SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'C9M'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 MET A 179
GLY A 209
LEU A 232
ASP A 272
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 ( 4.4A)
C9M  A 402 ( 2.3A)
None
 1.06A 3i5uA-4eviA:
25.3		 3i5uA-4eviA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		7 / 12 PHE A 175
MET A 179
GLY A 209
GLY A 210
LEU A 232
ASP A 272
TRP A 273
 SAH  A 401 (-4.8A)
SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 ( 3.8A)
SAH  A 401 ( 4.4A)
C9M  A 402 ( 2.3A)
None
 0.52A 3i5uA-4eviA:
25.3		 3i5uA-4eviA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		6 / 12 MET A 179
GLY A 209
GLY A 210
LEU A 232
ASP A 272
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 ( 3.8A)
SAH  A 401 ( 4.4A)
C9M  A 402 ( 2.3A)
None
 0.47A 3i5uB-4eviA:
25.4		 3i5uB-4eviA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 MET A 179
GLY A 209
LEU A 232
ASP A 272
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.9A)
SAH  A 401 ( 4.4A)
C9M  A 402 ( 2.3A)
None
 1.07A 3i5uB-4eviA:
25.4		 3i5uB-4eviA:
27.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 GLY A 208
GLY A 210
VAL A 235
ASP A 272
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.8A)
C9M  A 402 ( 2.3A)
None
 0.29A 4a6eA-4eviA:
34.0		 4a6eA-4eviA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		9 / 12 ASP A 206
GLY A 208
THR A 214
ASP A 231
LEU A 232
MET A 253
LYS A 267
ASP A 272
TRP A 273
 None
SAH  A 401 (-3.6A)
None
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.1A)
SAH  A 401 (-2.4A)
C9M  A 402 ( 2.3A)
None
 0.67A 4pghB-4eviA:
34.0		 4pghB-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		9 / 12 SER A 183
ASP A 206
GLY A 208
ASP A 231
LEU A 232
MET A 253
LYS A 267
ASP A 272
TRP A 273
 SAH  A 401 (-2.4A)
None
SAH  A 401 (-3.6A)
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.1A)
SAH  A 401 (-2.4A)
C9M  A 402 ( 2.3A)
None
 0.86A 4pghB-4eviA:
34.0		 4pghB-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		8 / 11 GLY A 208
ASP A 231
LEU A 232
VAL A 235
MET A 253
LYS A 267
TRP A 268
TRP A 273
 SAH  A 401 (-3.6A)
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.8A)
SAH  A 401 (-4.1A)
SAH  A 401 (-2.4A)
C9M  A 402 ( 3.8A)
None
 0.81A 4pghC-4eviA:
33.2		 4pghC-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 11 GLY A 209
ASP A 231
VAL A 235
LYS A 267
TRP A 268
 SAH  A 401 ( 3.9A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.8A)
SAH  A 401 (-2.4A)
C9M  A 402 ( 3.8A)
 1.34A 4pghC-4eviA:
33.2		 4pghC-4eviA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		5 / 12 GLY A 209
LEU A 232
VAL A 235
ASP A 272
TRP A 273
 SAH  A 401 ( 3.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.8A)
C9M  A 402 ( 2.3A)
None
 0.39A 5w7pA-4eviA:
26.5		 5w7pA-4eviA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		4 / 6 ASP A 272
LEU A 127
SER A 122
PHE A 171
 C9M  A 402 ( 2.3A)
None
C9M  A 402 (-2.6A)
None
 1.09A 6ekuA-4eviA:
undetectable		 6ekuA-4eviA:
19.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		9 / 11 GLY A 208
GLY A 210
ASP A 231
LEU A 232
VAL A 235
MET A 253
LYS A 267
TRP A 268
ASP A 272
 SAH  A 401 (-3.6A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.8A)
SAH  A 401 (-4.1A)
SAH  A 401 (-2.4A)
C9M  A 402 ( 3.8A)
C9M  A 402 ( 2.3A)
 0.75A 6i5zD-4eviA:
30.8		 6i5zD-4eviA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E
(Linum
nodiflorum) 		6 / 11 GLY A 209
ASP A 231
LEU A 232
MET A 253
TRP A 268
ASP A 272
 SAH  A 401 ( 3.9A)
SAH  A 401 (-2.9A)
SAH  A 401 ( 4.4A)
SAH  A 401 (-4.1A)
C9M  A 402 ( 3.8A)
C9M  A 402 ( 2.3A)
 1.28A 6i5zD-4eviA:
30.8		 6i5zD-4eviA:
31.23