SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'C6L'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 12 HIS A 305
PHE A 274
ILE A  95
HIS A 145
ASP A 258
 ZN  A 402 ( 3.3A)
C6L  A 403 (-4.7A)
None
ZN  A 401 (-3.3A)
ZN  A 402 (-2.3A)
 1.39A 2pgfA-4zo3A:
undetectable		 2pgfA-4zo3A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 12 HIS A 305
PHE A 274
ILE A  95
HIS A 150
HIS A 145
 ZN  A 402 ( 3.3A)
C6L  A 403 (-4.7A)
None
ZN  A 402 (-3.2A)
ZN  A 401 (-3.3A)
 1.37A 2pgfA-4zo3A:
undetectable		 2pgfA-4zo3A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 11 ASP A 149
HIS A 150
HIS A 237
ASP A 258
PHE A 274
 ZN  A 402 ( 2.6A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-2.3A)
C6L  A 403 (-4.7A)
 1.11A 2q0jB-4zo3A:
14.7		 2q0jB-4zo3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 5 HIS A 237
HIS A 261
HIS A 305
ASP A 149
 ZN  A 401 ( 3.2A)
C6L  A 403 (-3.8A)
ZN  A 402 ( 3.3A)
ZN  A 402 ( 2.6A)
 1.20A 3c0zA-4zo3A:
undetectable		 3c0zA-4zo3A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 12 ILE A 170
GLY A 114
LEU A 205
ILE A  60
ILE A  95
 None
None
None
C6L  A 403 ( 4.7A)
None
 1.08A 3pwwA-4zo3A:
undetectable		 3pwwA-4zo3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 7 MET A  93
ASP A 149
GLU A  62
HIS A 261
 None
ZN  A 402 ( 2.6A)
None
C6L  A 403 (-3.8A)
 1.24A 4aq7A-4zo3A:
undetectable		 4aq7A-4zo3A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 12 GLY A  58
LEU A  55
ILE A  60
HIS A 305
THR A 121
 None
None
C6L  A 403 ( 4.7A)
ZN  A 402 ( 3.3A)
None
 1.08A 5d4uA-4zo3A:
undetectable		 5d4uA-4zo3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 12 GLY A  58
LEU A  55
ILE A  60
HIS A 305
THR A 121
 None
None
C6L  A 403 ( 4.7A)
ZN  A 402 ( 3.3A)
None
 1.08A 5d4uB-4zo3A:
undetectable		 5d4uB-4zo3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		4 / 8 TRP A 323
PHE A 321
HIS A 261
THR A 245
 None
None
C6L  A 403 (-3.8A)
None
 1.44A 5hqaA-4zo3A:
undetectable		 5hqaA-4zo3A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		6 / 10 HIS A 145
HIS A 147
HIS A 150
HIS A 237
ASP A 258
HIS A 261
 ZN  A 401 (-3.3A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 402 (-2.3A)
C6L  A 403 (-3.8A)
 0.56A 5nzwA-4zo3A:
6.3		 5nzwA-4zo3A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4zo3 ACYLHOMOSERINE
LACTONASE
(Chryseobacterium
sp.
StRB126) 		5 / 10 HIS A 237
HIS A 145
HIS A 261
ASP A 258
HIS A 305
 ZN  A 401 ( 3.2A)
ZN  A 401 (-3.3A)
C6L  A 403 (-3.8A)
ZN  A 402 (-2.3A)
ZN  A 402 ( 3.3A)
 0.95A 5nzwA-4zo3A:
6.3		 5nzwA-4zo3A:
23.31