SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CCK'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		4 / 7 LYS X  69
LEU X  86
ILE X  95
ILE X 153
 CCK  X 351 (-3.5A)
None
None
None
 0.82A 1uwjA-3e3bX:
5.8		 1uwjA-3e3bX:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		7 / 12 LEU X  46
GLY X  47
VAL X  54
ASP X 157
LYS X 159
ASN X 162
MET X 164
 CCK  X 351 (-4.0A)
CCK  X 351 ( 4.9A)
CCK  X 351 ( 4.3A)
None
None
None
CCK  X 351 (-3.5A)
 0.84A 2fumA-3e3bX:
24.0		 2fumA-3e3bX:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		7 / 12 LEU X  46
GLY X  47
VAL X  54
TYR X 116
LYS X 159
ASN X 162
MET X 164
 CCK  X 351 (-4.0A)
CCK  X 351 ( 4.9A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-4.3A)
None
None
CCK  X 351 (-3.5A)
 0.95A 2fumB-3e3bX:
24.0		 2fumB-3e3bX:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		7 / 12 LEU X  46
GLY X  47
GLY X  49
VAL X  54
LYS X 159
ASN X 162
MET X 164
 CCK  X 351 (-4.0A)
CCK  X 351 ( 4.9A)
None
CCK  X 351 ( 4.3A)
None
None
CCK  X 351 (-3.5A)
 0.90A 2fumD-3e3bX:
14.8		 2fumD-3e3bX:
25.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		6 / 8 VAL X  54
ILE X  96
PHE X 114
MET X 164
ILE X 175
ASP X 176
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.6A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.9A)
CCK  X 351 (-4.1A)
 0.90A 3warA-3e3bX:
47.8		 3warA-3e3bX:
85.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		5 / 8 VAL X  54
LYS X  69
ILE X  96
PHE X 114
MET X 164
 CCK  X 351 ( 4.3A)
CCK  X 351 (-3.5A)
CCK  X 351 ( 4.6A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.5A)
 0.70A 3warA-3e3bX:
47.8		 3warA-3e3bX:
85.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		6 / 8 VAL X  54
VAL X  67
ILE X  96
MET X 164
ILE X 175
ASP X 176
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.6A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.9A)
CCK  X 351 (-4.1A)
 0.82A 3warA-3e3bX:
47.8		 3warA-3e3bX:
85.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		5 / 8 VAL X  54
VAL X  67
LYS X  69
ILE X  96
MET X 164
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.5A)
CCK  X 351 ( 4.6A)
CCK  X 351 (-3.5A)
 0.65A 3warA-3e3bX:
47.8		 3warA-3e3bX:
85.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		5 / 9 ILE X  85
LEU X  89
ILE X  95
ILE X  96
TYR X 116
 None
None
None
CCK  X 351 ( 4.6A)
CCK  X 351 (-4.3A)
 0.70A 3zosA-3e3bX:
12.1		 3zosA-3e3bX:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		5 / 9 LEU X  46
ILE X  85
LEU X  89
ILE X  95
TYR X 116
 CCK  X 351 (-4.0A)
None
None
None
CCK  X 351 (-4.3A)
 0.84A 3zosB-3e3bX:
11.9		 3zosB-3e3bX:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		4 / 5 LYS X  69
LEU X  89
TYR X 116
ARG X 156
 CCK  X 351 (-3.5A)
None
CCK  X 351 (-4.3A)
None
 1.10A 4bkjB-3e3bX:
5.2		 4bkjB-3e3bX:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		3 / 3 ASP X 166
ARG X  44
ARG X  65
 None
CCK  X 351 (-4.6A)
None
 0.91A 5eajB-3e3bX:
undetectable		 5eajB-3e3bX:
19.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		6 / 8 LEU X  46
VAL X  54
VAL X  67
LYS X  69
PHE X 114
ILE X 175
 CCK  X 351 (-4.0A)
CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.9A)
 1.01A 5y9mA-3e3bX:
36.1		 5y9mA-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		6 / 8 LEU X  46
VAL X  54
VAL X  67
PHE X 114
ILE X 175
ASP X 176
 CCK  X 351 (-4.0A)
CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.9A)
CCK  X 351 (-4.1A)
 1.07A 5y9mA-3e3bX:
36.1		 5y9mA-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		6 / 8 VAL X  54
VAL X  67
LYS X  69
PHE X 114
MET X 164
ILE X 175
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.9A)
 1.03A 5y9mA-3e3bX:
36.1		 5y9mA-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		6 / 8 VAL X  54
VAL X  67
PHE X 114
MET X 164
ILE X 175
ASP X 176
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.9A)
CCK  X 351 (-4.1A)
 1.09A 5y9mA-3e3bX:
36.1		 5y9mA-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		4 / 8 VAL X  54
MET X 164
ILE X 175
ASP X 176
 CCK  X 351 ( 4.3A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.9A)
CCK  X 351 (-4.1A)
 0.69A 5y9mX-3e3bX:
46.7		 5y9mX-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		6 / 7 VAL X  54
VAL X  67
LYS X  69
PHE X 114
MET X 164
ILE X 175
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.9A)
 1.05A 5yf9B-3e3bX:
46.8		 5yf9B-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		6 / 7 VAL X  54
VAL X  67
PHE X 114
MET X 164
ILE X 175
ASP X 176
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.9A)
CCK  X 351 (-4.1A)
 1.09A 5yf9B-3e3bX:
46.8		 5yf9B-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		6 / 9 LEU X  46
VAL X  54
VAL X  67
LYS X  69
PHE X 114
ILE X 175
 CCK  X 351 (-4.0A)
CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.9A)
 1.00A 5yf9X-3e3bX:
46.8		 5yf9X-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		7 / 9 LEU X  46
VAL X  54
VAL X  67
PHE X 114
MET X 164
ILE X 175
ASP X 176
 CCK  X 351 (-4.0A)
CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.9A)
CCK  X 351 (-4.1A)
 1.13A 5yf9X-3e3bX:
46.8		 5yf9X-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		6 / 9 VAL X  54
VAL X  67
ILE X  96
PHE X 114
ILE X 175
ASP X 176
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.6A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.9A)
CCK  X 351 (-4.1A)
 1.04A 5yf9X-3e3bX:
46.8		 5yf9X-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		6 / 9 VAL X  54
VAL X  67
LYS X  69
ILE X  96
PHE X 114
ILE X 175
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.5A)
CCK  X 351 ( 4.6A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.9A)
 0.93A 5yf9X-3e3bX:
46.8		 5yf9X-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		6 / 7 VAL X  54
VAL X  67
ILE X  96
PHE X 114
ILE X 175
ASP X 176
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.6A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.9A)
CCK  X 351 (-4.1A)
 1.04A 5ywmX-3e3bX:
40.8		 5ywmX-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens) 		6 / 7 VAL X  54
VAL X  67
LYS X  69
ILE X  96
PHE X 114
ILE X 175
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.5A)
CCK  X 351 ( 4.6A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.9A)
 0.88A 5ywmX-3e3bX:
40.8		 5ywmX-3e3bX:
100.00