SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'CA0'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A  70
GLY A 340
GLY A 309
GLY A 310
ASP A 137
 None
None
CA0  A 602 ( 4.0A)
CA0  A 602 (-3.2A)
FE2  A 601 ( 3.3A)
 1.04A 1mxdA-3vexA:
1.5		 1mxdA-3vexA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		3 / 3 TYR A 230
GLU A 172
ASN A 184
 None
CA0  A 602 (-3.3A)
None
 0.97A 2y7hC-3vexA:
1.9		 2y7hC-3vexA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 10 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.20A 3fhjA-3vexA:
undetectable		 3fhjA-3vexA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 10 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.20A 3fhjB-3vexA:
undetectable		 3fhjB-3vexA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 10 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.21A 3fhjC-3vexA:
undetectable		 3fhjC-3vexA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.21A 3fhjD-3vexA:
undetectable		 3fhjD-3vexA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 10 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.20A 3fhjE-3vexA:
undetectable		 3fhjE-3vexA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.20A 3fhjF-3vexA:
undetectable		 3fhjF-3vexA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.17A 3fi0A-3vexA:
undetectable		 3fi0A-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.15A 3fi0C-3vexA:
undetectable		 3fi0C-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.17A 3fi0D-3vexA:
undetectable		 3fi0D-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.14A 3fi0F-3vexA:
undetectable		 3fi0F-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.15A 3fi0H-3vexA:
undetectable		 3fi0H-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.16A 3fi0J-3vexA:
undetectable		 3fi0J-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.15A 3fi0K-3vexA:
undetectable		 3fi0K-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.16A 3fi0L-3vexA:
undetectable		 3fi0L-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.20A 3fi0M-3vexA:
undetectable		 3fi0M-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.13A 3fi0N-3vexA:
undetectable		 3fi0N-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.19A 3fi0O-3vexA:
undetectable		 3fi0O-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.11A 3fi0R-3vexA:
undetectable		 3fi0R-3vexA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 ALA A 336
VAL A 311
LEU A 321
ALA A 288
LEU A 292
 None
CA0  A 602 (-3.7A)
None
None
None
 1.27A 3ozuA-3vexA:
undetectable		 3ozuA-3vexA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		4 / 8 TYR A 171
GLN A 282
ALA A 193
LEU A 180
 CA0  A 602 (-3.4A)
None
None
None
 0.85A 3ozwA-3vexA:
undetectable		 3ozwA-3vexA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 GLY A 140
VAL A 161
GLY A  70
ALA A 119
ALA A 120
 CA0  A 602 ( 4.9A)
None
None
None
None
 1.02A 3sudD-3vexA:
undetectable		 3sudD-3vexA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 GLY A 140
VAL A 161
GLY A  70
ALA A 119
ALA A 120
 CA0  A 602 ( 4.9A)
None
None
None
None
 0.99A 3sueC-3vexA:
undetectable		 3sueC-3vexA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 GLY A 140
VAL A 161
GLY A  70
ALA A 119
ALA A 120
 CA0  A 602 ( 4.9A)
None
None
None
None
 0.98A 3sufD-3vexA:
undetectable		 3sufD-3vexA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 GLY A 309
GLY A 138
GLU A 141
VAL A 341
ALA A 345
 CA0  A 602 ( 4.0A)
CA0  A 602 (-3.1A)
None
None
None
 1.09A 3t7vA-3vexA:
undetectable		 3t7vA-3vexA:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VET_A_TOYA604_1
(O-CARBAMOYLTRANSFERA
SE TOBZ)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		8 / 9 ASP A  12
TYR A  42
PHE A 169
GLU A 172
GLU A 176
ASP A 183
ASP A 228
TYR A 230
 None
None
None
CA0  A 602 (-3.3A)
None
None
None
None
 0.42A 3vetA-3vexA:
64.3		 3vetA-3vexA:
99.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		4 / 8 SER A 337
GLU A  33
ARG A 423
GLY A 367
 CA0  A 602 (-4.3A)
None
None
None
 1.04A 4fgzA-3vexA:
undetectable
4fgzB-3vexA:
undetectable		 4fgzA-3vexA:
17.34
4fgzB-3vexA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 GLY A 140
GLY A 163
GLU A 141
HIS A 114
ASP A 228
 CA0  A 602 ( 4.9A)
None
None
FE2  A 601 ( 3.4A)
None
 0.90A 5c0oF-3vexA:
undetectable		 5c0oF-3vexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		3 / 3 ASN A   7
ASP A 137
GLY A 309
 None
FE2  A 601 ( 3.3A)
CA0  A 602 ( 4.0A)
 0.56A 5fctB-3vexA:
undetectable		 5fctB-3vexA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		3 / 3 ASN A  14
ASP A 137
GLY A 309
 None
FE2  A 601 ( 3.3A)
CA0  A 602 ( 4.0A)
 0.63A 5fctB-3vexA:
undetectable		 5fctB-3vexA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.18A 5v0iA-3vexA:
undetectable		 5v0iA-3vexA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 GLY A 309
HIS A 114
ASP A 338
ILE A 339
VAL A 335
 CA0  A 602 ( 4.0A)
FE2  A 601 ( 3.4A)
CA0  A 602 ( 2.8A)
None
None
 1.16A 5v0iB-3vexA:
undetectable		 5v0iB-3vexA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 9 ASP A 338
ASN A  14
ILE A 135
SER A 337
GLY A 312
 CA0  A 602 ( 2.8A)
None
None
CA0  A 602 (-4.3A)
None
 1.34A 6awpA-3vexA:
1.3		 6awpA-3vexA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 3vex O-CARBAMOYLTRANSFERA
SE TOBZ
(Streptoalloteich
us
tenebrarius) 		5 / 12 GLY A 140
VAL A 161
GLY A  70
ALA A 119
ALA A 120
 CA0  A 602 ( 4.9A)
None
None
None
None
 1.00A 6c2mD-3vexA:
undetectable		 6c2mD-3vexA:
8.61