SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CCX'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
4 / 6 LEU A1005
LYS A1033
VAL A1053
MET A1082
None
CCX  A   1 ( 3.7A)
None
None
0.88A 1opjB-3lw0A:
31.7
1opjB-3lw0A:
44.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
5 / 9 LEU A1005
VAL A1013
ALA A1031
MET A1079
GLY A1085
None
None
None
CCX  A   1 ( 3.9A)
None
0.41A 1xbbA-3lw0A:
29.3
1xbbA-3lw0A:
33.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
4 / 4 LEU A1005
LYS A1033
VAL A1063
MET A1082
None
CCX  A   1 ( 3.7A)
CCX  A   1 (-4.1A)
None
0.84A 2hyyD-3lw0A:
32.5
2hyyD-3lw0A:
44.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
7 / 12 GLY A1006
VAL A1013
ALA A1031
MET A1082
GLY A1085
MET A1142
ASP A1153
None
None
None
None
None
None
CCX  A   1 ( 4.3A)
1.06A 2wgjA-3lw0A:
32.7
2wgjA-3lw0A:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
6 / 9 LEU A1005
VAL A1013
ALA A1031
MET A1082
GLY A1085
GLY A1152
None
None
None
None
None
CCX  A   1 (-3.6A)
0.51A 2xp2A-3lw0A:
30.1
2xp2A-3lw0A:
41.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
6 / 9 LEU A1005
VAL A1013
ALA A1031
MET A1082
GLY A1152
ASP A1153
None
None
None
None
CCX  A   1 (-3.6A)
CCX  A   1 ( 4.3A)
0.79A 2xp2A-3lw0A:
30.1
2xp2A-3lw0A:
41.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
3 / 3 GLU A1050
ASP A1135
TYR A1165
CCX  A   1 ( 4.3A)
None
None
0.77A 2yvlB-3lw0A:
undetectable
2yvlB-3lw0A:
22.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
7 / 10 ARG A1003
LEU A1005
ALA A1031
VAL A1063
LEU A1081
MET A1082
GLY A1085
None
None
None
CCX  A   1 (-4.1A)
None
None
None
0.54A 3aoxA-3lw0A:
29.4
3aoxA-3lw0A:
39.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
5 / 12 ALA A1031
VAL A1053
GLY A1085
PHE A1131
HIS A1133
None
None
None
None
CCX  A   1 (-4.0A)
0.58A 3cs9D-3lw0A:
31.7
3cs9D-3lw0A:
44.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
4 / 7 LYS A1033
VAL A1062
LEU A1081
ILE A1151
CCX  A   1 ( 3.7A)
None
None
None
0.94A 3gp0A-3lw0A:
22.8
3gp0A-3lw0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
4 / 8 PHE A1189
ASP A1135
VAL A1176
LEU A1184
CCX  A   1 ( 4.4A)
None
None
None
1.10A 3jq7C-3lw0A:
undetectable
3jq7C-3lw0A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
5 / 11 ALA A1138
VAL A1149
ALA A1116
PRO A1107
LEU A1091
None
None
None
CCX  A1287 ( 4.8A)
None
1.04A 3sm2B-3lw0A:
undetectable
3sm2B-3lw0A:
18.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
7 / 12 LEU A1005
ALA A1031
LYS A1033
GLU A1050
VAL A1063
MET A1082
GLY A1085
None
None
CCX  A   1 ( 3.7A)
CCX  A   1 ( 4.3A)
CCX  A   1 (-4.1A)
None
None
1.01A 3ue4A-3lw0A:
30.4
3ue4A-3lw0A:
43.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
7 / 12 LEU A1005
VAL A1013
ALA A1031
LYS A1033
LEU A1081
MET A1082
GLY A1085
None
None
None
CCX  A   1 ( 3.7A)
None
None
None
0.73A 3ug2A-3lw0A:
28.2
3ug2A-3lw0A:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
7 / 12 LEU A1005
VAL A1013
ALA A1031
MET A1079
LEU A1081
MET A1082
GLY A1085
None
None
None
CCX  A   1 ( 3.9A)
None
None
None
0.52A 3ug2A-3lw0A:
28.2
3ug2A-3lw0A:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
6 / 12 ALA A1031
LEU A1081
MET A1082
GLY A1085
ASP A1086
GLY A1152
None
None
None
None
None
CCX  A   1 (-3.6A)
0.39A 3zbfA-3lw0A:
30.6
3zbfA-3lw0A:
44.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
6 / 9 LEU A1005
VAL A1013
ALA A1031
MET A1079
MET A1082
GLY A1085
None
None
None
CCX  A   1 ( 3.9A)
None
None
0.45A 4ansA-3lw0A:
29.9
4ansA-3lw0A:
39.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
4 / 7 ALA A1031
MET A1079
MET A1082
ASP A1086
None
CCX  A   1 ( 3.9A)
None
None
0.70A 4l9iA-3lw0A:
8.3
4l9iA-3lw0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
4 / 7 VAL A1013
ALA A1031
MET A1079
ASP A1086
None
None
CCX  A   1 ( 3.9A)
None
0.73A 4l9iA-3lw0A:
8.3
4l9iA-3lw0A:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
9 / 12 LEU A1005
GLY A1008
VAL A1013
ALA A1031
LYS A1033
LEU A1081
GLY A1085
ASP A1086
SER A1089
None
None
None
None
CCX  A   1 ( 3.7A)
None
None
None
None
0.70A 4mkcA-3lw0A:
30.4
4mkcA-3lw0A:
37.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
7 / 12 LEU A1005
VAL A1013
ALA A1031
LYS A1033
VAL A1063
MET A1082
GLY A1085
None
None
None
CCX  A   1 ( 3.7A)
CCX  A   1 (-4.1A)
None
None
0.80A 4mxxB-3lw0A:
29.2
4mxxB-3lw0A:
36.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
5 / 6 ARG A1003
LEU A1005
ALA A1031
MET A1079
MET A1082
None
None
None
CCX  A   1 ( 3.9A)
None
0.61A 4wboC-3lw0A:
22.4
4wboC-3lw0A:
21.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
7 / 9 LEU A1005
VAL A1013
ALA A1031
MET A1082
GLY A1085
GLY A1152
ASP A1153
None
None
None
None
None
CCX  A   1 (-3.6A)
CCX  A   1 ( 4.3A)
0.68A 5aaaA-3lw0A:
30.4
5aaaA-3lw0A:
41.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
7 / 10 LEU A1005
VAL A1013
ALA A1031
LYS A1033
MET A1082
GLY A1085
GLY A1152
None
None
None
CCX  A   1 ( 3.7A)
None
None
CCX  A   1 (-3.6A)
0.79A 5aabA-3lw0A:
30.2
5aabA-3lw0A:
41.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
7 / 10 LEU A1005
VAL A1013
ALA A1031
LYS A1033
MET A1082
GLY A1152
ASP A1153
None
None
None
CCX  A   1 ( 3.7A)
None
CCX  A   1 (-3.6A)
CCX  A   1 ( 4.3A)
1.01A 5aabA-3lw0A:
30.2
5aabA-3lw0A:
41.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
7 / 10 LEU A1005
VAL A1013
ALA A1031
LYS A1033
MET A1082
GLY A1085
GLY A1152
None
None
None
CCX  A   1 ( 3.7A)
None
None
CCX  A   1 (-3.6A)
0.95A 5aacA-3lw0A:
29.9
5aacA-3lw0A:
41.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
7 / 10 VAL A1013
ALA A1031
LYS A1033
MET A1082
GLY A1085
GLY A1152
ASP A1153
None
None
CCX  A   1 ( 3.7A)
None
None
CCX  A   1 (-3.6A)
CCX  A   1 ( 4.3A)
1.12A 5aacA-3lw0A:
29.9
5aacA-3lw0A:
41.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
6 / 12 LEU A1005
VAL A1013
ALA A1031
LEU A1081
GLY A1085
GLY A1152
None
None
None
None
None
CCX  A   1 (-3.6A)
0.78A 5h2uA-3lw0A:
27.9
5h2uA-3lw0A:
37.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
6 / 12 LEU A1005
VAL A1013
ALA A1031
LEU A1081
GLY A1085
GLY A1152
None
None
None
None
None
CCX  A   1 (-3.6A)
0.79A 5h2uB-3lw0A:
28.2
5h2uB-3lw0A:
37.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
6 / 10 GLY A1006
VAL A1013
ALA A1031
MET A1079
LEU A1081
MET A1082
None
None
None
CCX  A   1 ( 3.9A)
None
None
0.73A 5lw1E-3lw0A:
21.5
5lw1E-3lw0A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
6 / 9 GLY A1006
VAL A1013
ALA A1031
MET A1079
LEU A1081
MET A1082
None
None
None
CCX  A   1 ( 3.9A)
None
None
0.69A 5lw1H-3lw0A:
21.7
5lw1H-3lw0A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
4 / 4 VAL A1013
LYS A1033
VAL A1063
ASN A1140
None
CCX  A   1 ( 3.7A)
CCX  A   1 (-4.1A)
None
0.99A 5vc3A-3lw0A:
22.7
5vc3A-3lw0A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
6 / 12 LEU A1005
ALA A1031
LYS A1033
VAL A1063
GLY A1085
GLY A1152
None
None
CCX  A   1 ( 3.7A)
CCX  A   1 (-4.1A)
None
CCX  A   1 (-3.6A)
1.09A 5vcvA-3lw0A:
22.5
5vcvA-3lw0A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
5 / 9 LEU A1005
ALA A1031
VAL A1063
MET A1079
GLY A1085
None
None
CCX  A   1 (-4.1A)
CCX  A   1 ( 3.9A)
None
0.59A 5w5vA-3lw0A:
13.0
5w5vA-3lw0A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
7 / 12 ARG A1003
LEU A1005
VAL A1013
ALA A1031
LYS A1033
LEU A1081
GLY A1085
None
None
None
None
CCX  A   1 ( 3.7A)
None
None
0.70A 5y7zA-3lw0A:
22.2
5y7zA-3lw0A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
7 / 12 ARG A1003
LEU A1005
VAL A1013
ALA A1031
LYS A1033
LEU A1081
GLY A1085
None
None
None
None
CCX  A   1 ( 3.7A)
None
None
0.70A 5y7zA-3lw0A:
22.2
5y7zA-3lw0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo
sapiens)
4 / 4 VAL A1063
GLY A1152
ASP A1153
ASP A1086
CCX  A   1 (-4.1A)
CCX  A   1 (-3.6A)
CCX  A   1 ( 4.3A)
None
1.24A 6cjkC-3lw0A:
undetectable
6cjkC-3lw0A:
21.60