SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'C6P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 12 PHE A 228
ALA A 204
SER A 203
ALA A  73
GLY A 209
 None
None
C6P  A 502 (-2.4A)
C6P  A 502 (-3.8A)
None
 1.12A 2igtA-5wt4A:
3.5		 2igtA-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 12 PHE A 228
ALA A 204
SER A 203
ALA A  73
GLY A 209
 None
None
C6P  A 502 (-2.4A)
C6P  A 502 (-3.8A)
None
 1.12A 2igtB-5wt4A:
3.3		 2igtB-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 12 PHE A 228
ALA A 204
SER A 203
ALA A  73
GLY A 209
 None
None
C6P  A 502 (-2.4A)
C6P  A 502 (-3.8A)
None
 1.14A 2igtC-5wt4A:
3.6		 2igtC-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 8 ALA A  11
HIS A 104
ASN A 155
LYS A 206
ARG A 354
 C6P  A 502 ( 4.1A)
C6P  A 502 (-3.4A)
C6P  A 502 (-3.8A)
C6P  A 502 (-2.9A)
C6P  A 502 (-3.8A)
 0.77A 5db5A-5wt4A:
40.0
5db5B-5wt4A:
40.1		 5db5A-5wt4A:
undetectable
5db5B-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		5 / 12 GLU A 266
ASP A 262
ASP A 273
GLN A 183
GLY A 186
 None
None
None
C6P  A 502 (-3.8A)
None
 1.31A 5syeB-5wt4A:
undetectable		 5syeB-5wt4A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5wt4 CYSTEINE DESULFURASE
ISCS
(Helicobacter
pylori) 		4 / 5 VAL A  80
LEU A 114
CYH A 111
ASP A 180
 None
None
None
C6P  A 502 (-2.9A)
 1.41A 5vcvA-5wt4A:
undetectable		 5vcvA-5wt4A:
12.66