SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'C4F'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
GLY A 567
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.60A 1iepA-3c4fA:
31.7		 1iepA-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-3.6A)
 0.67A 1iepB-3c4fA:
31.5		 1iepB-3c4fA:
39.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 9 LEU A 484
VAL A 492
ALA A 512
TYR A 563
ALA A 564
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 (-3.5A)
C4F  A   1 (-4.6A)
 0.64A 1muoA-3c4fA:
8.1		 1muoA-3c4fA:
28.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
ILE A 538
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.63A 1opjA-3c4fA:
31.6		 1opjA-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
MET A 535
ILE A 538
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.63A 1opjA-3c4fA:
31.6		 1opjA-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-3.6A)
 0.71A 1opjB-3c4fA:
24.6		 1opjB-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 VAL A 492
ALA A 512
GLU A 531
LEU A 614
HIS A 621
 None
C4F  A   1 (-3.3A)
None
None
None
 0.50A 1uwjA-3c4fA:
7.5		 1uwjA-3c4fA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 VAL A 492
ALA A 512
GLU A 531
LEU A 614
HIS A 621
 None
C4F  A   1 (-3.3A)
None
None
None
 0.51A 1uwjB-3c4fA:
7.4		 1uwjB-3c4fA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 9 LEU A 484
VAL A 492
ALA A 512
ALA A 564
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
C4F  A   1 (-3.5A)
None
C4F  A   1 (-4.6A)
 0.78A 1xbbA-3c4fA:
30.3		 1xbbA-3c4fA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
GLY A 485
VAL A 492
ALA A 512
TYR A 563
ASN A 628
ASP A 641
 C4F  A   1 ( 3.9A)
C4F  A   1 ( 4.5A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.5A)
 1.10A 2fumB-3c4fA:
24.5		 2fumB-3c4fA:
26.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.69A 2hyyA-3c4fA:
31.7		 2hyyA-3c4fA:
40.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.72A 2hyyB-3c4fA:
31.8		 2hyyB-3c4fA:
40.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLU A 531
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.63A 2hyyC-3c4fA:
31.7		 2hyyC-3c4fA:
40.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.65A 2hyyD-3c4fA:
31.8		 2hyyD-3c4fA:
40.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
VAL A 561
TYR A 563
ALA A 564
LEU A 630
ASP A 641
 C4F  A   1 ( 3.9A)
None
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-3.5A)
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.80A 2ivuA-3c4fA:
33.9		 2ivuA-3c4fA:
51.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.74A 2oiqA-3c4fA:
25.0		 2oiqA-3c4fA:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
LYS A 514
GLU A 531
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.78A 2oiqA-3c4fA:
25.0		 2oiqA-3c4fA:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PL0_A_STIA200_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
LYS A 514
GLU A 531
TYR A 563
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.96A 2pl0A-3c4fA:
28.7		 2pl0A-3c4fA:
38.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LYS A 482
ALA A 512
LYS A 514
GLU A 531
TYR A 563
GLY A 567
LEU A 630
 None
C4F  A   1 (-3.3A)
None
None
None
None
C4F  A   1 (-4.6A)
 1.00A 2y6oA-3c4fA:
31.9		 2y6oA-3c4fA:
33.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 10 VAL A 492
ALA A 512
ILE A 545
GLY A 567
LEU A 630
ASP A 641
 None
C4F  A   1 (-3.3A)
C4F  A   1 ( 4.0A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.82A 2y7jB-3c4fA:
23.6		 2y7jB-3c4fA:
24.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLY A 567
LEU A 630
ASP A 641
PHE A 642
LEU A 644
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
C4F  A   1 ( 4.5A)
None
 1.06A 3bbtB-3c4fA:
29.6		 3bbtB-3c4fA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLY A 567
LEU A 630
ASP A 641
PHE A 642
LEU A 644
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
C4F  A   1 ( 4.5A)
None
 1.19A 3bbtD-3c4fA:
29.9		 3bbtD-3c4fA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 512
GLU A 531
GLY A 567
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.61A 3cs9A-3c4fA:
31.8		 3cs9A-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 512
GLU A 531
ILE A 538
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.79A 3cs9A-3c4fA:
31.8		 3cs9A-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 512
MET A 535
GLY A 567
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.63A 3cs9A-3c4fA:
31.8		 3cs9A-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 512
MET A 535
ILE A 538
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.82A 3cs9A-3c4fA:
31.8		 3cs9A-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 512
GLU A 531
GLY A 567
ALA A 640
PHE A 489
 C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.82A 3cs9B-3c4fA:
31.8		 3cs9B-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 512
GLU A 531
GLY A 567
HIS A 621
ALA A 640
 C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-3.6A)
 0.49A 3cs9B-3c4fA:
31.8		 3cs9B-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 512
MET A 535
GLY A 567
HIS A 621
ALA A 640
 C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-3.6A)
 0.56A 3cs9B-3c4fA:
31.8		 3cs9B-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 512
GLU A 531
MET A 535
ILE A 538
HIS A 621
ALA A 640
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-3.6A)
 0.67A 3cs9C-3c4fA:
30.9		 3cs9C-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 512
GLU A 531
MET A 535
GLY A 567
HIS A 621
ALA A 640
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-3.6A)
 0.66A 3cs9D-3c4fA:
30.4		 3cs9D-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 512
GLU A 531
MET A 535
ILE A 538
HIS A 621
ALA A 640
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-3.6A)
 0.72A 3cs9D-3c4fA:
30.4		 3cs9D-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		4 / 6 LEU A 484
VAL A 492
LYS A 514
LEU A 630
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 (-4.6A)
 0.67A 3cs9D-3c4fA:
30.4		 3cs9D-3c4fA:
40.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 11 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.6A)
 0.36A 3g0eA-3c4fA:
31.7		 3g0eA-3c4fA:
47.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 11 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
PHE A 489
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.7A)
 0.66A 3g0fA-3c4fA:
24.3		 3g0fA-3c4fA:
46.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 10 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
PHE A 489
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.7A)
 0.75A 3g0fB-3c4fA:
32.8		 3g0fB-3c4fA:
46.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.83A 3g5dB-3c4fA:
30.5		 3g5dB-3c4fA:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.63A 3gvuA-3c4fA:
31.5		 3gvuA-3c4fA:
38.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 512
GLU A 531
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.47A 3ik3A-3c4fA:
25.5		 3ik3A-3c4fA:
40.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 512
MET A 535
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.49A 3ik3A-3c4fA:
25.5		 3ik3A-3c4fA:
40.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 512
GLU A 531
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.49A 3ik3B-3c4fA:
25.2		 3ik3B-3c4fA:
40.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 512
MET A 535
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.49A 3ik3B-3c4fA:
25.2		 3ik3B-3c4fA:
40.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.64A 3k5vA-3c4fA:
31.3		 3k5vA-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.67A 3k5vB-3c4fA:
31.1		 3k5vB-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.71A 3ms9A-3c4fA:
31.0		 3ms9A-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.69A 3ms9B-3c4fA:
31.3		 3ms9B-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.73A 3mssA-3c4fA:
31.2		 3mssA-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.67A 3mssB-3c4fA:
31.3		 3mssB-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.67A 3mssB-3c4fA:
31.3		 3mssB-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.73A 3mssC-3c4fA:
31.2		 3mssC-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
ALA A 512
GLU A 531
MET A 535
ILE A 538
GLY A 567
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.76A 3mssD-3c4fA:
31.2		 3mssD-3c4fA:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.80A 3oezB-3c4fA:
29.9		 3oezB-3c4fA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 512
GLU A 531
MET A 535
GLY A 567
HIS A 621
ALA A 640
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-3.6A)
 0.56A 3oxzA-3c4fA:
31.8		 3oxzA-3c4fA:
40.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
GLY A 567
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-3.6A)
 0.70A 3pyyA-3c4fA:
31.8		 3pyyA-3c4fA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 LEU A 484
VAL A 492
ALA A 512
MET A 535
GLY A 567
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-3.6A)
 0.72A 3pyyA-3c4fA:
31.8		 3pyyA-3c4fA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 492
ALA A 512
GLU A 531
GLY A 567
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.58A 3pyyA-3c4fA:
31.8		 3pyyA-3c4fA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 492
ALA A 512
MET A 535
GLY A 567
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.60A 3pyyA-3c4fA:
31.8		 3pyyA-3c4fA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.59A 3pyyB-3c4fA:
31.2		 3pyyB-3c4fA:
40.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.86A 3qlgA-3c4fA:
30.3		 3qlgA-3c4fA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.93A 3qlgA-3c4fA:
30.3		 3qlgA-3c4fA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		10 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
ASP A 641
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-4.5A)
 0.79A 3qlgB-3c4fA:
25.1		 3qlgB-3c4fA:
36.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 ALA A 512
GLU A 531
ILE A 545
TYR A 563
ALA A 564
LEU A 614
HIS A 621
ALA A 640
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.0A)
None
C4F  A   1 (-3.5A)
None
None
C4F  A   1 (-3.6A)
 1.05A 3rgfA-3c4fA:
21.1		 3rgfA-3c4fA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
ILE A 545
ALA A 564
LEU A 614
HIS A 621
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.0A)
C4F  A   1 (-3.5A)
None
None
C4F  A   1 (-3.6A)
 0.81A 3rgfA-3c4fA:
21.1		 3rgfA-3c4fA:
26.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
MET A 535
TYR A 563
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
 0.62A 3sxrB-3c4fA:
29.3		 3sxrB-3c4fA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
 0.80A 3ue4B-3c4fA:
31.7		 3ue4B-3c4fA:
40.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
GLY A 485
VAL A 492
ALA A 512
GLU A 531
VAL A 561
GLY A 567
PHE A 642
 C4F  A   1 ( 3.9A)
C4F  A   1 ( 4.5A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
None
C4F  A   1 ( 4.5A)
 0.73A 3wzdA-3c4fA:
35.0		 3wzdA-3c4fA:
55.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
VAL A 561
GLY A 567
LEU A 644
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
None
None
 0.79A 3wzdA-3c4fA:
35.0		 3wzdA-3c4fA:
55.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
ILE A 538
VAL A 561
GLY A 567
LEU A 614
HIS A 621
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 4.8A)
None
None
None
 0.74A 3wzeA-3c4fA:
33.8		 3wzeA-3c4fA:
55.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 484
ALA A 512
GLU A 531
LEU A 614
HIS A 621
ARG A 622
LEU A 630
ALA A 640
PHE A 489
 C4F  A   1 ( 3.9A)
C4F  A   1 (-3.3A)
None
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.90A 3zosA-3c4fA:
24.5		 3zosA-3c4fA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 9 MET A 535
ILE A 544
ILE A 545
TYR A 563
ILE A 639
 C4F  A   1 ( 3.7A)
None
C4F  A   1 ( 4.0A)
None
None
 0.81A 3zosA-3c4fA:
24.5		 3zosA-3c4fA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 ALA A 512
GLU A 531
ILE A 545
LEU A 614
HIS A 621
ARG A 622
LEU A 630
ALA A 640
PHE A 489
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.0A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.87A 3zosB-3c4fA:
24.5		 3zosB-3c4fA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 9 LEU A 484
MET A 535
ILE A 544
TYR A 563
ILE A 639
 C4F  A   1 ( 3.9A)
C4F  A   1 ( 3.7A)
None
None
None
 0.62A 3zosB-3c4fA:
24.5		 3zosB-3c4fA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
VAL A 561
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-4.6A)
 0.57A 4ag8A-3c4fA:
27.8		 4ag8A-3c4fA:
54.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
VAL A 561
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-4.6A)
 0.59A 4agcA-3c4fA:
33.4		 4agcA-3c4fA:
54.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 11 LEU A 484
ALA A 512
VAL A 561
GLY A 567
LEU A 630
PHE A 489
 C4F  A   1 ( 3.9A)
C4F  A   1 (-3.3A)
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.7A)
 0.78A 4agdA-3c4fA:
33.5		 4agdA-3c4fA:
54.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 9 LEU A 484
VAL A 492
ALA A 512
GLY A 567
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.77A 4anqA-3c4fA:
31.0		 4anqA-3c4fA:
35.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
ALA A 512
GLU A 531
VAL A 561
GLY A 567
LEU A 614
HIS A 621
PHE A 489
 C4F  A   1 ( 3.9A)
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
None
None
None
C4F  A   1 (-3.7A)
 0.80A 4asdA-3c4fA:
25.6		 4asdA-3c4fA:
54.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
VAL A 561
GLY A 567
LEU A 614
HIS A 621
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
None
None
None
 0.64A 4asdA-3c4fA:
25.6		 4asdA-3c4fA:
54.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 545
TYR A 563
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 1.05A 4bkjA-3c4fA:
26.5		 4bkjA-3c4fA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 545
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.92A 4bkjB-3c4fA:
29.9		 4bkjB-3c4fA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
LEU A 630
ALA A 640
PHE A 489
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.94A 4bkjB-3c4fA:
29.9		 4bkjB-3c4fA:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 512
GLU A 531
ILE A 544
HIS A 621
LEU A 630
ALA A 640
PHE A 489
 C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.85A 4c8bB-3c4fA:
26.5		 4c8bB-3c4fA:
26.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 11 LEU A 484
GLY A 487
ALA A 512
VAL A 561
TYR A 563
ALA A 564
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-3.5A)
None
C4F  A   1 (-4.6A)
 1.21A 4ckiA-3c4fA:
34.3		 4ckiA-3c4fA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 11 LEU A 484
GLY A 487
VAL A 492
ALA A 512
VAL A 561
TYR A 563
ALA A 564
LEU A 630
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-3.5A)
C4F  A   1 (-4.6A)
 1.25A 4ckiA-3c4fA:
34.3		 4ckiA-3c4fA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 11 LEU A 484
GLY A 490
VAL A 492
ALA A 512
VAL A 561
TYR A 563
ALA A 564
LEU A 630
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-3.5A)
C4F  A   1 (-4.6A)
 0.78A 4ckiA-3c4fA:
34.3		 4ckiA-3c4fA:
51.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 10 LEU A 484
VAL A 492
ALA A 512
VAL A 561
TYR A 563
ALA A 564
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-3.5A)
C4F  A   1 (-4.6A)
 0.49A 4ckjA-3c4fA:
27.6		 4ckjA-3c4fA:
51.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
LEU A 630
ALA A 640
PHE A 489
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.72A 4csvA-3c4fA:
25.4		 4csvA-3c4fA:
41.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
GLY A 490
VAL A 492
ALA A 512
GLY A 567
LEU A 630
ASP A 641
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 (-3.3A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.83A 4mkcA-3c4fA:
31.6		 4mkcA-3c4fA:
36.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
ASP A 641
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.5A)
 0.84A 4mxoA-3c4fA:
29.6		 4mxoA-3c4fA:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
TYR A 563
GLY A 567
LEU A 630
ALA A 640
ASP A 641
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-4.5A)
 0.92A 4mxyB-3c4fA:
29.8		 4mxyB-3c4fA:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
TYR A 563
GLY A 567
LEU A 630
ALA A 640
ASP A 641
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-4.5A)
 0.92A 4mxzB-3c4fA:
29.8		 4mxzB-3c4fA:
36.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
TYR A 563
GLY A 567
LEU A 630
ALA A 640
ASP A 641
 C4F  A   1 ( 3.9A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-4.5A)
 0.79A 4otwA-3c4fA:
29.0		 4otwA-3c4fA:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 512
LYS A 514
GLU A 531
TYR A 563
LEU A 630
ALA A 640
ASP A 641
 C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-4.5A)
 0.89A 4qmnA-3c4fA:
25.0		 4qmnA-3c4fA:
28.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 11 ALA A 512
LYS A 514
GLU A 531
TYR A 563
LEU A 630
ASP A 641
 C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.86A 4qmsA-3c4fA:
25.0		 4qmsA-3c4fA:
28.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 512
GLU A 531
MET A 535
VAL A 561
LEU A 614
ARG A 622
ALA A 640
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
None
None
C4F  A   1 (-3.6A)
 0.92A 4qrcA-3c4fA:
40.3		 4qrcA-3c4fA:
70.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 512
GLU A 531
MET A 535
VAL A 561
LEU A 614
CYH A 619
ALA A 640
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
None
None
C4F  A   1 (-3.6A)
 0.46A 4qrcA-3c4fA:
40.3		 4qrcA-3c4fA:
70.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 GLU A 531
MET A 535
VAL A 561
LEU A 614
ARG A 622
ALA A 640
PHE A 489
 None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
None
None
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 1.18A 4qrcA-3c4fA:
40.3		 4qrcA-3c4fA:
70.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
CYH A 619
LEU A 630
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
 0.51A 4r7iA-3c4fA:
27.6		 4r7iA-3c4fA:
48.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
LEU A 630
PHE A 489
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 (-4.6A)
C4F  A   1 (-3.7A)
 0.81A 4r7iA-3c4fA:
27.6		 4r7iA-3c4fA:
48.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLY A 567
ASN A 628
LEU A 630
ALA A 640
ASP A 641
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-4.5A)
 0.95A 4twpA-3c4fA:
32.3		 4twpA-3c4fA:
40.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLY A 567
ASN A 628
LEU A 630
ALA A 640
ASP A 641
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-4.5A)
 0.99A 4twpB-3c4fA:
32.4		 4twpB-3c4fA:
40.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 ALA A 512
GLU A 531
MET A 535
ALA A 564
CYH A 619
HIS A 621
LEU A 630
ALA A 640
PHE A 489
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 (-3.5A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.73A 4tyjA-3c4fA:
36.1		 4tyjA-3c4fA:
72.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		10 / 12 ALA A 512
GLU A 531
MET A 535
ILE A 538
VAL A 561
ALA A 564
CYH A 619
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.67A 4tyjA-3c4fA:
36.1		 4tyjA-3c4fA:
72.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		4 / 6 LEU A 484
VAL A 492
ILE A 544
ILE A 639
 C4F  A   1 ( 3.9A)
None
None
None
 0.59A 4tyjA-3c4fA:
36.1		 4tyjA-3c4fA:
72.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 10 LEU A 484
VAL A 492
GLU A 531
ILE A 544
VAL A 559
TYR A 563
ILE A 639
 C4F  A   1 ( 3.9A)
None
None
None
None
None
None
 0.64A 4u0iA-3c4fA:
33.0		 4u0iA-3c4fA:
48.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 512
GLY A 567
CYH A 619
HIS A 621
LEU A 630
PHE A 489
 C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.7A)
 0.67A 4u0iA-3c4fA:
33.0		 4u0iA-3c4fA:
48.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 11 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
ASN A 628
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.65A 4u5jA-3c4fA:
30.6		 4u5jA-3c4fA:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 9 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.6A)
 0.73A 4u5jB-3c4fA:
24.9		 4u5jB-3c4fA:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 484
ALA A 512
GLU A 531
VAL A 561
LEU A 614
CYH A 619
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.58A 4uxqA-3c4fA:
38.3		 4uxqA-3c4fA:
73.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
GLU A 531
LEU A 614
CYH A 619
LEU A 630
ALA A 640
PHE A 489
 C4F  A   1 ( 3.9A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.90A 4uxqA-3c4fA:
38.3		 4uxqA-3c4fA:
73.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 7 VAL A 492
LYS A 514
ILE A 545
ALA A 564
ARG A 622
ILE A 639
 None
None
C4F  A   1 ( 4.0A)
C4F  A   1 (-3.5A)
None
None
 0.74A 4uxqA-3c4fA:
38.3		 4uxqA-3c4fA:
73.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 7 VAL A 492
MET A 535
ILE A 545
ALA A 564
ARG A 622
ILE A 639
 None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
C4F  A   1 (-3.5A)
None
None
 0.77A 4uxqA-3c4fA:
38.3		 4uxqA-3c4fA:
73.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		10 / 12 ALA A 512
GLU A 531
MET A 534
MET A 535
ILE A 538
VAL A 561
ALA A 564
LEU A 614
HIS A 621
ALA A 640
 C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
None
C4F  A   1 (-3.6A)
 0.60A 4v01A-3c4fA:
41.8		 4v01A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 ALA A 512
GLU A 531
MET A 535
ILE A 538
ALA A 564
LEU A 614
HIS A 621
ALA A 640
PHE A 489
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-3.5A)
None
None
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.75A 4v01A-3c4fA:
41.8		 4v01A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 9 LEU A 484
VAL A 492
LYS A 514
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
None
 0.71A 4v01A-3c4fA:
41.8		 4v01A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 9 LEU A 484
VAL A 492
LYS A 514
ILE A 545
TYR A 563
CYH A 619
LEU A 630
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
 0.86A 4v01A-3c4fA:
41.8		 4v01A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 ALA A 512
GLU A 531
MET A 535
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
None
None
C4F  A   1 (-3.6A)
 0.41A 4v01B-3c4fA:
40.9		 4v01B-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 ALA A 512
MET A 534
MET A 535
VAL A 561
ALA A 564
LEU A 614
CYH A 619
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
None
 0.67A 4v01B-3c4fA:
40.9		 4v01B-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 GLU A 531
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
PHE A 489
 None
C4F  A   1 (-3.5A)
None
None
None
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.74A 4v01B-3c4fA:
40.9		 4v01B-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 9 LEU A 484
VAL A 492
ILE A 538
ILE A 545
TYR A 563
LEU A 630
ILE A 639
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 ( 4.0A)
None
C4F  A   1 (-4.6A)
None
 0.60A 4v01B-3c4fA:
40.9		 4v01B-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		11 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 534
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
GLY A 643
 None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
None
None
C4F  A   1 (-3.6A)
None
 0.55A 4v04A-3c4fA:
42.7		 4v04A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 8 LYS A 514
ILE A 545
TYR A 563
ARG A 622
LEU A 630
 None
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
 0.61A 4v04A-3c4fA:
42.7		 4v04A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 8 MET A 535
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
 C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
None
 0.37A 4v04A-3c4fA:
42.7		 4v04A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 8 MET A 535
ILE A 545
TYR A 563
LEU A 630
ILE A 639
PHE A 489
 C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
None
C4F  A   1 (-4.6A)
None
C4F  A   1 (-3.7A)
 0.74A 4v04A-3c4fA:
42.7		 4v04A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 10 LEU A 484
VAL A 492
LYS A 514
MET A 535
ILE A 545
TYR A 563
LEU A 630
ILE A 639
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
None
C4F  A   1 (-4.6A)
None
 0.55A 4v04B-3c4fA:
42.4		 4v04B-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 10 LEU A 484
VAL A 492
MET A 535
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
LEU A 644
 C4F  A   1 ( 3.9A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
None
None
 0.42A 4v04B-3c4fA:
42.4		 4v04B-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		10 / 12 ALA A 512
GLU A 531
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
PHE A 489
GLY A 643
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
None
None
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
None
 0.66A 4v04B-3c4fA:
42.4		 4v04B-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 ALA A 512
MET A 534
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
GLY A 643
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
None
None
C4F  A   1 (-3.6A)
None
 0.56A 4v04B-3c4fA:
42.4		 4v04B-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
MET A 535
GLY A 567
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.80A 4xeyA-3c4fA:
32.0		 4xeyA-3c4fA:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 484
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.72A 4xliA-3c4fA:
31.1		 4xliA-3c4fA:
41.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
ALA A 512
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.78A 4xliB-3c4fA:
31.2		 4xliB-3c4fA:
41.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
ALA A 512
LYS A 514
GLU A 531
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
C4F  A   1 (-3.3A)
None
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.87A 4xliB-3c4fA:
31.2		 4xliB-3c4fA:
41.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 LEU A 484
ALA A 512
GLY A 567
LEU A 630
ALA A 640
ASP A 641
 C4F  A   1 ( 3.9A)
C4F  A   1 (-3.3A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-4.5A)
 0.82A 5ajqA-3c4fA:
22.7		 5ajqA-3c4fA:
28.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		10 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 545
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.81A 5bvwA-3c4fA:
30.7		 5bvwA-3c4fA:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		9 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.73A 5bvwA-3c4fA:
30.7		 5bvwA-3c4fA:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 LEU A 484
VAL A 492
ALA A 512
GLY A 567
LEU A 630
ASP A 641
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.84A 5h2uB-3c4fA:
29.8		 5h2uB-3c4fA:
41.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 492
ALA A 512
ILE A 545
ALA A 564
PHE A 642
GLY A 643
 None
C4F  A   1 (-3.3A)
C4F  A   1 ( 4.0A)
C4F  A   1 (-3.5A)
C4F  A   1 ( 4.5A)
None
 0.88A 5hesA-3c4fA:
27.2		 5hesA-3c4fA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 ALA A 512
LYS A 514
ILE A 545
TYR A 563
GLY A 567
LEU A 630
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
 0.69A 5i9xA-3c4fA:
32.0		 5i9xA-3c4fA:
33.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 11 LEU A 484
VAL A 492
ALA A 512
TYR A 563
ALA A 564
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 (-3.5A)
C4F  A   1 (-4.6A)
 0.45A 5lvnA-3c4fA:
23.1		 5lvnA-3c4fA:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 10 LEU A 484
VAL A 492
LYS A 514
GLU A 531
GLY A 567
PHE A 489
 C4F  A   1 ( 3.9A)
None
None
None
None
C4F  A   1 (-3.7A)
 0.76A 5mo4A-3c4fA:
9.9		 5mo4A-3c4fA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		5 / 12 ALA A 512
MET A 535
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.53A 5mo4A-3c4fA:
9.9		 5mo4A-3c4fA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 LEU A 494
ALA A 512
GLU A 531
MET A 535
GLY A 567
LEU A 630
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
 0.61A 5te0A-3c4fA:
22.5		 5te0A-3c4fA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
 0.90A 5y7zA-3c4fA:
22.0		 5y7zA-3c4fA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
 0.90A 5y7zA-3c4fA:
22.0		 5y7zA-3c4fA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
ASP A 641
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.81A 5y80A-3c4fA:
21.6		 5y80A-3c4fA:
12.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 GLY A 487
PHE A 489
VAL A 492
GLU A 531
MET A 535
VAL A 561
ALA A 640
 None
C4F  A   1 (-3.7A)
None
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.6A)
 1.34A 5zv2A-3c4fA:
43.9		 5zv2A-3c4fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		12 / 12 LEU A 484
GLY A 485
PHE A 489
VAL A 492
ALA A 512
GLU A 531
MET A 535
VAL A 561
TYR A 563
ALA A 564
GLY A 567
ALA A 640
 C4F  A   1 ( 3.9A)
C4F  A   1 ( 4.5A)
C4F  A   1 (-3.7A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-3.5A)
None
C4F  A   1 (-3.6A)
 0.50A 5zv2A-3c4fA:
43.9		 5zv2A-3c4fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		3 / 3 LYS A 514
LEU A 630
ASP A 641
 None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.72A 5zv2A-3c4fA:
43.9		 5zv2A-3c4fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 GLY A 487
PHE A 489
VAL A 492
ALA A 512
MET A 535
VAL A 561
ALA A 640
 None
C4F  A   1 (-3.7A)
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.6A)
 1.37A 5zv2B-3c4fA:
42.4		 5zv2B-3c4fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		11 / 12 LEU A 484
GLY A 485
PHE A 489
VAL A 492
ALA A 512
GLU A 531
MET A 535
VAL A 561
ALA A 564
GLY A 567
ALA A 640
 C4F  A   1 ( 3.9A)
C4F  A   1 ( 4.5A)
C4F  A   1 (-3.7A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
C4F  A   1 (-3.6A)
 0.61A 5zv2B-3c4fA:
42.4		 5zv2B-3c4fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		11 / 12 LEU A 484
GLY A 485
PHE A 489
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
VAL A 561
ALA A 564
GLY A 567
 C4F  A   1 ( 3.9A)
C4F  A   1 ( 4.5A)
C4F  A   1 (-3.7A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
 0.79A 5zv2B-3c4fA:
42.4		 5zv2B-3c4fA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		3 / 3 TYR A 563
LEU A 630
ASP A 641
 None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.31A 5zv2B-3c4fA:
18.1		 5zv2B-3c4fA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 545
TYR A 563
GLY A 567
LEU A 630
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
 0.90A 6bsdA-3c4fA:
26.0		 6bsdA-3c4fA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		8 / 12 VAL A 492
ALA A 512
LYS A 514
GLU A 531
ILE A 545
TYR A 563
GLY A 567
LEU A 630
 None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
 0.91A 6bsdA-3c4fA:
26.0		 6bsdA-3c4fA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.68A 6hd4A-3c4fA:
24.7		 6hd4A-3c4fA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.68A 6hd4B-3c4fA:
30.9		 6hd4B-3c4fA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		6 / 12 VAL A 492
ALA A 512
LYS A 514
GLU A 531
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.59A 6hd4B-3c4fA:
30.9		 6hd4B-3c4fA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens) 		7 / 12 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
 0.76A 6hd6B-3c4fA:
30.7		 6hd6B-3c4fA:
14.53