A 406
THR A 402
PHE A 265
 None
CDU  A1100 (-4.6A)
None
None
 1.00A 4ejjB-1ek2A:
0.0		 4ejjB-1ek2A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		4 / 5 PHE A 385
PHE A 406
ILE A 427
THR A 402
 None
CDU  A1100 (-4.6A)
None
None
 0.98A 4ejjC-1ek2A:
0.0		 4ejjC-1ek2A:
23.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 1ek2 EPOXIDE HYDROLASE
(Mus
musculus) 		8 / 12 ASP A 333
PHE A 379
TYR A 381
PHE A 385
TYR A 465
LEU A 498
HIS A 523
TRP A 524
 CDU  A1100 (-3.2A)
None
CDU  A1100 (-4.4A)
None
CDU  A1100 (-4.2A)
None
CDU  A1100 (-4.1A)
None
 0.45A 4j03A-1ek2A:
50.9		 4j03A-1ek2A:
73.02