SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'C2O'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 243
LEU A 121
LEU A 163
GLY A 270
 C2O  A 340 (-3.3A)
None
None
None
 0.98A 1a4lB-2p3xA:
undetectable		 1a4lB-2p3xA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 6 HIS A 201
HIS A 203
HIS A 602
HIS A 527
HIS A 163
 C2O  A1002 (-3.7A)
C2O  A1002 (-3.4A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 1.20A 1fweC-3gyrA:
undetectable		 1fweC-3gyrA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 8 ASP A 471
ASP A 260
HIS A 141
LEU A 503
 None
None
C2O  A 602 (-3.2A)
None
 0.97A 1pk2A-2fqdA:
undetectable		 1pk2A-2fqdA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 8 ASP A 576
ASP A 339
HIS A 201
LEU A 606
 None
None
C2O  A1002 (-3.7A)
None
 1.09A 1pk2A-3gyrA:
undetectable		 1pk2A-3gyrA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 12 PHE A 115
PHE A 270
VAL A 277
ALA A 232
HIS A 109
 None
C2O  A 500 ( 4.8A)
None
None
C2O  A 500 ( 3.3A)
 1.24A 1q23H-1bt2A:
0.0
1q23I-1bt2A:
0.0		 1q23H-1bt2A:
19.57
1q23I-1bt2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 7 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.19A 1v55C-3aw5A:
undetectable
1v55N-3aw5A:
undetectable
1v55P-3aw5A:
undetectable		 1v55C-3aw5A:
18.91
1v55N-3aw5A:
22.18
1v55P-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 HIS A 272
HIS A 239
HIS A 117
 C2O  A 340 (-3.1A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
 0.74A 1w2zA-2p3xA:
undetectable		 1w2zA-2p3xA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		3 / 3 THR A  99
GLU A 506
HIS A 103
 None
C2O  A 602 ( 4.9A)
C2O  A 602 (-3.0A)
 0.75A 1xwfA-2fqdA:
undetectable		 1xwfA-2fqdA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		3 / 3 THR A  99
GLU A 506
HIS A 103
 None
C2O  A 602 ( 4.9A)
C2O  A 602 (-3.0A)
 0.74A 1xwfB-2fqdA:
undetectable		 1xwfB-2fqdA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		3 / 3 THR A  99
GLU A 506
HIS A 103
 None
C2O  A 602 ( 4.9A)
C2O  A 602 (-3.0A)
 0.73A 1xwfC-2fqdA:
undetectable		 1xwfC-2fqdA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		3 / 3 THR A  99
GLU A 506
HIS A 103
 None
C2O  A 602 ( 4.9A)
C2O  A 602 (-3.0A)
 0.73A 1xwfD-2fqdA:
undetectable		 1xwfD-2fqdA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_D_H4BD1006_1
(HYPOTHETICAL PROTEIN
PH0634)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 10 HIS A 501
HIS A 446
HIS A 499
THR A 148
GLU A 506
 C2O  A 602 (-3.4A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
None
C2O  A 602 ( 4.9A)
 1.40A 2dttD-2fqdA:
undetectable
2dttF-2fqdA:
undetectable		 2dttD-2fqdA:
13.63
2dttF-2fqdA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.44A 2dysA-2p3xA:
undetectable
2dysC-2p3xA:
undetectable		 2dysA-2p3xA:
19.17
2dysC-2p3xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.45A 2eilA-2p3xA:
undetectable
2eilC-2p3xA:
undetectable		 2eilA-2p3xA:
19.17
2eilC-2p3xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.48A 2einA-2p3xA:
0.5
2einC-2p3xA:
undetectable		 2einA-2p3xA:
19.17
2einC-2p3xA:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.15A 2fqeA-2fqdA:
71.9		 2fqeA-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 101
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 1.35A 2fqeA-2fqdA:
71.9		 2fqeA-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.80A 2fqeA-2fqdA:
71.9		 2fqeA-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.28A 2fqeA-2fqdA:
71.9		 2fqeA-2fqdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.21A 2fqeA-3aw5A:
45.4		 2fqeA-3aw5A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.83A 2fqeA-3aw5A:
45.4		 2fqeA-3aw5A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 459
HIS A 394
HIS A 396
HIS A 134
 C2O  A 702 (-3.4A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.3A)
 1.35A 2fqeA-3aw5A:
45.4		 2fqeA-3aw5A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.30A 2fqeA-3gyrA:
37.3		 2fqeA-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.87A 2fqeA-3gyrA:
37.3		 2fqeA-3gyrA:
27.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FQF_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.10A 2fqfA-2fqdA:
71.8		 2fqfA-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FQF_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.78A 2fqfA-2fqdA:
71.8		 2fqfA-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FQF_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.33A 2fqfA-2fqdA:
71.8		 2fqfA-2fqdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.17A 2fqfA-3aw5A:
45.2		 2fqfA-3aw5A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.81A 2fqfA-3aw5A:
45.2		 2fqfA-3aw5A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.21A 2fqfA-3gyrA:
37.3		 2fqfA-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.83A 2fqfA-3gyrA:
37.3		 2fqfA-3gyrA:
27.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FQG_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.16A 2fqgA-2fqdA:
71.7		 2fqgA-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FQG_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 141
HIS A 143
HIS A 499
HIS A 501
 C2O  A 602 (-3.2A)
C2O  A 602 (-3.5A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.4A)
 1.22A 2fqgA-2fqdA:
71.7		 2fqgA-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FQG_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.79A 2fqgA-2fqdA:
71.7		 2fqgA-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FQG_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.36A 2fqgA-2fqdA:
71.7		 2fqgA-2fqdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.20A 2fqgA-3aw5A:
45.3		 2fqgA-3aw5A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.82A 2fqgA-3aw5A:
45.3		 2fqgA-3aw5A:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.15A 2fqgA-3gyrA:
37.4		 2fqgA-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.34A 2fqgA-3gyrA:
37.4		 2fqgA-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.81A 2fqgA-3gyrA:
37.4		 2fqgA-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 8 HIS A  88
HIS A 274
HIS A 118
VAL A 108
HIS A 244
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
C2O  A 500 ( 3.2A)
 1.45A 2it4A-1bt2A:
undetectable		 2it4A-1bt2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		3 / 3 HIS A 134
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.56A 2ozrF-3aw5A:
undetectable		 2ozrF-3aw5A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		3 / 3 HIS A 602
HIS A 604
HIS A 527
 C2O  A1002 (-3.4A)
C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
 0.70A 2w0qA-3gyrA:
undetectable		 2w0qA-3gyrA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 143
HIS A 141
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.5A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.3A)
 1.03A 2wkoA-2fqdA:
undetectable		 2wkoA-2fqdA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_A_CUA154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A 134
HIS A 132
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
C2O  A 702 (-3.3A)
C2O  A 702 ( 3.3A)
 1.07A 2wkoA-3aw5A:
undetectable		 2wkoA-3aw5A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A 240
HIS A 244
VAL A 277
HIS A 274
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
 0.89A 2wkoF-1bt2A:
undetectable		 2wkoF-1bt2A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 239
HIS A 243
VAL A 275
HIS A 272
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
C2O  A 340 (-3.1A)
 0.93A 2wkoF-2p3xA:
undetectable		 2wkoF-2p3xA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.21A 2zweA-1bt2A:
20.9
2zweB-1bt2A:
undetectable		 2zweA-1bt2A:
26.67
2zweB-1bt2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
ILE A 241
HIS A 244
HIS A  88
HIS A 109
 C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
 1.12A 2zweA-1bt2A:
20.9
2zweB-1bt2A:
undetectable		 2zweA-1bt2A:
26.67
2zweB-1bt2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.35A 2zweA-2p3xA:
21.1
2zweB-2p3xA:
undetectable		 2zweA-2p3xA:
24.46
2zweB-2p3xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.15A 2zweA-2p3xA:
21.1
2zweB-2p3xA:
undetectable		 2zweA-2p3xA:
24.46
2zweB-2p3xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.25A 2zwfA-1bt2A:
20.9
2zwfB-1bt2A:
undetectable		 2zwfA-1bt2A:
26.67
2zwfB-1bt2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.23A 2zwfA-1bt2A:
20.9
2zwfB-1bt2A:
undetectable		 2zwfA-1bt2A:
26.67
2zwfB-1bt2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
ILE A 241
HIS A 244
HIS A  88
HIS A 109
 C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
 1.14A 2zwfA-1bt2A:
20.9
2zwfB-1bt2A:
undetectable		 2zwfA-1bt2A:
26.67
2zwfB-1bt2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.35A 2zwfA-2p3xA:
21.2
2zwfB-2p3xA:
undetectable		 2zwfA-2p3xA:
24.46
2zwfB-2p3xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 117
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 1.49A 2zwfA-2p3xA:
21.2
2zwfB-2p3xA:
undetectable		 2zwfA-2p3xA:
24.46
2zwfB-2p3xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.19A 2zwfA-2p3xA:
21.2
2zwfB-2p3xA:
undetectable		 2zwfA-2p3xA:
24.46
2zwfB-2p3xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.25A 2zwgA-1bt2A:
20.9
2zwgB-1bt2A:
undetectable		 2zwgA-1bt2A:
26.67
2zwgB-1bt2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.21A 2zwgA-1bt2A:
20.9
2zwgB-1bt2A:
undetectable		 2zwgA-1bt2A:
26.67
2zwgB-1bt2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.35A 2zwgA-2p3xA:
21.1
2zwgB-2p3xA:
undetectable		 2zwgA-2p3xA:
24.46
2zwgB-2p3xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.18A 2zwgA-2p3xA:
21.1
2zwgB-2p3xA:
undetectable		 2zwgA-2p3xA:
24.46
2zwgB-2p3xA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.45A 2zxwA-2p3xA:
undetectable
2zxwC-2p3xA:
undetectable		 2zxwA-2p3xA:
19.17
2zxwC-2p3xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.47A 2zxwN-2p3xA:
undetectable
2zxwP-2p3xA:
undetectable		 2zxwN-2p3xA:
19.17
2zxwP-2p3xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.42A 3abkA-2p3xA:
undetectable
3abkC-2p3xA:
undetectable		 3abkA-2p3xA:
19.17
3abkC-2p3xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.12A 3ablA-3aw5A:
undetectable
3ablC-3aw5A:
undetectable
3ablP-3aw5A:
undetectable		 3ablA-3aw5A:
22.18
3ablC-3aw5A:
18.91
3ablP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 8 LEU A 200
HIS A 448
THR A 148
HIS A 446
 None
C2O  A 602 (-3.3A)
None
C2O  A 602 (-4.0A)
 1.09A 3ablC-2fqdA:
undetectable
3ablN-2fqdA:
undetectable
3ablP-2fqdA:
undetectable		 3ablC-2fqdA:
17.76
3ablN-2fqdA:
22.44
3ablP-2fqdA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.15A 3ablC-3aw5A:
undetectable
3ablN-3aw5A:
undetectable
3ablP-3aw5A:
undetectable		 3ablC-3aw5A:
18.91
3ablN-3aw5A:
22.18
3ablP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.16A 3abmA-3aw5A:
undetectable
3abmC-3aw5A:
undetectable
3abmP-3aw5A:
undetectable		 3abmA-3aw5A:
22.18
3abmC-3aw5A:
18.91
3abmP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.42A 3ag3N-2p3xA:
undetectable
3ag3P-2p3xA:
undetectable		 3ag3N-2p3xA:
19.17
3ag3P-2p3xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.15A 3asnC-3aw5A:
undetectable
3asnN-3aw5A:
undetectable
3asnP-3aw5A:
undetectable		 3asnC-3aw5A:
18.91
3asnN-3aw5A:
22.18
3asnP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.16A 3asoA-3aw5A:
undetectable
3asoC-3aw5A:
undetectable
3asoP-3aw5A:
undetectable		 3asoA-3aw5A:
22.18
3asoC-3aw5A:
18.91
3asoP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.16A 3asoC-3aw5A:
undetectable
3asoN-3aw5A:
undetectable
3asoP-3aw5A:
undetectable		 3asoC-3aw5A:
18.91
3asoN-3aw5A:
22.18
3asoP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 12 HIS A 501
THR A 472
GLU A 506
THR A 148
HIS A 448
 C2O  A 602 (-3.4A)
None
C2O  A 602 ( 4.9A)
None
C2O  A 602 (-3.3A)
 1.37A 3ce6D-2fqdA:
undetectable		 3ce6D-2fqdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 12 HIS A 461
THR A 432
GLU A 466
THR A 139
HIS A 396
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 4.5A)
None
C2O  A 702 ( 3.3A)
 1.42A 3ce6D-3aw5A:
undetectable		 3ce6D-3aw5A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 7 HIS A 499
GLN A 451
PHE A 452
VAL A 482
 C2O  A 602 (-3.3A)
None
None
None
 1.13A 3jwqC-2fqdA:
undetectable		 3jwqC-2fqdA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		3 / 3 HIS A 499
HIS A 446
HIS A 448
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.78A 3mihA-2fqdA:
undetectable		 3mihA-2fqdA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		3 / 3 HIS A 459
HIS A 394
HIS A 396
 C2O  A 702 (-3.4A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.77A 3mihA-3aw5A:
undetectable		 3mihA-3aw5A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		3 / 3 HIS A 602
HIS A 527
HIS A 529
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.77A 3mihA-3gyrA:
undetectable		 3mihA-3gyrA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		3 / 3 HIS A 109
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.24A 3qpkA-1bt2A:
undetectable		 3qpkA-1bt2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		3 / 3 HIS A 143
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.31A 3qpkA-2fqdA:
28.6		 3qpkA-2fqdA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 HIS A 108
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.21A 3qpkA-2p3xA:
undetectable		 3qpkA-2p3xA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		3 / 3 HIS A 134
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.26A 3qpkA-3aw5A:
27.6		 3qpkA-3aw5A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		3 / 3 HIS A 203
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.22A 3qpkA-3gyrA:
22.4		 3qpkA-3gyrA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA603_0
(LACCASE-1)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.26A 3qpkA-2fqdA:
28.6		 3qpkA-2fqdA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA603_0
(LACCASE-1)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 163
TRP A 199
HIS A 201
HIS A 604
 C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.29A 3qpkA-3gyrA:
22.5		 3qpkA-3gyrA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA604_0
(LACCASE-1)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.25A 3qpkA-2fqdA:
28.5		 3qpkA-2fqdA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA604_0
(LACCASE-1)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.83A 3qpkA-2fqdA:
28.5		 3qpkA-2fqdA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA604_0
(LACCASE-1)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.29A 3qpkA-2fqdA:
28.5		 3qpkA-2fqdA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA604_0
(LACCASE-1)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.16A 3qpkA-3aw5A:
27.6		 3qpkA-3aw5A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA604_0
(LACCASE-1)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.85A 3qpkA-3aw5A:
27.6		 3qpkA-3aw5A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA604_0
(LACCASE-1)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.26A 3qpkA-3gyrA:
22.4		 3qpkA-3gyrA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA604_0
(LACCASE-1)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.88A 3qpkA-3gyrA:
22.4		 3qpkA-3gyrA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		3 / 3 HIS A 109
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.25A 3qpkB-1bt2A:
undetectable		 3qpkB-1bt2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		3 / 3 HIS A 143
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.27A 3qpkB-2fqdA:
28.7		 3qpkB-2fqdA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 HIS A 108
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.24A 3qpkB-2p3xA:
undetectable		 3qpkB-2p3xA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		3 / 3 HIS A 134
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.26A 3qpkB-3aw5A:
27.7		 3qpkB-3aw5A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		3 / 3 HIS A 203
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.22A 3qpkB-3gyrA:
22.5		 3qpkB-3gyrA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB603_0
(LACCASE-1)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.23A 3qpkB-2fqdA:
28.8		 3qpkB-2fqdA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB603_0
(LACCASE-1)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 163
TRP A 199
HIS A 201
HIS A 604
 C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.31A 3qpkB-3gyrA:
22.5		 3qpkB-3gyrA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB604_0
(LACCASE-1)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.25A 3qpkB-2fqdA:
28.7		 3qpkB-2fqdA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB604_0
(LACCASE-1)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 101
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 1.32A 3qpkB-2fqdA:
28.7		 3qpkB-2fqdA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB604_0
(LACCASE-1)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.80A 3qpkB-2fqdA:
28.7		 3qpkB-2fqdA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB604_0
(LACCASE-1)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.34A 3qpkB-2fqdA:
28.7		 3qpkB-2fqdA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB604_0
(LACCASE-1)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.16A 3qpkB-3aw5A:
27.7		 3qpkB-3aw5A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB604_0
(LACCASE-1)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.83A 3qpkB-3aw5A:
27.7		 3qpkB-3aw5A:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB604_0
(LACCASE-1)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.21A 3qpkB-3gyrA:
22.5		 3qpkB-3gyrA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB604_0
(LACCASE-1)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.25A 3qpkB-3gyrA:
22.5		 3qpkB-3gyrA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB604_0
(LACCASE-1)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.85A 3qpkB-3gyrA:
22.5		 3qpkB-3gyrA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 6 HIS A 163
ASP A 224
ASP A 339
GLU A 227
 C2O  A1002 (-3.3A)
None
None
None
 1.33A 3vywA-3gyrA:
undetectable		 3vywA-3gyrA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.17A 3wg7A-3aw5A:
undetectable
3wg7C-3aw5A:
undetectable
3wg7P-3aw5A:
undetectable		 3wg7A-3aw5A:
22.18
3wg7C-3aw5A:
18.91
3wg7P-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.14A 3wg7C-3aw5A:
undetectable
3wg7N-3aw5A:
undetectable
3wg7P-3aw5A:
undetectable		 3wg7C-3aw5A:
18.91
3wg7N-3aw5A:
22.18
3wg7P-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.17A 3x2qA-3aw5A:
undetectable
3x2qC-3aw5A:
undetectable
3x2qP-3aw5A:
undetectable		 3x2qA-3aw5A:
22.18
3x2qC-3aw5A:
18.91
3x2qP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 8 LEU A 200
HIS A 448
THR A 148
HIS A 446
 None
C2O  A 602 (-3.3A)
None
C2O  A 602 (-4.0A)
 1.12A 3x2qC-2fqdA:
undetectable
3x2qN-2fqdA:
undetectable
3x2qP-2fqdA:
undetectable		 3x2qC-2fqdA:
17.76
3x2qN-2fqdA:
22.44
3x2qP-2fqdA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.16A 3x2qC-3aw5A:
undetectable
3x2qN-3aw5A:
undetectable
3x2qP-3aw5A:
undetectable		 3x2qC-3aw5A:
18.91
3x2qN-3aw5A:
22.18
3x2qP-3aw5A:
18.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 103
HIS A 141
HIS A 446
HIS A 501
 C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.4A)
 0.11A 4ef3A-2fqdA:
70.4		 4ef3A-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 448
HIS A 499
HIS A 101
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.5A)
 0.67A 4ef3A-2fqdA:
70.4		 4ef3A-2fqdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  94
HIS A 132
HIS A 394
HIS A 461
 C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
 0.22A 4ef3A-3aw5A:
45.2		 4ef3A-3aw5A:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 396
HIS A 459
HIS A  92
HIS A 134
 C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
 0.66A 4ef3A-3aw5A:
45.2		 4ef3A-3aw5A:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 163
HIS A 201
HIS A 527
HIS A 604
 C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.9A)
 0.30A 4ef3A-3gyrA:
37.2		 4ef3A-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 529
HIS A 602
HIS A 161
HIS A 203
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.72A 4ef3A-3gyrA:
37.2		 4ef3A-3gyrA:
27.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.22A 4ef3A-2fqdA:
70.4		 4ef3A-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 103
HIS A 101
HIS A 499
HIS A 446
HIS A 448
 C2O  A 602 (-3.0A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 1.41A 4ef3A-2fqdA:
70.4		 4ef3A-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 446
HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.66A 4ef3A-2fqdA:
70.4		 4ef3A-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 499
HIS A 448
HIS A 141
HIS A 143
HIS A 101
 C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.5A)
C2O  A 602 (-3.9A)
 1.27A 4ef3A-2fqdA:
70.4		 4ef3A-2fqdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 5 HIS A  92
HIS A 134
HIS A 394
HIS A 396
HIS A 459
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.17A 4ef3A-3aw5A:
45.2		 4ef3A-3aw5A:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 5 HIS A 394
HIS A 461
HIS A  92
HIS A  94
HIS A 132
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.67A 4ef3A-3aw5A:
45.2		 4ef3A-3aw5A:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 203
HIS A 527
HIS A 529
HIS A 602
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.25A 4ef3A-3gyrA:
37.2		 4ef3A-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1003_0
(BLUE COPPER OXIDASE
CUEO)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 527
HIS A 604
HIS A 161
HIS A 163
HIS A 201
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.71A 4ef3A-3gyrA:
37.2		 4ef3A-3gyrA:
27.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EF3_A_CUA1004_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.20A 4ef3A-2fqdA:
70.4		 4ef3A-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EF3_A_CUA1004_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 101
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 1.37A 4ef3A-2fqdA:
70.4		 4ef3A-2fqdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EF3_A_CUA1004_0
(BLUE COPPER OXIDASE
CUEO)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.80A 4ef3A-2fqdA:
70.4		 4ef3A-2fqdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1004_0
(BLUE COPPER OXIDASE
CUEO)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.20A 4ef3A-3aw5A:
45.2		 4ef3A-3aw5A:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1004_0
(BLUE COPPER OXIDASE
CUEO)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.84A 4ef3A-3aw5A:
45.2		 4ef3A-3aw5A:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1004_0
(BLUE COPPER OXIDASE
CUEO)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.16A 4ef3A-3gyrA:
37.2		 4ef3A-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1004_0
(BLUE COPPER OXIDASE
CUEO)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.84A 4ef3A-3gyrA:
37.2		 4ef3A-3gyrA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 136
THR A 139
GLU A 466
HIS A  92
 None
None
C2O  A 702 ( 4.5A)
CU  A 703 ( 3.0A)
 1.35A 4hvcB-3aw5A:
undetectable		 4hvcB-3aw5A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_1
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 136
THR A 139
GLU A 466
HIS A 396
 None
None
C2O  A 702 ( 4.5A)
C2O  A 702 ( 3.3A)
 0.98A 4hvcB-3aw5A:
undetectable		 4hvcB-3aw5A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 12 PHE A 270
ASP A 267
ASP A 257
MET A 258
GLY A 259
 C2O  A 500 ( 4.8A)
None
None
None
None
 1.28A 4j7xF-1bt2A:
undetectable		 4j7xF-1bt2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 201
GLU A 607
HIS A 262
LEU A 154
 C2O  A1002 (-3.7A)
None
None
None
 1.39A 4m2rA-3gyrA:
undetectable		 4m2rA-3gyrA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 7 PHE A 117
HIS A 118
PHE A 261
ASN A  93
 None
C2O  A 500 ( 3.3A)
C2O  A 500 (-3.6A)
None
 1.35A 4o7gA-1bt2A:
0.2
4o7gB-1bt2A:
0.5		 4o7gA-1bt2A:
19.82
4o7gB-1bt2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 7 PHE A 261
HIS A 244
ILE A 241
PHE A 114
 C2O  A 500 (-3.6A)
C2O  A 500 ( 3.2A)
None
None
 1.19A 4o7gA-1bt2A:
0.2
4o7gB-1bt2A:
0.5		 4o7gA-1bt2A:
19.82
4o7gB-1bt2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 6 PHE A 117
HIS A 118
PHE A 261
ASN A  93
 None
C2O  A 500 ( 3.3A)
C2O  A 500 (-3.6A)
None
 1.34A 4o7gB-1bt2A:
0.5		 4o7gB-1bt2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 6 PHE A 261
HIS A 244
ILE A 241
PHE A 114
 C2O  A 500 (-3.6A)
C2O  A 500 ( 3.2A)
None
None
 1.13A 4o7gB-1bt2A:
0.5		 4o7gB-1bt2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 7 HIS A  88
HIS A 109
HIS A 240
HIS A 244
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 0.55A 4p6sA-1bt2A:
21.1		 4p6sA-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		6 / 7 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
ALA A 262
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
None
 0.48A 4p6sA-2p3xA:
21.1		 4p6sA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 239
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.16A 4p6sA-2p3xA:
21.1		 4p6sA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 272
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.41A 4p6sA-2p3xA:
21.1		 4p6sA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 7 HIS A  88
HIS A 109
HIS A 240
HIS A 244
ARG A 245
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 0.89A 4p6sB-1bt2A:
21.1		 4p6sB-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.49A 4p6sB-2p3xA:
21.2		 4p6sB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 HIS A 108
HIS A  87
HIS A 243
HIS A 239
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
 0.98A 4p6sB-2p3xA:
21.2		 4p6sB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 MET A 152
ASP A 265
PHE A 268
 None
None
C2O  A 340 ( 4.7A)
 0.92A 4xeyA-2p3xA:
undetectable		 4xeyA-2p3xA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 MET A 152
ASP A 265
PHE A 268
 None
None
C2O  A 340 ( 4.7A)
 0.87A 4xeyB-2p3xA:
undetectable		 4xeyB-2p3xA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.18A 5b1aA-3aw5A:
undetectable
5b1aC-3aw5A:
undetectable
5b1aP-3aw5A:
undetectable		 5b1aA-3aw5A:
22.18
5b1aC-3aw5A:
18.91
5b1aP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.19A 5b3sA-3aw5A:
undetectable
5b3sC-3aw5A:
undetectable
5b3sP-3aw5A:
undetectable		 5b3sA-3aw5A:
22.18
5b3sC-3aw5A:
18.91
5b3sP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 12 PRO A 444
HIS A 101
HIS A 141
HIS A 103
ASP A 471
 None
C2O  A 602 (-3.9A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.0A)
None
 1.48A 5ef8A-2fqdA:
undetectable		 5ef8A-2fqdA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 9 HIS A 143
GLY A 113
GLY A 114
HIS A 141
HIS A 448
 C2O  A 602 (-3.5A)
None
None
C2O  A 602 (-3.2A)
C2O  A 602 (-3.3A)
 1.46A 5f8yA-2fqdA:
undetectable		 5f8yA-2fqdA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 9 HIS A 143
GLY A 113
GLY A 114
HIS A 141
HIS A 448
 C2O  A 602 (-3.5A)
None
None
C2O  A 602 (-3.2A)
C2O  A 602 (-3.3A)
 1.49A 5f8yB-2fqdA:
0.0		 5f8yB-2fqdA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 9 HIS A 143
GLY A 113
GLY A 114
HIS A 141
HIS A 448
 C2O  A 602 (-3.5A)
None
None
C2O  A 602 (-3.2A)
C2O  A 602 (-3.3A)
 1.45A 5f8yB-2fqdA:
0.0		 5f8yB-2fqdA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 12 LEU A 463
PHE A 143
ILE A 173
GLY A 225
HIS A 396
 None
None
None
None
C2O  A 702 ( 3.3A)
 1.23A 5fsaB-3aw5A:
undetectable		 5fsaB-3aw5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 7 HIS A  88
HIS A 109
HIS A 240
HIS A 244
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 0.49A 5i3aA-1bt2A:
21.4		 5i3aA-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		6 / 7 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
ALA A 262
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
None
 0.44A 5i3aA-2p3xA:
21.3		 5i3aA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 239
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.14A 5i3aA-2p3xA:
21.3		 5i3aA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 239
HIS A 117
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
None
 1.50A 5i3aA-2p3xA:
21.3		 5i3aA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 272
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.46A 5i3aA-2p3xA:
21.3		 5i3aA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 7 HIS A  88
HIS A 109
HIS A 240
HIS A 244
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 0.48A 5i3aB-1bt2A:
21.4		 5i3aB-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		6 / 7 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
ALA A 262
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
None
 0.41A 5i3aB-2p3xA:
21.2		 5i3aB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 239
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.15A 5i3aB-2p3xA:
21.2		 5i3aB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 272
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.44A 5i3aB-2p3xA:
21.2		 5i3aB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 7 HIS A  88
HIS A 109
HIS A 240
HIS A 244
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 0.52A 5i3bA-1bt2A:
21.5		 5i3bA-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 7 HIS A 244
HIS A 240
HIS A 109
HIS A  88
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
None
 1.10A 5i3bA-1bt2A:
21.5		 5i3bA-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 7 HIS A 244
HIS A 240
HIS A 118
HIS A  88
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
None
 1.49A 5i3bA-1bt2A:
21.5		 5i3bA-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		6 / 7 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
ALA A 262
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
None
 0.47A 5i3bA-2p3xA:
21.4		 5i3bA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 239
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.14A 5i3bA-2p3xA:
21.4		 5i3bA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 239
HIS A 117
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
None
 1.49A 5i3bA-2p3xA:
21.4		 5i3bA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 7 HIS A 243
HIS A 272
HIS A 108
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.46A 5i3bA-2p3xA:
21.4		 5i3bA-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A  88
HIS A 109
HIS A 244
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
None
 0.46A 5i3bB-1bt2A:
21.5		 5i3bB-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A 244
HIS A 240
HIS A  88
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 0.92A 5i3bB-1bt2A:
21.5		 5i3bB-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A 244
HIS A 274
HIS A  88
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 1.01A 5i3bB-1bt2A:
21.5		 5i3bB-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
HIS A 108
HIS A 243
ALA A 262
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.3A)
None
 0.41A 5i3bB-2p3xA:
21.4		 5i3bB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
HIS A 117
HIS A 243
ALA A 262
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.3A)
None
 1.35A 5i3bB-2p3xA:
21.4		 5i3bB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 243
HIS A 239
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.2A)
None
 1.00A 5i3bB-2p3xA:
21.4		 5i3bB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 243
HIS A 272
HIS A  87
ALA A 262
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.2A)
None
 0.85A 5i3bB-2p3xA:
21.4		 5i3bB-2p3xA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.44A 5iy5A-2p3xA:
undetectable
5iy5C-2p3xA:
undetectable		 5iy5A-2p3xA:
19.17
5iy5C-2p3xA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 8 LEU A 200
HIS A 448
THR A 148
HIS A 446
 None
C2O  A 602 (-3.3A)
None
C2O  A 602 (-4.0A)
 1.11A 5iy5C-2fqdA:
undetectable
5iy5N-2fqdA:
undetectable
5iy5P-2fqdA:
undetectable		 5iy5C-2fqdA:
17.98
5iy5N-2fqdA:
22.44
5iy5P-2fqdA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.12A 5iy5C-3aw5A:
undetectable
5iy5N-3aw5A:
undetectable
5iy5P-3aw5A:
undetectable		 5iy5C-3aw5A:
18.92
5iy5N-3aw5A:
22.18
5iy5P-3aw5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 10 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.46A 5m8nA-2p3xA:
21.0		 5m8nA-2p3xA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 10 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.51A 5m8nB-2p3xA:
20.4		 5m8nB-2p3xA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 9 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.48A 5m8nC-2p3xA:
20.4		 5m8nC-2p3xA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 7 HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.35A 5m8rA-2p3xA:
20.4		 5m8rA-2p3xA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 8 HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.32A 5m8rB-2p3xA:
20.4		 5m8rB-2p3xA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 8 HIS A 109
HIS A 240
HIS A 244
GLY A 259
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 0.45A 5m8rC-1bt2A:
16.8		 5m8rC-1bt2A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 8 HIS A 108
HIS A 239
ASN A 240
HIS A 243
GLY A 257
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
None
 0.41A 5m8rC-2p3xA:
3.8		 5m8rC-2p3xA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 8 HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.30A 5m8rD-2p3xA:
20.4		 5m8rD-2p3xA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.24A 5mejA-2fqdA:
32.8		 5mejA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 446
HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.64A 5mejA-2fqdA:
32.8		 5mejA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 5 HIS A  92
HIS A 134
HIS A 394
HIS A 396
HIS A 459
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.12A 5mejA-3aw5A:
13.3		 5mejA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 5 HIS A 394
HIS A 461
HIS A  92
HIS A  94
HIS A 132
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.66A 5mejA-3aw5A:
13.3		 5mejA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 203
HIS A 527
HIS A 529
HIS A 602
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.20A 5mejA-3gyrA:
26.0		 5mejA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA501_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 527
HIS A 604
HIS A 161
HIS A 163
HIS A 201
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.70A 5mejA-3gyrA:
26.0		 5mejA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA502_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		6 / 6 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 446
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.4A)
 0.28A 5mejA-2fqdA:
32.8		 5mejA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA502_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 6 HIS A 446
HIS A 448
HIS A 499
HIS A 101
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.5A)
 0.65A 5mejA-2fqdA:
32.8		 5mejA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA502_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 6 HIS A  92
HIS A  94
HIS A 132
HIS A 394
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
 0.20A 5mejA-3aw5A:
13.3		 5mejA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA502_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 6 HIS A 394
HIS A 396
HIS A 459
HIS A  92
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
 0.64A 5mejA-3aw5A:
13.3		 5mejA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA502_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 6 HIS A 394
HIS A 461
HIS A  92
HIS A 132
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
 0.78A 5mejA-3aw5A:
13.3		 5mejA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA502_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		6 / 6 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 527
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.9A)
 0.34A 5mejA-3gyrA:
26.0		 5mejA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA502_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 6 HIS A 161
HIS A 203
HIS A 527
HIS A 602
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.77A 5mejA-3gyrA:
26.0		 5mejA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA502_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 6 HIS A 527
HIS A 529
HIS A 602
HIS A 161
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.68A 5mejA-3gyrA:
26.0		 5mejA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA503_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.22A 5mejA-2fqdA:
32.8		 5mejA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA503_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 101
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 1.31A 5mejA-2fqdA:
32.8		 5mejA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA503_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.77A 5mejA-2fqdA:
32.8		 5mejA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA503_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.13A 5mejA-3aw5A:
13.3		 5mejA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA503_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5mejA-3aw5A:
13.3		 5mejA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA503_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.18A 5mejA-3gyrA:
26.0		 5mejA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA503_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.23A 5mejA-3gyrA:
26.0		 5mejA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA503_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.81A 5mejA-3gyrA:
26.0		 5mejA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.26A 5mewA-2fqdA:
32.8		 5mewA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 446
HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.63A 5mewA-2fqdA:
32.8		 5mewA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 5 HIS A  92
HIS A 134
HIS A 394
HIS A 396
HIS A 459
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.14A 5mewA-3aw5A:
13.2		 5mewA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 5 HIS A 394
HIS A 461
HIS A  92
HIS A  94
HIS A 132
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.64A 5mewA-3aw5A:
13.2		 5mewA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 5 HIS A 459
HIS A 394
HIS A 134
HIS A 396
HIS A  92
 C2O  A 702 (-3.4A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
 1.46A 5mewA-3aw5A:
13.2		 5mewA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 203
HIS A 527
HIS A 529
HIS A 602
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.20A 5mewA-3gyrA:
26.1		 5mewA-3gyrA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA501_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 527
HIS A 604
HIS A 161
HIS A 163
HIS A 201
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.67A 5mewA-3gyrA:
26.1		 5mewA-3gyrA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA502_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		6 / 6 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 446
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.4A)
 0.28A 5mewA-2fqdA:
32.8		 5mewA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA502_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 6 HIS A 446
HIS A 448
HIS A 499
HIS A 101
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.5A)
 0.66A 5mewA-2fqdA:
32.8		 5mewA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA502_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 6 HIS A  92
HIS A  94
HIS A 132
HIS A 394
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
 0.19A 5mewA-3aw5A:
13.2		 5mewA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA502_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 6 HIS A 394
HIS A 396
HIS A 459
HIS A  92
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
 0.65A 5mewA-3aw5A:
13.2		 5mewA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA502_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 6 HIS A 394
HIS A 461
HIS A  92
HIS A 132
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
 0.77A 5mewA-3aw5A:
13.2		 5mewA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA502_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		6 / 6 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 527
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.9A)
 0.34A 5mewA-3gyrA:
26.1		 5mewA-3gyrA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA502_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 6 HIS A 161
HIS A 203
HIS A 527
HIS A 602
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.77A 5mewA-3gyrA:
26.1		 5mewA-3gyrA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA502_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 6 HIS A 527
HIS A 529
HIS A 602
HIS A 161
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.69A 5mewA-3gyrA:
26.1		 5mewA-3gyrA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA503_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.23A 5mewA-2fqdA:
32.8		 5mewA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA503_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 101
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 1.32A 5mewA-2fqdA:
32.8		 5mewA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA503_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.76A 5mewA-2fqdA:
32.8		 5mewA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA503_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.13A 5mewA-3aw5A:
13.2		 5mewA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA503_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5mewA-3aw5A:
13.2		 5mewA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA503_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.18A 5mewA-3gyrA:
26.1		 5mewA-3gyrA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA503_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.23A 5mewA-3gyrA:
26.1		 5mewA-3gyrA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA503_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.81A 5mewA-3gyrA:
26.1		 5mewA-3gyrA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.26A 5mhuA-2fqdA:
32.8		 5mhuA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 446
HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.64A 5mhuA-2fqdA:
32.8		 5mhuA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 5 HIS A  92
HIS A 134
HIS A 394
HIS A 396
HIS A 459
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.15A 5mhuA-3aw5A:
13.3		 5mhuA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 5 HIS A 394
HIS A 461
HIS A  92
HIS A  94
HIS A 132
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.65A 5mhuA-3aw5A:
13.3		 5mhuA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 5 HIS A 459
HIS A 394
HIS A 134
HIS A 396
HIS A  92
 C2O  A 702 (-3.4A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
 1.47A 5mhuA-3aw5A:
13.3		 5mhuA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 203
HIS A 527
HIS A 529
HIS A 602
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.20A 5mhuA-3gyrA:
26.0		 5mhuA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA501_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 527
HIS A 604
HIS A 161
HIS A 163
HIS A 201
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.67A 5mhuA-3gyrA:
26.0		 5mhuA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA502_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		6 / 6 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 446
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.4A)
 0.28A 5mhuA-2fqdA:
32.8		 5mhuA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA502_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 6 HIS A 446
HIS A 448
HIS A 499
HIS A 101
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.5A)
 0.66A 5mhuA-2fqdA:
32.8		 5mhuA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA502_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 6 HIS A  92
HIS A  94
HIS A 132
HIS A 394
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
 0.19A 5mhuA-3aw5A:
13.3		 5mhuA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA502_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 6 HIS A 394
HIS A 396
HIS A 459
HIS A  92
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
 0.65A 5mhuA-3aw5A:
13.3		 5mhuA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA502_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 6 HIS A 394
HIS A 461
HIS A  92
HIS A 132
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
 0.78A 5mhuA-3aw5A:
13.3		 5mhuA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA502_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		6 / 6 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 527
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.9A)
 0.34A 5mhuA-3gyrA:
26.0		 5mhuA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA502_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 6 HIS A 161
HIS A 203
HIS A 527
HIS A 602
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.78A 5mhuA-3gyrA:
26.0		 5mhuA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA502_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 6 HIS A 527
HIS A 529
HIS A 602
HIS A 161
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.69A 5mhuA-3gyrA:
26.0		 5mhuA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA503_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.21A 5mhuA-2fqdA:
32.8		 5mhuA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA503_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.76A 5mhuA-2fqdA:
32.8		 5mhuA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA503_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.11A 5mhuA-3aw5A:
13.3		 5mhuA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA503_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5mhuA-3aw5A:
13.3		 5mhuA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA503_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.17A 5mhuA-3gyrA:
26.0		 5mhuA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA503_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.25A 5mhuA-3gyrA:
26.0		 5mhuA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA503_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.81A 5mhuA-3gyrA:
26.0		 5mhuA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.27A 5mhvA-2fqdA:
32.8		 5mhvA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 446
HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.64A 5mhvA-2fqdA:
32.8		 5mhvA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 5 HIS A  92
HIS A 134
HIS A 394
HIS A 396
HIS A 459
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.16A 5mhvA-3aw5A:
31.6		 5mhvA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 5 HIS A 394
HIS A 461
HIS A  92
HIS A  94
HIS A 132
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.64A 5mhvA-3aw5A:
31.6		 5mhvA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 5 HIS A 459
HIS A 394
HIS A 134
HIS A 396
HIS A  92
 C2O  A 702 (-3.4A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
 1.47A 5mhvA-3aw5A:
31.6		 5mhvA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 203
HIS A 527
HIS A 529
HIS A 602
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.20A 5mhvA-3gyrA:
26.1		 5mhvA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA501_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 527
HIS A 604
HIS A 161
HIS A 163
HIS A 201
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.67A 5mhvA-3gyrA:
26.1		 5mhvA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA502_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		6 / 6 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 446
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.4A)
 0.29A 5mhvA-2fqdA:
32.8		 5mhvA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA502_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 6 HIS A 446
HIS A 448
HIS A 499
HIS A 101
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.5A)
 0.67A 5mhvA-2fqdA:
32.8		 5mhvA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA502_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 6 HIS A  92
HIS A  94
HIS A 132
HIS A 394
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
 0.18A 5mhvA-3aw5A:
31.5		 5mhvA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA502_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 6 HIS A 394
HIS A 396
HIS A 459
HIS A  92
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
 0.66A 5mhvA-3aw5A:
31.5		 5mhvA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA502_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 6 HIS A 394
HIS A 461
HIS A  92
HIS A 132
 CU  A 703 ( 3.0A)
C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.3A)
 0.77A 5mhvA-3aw5A:
31.5		 5mhvA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA502_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		6 / 6 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 527
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.9A)
 0.34A 5mhvA-3gyrA:
26.1		 5mhvA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA502_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 6 HIS A 161
HIS A 203
HIS A 527
HIS A 602
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.78A 5mhvA-3gyrA:
26.1		 5mhvA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA502_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 6 HIS A 527
HIS A 529
HIS A 602
HIS A 161
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.69A 5mhvA-3gyrA:
26.1		 5mhvA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA503_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.22A 5mhvA-2fqdA:
32.8		 5mhvA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA503_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.77A 5mhvA-2fqdA:
32.8		 5mhvA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA503_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.32A 5mhvA-2fqdA:
32.8		 5mhvA-2fqdA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA503_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.10A 5mhvA-3aw5A:
31.5		 5mhvA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA503_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5mhvA-3aw5A:
31.5		 5mhvA-3aw5A:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA503_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.17A 5mhvA-3gyrA:
26.1		 5mhvA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA503_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.25A 5mhvA-3gyrA:
26.1		 5mhvA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA503_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.81A 5mhvA-3gyrA:
26.1		 5mhvA-3gyrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.88A 5mhwA-1bt2A:
undetectable		 5mhwA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.26A 5mhwA-2fqdA:
32.8		 5mhwA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.64A 5mhwA-2fqdA:
32.8		 5mhwA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.86A 5mhwA-2p3xA:
undetectable		 5mhwA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 134
HIS A 394
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.18A 5mhwA-3aw5A:
31.5		 5mhwA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 461
HIS A  92
HIS A  94
HIS A 132
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.68A 5mhwA-3aw5A:
31.5		 5mhwA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 527
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.17A 5mhwA-3gyrA:
26.1		 5mhwA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 604
HIS A 161
HIS A 163
HIS A 201
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.68A 5mhwA-3gyrA:
26.1		 5mhwA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.26A 5mhwA-2fqdA:
32.8		 5mhwA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 446
HIS A 448
HIS A 499
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 0.71A 5mhwA-2fqdA:
32.8		 5mhwA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 501
HIS A 446
HIS A 499
HIS A 448
 C2O  A 602 (-3.4A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.88A 5mhwA-2fqdA:
32.8		 5mhwA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A  92
HIS A  94
HIS A 132
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
C2O  A 702 (-3.5A)
 0.18A 5mhwA-3aw5A:
31.5		 5mhwA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 394
HIS A 396
HIS A 459
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
C2O  A 702 (-3.3A)
 0.72A 5mhwA-3aw5A:
31.5		 5mhwA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 461
HIS A 394
HIS A 459
HIS A 396
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.4A)
C2O  A 702 ( 3.3A)
 0.87A 5mhwA-3aw5A:
31.5		 5mhwA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.34A 5mhwA-3gyrA:
26.1		 5mhwA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 527
HIS A 529
HIS A 602
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
C2O  A1002 (-3.4A)
 0.73A 5mhwA-3gyrA:
26.1		 5mhwA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 604
HIS A 527
HIS A 602
HIS A 529
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
 0.91A 5mhwA-3gyrA:
26.1		 5mhwA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.22A 5mhwA-2fqdA:
32.8		 5mhwA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.77A 5mhwA-2fqdA:
32.8		 5mhwA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.30A 5mhwA-2fqdA:
32.8		 5mhwA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.10A 5mhwA-3aw5A:
31.5		 5mhwA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5mhwA-3aw5A:
31.5		 5mhwA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.17A 5mhwA-3gyrA:
26.1		 5mhwA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.26A 5mhwA-3gyrA:
26.1		 5mhwA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.81A 5mhwA-3gyrA:
26.1		 5mhwA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.88A 5mhxA-1bt2A:
undetectable		 5mhxA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.26A 5mhxA-2fqdA:
32.7		 5mhxA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.65A 5mhxA-2fqdA:
32.7		 5mhxA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.86A 5mhxA-2p3xA:
undetectable		 5mhxA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 134
HIS A 394
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.18A 5mhxA-3aw5A:
13.2		 5mhxA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 461
HIS A  92
HIS A  94
HIS A 132
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.68A 5mhxA-3aw5A:
13.2		 5mhxA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 527
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.17A 5mhxA-3gyrA:
26.0		 5mhxA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 604
HIS A 161
HIS A 163
HIS A 201
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.69A 5mhxA-3gyrA:
26.0		 5mhxA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.26A 5mhxA-2fqdA:
32.7		 5mhxA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 446
HIS A 448
HIS A 499
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 0.71A 5mhxA-2fqdA:
32.7		 5mhxA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 501
HIS A 446
HIS A 499
HIS A 448
 C2O  A 602 (-3.4A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.88A 5mhxA-2fqdA:
32.7		 5mhxA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A  92
HIS A  94
HIS A 132
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
C2O  A 702 (-3.5A)
 0.19A 5mhxA-3aw5A:
13.2		 5mhxA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 394
HIS A 396
HIS A 459
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
C2O  A 702 (-3.3A)
 0.72A 5mhxA-3aw5A:
13.2		 5mhxA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 461
HIS A 394
HIS A 459
HIS A 396
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.4A)
C2O  A 702 ( 3.3A)
 0.87A 5mhxA-3aw5A:
13.2		 5mhxA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.35A 5mhxA-3gyrA:
26.0		 5mhxA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 527
HIS A 529
HIS A 602
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
C2O  A1002 (-3.4A)
 0.73A 5mhxA-3gyrA:
26.0		 5mhxA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 604
HIS A 527
HIS A 602
HIS A 529
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
 0.91A 5mhxA-3gyrA:
26.0		 5mhxA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.22A 5mhxA-2fqdA:
32.7		 5mhxA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.77A 5mhxA-2fqdA:
32.7		 5mhxA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.30A 5mhxA-2fqdA:
32.7		 5mhxA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.09A 5mhxA-3aw5A:
13.2		 5mhxA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5mhxA-3aw5A:
13.2		 5mhxA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.17A 5mhxA-3gyrA:
26.0		 5mhxA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.26A 5mhxA-3gyrA:
26.0		 5mhxA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.82A 5mhxA-3gyrA:
26.0		 5mhxA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.88A 5mhyA-1bt2A:
undetectable		 5mhyA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.26A 5mhyA-2fqdA:
32.8		 5mhyA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.65A 5mhyA-2fqdA:
32.8		 5mhyA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.86A 5mhyA-2p3xA:
undetectable		 5mhyA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 134
HIS A 394
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.19A 5mhyA-3aw5A:
13.2		 5mhyA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 461
HIS A  92
HIS A  94
HIS A 132
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.68A 5mhyA-3aw5A:
13.2		 5mhyA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 527
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.17A 5mhyA-3gyrA:
26.1		 5mhyA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 604
HIS A 161
HIS A 163
HIS A 201
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.68A 5mhyA-3gyrA:
26.1		 5mhyA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.27A 5mhyA-2fqdA:
32.8		 5mhyA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 446
HIS A 448
HIS A 499
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 0.71A 5mhyA-2fqdA:
32.8		 5mhyA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 501
HIS A 446
HIS A 499
HIS A 448
 C2O  A 602 (-3.4A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.88A 5mhyA-2fqdA:
32.8		 5mhyA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A  92
HIS A  94
HIS A 132
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
C2O  A 702 (-3.5A)
 0.19A 5mhyA-3aw5A:
13.2		 5mhyA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 394
HIS A 396
HIS A 459
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
C2O  A 702 (-3.3A)
 0.72A 5mhyA-3aw5A:
13.2		 5mhyA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 461
HIS A 394
HIS A 459
HIS A 396
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.4A)
C2O  A 702 ( 3.3A)
 0.87A 5mhyA-3aw5A:
13.2		 5mhyA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.35A 5mhyA-3gyrA:
26.1		 5mhyA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 527
HIS A 529
HIS A 602
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
C2O  A1002 (-3.4A)
 0.73A 5mhyA-3gyrA:
26.1		 5mhyA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 604
HIS A 527
HIS A 602
HIS A 529
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
 0.91A 5mhyA-3gyrA:
26.1		 5mhyA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.22A 5mhyA-2fqdA:
32.8		 5mhyA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.77A 5mhyA-2fqdA:
32.8		 5mhyA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.29A 5mhyA-2fqdA:
32.8		 5mhyA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.09A 5mhyA-3aw5A:
13.2		 5mhyA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5mhyA-3aw5A:
13.2		 5mhyA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.17A 5mhyA-3gyrA:
26.1		 5mhyA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.26A 5mhyA-3gyrA:
26.1		 5mhyA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.82A 5mhyA-3gyrA:
26.1		 5mhyA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.87A 5mhzA-1bt2A:
undetectable		 5mhzA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.27A 5mhzA-2fqdA:
32.8		 5mhzA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.65A 5mhzA-2fqdA:
32.8		 5mhzA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.86A 5mhzA-2p3xA:
undetectable		 5mhzA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 134
HIS A 394
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.20A 5mhzA-3aw5A:
31.6		 5mhzA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 461
HIS A  92
HIS A  94
HIS A 132
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.68A 5mhzA-3aw5A:
31.6		 5mhzA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 527
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.18A 5mhzA-3gyrA:
26.2		 5mhzA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 604
HIS A 161
HIS A 163
HIS A 201
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.68A 5mhzA-3gyrA:
26.2		 5mhzA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.27A 5mhzA-2fqdA:
32.8		 5mhzA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 446
HIS A 448
HIS A 499
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 0.72A 5mhzA-2fqdA:
32.8		 5mhzA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 501
HIS A 446
HIS A 499
HIS A 448
 C2O  A 602 (-3.4A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.89A 5mhzA-2fqdA:
32.8		 5mhzA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A  92
HIS A  94
HIS A 132
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
C2O  A 702 (-3.5A)
 0.19A 5mhzA-3aw5A:
31.5		 5mhzA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 394
HIS A 396
HIS A 459
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
C2O  A 702 (-3.3A)
 0.73A 5mhzA-3aw5A:
31.5		 5mhzA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 461
HIS A 394
HIS A 459
HIS A 396
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.4A)
C2O  A 702 ( 3.3A)
 0.87A 5mhzA-3aw5A:
31.5		 5mhzA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.35A 5mhzA-3gyrA:
26.2		 5mhzA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 527
HIS A 529
HIS A 602
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
C2O  A1002 (-3.4A)
 0.74A 5mhzA-3gyrA:
26.2		 5mhzA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 604
HIS A 527
HIS A 602
HIS A 529
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
 0.91A 5mhzA-3gyrA:
26.2		 5mhzA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.22A 5mhzA-2fqdA:
32.8		 5mhzA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.77A 5mhzA-2fqdA:
32.8		 5mhzA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.28A 5mhzA-2fqdA:
32.8		 5mhzA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.09A 5mhzA-3aw5A:
31.5		 5mhzA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5mhzA-3aw5A:
31.5		 5mhzA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.17A 5mhzA-3gyrA:
26.2		 5mhzA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.27A 5mhzA-3gyrA:
26.2		 5mhzA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.82A 5mhzA-3gyrA:
26.2		 5mhzA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.87A 5mi1A-1bt2A:
undetectable		 5mi1A-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.28A 5mi1A-2fqdA:
32.8		 5mi1A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.65A 5mi1A-2fqdA:
32.8		 5mi1A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.85A 5mi1A-2p3xA:
undetectable		 5mi1A-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 134
HIS A 394
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.20A 5mi1A-3aw5A:
13.2		 5mi1A-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 461
HIS A  92
HIS A  94
HIS A 132
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.68A 5mi1A-3aw5A:
13.2		 5mi1A-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 527
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.18A 5mi1A-3gyrA:
26.1		 5mi1A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 604
HIS A 161
HIS A 163
HIS A 201
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.68A 5mi1A-3gyrA:
26.1		 5mi1A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.27A 5mi1A-2fqdA:
32.8		 5mi1A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 446
HIS A 448
HIS A 499
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 0.72A 5mi1A-2fqdA:
32.8		 5mi1A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 501
HIS A 446
HIS A 499
HIS A 448
 C2O  A 602 (-3.4A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.89A 5mi1A-2fqdA:
32.8		 5mi1A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A  92
HIS A  94
HIS A 132
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
C2O  A 702 (-3.5A)
 0.19A 5mi1A-3aw5A:
13.2		 5mi1A-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 394
HIS A 396
HIS A 459
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
C2O  A 702 (-3.3A)
 0.72A 5mi1A-3aw5A:
13.2		 5mi1A-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 461
HIS A 394
HIS A 459
HIS A 396
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.4A)
C2O  A 702 ( 3.3A)
 0.87A 5mi1A-3aw5A:
13.2		 5mi1A-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.35A 5mi1A-3gyrA:
26.1		 5mi1A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 527
HIS A 529
HIS A 602
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
C2O  A1002 (-3.4A)
 0.74A 5mi1A-3gyrA:
26.1		 5mi1A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 604
HIS A 527
HIS A 602
HIS A 529
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
 0.91A 5mi1A-3gyrA:
26.1		 5mi1A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.22A 5mi1A-2fqdA:
32.8		 5mi1A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.77A 5mi1A-2fqdA:
32.8		 5mi1A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.28A 5mi1A-2fqdA:
32.8		 5mi1A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.09A 5mi1A-3aw5A:
13.2		 5mi1A-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5mi1A-3aw5A:
13.2		 5mi1A-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.17A 5mi1A-3gyrA:
26.1		 5mi1A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.27A 5mi1A-3gyrA:
26.1		 5mi1A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.82A 5mi1A-3gyrA:
26.1		 5mi1A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.87A 5mi2A-1bt2A:
undetectable		 5mi2A-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.28A 5mi2A-2fqdA:
32.8		 5mi2A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.65A 5mi2A-2fqdA:
32.8		 5mi2A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.85A 5mi2A-2p3xA:
undetectable		 5mi2A-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 134
HIS A 394
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.20A 5mi2A-3aw5A:
13.2		 5mi2A-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 461
HIS A  92
HIS A  94
HIS A 132
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.68A 5mi2A-3aw5A:
13.2		 5mi2A-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 527
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.18A 5mi2A-3gyrA:
26.1		 5mi2A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 604
HIS A 161
HIS A 163
HIS A 201
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.68A 5mi2A-3gyrA:
26.1		 5mi2A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.27A 5mi2A-2fqdA:
32.8		 5mi2A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 446
HIS A 448
HIS A 499
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 0.71A 5mi2A-2fqdA:
32.8		 5mi2A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 501
HIS A 446
HIS A 499
HIS A 448
 C2O  A 602 (-3.4A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.88A 5mi2A-2fqdA:
32.8		 5mi2A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A  92
HIS A  94
HIS A 132
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
C2O  A 702 (-3.5A)
 0.19A 5mi2A-3aw5A:
13.2		 5mi2A-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 394
HIS A 396
HIS A 459
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
C2O  A 702 (-3.3A)
 0.72A 5mi2A-3aw5A:
13.2		 5mi2A-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 461
HIS A 394
HIS A 459
HIS A 396
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.4A)
C2O  A 702 ( 3.3A)
 0.87A 5mi2A-3aw5A:
13.2		 5mi2A-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.35A 5mi2A-3gyrA:
26.1		 5mi2A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 527
HIS A 529
HIS A 602
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
C2O  A1002 (-3.4A)
 0.73A 5mi2A-3gyrA:
26.1		 5mi2A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 604
HIS A 527
HIS A 602
HIS A 529
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
 0.91A 5mi2A-3gyrA:
26.1		 5mi2A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.22A 5mi2A-2fqdA:
32.8		 5mi2A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.77A 5mi2A-2fqdA:
32.8		 5mi2A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.28A 5mi2A-2fqdA:
32.8		 5mi2A-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.09A 5mi2A-3aw5A:
13.2		 5mi2A-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5mi2A-3aw5A:
13.2		 5mi2A-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.17A 5mi2A-3gyrA:
26.1		 5mi2A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.26A 5mi2A-3gyrA:
26.1		 5mi2A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.82A 5mi2A-3gyrA:
26.1		 5mi2A-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.87A 5miaA-1bt2A:
undetectable		 5miaA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.28A 5miaA-2fqdA:
32.8		 5miaA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.65A 5miaA-2fqdA:
32.8		 5miaA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.85A 5miaA-2p3xA:
undetectable		 5miaA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 134
HIS A 394
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.21A 5miaA-3aw5A:
13.2		 5miaA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 461
HIS A  92
HIS A  94
HIS A 132
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.67A 5miaA-3aw5A:
13.2		 5miaA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 527
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.18A 5miaA-3gyrA:
26.1		 5miaA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 604
HIS A 161
HIS A 163
HIS A 201
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.67A 5miaA-3gyrA:
26.1		 5miaA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.27A 5miaA-2fqdA:
32.8		 5miaA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 446
HIS A 448
HIS A 499
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 0.71A 5miaA-2fqdA:
32.8		 5miaA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 501
HIS A 446
HIS A 499
HIS A 448
 C2O  A 602 (-3.4A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.89A 5miaA-2fqdA:
32.8		 5miaA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A  92
HIS A  94
HIS A 132
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
C2O  A 702 (-3.5A)
 0.19A 5miaA-3aw5A:
13.2		 5miaA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 394
HIS A 396
HIS A 459
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
C2O  A 702 (-3.3A)
 0.72A 5miaA-3aw5A:
13.2		 5miaA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 461
HIS A 394
HIS A 459
HIS A 396
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.4A)
C2O  A 702 ( 3.3A)
 0.87A 5miaA-3aw5A:
13.2		 5miaA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.35A 5miaA-3gyrA:
26.1		 5miaA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 527
HIS A 529
HIS A 602
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
C2O  A1002 (-3.4A)
 0.74A 5miaA-3gyrA:
26.1		 5miaA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 604
HIS A 527
HIS A 602
HIS A 529
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
 0.91A 5miaA-3gyrA:
26.1		 5miaA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.22A 5miaA-2fqdA:
32.8		 5miaA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.77A 5miaA-2fqdA:
32.8		 5miaA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.28A 5miaA-2fqdA:
32.8		 5miaA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.09A 5miaA-3aw5A:
13.2		 5miaA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5miaA-3aw5A:
13.2		 5miaA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.17A 5miaA-3gyrA:
26.1		 5miaA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.27A 5miaA-3gyrA:
26.1		 5miaA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.81A 5miaA-3gyrA:
26.1		 5miaA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.87A 5mibA-1bt2A:
undetectable		 5mibA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.29A 5mibA-2fqdA:
32.8		 5mibA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.65A 5mibA-2fqdA:
32.8		 5mibA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.85A 5mibA-2p3xA:
undetectable		 5mibA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 134
HIS A 394
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.21A 5mibA-3aw5A:
13.2		 5mibA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 461
HIS A  92
HIS A  94
HIS A 132
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.68A 5mibA-3aw5A:
13.2		 5mibA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 527
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.18A 5mibA-3gyrA:
26.1		 5mibA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 604
HIS A 161
HIS A 163
HIS A 201
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.68A 5mibA-3gyrA:
26.1		 5mibA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.27A 5mibA-2fqdA:
32.8		 5mibA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 446
HIS A 448
HIS A 499
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 0.72A 5mibA-2fqdA:
32.8		 5mibA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 501
HIS A 446
HIS A 499
HIS A 448
 C2O  A 602 (-3.4A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.88A 5mibA-2fqdA:
32.8		 5mibA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A  92
HIS A  94
HIS A 132
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
C2O  A 702 (-3.5A)
 0.19A 5mibA-3aw5A:
13.2		 5mibA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 394
HIS A 396
HIS A 459
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
C2O  A 702 (-3.3A)
 0.72A 5mibA-3aw5A:
13.2		 5mibA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 461
HIS A 394
HIS A 459
HIS A 396
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.4A)
C2O  A 702 ( 3.3A)
 0.87A 5mibA-3aw5A:
13.2		 5mibA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.35A 5mibA-3gyrA:
26.1		 5mibA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 527
HIS A 529
HIS A 602
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
C2O  A1002 (-3.4A)
 0.74A 5mibA-3gyrA:
26.1		 5mibA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 604
HIS A 527
HIS A 602
HIS A 529
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
 0.91A 5mibA-3gyrA:
26.1		 5mibA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.22A 5mibA-2fqdA:
32.8		 5mibA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.77A 5mibA-2fqdA:
32.8		 5mibA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.28A 5mibA-2fqdA:
32.8		 5mibA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.08A 5mibA-3aw5A:
13.2		 5mibA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5mibA-3aw5A:
13.2		 5mibA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.17A 5mibA-3gyrA:
26.1		 5mibA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.27A 5mibA-3gyrA:
26.1		 5mibA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.82A 5mibA-3gyrA:
26.1		 5mibA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.86A 5micA-1bt2A:
undetectable		 5micA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.28A 5micA-2fqdA:
32.8		 5micA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.66A 5micA-2fqdA:
32.8		 5micA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.85A 5micA-2p3xA:
undetectable		 5micA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 134
HIS A 394
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.21A 5micA-3aw5A:
13.1		 5micA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 461
HIS A  92
HIS A  94
HIS A 132
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.68A 5micA-3aw5A:
13.1		 5micA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 527
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.18A 5micA-3gyrA:
26.1		 5micA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 604
HIS A 161
HIS A 163
HIS A 201
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.68A 5micA-3gyrA:
26.1		 5micA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.27A 5micA-2fqdA:
32.7		 5micA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 446
HIS A 448
HIS A 499
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 0.72A 5micA-2fqdA:
32.7		 5micA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 501
HIS A 446
HIS A 499
HIS A 448
 C2O  A 602 (-3.4A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.89A 5micA-2fqdA:
32.7		 5micA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A  92
HIS A  94
HIS A 132
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
C2O  A 702 (-3.5A)
 0.19A 5micA-3aw5A:
13.1		 5micA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 394
HIS A 396
HIS A 459
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
C2O  A 702 (-3.3A)
 0.73A 5micA-3aw5A:
13.1		 5micA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 461
HIS A 394
HIS A 459
HIS A 396
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.4A)
C2O  A 702 ( 3.3A)
 0.88A 5micA-3aw5A:
13.1		 5micA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.35A 5micA-3gyrA:
26.1		 5micA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 527
HIS A 529
HIS A 602
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
C2O  A1002 (-3.4A)
 0.74A 5micA-3gyrA:
26.1		 5micA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 604
HIS A 527
HIS A 602
HIS A 529
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
 0.92A 5micA-3gyrA:
26.1		 5micA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.22A 5micA-2fqdA:
32.7		 5micA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.77A 5micA-2fqdA:
32.7		 5micA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.28A 5micA-2fqdA:
32.7		 5micA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.08A 5micA-3aw5A:
13.1		 5micA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5micA-3aw5A:
13.1		 5micA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.17A 5micA-3gyrA:
26.1		 5micA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.27A 5micA-3gyrA:
26.1		 5micA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.82A 5micA-3gyrA:
26.1		 5micA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.87A 5midA-1bt2A:
undetectable		 5midA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.28A 5midA-2fqdA:
32.8		 5midA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.65A 5midA-2fqdA:
32.8		 5midA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.85A 5midA-2p3xA:
undetectable		 5midA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 134
HIS A 394
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.21A 5midA-3aw5A:
10.2		 5midA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 461
HIS A  92
HIS A  94
HIS A 132
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.68A 5midA-3aw5A:
10.2		 5midA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 527
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.18A 5midA-3gyrA:
26.0		 5midA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 604
HIS A 161
HIS A 163
HIS A 201
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.68A 5midA-3gyrA:
26.0		 5midA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.27A 5midA-2fqdA:
32.8		 5midA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 446
HIS A 448
HIS A 499
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 0.72A 5midA-2fqdA:
32.8		 5midA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 501
HIS A 446
HIS A 499
HIS A 448
 C2O  A 602 (-3.4A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.89A 5midA-2fqdA:
32.8		 5midA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A  92
HIS A  94
HIS A 132
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
C2O  A 702 (-3.5A)
 0.19A 5midA-3aw5A:
13.2		 5midA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 394
HIS A 396
HIS A 459
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
C2O  A 702 (-3.3A)
 0.72A 5midA-3aw5A:
13.2		 5midA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 461
HIS A 394
HIS A 459
HIS A 396
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.4A)
C2O  A 702 ( 3.3A)
 0.88A 5midA-3aw5A:
13.2		 5midA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.35A 5midA-3gyrA:
26.0		 5midA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 527
HIS A 529
HIS A 602
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
C2O  A1002 (-3.4A)
 0.74A 5midA-3gyrA:
26.0		 5midA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 604
HIS A 527
HIS A 602
HIS A 529
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
 0.92A 5midA-3gyrA:
26.0		 5midA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.22A 5midA-2fqdA:
32.8		 5midA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.77A 5midA-2fqdA:
32.8		 5midA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.27A 5midA-2fqdA:
32.8		 5midA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.08A 5midA-3aw5A:
10.2		 5midA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5midA-3aw5A:
10.2		 5midA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.18A 5midA-3gyrA:
26.0		 5midA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.27A 5midA-3gyrA:
26.0		 5midA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.82A 5midA-3gyrA:
26.0		 5midA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.87A 5mieA-1bt2A:
undetectable		 5mieA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 143
HIS A 446
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.28A 5mieA-2fqdA:
32.8		 5mieA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 501
HIS A 101
HIS A 103
HIS A 141
 C2O  A 602 (-3.4A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-3.2A)
 0.65A 5mieA-2fqdA:
32.8		 5mieA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 108
HIS A 272
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.85A 5mieA-2p3xA:
undetectable		 5mieA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 134
HIS A 394
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.21A 5mieA-3aw5A:
10.5		 5mieA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 461
HIS A  92
HIS A  94
HIS A 132
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
 0.68A 5mieA-3aw5A:
10.5		 5mieA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 527
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.19A 5mieA-3gyrA:
26.1		 5mieA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 604
HIS A 161
HIS A 163
HIS A 201
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
C2O  A1002 (-3.7A)
 0.68A 5mieA-3gyrA:
26.1		 5mieA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.27A 5mieA-2fqdA:
32.8		 5mieA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 446
HIS A 448
HIS A 499
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 0.72A 5mieA-2fqdA:
32.8		 5mieA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 501
HIS A 446
HIS A 499
HIS A 448
 C2O  A 602 (-3.4A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.89A 5mieA-2fqdA:
32.8		 5mieA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A  92
HIS A  94
HIS A 132
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
C2O  A 702 (-3.5A)
 0.19A 5mieA-3aw5A:
10.5		 5mieA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 394
HIS A 396
HIS A 459
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
C2O  A 702 (-3.3A)
 0.73A 5mieA-3aw5A:
10.5		 5mieA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 461
HIS A 394
HIS A 459
HIS A 396
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.4A)
C2O  A 702 ( 3.3A)
 0.88A 5mieA-3aw5A:
10.5		 5mieA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.35A 5mieA-3gyrA:
26.1		 5mieA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 527
HIS A 529
HIS A 602
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
C2O  A1002 (-3.4A)
 0.74A 5mieA-3gyrA:
26.1		 5mieA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 604
HIS A 527
HIS A 602
HIS A 529
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
 0.92A 5mieA-3gyrA:
26.1		 5mieA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.22A 5mieA-2fqdA:
32.8		 5mieA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.77A 5mieA-2fqdA:
32.8		 5mieA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.28A 5mieA-2fqdA:
32.8		 5mieA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.08A 5mieA-3aw5A:
10.5		 5mieA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5mieA-3aw5A:
10.5		 5mieA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.17A 5mieA-3gyrA:
26.1		 5mieA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.27A 5mieA-3gyrA:
26.1		 5mieA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.82A 5mieA-3gyrA:
26.1		 5mieA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		3 / 3 HIS A 109
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.24A 5migA-1bt2A:
undetectable		 5migA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		3 / 3 HIS A 143
HIS A 448
HIS A 499
 C2O  A 602 (-3.5A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.25A 5migA-2fqdA:
32.6		 5migA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 HIS A 108
HIS A 117
HIS A  87
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
 0.18A 5migA-2p3xA:
undetectable		 5migA-2p3xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		3 / 3 HIS A 134
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.19A 5migA-3aw5A:
13.1		 5migA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		3 / 3 HIS A 203
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 0.20A 5migA-3gyrA:
26.2		 5migA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		5 / 5 HIS A 101
HIS A 103
TRP A 139
HIS A 141
HIS A 501
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 ( 4.6A)
C2O  A 602 (-3.2A)
C2O  A 602 (-3.4A)
 0.28A 5migA-2fqdA:
32.8		 5migA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 446
HIS A 448
HIS A 499
HIS A 143
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 0.72A 5migA-2fqdA:
32.8		 5migA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA602_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 5 HIS A 501
HIS A 446
HIS A 499
HIS A 448
 C2O  A 602 (-3.4A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.3A)
 0.89A 5migA-2fqdA:
32.8		 5migA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A  92
HIS A  94
HIS A 132
HIS A 461
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
C2O  A 702 (-3.3A)
C2O  A 702 (-3.5A)
 0.20A 5migA-3aw5A:
13.1		 5migA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 394
HIS A 396
HIS A 459
HIS A 134
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
C2O  A 702 (-3.3A)
 0.73A 5migA-3aw5A:
13.1		 5migA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA602_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A 461
HIS A 394
HIS A 459
HIS A 396
 C2O  A 702 (-3.5A)
CU  A 703 ( 3.0A)
C2O  A 702 (-3.4A)
C2O  A 702 ( 3.3A)
 0.87A 5migA-3aw5A:
13.1		 5migA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		5 / 5 HIS A 161
HIS A 163
TRP A 199
HIS A 201
HIS A 604
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
None
C2O  A1002 (-3.7A)
C2O  A1002 (-3.9A)
 0.36A 5migA-3gyrA:
26.2		 5migA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 527
HIS A 529
HIS A 602
HIS A 203
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
C2O  A1002 (-3.4A)
 0.74A 5migA-3gyrA:
26.2		 5migA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA602_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 5 HIS A 604
HIS A 527
HIS A 602
HIS A 529
 C2O  A1002 (-3.9A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
 0.92A 5migA-3gyrA:
26.2		 5migA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 101
HIS A 103
HIS A 446
HIS A 448
 C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
 0.22A 5migA-2fqdA:
32.8		 5migA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 446
HIS A 448
HIS A 101
HIS A 103
 C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.9A)
C2O  A 602 (-3.0A)
 0.77A 5migA-2fqdA:
32.8		 5migA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA603_0
(LACCASE 2)		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		4 / 4 HIS A 499
HIS A 446
HIS A 448
HIS A 143
 C2O  A 602 (-3.3A)
C2O  A 602 (-4.0A)
C2O  A 602 (-3.3A)
C2O  A 602 (-3.5A)
 1.28A 5migA-2fqdA:
32.8		 5migA-2fqdA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A  92
HIS A  94
HIS A 394
HIS A 396
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
 0.08A 5migA-3aw5A:
13.1		 5migA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA603_0
(LACCASE 2)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 4 HIS A 394
HIS A 396
HIS A  92
HIS A  94
 CU  A 703 ( 3.0A)
C2O  A 702 ( 3.3A)
CU  A 703 ( 3.0A)
C2O  A 702 ( 3.2A)
 0.79A 5migA-3aw5A:
13.1		 5migA-3aw5A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 161
HIS A 163
HIS A 527
HIS A 529
 CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
 0.18A 5migA-3gyrA:
26.2		 5migA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 203
HIS A 161
HIS A 529
HIS A 602
 C2O  A1002 (-3.4A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.4A)
 1.27A 5migA-3gyrA:
26.2		 5migA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA603_0
(LACCASE 2)		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		4 / 4 HIS A 527
HIS A 529
HIS A 161
HIS A 163
 CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
CU  A1004 ( 3.2A)
C2O  A1002 (-3.3A)
 0.81A 5migA-3gyrA:
26.2		 5migA-3gyrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.16A 5w97A-3aw5A:
undetectable
5w97C-3aw5A:
undetectable
5w97c-3aw5A:
undetectable		 5w97A-3aw5A:
22.18
5w97C-3aw5A:
18.91
5w97c-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 7 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.19A 5w97C-3aw5A:
undetectable
5w97a-3aw5A:
undetectable
5w97c-3aw5A:
undetectable		 5w97C-3aw5A:
18.91
5w97a-3aw5A:
22.18
5w97c-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 7 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.17A 5wauC-3aw5A:
undetectable
5waua-3aw5A:
undetectable
5wauc-3aw5A:
undetectable		 5wauC-3aw5A:
18.91
5waua-3aw5A:
22.18
5wauc-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.15A 5x19A-3aw5A:
undetectable
5x19C-3aw5A:
undetectable
5x19P-3aw5A:
undetectable		 5x19A-3aw5A:
22.18
5x19C-3aw5A:
18.91
5x19P-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 7 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.12A 5x1bA-3aw5A:
undetectable
5x1bC-3aw5A:
undetectable
5x1bP-3aw5A:
undetectable		 5x1bA-3aw5A:
22.18
5x1bC-3aw5A:
18.91
5x1bP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.47A 5x1bN-2p3xA:
undetectable
5x1bP-2p3xA:
undetectable		 5x1bN-2p3xA:
19.17
5x1bP-2p3xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 7 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.14A 5x1fA-3aw5A:
undetectable
5x1fC-3aw5A:
undetectable
5x1fP-3aw5A:
undetectable		 5x1fA-3aw5A:
22.18
5x1fC-3aw5A:
18.91
5x1fP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.14A 5xdqA-3aw5A:
undetectable
5xdqC-3aw5A:
undetectable
5xdqP-3aw5A:
undetectable		 5xdqA-3aw5A:
22.18
5xdqC-3aw5A:
18.91
5xdqP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.13A 5xdqC-3aw5A:
undetectable
5xdqN-3aw5A:
undetectable
5xdqP-3aw5A:
undetectable		 5xdqC-3aw5A:
18.91
5xdqN-3aw5A:
22.18
5xdqP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.14A 5xdxC-3aw5A:
undetectable
5xdxN-3aw5A:
undetectable
5xdxP-3aw5A:
undetectable		 5xdxC-3aw5A:
18.91
5xdxN-3aw5A:
22.18
5xdxP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		3 / 3 THR A 148
GLU A 506
HIS A 446
 None
C2O  A 602 ( 4.9A)
C2O  A 602 (-4.0A)
 0.72A 5xioA-2fqdA:
undetectable		 5xioA-2fqdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		3 / 3 THR A 148
GLU A 506
HIS A 448
 None
C2O  A 602 ( 4.9A)
C2O  A 602 (-3.3A)
 0.75A 5xioA-2fqdA:
undetectable		 5xioA-2fqdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		3 / 3 THR A 139
GLU A 466
HIS A 396
 None
C2O  A 702 ( 4.5A)
C2O  A 702 ( 3.3A)
 0.88A 5xioA-3aw5A:
undetectable		 5xioA-3aw5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		3 / 3 THR A 208
GLU A 609
HIS A 529
 None
C2O  A1002 ( 4.8A)
CU  A1004 ( 3.2A)
 0.90A 5xioA-3gyrA:
undetectable		 5xioA-3gyrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		3 / 3 THR A 148
GLU A 506
HIS A 448
 None
C2O  A 602 ( 4.9A)
C2O  A 602 (-3.3A)
 0.76A 5xiqB-2fqdA:
undetectable		 5xiqB-2fqdA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		3 / 3 THR A 139
GLU A 466
HIS A 396
 None
C2O  A 702 ( 4.5A)
C2O  A 702 ( 3.3A)
 0.91A 5xiqB-3aw5A:
undetectable		 5xiqB-3aw5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		3 / 3 THR A 148
GLU A 506
HIS A 446
 None
C2O  A 602 ( 4.9A)
C2O  A 602 (-4.0A)
 0.74A 5xiqD-2fqdA:
undetectable		 5xiqD-2fqdA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2fqd BLUE COPPER OXIDASE
CUEO
(Escherichia
coli) 		3 / 3 THR A 148
GLU A 506
HIS A 448
 None
C2O  A 602 ( 4.9A)
C2O  A 602 (-3.3A)
 0.74A 5xiqD-2fqdA:
undetectable		 5xiqD-2fqdA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		3 / 3 THR A 139
GLU A 466
HIS A 396
 None
C2O  A 702 ( 4.5A)
C2O  A 702 ( 3.3A)
 0.88A 5xiqD-3aw5A:
undetectable		 5xiqD-3aw5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3gyr PHENOXAZINONE
SYNTHASE
(Streptomyces
antibioticus) 		3 / 3 THR A 208
GLU A 609
HIS A 529
 None
C2O  A1002 ( 4.8A)
CU  A1004 ( 3.2A)
 0.90A 5xiqD-3gyrA:
undetectable		 5xiqD-3gyrA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.21A 5z0fA-1bt2A:
20.9
5z0fB-1bt2A:
0.0		 5z0fA-1bt2A:
13.04
5z0fB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.22A 5z0fA-1bt2A:
20.9
5z0fB-1bt2A:
0.0		 5z0fA-1bt2A:
13.04
5z0fB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
ILE A 241
HIS A 244
HIS A  88
HIS A 109
 C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
 1.14A 5z0fA-1bt2A:
20.9
5z0fB-1bt2A:
0.0		 5z0fA-1bt2A:
13.04
5z0fB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 244
HIS A 240
HIS A 109
HIS A  88
VAL A  87
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
None
 1.18A 5z0fA-1bt2A:
20.9
5z0fB-1bt2A:
0.0		 5z0fA-1bt2A:
13.04
5z0fB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.38A 5z0fA-2p3xA:
21.1
5z0fB-2p3xA:
undetectable		 5z0fA-2p3xA:
14.51
5z0fB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 117
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 1.49A 5z0fA-2p3xA:
21.1
5z0fB-2p3xA:
undetectable		 5z0fA-2p3xA:
14.51
5z0fB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.18A 5z0fA-2p3xA:
21.1
5z0fB-2p3xA:
undetectable		 5z0fA-2p3xA:
14.51
5z0fB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 243
HIS A 239
HIS A 108
HIS A  87
VAL A  86
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.11A 5z0fA-2p3xA:
21.1
5z0fB-2p3xA:
undetectable		 5z0fA-2p3xA:
14.51
5z0fB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.22A 5z0gA-1bt2A:
20.8
5z0gB-1bt2A:
undetectable		 5z0gA-1bt2A:
13.04
5z0gB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
ILE A 241
HIS A 244
HIS A  88
HIS A 109
 C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
 1.11A 5z0gA-1bt2A:
20.8
5z0gB-1bt2A:
undetectable		 5z0gA-1bt2A:
13.04
5z0gB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 244
HIS A 240
HIS A 109
HIS A  88
VAL A  87
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
None
 1.19A 5z0gA-1bt2A:
20.8
5z0gB-1bt2A:
undetectable		 5z0gA-1bt2A:
13.04
5z0gB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.34A 5z0gA-2p3xA:
21.1
5z0gB-2p3xA:
undetectable		 5z0gA-2p3xA:
14.51
5z0gB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.16A 5z0gA-2p3xA:
21.1
5z0gB-2p3xA:
undetectable		 5z0gA-2p3xA:
14.51
5z0gB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 243
HIS A 239
HIS A 108
HIS A  87
VAL A  86
 C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
 1.13A 5z0gA-2p3xA:
21.1
5z0gB-2p3xA:
undetectable		 5z0gA-2p3xA:
14.51
5z0gB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.25A 5z0hA-1bt2A:
20.9
5z0hB-1bt2A:
undetectable		 5z0hA-1bt2A:
13.04
5z0hB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.22A 5z0hA-1bt2A:
20.9
5z0hB-1bt2A:
undetectable		 5z0hA-1bt2A:
13.04
5z0hB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.37A 5z0hA-2p3xA:
21.1
5z0hB-2p3xA:
undetectable		 5z0hA-2p3xA:
14.51
5z0hB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 117
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 1.45A 5z0hA-2p3xA:
21.1
5z0hB-2p3xA:
undetectable		 5z0hA-2p3xA:
14.51
5z0hB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.18A 5z0hA-2p3xA:
21.1
5z0hB-2p3xA:
undetectable		 5z0hA-2p3xA:
14.51
5z0hB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.25A 5z0iA-1bt2A:
20.9
5z0iB-1bt2A:
undetectable		 5z0iA-1bt2A:
13.04
5z0iB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.23A 5z0iA-1bt2A:
20.9
5z0iB-1bt2A:
undetectable		 5z0iA-1bt2A:
13.04
5z0iB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
ILE A 241
HIS A 244
HIS A  88
HIS A 109
 C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
 1.10A 5z0iA-1bt2A:
20.9
5z0iB-1bt2A:
undetectable		 5z0iA-1bt2A:
13.04
5z0iB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.36A 5z0iA-2p3xA:
21.1
5z0iB-2p3xA:
undetectable		 5z0iA-2p3xA:
14.51
5z0iB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 117
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 1.49A 5z0iA-2p3xA:
21.1
5z0iB-2p3xA:
undetectable		 5z0iA-2p3xA:
14.51
5z0iB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.18A 5z0iA-2p3xA:
21.1
5z0iB-2p3xA:
undetectable		 5z0iA-2p3xA:
14.51
5z0iB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.22A 5z0jA-1bt2A:
20.9
5z0jB-1bt2A:
undetectable		 5z0jA-1bt2A:
13.04
5z0jB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.19A 5z0jA-1bt2A:
20.9
5z0jB-1bt2A:
undetectable		 5z0jA-1bt2A:
13.04
5z0jB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.37A 5z0jA-2p3xA:
21.1
5z0jB-2p3xA:
undetectable		 5z0jA-2p3xA:
14.51
5z0jB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.16A 5z0jA-2p3xA:
21.1
5z0jB-2p3xA:
undetectable		 5z0jA-2p3xA:
14.51
5z0jB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.21A 5z0kA-1bt2A:
20.8
5z0kB-1bt2A:
undetectable		 5z0kA-1bt2A:
13.04
5z0kB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.21A 5z0kA-1bt2A:
20.8
5z0kB-1bt2A:
undetectable		 5z0kA-1bt2A:
13.04
5z0kB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.36A 5z0kA-2p3xA:
21.1
5z0kB-2p3xA:
undetectable		 5z0kA-2p3xA:
14.51
5z0kB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.18A 5z0kA-2p3xA:
21.1
5z0kB-2p3xA:
undetectable		 5z0kA-2p3xA:
14.51
5z0kB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.25A 5z0lA-1bt2A:
20.8
5z0lB-1bt2A:
undetectable		 5z0lA-1bt2A:
13.04
5z0lB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.23A 5z0lA-1bt2A:
20.8
5z0lB-1bt2A:
undetectable		 5z0lA-1bt2A:
13.04
5z0lB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
ILE A 241
HIS A 244
HIS A  88
HIS A 109
 C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
 1.18A 5z0lA-1bt2A:
20.8
5z0lB-1bt2A:
undetectable		 5z0lA-1bt2A:
13.04
5z0lB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.36A 5z0lA-2p3xA:
21.1
5z0lB-2p3xA:
undetectable		 5z0lA-2p3xA:
14.51
5z0lB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 117
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 1.46A 5z0lA-2p3xA:
21.1
5z0lB-2p3xA:
undetectable		 5z0lA-2p3xA:
14.51
5z0lB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A 239
HIS A 243
HIS A  87
HIS A 108
PRO A  17
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
 1.19A 5z0lA-2p3xA:
21.1
5z0lB-2p3xA:
undetectable		 5z0lA-2p3xA:
14.51
5z0lB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.32A 5z0mA-1bt2A:
20.9
5z0mB-1bt2A:
undetectable		 5z0mA-1bt2A:
13.38
5z0mB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 11 HIS A  87
HIS A 108
HIS A 239
ASN A 240
HIS A 243
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.2A)
None
C2O  A 340 (-3.3A)
 0.44A 5z0mA-2p3xA:
21.1
5z0mB-2p3xA:
undetectable		 5z0mA-2p3xA:
13.58
5z0mB-2p3xA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		5 / 11 HIS A 459
HIS A 461
HIS A 134
VAL A  91
HIS A  94
 C2O  A 702 (-3.4A)
C2O  A 702 (-3.5A)
C2O  A 702 (-3.3A)
None
C2O  A 702 ( 3.2A)
 1.44A 5z0mA-3aw5A:
undetectable
5z0mB-3aw5A:
undetectable		 5z0mA-3aw5A:
13.55
5z0mB-3aw5A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.18A 5z84A-3aw5A:
undetectable
5z84C-3aw5A:
undetectable
5z84P-3aw5A:
undetectable		 5z84A-3aw5A:
22.18
5z84C-3aw5A:
18.91
5z84P-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 7 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.17A 5z84C-3aw5A:
undetectable
5z84N-3aw5A:
undetectable
5z84P-3aw5A:
undetectable		 5z84C-3aw5A:
18.91
5z84N-3aw5A:
22.18
5z84P-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.19A 5z85A-3aw5A:
undetectable
5z85C-3aw5A:
undetectable
5z85P-3aw5A:
undetectable		 5z85A-3aw5A:
22.18
5z85C-3aw5A:
18.91
5z85P-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 7 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.17A 5z85C-3aw5A:
undetectable
5z85N-3aw5A:
undetectable
5z85P-3aw5A:
undetectable		 5z85C-3aw5A:
18.91
5z85N-3aw5A:
22.18
5z85P-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.17A 5z86A-3aw5A:
undetectable
5z86C-3aw5A:
undetectable
5z86P-3aw5A:
undetectable		 5z86A-3aw5A:
22.18
5z86C-3aw5A:
18.91
5z86P-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.16A 5z86C-3aw5A:
undetectable
5z86N-3aw5A:
undetectable
5z86P-3aw5A:
undetectable		 5z86C-3aw5A:
18.91
5z86N-3aw5A:
22.18
5z86P-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.17A 5zcoA-3aw5A:
undetectable
5zcoC-3aw5A:
undetectable
5zcoP-3aw5A:
undetectable		 5zcoA-3aw5A:
22.18
5zcoC-3aw5A:
18.91
5zcoP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.17A 5zcoC-3aw5A:
undetectable
5zcoN-3aw5A:
undetectable
5zcoP-3aw5A:
undetectable		 5zcoC-3aw5A:
18.91
5zcoN-3aw5A:
22.18
5zcoP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.19A 5zcpA-3aw5A:
undetectable
5zcpC-3aw5A:
undetectable
5zcpP-3aw5A:
undetectable		 5zcpA-3aw5A:
22.18
5zcpC-3aw5A:
18.91
5zcpP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.18A 5zcpC-3aw5A:
undetectable
5zcpN-3aw5A:
undetectable
5zcpP-3aw5A:
undetectable		 5zcpC-3aw5A:
18.91
5zcpN-3aw5A:
22.18
5zcpP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 HIS A 461
THR A 139
HIS A  94
LEU A  85
 C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
None
 1.17A 5zcqA-3aw5A:
undetectable
5zcqC-3aw5A:
undetectable
5zcqP-3aw5A:
undetectable		 5zcqA-3aw5A:
22.18
5zcqC-3aw5A:
18.91
5zcqP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		3 / 3 HIS A 240
HIS A 244
HIS A 274
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
 0.24A 5zrdA-1bt2A:
3.3		 5zrdA-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 HIS A 239
HIS A 243
HIS A 272
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
 0.14A 5zrdA-2p3xA:
3.0		 5zrdA-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 5 HIS A 240
HIS A 244
PHE A 270
HIS A 273
HIS A 274
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 4.8A)
None
C2O  A 500 ( 3.2A)
 0.35A 5zrdB-1bt2A:
undetectable		 5zrdB-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 117
HIS A  87
PHE A 259
HIS A 108
 C2O  A 340 (-3.5A)
C2O  A 340 (-3.2A)
C2O  A 340 (-4.2A)
C2O  A 340 (-3.3A)
 1.09A 5zrdB-2p3xA:
3.6		 5zrdB-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		5 / 5 HIS A 239
HIS A 243
PHE A 268
HIS A 271
HIS A 272
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 ( 4.7A)
None
C2O  A 340 (-3.1A)
 0.20A 5zrdB-2p3xA:
3.6		 5zrdB-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A  88
CYH A  92
HIS A 109
PHE A 270
 C2O  A 500 ( 3.2A)
C2O  A 500 (-3.5A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 4.8A)
 1.07A 5zrdB-1bt2A:
undetectable		 5zrdB-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A  88
HIS A 109
HIS A 118
PHE A 270
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 4.8A)
 0.31A 5zrdB-1bt2A:
undetectable		 5zrdB-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A 240
HIS A 244
HIS A 274
PHE A 114
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 1.07A 5zrdB-1bt2A:
undetectable		 5zrdB-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
CYH A  91
HIS A 108
PHE A 268
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.6A)
C2O  A 340 (-3.3A)
C2O  A 340 ( 4.7A)
 1.17A 5zrdB-2p3xA:
3.6		 5zrdB-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
HIS A 108
HIS A 117
PHE A 268
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.5A)
C2O  A 340 ( 4.7A)
 0.29A 5zrdB-2p3xA:
3.6		 5zrdB-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 239
HIS A 243
HIS A 272
PHE A 113
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
None
 0.96A 5zrdB-2p3xA:
3.6		 5zrdB-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 240
HIS A 244
HIS A 273
HIS A 274
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
 0.29A 5zrdC-1bt2A:
3.2		 5zrdC-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 239
HIS A 243
HIS A 271
HIS A 272
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
C2O  A 340 (-3.1A)
 0.17A 5zrdC-2p3xA:
3.1		 5zrdC-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A  88
CYH A  92
HIS A 109
PHE A 270
 C2O  A 500 ( 3.2A)
C2O  A 500 (-3.5A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 4.8A)
 1.08A 5zrdC-1bt2A:
3.2		 5zrdC-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A  88
HIS A 109
HIS A 118
PHE A 270
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 4.8A)
 0.23A 5zrdC-1bt2A:
3.2		 5zrdC-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A 240
HIS A 244
HIS A 274
PHE A 114
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 1.11A 5zrdC-1bt2A:
3.2		 5zrdC-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
CYH A  91
HIS A 108
PHE A 268
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.6A)
C2O  A 340 (-3.3A)
C2O  A 340 ( 4.7A)
 1.18A 5zrdC-2p3xA:
3.1		 5zrdC-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
HIS A 108
HIS A 117
PHE A 268
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.5A)
C2O  A 340 ( 4.7A)
 0.24A 5zrdC-2p3xA:
3.1		 5zrdC-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 239
HIS A 243
HIS A 272
PHE A 113
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
None
 1.01A 5zrdC-2p3xA:
3.1		 5zrdC-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A  88
CYH A  92
HIS A 109
PHE A 270
 C2O  A 500 ( 3.2A)
C2O  A 500 (-3.5A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 4.8A)
 1.07A 5zrdD-1bt2A:
4.5		 5zrdD-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A  88
HIS A 109
HIS A 118
PHE A 270
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 4.8A)
 0.31A 5zrdD-1bt2A:
4.5		 5zrdD-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A 240
HIS A 244
HIS A 274
PHE A 114
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 1.09A 5zrdD-1bt2A:
4.5		 5zrdD-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
CYH A  91
HIS A 108
PHE A 268
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.6A)
C2O  A 340 (-3.3A)
C2O  A 340 ( 4.7A)
 1.17A 5zrdD-2p3xA:
4.2		 5zrdD-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A  87
HIS A 108
HIS A 117
PHE A 268
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.5A)
C2O  A 340 ( 4.7A)
 0.35A 5zrdD-2p3xA:
4.2		 5zrdD-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 5 HIS A 239
HIS A 243
HIS A 272
PHE A 113
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
C2O  A 340 (-3.1A)
None
 0.98A 5zrdD-2p3xA:
4.2		 5zrdD-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 240
HIS A 244
HIS A 273
HIS A 274
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
 0.31A 5zrdD-1bt2A:
4.5		 5zrdD-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 4 HIS A 239
HIS A 243
HIS A 271
HIS A 272
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.3A)
None
C2O  A 340 (-3.1A)
 0.20A 5zrdD-2p3xA:
4.2		 5zrdD-2p3xA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 TYR A 120
HIS A 117
PHE A 268
 None
C2O  A 340 (-3.5A)
C2O  A 340 ( 4.7A)
 1.06A 6esmA-2p3xA:
undetectable		 6esmA-2p3xA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 HIS A 239
HIS A 272
HIS A 271
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.1A)
None
 0.73A 6giqa-2p3xA:
undetectable		 6giqa-2p3xA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		3 / 3 HIS A 239
HIS A 272
HIS A 271
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.1A)
None
 0.74A 6hu9a-2p3xA:
0.5		 6hu9a-2p3xA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3aw5 MULTICOPPER OXIDASE
(Pyrobaculum
aerophilum) 		4 / 8 LEU A  85
HIS A 461
THR A 139
HIS A  94
 None
C2O  A 702 (-3.5A)
None
C2O  A 702 ( 3.2A)
 1.16A 6nknC-3aw5A:
undetectable
6nknN-3aw5A:
undetectable
6nknP-3aw5A:
undetectable		 6nknC-3aw5A:
18.91
6nknN-3aw5A:
22.18
6nknP-3aw5A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2p3x POLYPHENOL OXIDASE,
CHLOROPLAST
(Vitis
vinifera) 		4 / 6 HIS A 243
ASP A 181
TYR A 182
HIS A 272
 C2O  A 340 (-3.3A)
None
None
C2O  A 340 (-3.1A)
 1.48A 6nmpA-2p3xA:
undetectable
6nmpC-2p3xA:
undetectable		 6nmpA-2p3xA:
19.17
6nmpC-2p3xA:
19.65