SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'C1N'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1zcm CALPAIN 1, LARGE
[CATALYTIC] SUBUNIT
(Homo
sapiens) 		5 / 12 THR A 210
GLY A 208
GLY A 207
GLY A 113
PHE A 214
 C1N  A1115 (-4.7A)
C1N  A1115 (-3.5A)
C1N  A1115 (-3.3A)
C1N  A1115 (-3.1A)
None
 1.08A 1wg8A-1zcmA:
undetectable		 1wg8A-1zcmA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1zcm CALPAIN 1, LARGE
[CATALYTIC] SUBUNIT
(Homo
sapiens) 		5 / 12 THR A 210
GLY A 208
GLY A 207
GLY A 113
PHE A 214
 C1N  A1115 (-4.7A)
C1N  A1115 (-3.5A)
C1N  A1115 (-3.3A)
C1N  A1115 (-3.1A)
None
 1.08A 1wg8B-1zcmA:
undetectable		 1wg8B-1zcmA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1zcm CALPAIN 1, LARGE
[CATALYTIC] SUBUNIT
(Homo
sapiens) 		4 / 7 GLN A 109
GLY A 113
HIS A 272
TRP A 298
 C1N  A1115 (-3.4A)
C1N  A1115 (-3.1A)
C1N  A1115 (-4.2A)
None
 0.51A 3ai8A-1zcmA:
4.6		 3ai8A-1zcmA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 1zcm CALPAIN 1, LARGE
[CATALYTIC] SUBUNIT
(Homo
sapiens) 		3 / 3 LEU A 118
TRP A 116
GLY A 207
 None
None
C1N  A1115 (-3.3A)
 0.72A 3l35A-1zcmA:
undetectable
3l35H-1zcmA:
undetectable		 3l35A-1zcmA:
6.62
3l35H-1zcmA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 1zcm CALPAIN 1, LARGE
[CATALYTIC] SUBUNIT
(Homo
sapiens) 		3 / 3 LEU A 118
TRP A 116
GLY A 207
 None
None
C1N  A1115 (-3.3A)
 0.80A 3l35B-1zcmA:
undetectable
3l35K-1zcmA:
undetectable		 3l35B-1zcmA:
6.62
3l35K-1zcmA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1zcm CALPAIN 1, LARGE
[CATALYTIC] SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A 249
ALA A 273
PHE A 345
VAL A 276
ILE A 292
 None
C1N  A1115 ( 4.0A)
None
None
None
 1.00A 4uw0A-1zcmA:
undetectable		 4uw0A-1zcmA:
20.71