SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CDC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4zcs CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 6 TYR A 626
CYH A 690
ASP A 623
VAL A 653
 CDC  A 801 (-4.3A)
CDC  A 801 ( 4.9A)
CDC  A 801 (-3.5A)
None
 1.14A 1ekjC-4zcsA:
undetectable
1ekjD-4zcsA:
undetectable		 1ekjC-4zcsA:
19.30
1ekjD-4zcsA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 4zcs CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Plasmodium
falciparum) 		4 / 6 CYH A 690
ASP A 623
VAL A 653
TYR A 626
 CDC  A 801 ( 4.9A)
CDC  A 801 (-3.5A)
None
CDC  A 801 (-4.3A)
 1.13A 1ekjC-4zcsA:
undetectable
1ekjD-4zcsA:
undetectable		 1ekjC-4zcsA:
19.30
1ekjD-4zcsA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_A_RIOA500_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 9 ASP A 218
ASP A 107
GLY A  14
ASP A 192
ASP A 105
 MG  A1996 ( 2.8A)
MG  A1996 ( 2.4A)
CDC  A1991 (-3.4A)
CDC  A1991 (-3.3A)
CDC  A1991 ( 4.0A)
 1.29A 1m4gA-1jylA:
0.0		 1m4gA-1jylA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 9 ASP A 218
ASP A 107
GLY A  14
ASP A 192
ASP A 105
 MG  A1996 ( 2.8A)
MG  A1996 ( 2.4A)
CDC  A1991 (-3.4A)
CDC  A1991 (-3.3A)
CDC  A1991 ( 4.0A)
 1.31A 1m4gB-1jylA:
0.0		 1m4gB-1jylA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 8 ASP A 218
ASP A 107
GLY A  14
ASP A 192
ASP A 105
 MG  A1996 ( 2.8A)
MG  A1996 ( 2.4A)
CDC  A1991 (-3.4A)
CDC  A1991 (-3.3A)
CDC  A1991 ( 4.0A)
 1.39A 1m4iA-1jylA:
0.0		 1m4iA-1jylA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 5 LEU A 153
VAL A 181
TYR A 182
THR A 152
 None
None
CDC  A 401 (-4.6A)
None
 1.12A 1nw3A-4mvcA:
undetectable		 1nw3A-4mvcA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4zcs CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
(Plasmodium
falciparum) 		3 / 3 LYS A 719
ASP A 623
CYH A 690
 None
CDC  A 801 (-3.5A)
CDC  A 801 ( 4.9A)
 1.48A 2br4F-4zcsA:
undetectable		 2br4F-4zcsA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 3hl4 CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 8 PHE A  85
LEU A 108
VAL A 142
LEU A  96
 CDC  A 237 (-4.4A)
None
None
None
 0.83A 2w98B-3hl4A:
2.6		 2w98B-3hl4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 8 TRP A 151
ILE A  84
HIS A 119
ASP A 115
 CDC  A 401 (-3.8A)
CDC  A 401 (-4.4A)
None
None
 1.12A 2xadA-4mvcA:
3.6		 2xadA-4mvcA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 8 TRP A 151
ILE A  84
HIS A 119
ASP A 115
 CDC  A 401 (-3.8A)
CDC  A 401 (-4.4A)
None
None
 1.07A 2xadB-4mvcA:
3.8		 2xadB-4mvcA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 8 TRP A 151
ILE A  84
HIS A 119
ASP A 115
 CDC  A 401 (-3.8A)
CDC  A 401 (-4.4A)
None
None
 1.08A 2xadC-4mvcA:
3.7		 2xadC-4mvcA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 8 TRP A 151
ILE A  84
HIS A 119
ASP A 115
 CDC  A 401 (-3.8A)
CDC  A 401 (-4.4A)
None
None
 1.05A 2xadD-4mvcA:
3.7		 2xadD-4mvcA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A  30
ALA A 106
ASP A 105
ASN A 108
ILE A  54
 None
CDC  A1991 (-3.6A)
CDC  A1991 ( 4.0A)
None
None
 1.03A 3ucbA-1jylA:
undetectable		 3ucbA-1jylA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 162
GLY A 161
TYR A 124
ASP A 192
 None
None
None
CDC  A1991 (-3.3A)
 1.30A 3w9tA-1jylA:
undetectable		 3w9tA-1jylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 162
GLY A 161
TYR A 124
ASP A 192
 None
None
None
CDC  A1991 (-3.3A)
 1.30A 3w9tB-1jylA:
undetectable		 3w9tB-1jylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 162
GLY A 161
TYR A 124
ASP A 192
 None
None
None
CDC  A1991 (-3.3A)
 1.30A 3w9tC-1jylA:
undetectable		 3w9tC-1jylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 162
GLY A 161
TYR A 124
ASP A 192
 None
None
None
CDC  A1991 (-3.3A)
 1.30A 3w9tD-1jylA:
undetectable		 3w9tD-1jylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 162
GLY A 161
TYR A 124
ASP A 192
 None
None
None
CDC  A1991 (-3.3A)
 1.30A 3w9tE-1jylA:
undetectable		 3w9tE-1jylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 162
GLY A 161
TYR A 124
ASP A 192
 None
None
None
CDC  A1991 (-3.3A)
 1.30A 3w9tF-1jylA:
undetectable		 3w9tF-1jylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 162
GLY A 161
TYR A 124
ASP A 192
 None
None
None
CDC  A1991 (-3.3A)
 1.29A 3w9tG-1jylA:
undetectable		 3w9tG-1jylA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 6 PHE A  85
PHE A  88
ALA A  95
LEU A 108
 CDC  A 401 (-4.6A)
None
CDC  A 401 (-3.5A)
None
 1.01A 4ejgD-4mvcA:
undetectable		 4ejgD-4mvcA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3hl4 CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 7 TYR A 173
TYR A 182
ALA A 149
ILE A  84
 CDC  A 237 (-3.7A)
None
None
CDC  A 237 (-4.2A)
 0.78A 4uymB-3hl4A:
undetectable		 4uymB-3hl4A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 1jyl CTP:PHOSPHOCHOLINE
CYTIDYLYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A  76
LEU A  68
ILE A  10
ALA A 106
ILE A  43
 None
None
None
CDC  A1991 (-3.6A)
None
 1.01A 5eypB-1jylA:
undetectable		 5eypB-1jylA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3hl4 CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 7 GLY A  83
PHE A  85
HIS A  92
SER A 201
 CDC  A 237 (-3.3A)
CDC  A 237 (-4.4A)
CDC  A 237 (-4.3A)
None
 0.77A 6jnhA-3hl4A:
10.6		 6jnhA-3hl4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4mvc CHOLINE-PHOSPHATE
CYTIDYLYLTRANSFERASE
A
(Rattus
norvegicus) 		4 / 7 GLY A  83
PHE A  85
HIS A  92
SER A 201
 CDC  A 401 (-3.0A)
CDC  A 401 (-4.6A)
CDC  A 401 ( 4.5A)
None
 0.72A 6jnhA-4mvcA:
9.8		 6jnhA-4mvcA:
18.94