SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CDL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT
(Ovis
aries) 		5 / 12 GLY L 148
GLU L 145
GLY L 146
GLY L 143
GLY L 222
 None
None
CDL  L 601 ( 4.6A)
None
None
 0.94A 1n2xB-5lnkL:
undetectable		 1n2xB-5lnkL:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
CYTOCHROME B556(FDN)
SUBUNIT
(Escherichia
coli) 		5 / 12 ILE C 163
ILE C 166
ALA C 165
MET C 116
LEU C  68
 CDL  C 812 ( 4.9A)
HEM  C 810 (-4.0A)
None
None
None
 1.26A 1xzxX-1kqfC:
0.8		 1xzxX-1kqfC:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		5 / 9 PHE A 153
ARG A 137
ALA A 141
LEU A 140
ALA A 136
 None
None
None
CDL  A 800 (-3.8A)
None
 1.48A 2o01B-1okcA:
undetectable		 2o01B-1okcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Mus
musculus) 		4 / 8 LEU M 360
THR M 357
ALA M 438
ILE M 445
 None
CDL  L 702 (-4.1A)
None
3PE  M 503 (-4.2A)
 0.77A 3jusA-6g2jM:
undetectable		 3jusA-6g2jM:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Mus
musculus) 		4 / 8 LEU M 360
THR M 357
ALA M 438
ILE M 445
 None
CDL  L 702 (-4.1A)
None
3PE  M 503 (-4.2A)
 0.77A 3jusA-6g2jM:
undetectable		 3jusA-6g2jM:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
(Homo
sapiens) 		5 / 12 PHE g  67
GLY g  37
ALA i 331
THR i 334
ILE i 209
 PLX  g 203 (-4.3A)
None
None
CDL  i 401 ( 4.3A)
PLX  g 201 ( 4.6A)
 1.20A 3ld6A-5xtcg:
undetectable		 3ld6A-5xtcg:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		5 / 10 GLN A  84
ALA A  18
ALA A  19
THR A  23
LEU A  74
 CXT  A 401 ( 4.5A)
None
None
CDL  A 800 ( 4.1A)
CDL  A 800 ( 3.9A)
 1.18A 4j6cB-1okcA:
3.8		 4j6cB-1okcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5nmi CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B
(Bos
taurus;
Bos
taurus) 		3 / 3 ASN C  16
ASP C  20
ASP A 333
 None
CDL  C 505 (-3.9A)
None
 0.56A 4obwD-5nmiC:
undetectable		 4obwD-5nmiC:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5
(Mus
musculus) 		4 / 6 PHE L 124
MET L 252
LEU L 153
LEU L 154
 None
None
CDL  L 702 (-4.6A)
None
 1.38A 5dzke-6g2jL:
undetectable
5dzks-6g2jL:
undetectable		 5dzke-6g2jL:
undetectable
5dzks-6g2jL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1
(Bos
taurus) 		4 / 5 PHE A 129
THR A  83
ASP A 134
ASN A 177
 None
CXT  A 401 ( 3.9A)
CXT  A 401 ( 4.7A)
CDL  A 802 (-3.0A)
 1.00A 5ybbA-1okcA:
undetectable		 5ybbA-1okcA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Mus
musculus;
Mus
musculus) 		4 / 6 GLY M 311
LEU M 315
VAL L  69
PHE L 138
 None
None
None
CDL  L 703 (-4.9A)
 1.01A 6h7lA-6g2jM:
undetectable		 6h7lA-6g2jM:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
(Mus
musculus;
Mus
musculus) 		4 / 6 GLY M 311
LEU M 315
VAL L  69
PHE L 138
 None
None
None
CDL  L 703 (-4.9A)
 1.00A 6h7lB-6g2jM:
undetectable		 6h7lB-6g2jM:
20.48