SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'C2X'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		4 / 8 LEU A  65
ILE A 126
TYR A 119
PHE A  91
 None
None
None
C2X  A 260 ( 4.6A)
 0.99A 2weyB-3hiwA:
undetectable		 2weyB-3hiwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		3 / 3 GLU A 174
ALA A 175
PHE A 178
 C2X  A 260 (-3.0A)
None
None
 0.62A 4v1fA-3hiwA:
undetectable		 4v1fA-3hiwA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		3 / 3 GLU A 174
ALA A 175
PHE A 178
 C2X  A 260 (-3.0A)
None
None
 0.59A 4v1fC-3hiwA:
undetectable		 4v1fC-3hiwA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 9 TYR A  73
PHE A  91
TYR A 123
GLU A 174
ARG A 177
 C2X  A 260 (-3.4A)
C2X  A 260 ( 4.6A)
C2X  A 260 (-3.7A)
C2X  A 260 (-3.0A)
C2X  A 260 (-2.9A)
 0.36A 4yp2B-3hiwA:
27.5		 4yp2B-3hiwA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 9 TYR A  73
PHE A  91
TYR A 123
GLU A 174
ARG A 177
 C2X  A 260 (-3.4A)
C2X  A 260 ( 4.6A)
C2X  A 260 (-3.7A)
C2X  A 260 (-3.0A)
C2X  A 260 (-2.9A)
 0.35A 5cf9B-3hiwA:
27.5		 5cf9B-3hiwA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 3hiw VACUOLAR SAPORIN
(Saponaria
officinalis) 		5 / 6 TYR A  73
VAL A  74
TYR A 123
GLU A 174
ARG A 177
 C2X  A 260 (-3.4A)
C2X  A 260 (-3.9A)
C2X  A 260 (-3.7A)
C2X  A 260 (-3.0A)
C2X  A 260 (-2.9A)
 0.30A 5z3jA-3hiwA:
28.5		 5z3jA-3hiwA:
27.11