SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'C90'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 192
VAL A 216
GLU A 233
ILE A 197
HIS A  78
 C90  A 502 ( 4.5A)
C90  A 502 (-4.8A)
None
C90  A 502 (-4.0A)
ZN  A 501 ( 3.3A)
 1.17A 1vhwA-5u39A:
undetectable
1vhwD-5u39A:
undetectable		 1vhwA-5u39A:
21.45
1vhwD-5u39A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 192
VAL A 216
GLU A 233
ILE A 197
HIS A  78
 C90  A 502 ( 4.5A)
C90  A 502 (-4.8A)
None
C90  A 502 (-4.0A)
ZN  A 501 ( 3.3A)
 1.17A 1vhwC-5u39A:
undetectable
1vhwE-5u39A:
undetectable		 1vhwC-5u39A:
21.45
1vhwE-5u39A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  78
GLY A 192
VAL A 216
GLU A 233
ILE A 197
 ZN  A 501 ( 3.3A)
C90  A 502 ( 4.5A)
C90  A 502 (-4.8A)
None
C90  A 502 (-4.0A)
 1.17A 1vhwA-5u39A:
undetectable
1vhwD-5u39A:
undetectable		 1vhwA-5u39A:
21.45
1vhwD-5u39A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 11 HIS A  78
GLY A 192
VAL A 216
GLU A 233
ILE A 197
 ZN  A 501 ( 3.3A)
C90  A 502 ( 4.5A)
C90  A 502 (-4.8A)
None
C90  A 502 (-4.0A)
 1.17A 1vhwC-5u39A:
undetectable
1vhwE-5u39A:
undetectable		 1vhwC-5u39A:
21.45
1vhwE-5u39A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5vwm UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 110
LEU A  95
SER A  63
MET A  62
 None
None
EDO  A 406 (-2.8A)
C90  A 401 ( 4.5A)
 1.16A 1wrlE-5vwmA:
undetectable		 1wrlE-5vwmA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 240
ASP A 241
GLY A 192
ALA A 188
 None
ZN  A 501 ( 2.0A)
C90  A 502 ( 4.5A)
None
 0.90A 2aohA-5u39A:
undetectable		 2aohA-5u39A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  18
GLY A 208
LEU A 207
LEU A 200
ARG A 201
 None
None
None
None
C90  A 502 (-3.3A)
 1.07A 2f8dA-5u39A:
undetectable		 2f8dA-5u39A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  18
GLY A 208
LEU A 207
LEU A 200
ARG A 201
 None
None
None
None
C90  A 502 (-3.3A)
 1.08A 2f8dB-5u39A:
undetectable		 2f8dB-5u39A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5u39 UDP-3-O-ACYL-N-ACETY
LGLUCOSAMINE
DEACETYLASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A  99
ARG A 201
GLY A 208
GLY A  17
 None
C90  A 502 (-3.3A)
None
None
 0.84A 4rdxA-5u39A:
undetectable		 4rdxA-5u39A:
23.02