SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CB8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A4L_B_DCFB853_2 (ADENOSINE DEAMINASE)	2y77	3-DEHYDROQUINATE DEHYDRATASE (Mycobacterium tuberculosis)	4 / 5	LEU A 13 SER A 115 LEU A 117 GLY A 77	CB8 A1144 (-4.5A) None None CB8 A1144 (-3.4A)	1.14A	1a4lB-2y77A: undetectable	1a4lB-2y77A: 16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F84_A_SAMA501_0 (GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERAS E)	2y77	3-DEHYDROQUINATE DEHYDRATASE (Mycobacterium tuberculosis)	5 / 12	HIS A 81 GLY A 78 LEU A 86 SER A 115 TYR A 116	CB8 A1144 (-3.8A) CB8 A1144 (-3.3A) None None None	1.23A	4f84A-2y77A: undetectable	4f84A-2y77A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ECX_A_SAMA1301_0 (STIE PROTEIN)	2y77	3-DEHYDROQUINATE DEHYDRATASE (Mycobacterium tuberculosis)	5 / 12	LEU A 13 GLY A 132 ILE A 36 VAL A 100 ILE A 73	CB8 A1144 (-4.5A) None None None None	1.02A	6ecxA-2y77A: 2.0	6ecxA-2y77A: 18.07