SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'C12'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TRP C 158
VAL C 259
TRP C 340
 None
None
MTT  C1203 (-4.0A)
 1.24A 1c4dA-5jj4C:
undetectable
1c4dB-5jj4C:
undetectable		 1c4dA-5jj4C:
2.29
1c4dB-5jj4C:
2.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 4y7m TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		3 / 3 TRP C 887
ALA C 882
VAL C 884
 None
SO4  C1201 ( 4.0A)
None
 0.90A 1c4dC-4y7mC:
undetectable
1c4dD-4y7mC:
undetectable		 1c4dC-4y7mC:
4.21
1c4dD-4y7mC:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Thermus
thermophilus) 		4 / 6 HIS C  21
TRP C  14
PHE C  22
VAL C  25
 MQ7  C1252 (-4.1A)
MQ7  C1252 ( 4.5A)
None
None
 1.06A 1ibgH-2vpwC:
undetectable		 1ibgH-2vpwC:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 2nty RAC-LIKE GTP-BINDING
PROTEIN ARAC5
(Arabidopsis
thaliana) 		5 / 11 PHE C 170
THR C  11
GLY C  18
VAL C 116
ILE C  82
 None
None
GDP  C1200 (-2.6A)
None
None
 1.14A 1phgA-2ntyC:
undetectable		 1phgA-2ntyC:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		5 / 10 HIS A 210
LEU A 327
LEU A 338
THR A 336
THR A 337
 None
None
C12  A 340 ( 4.3A)
C12  A 340 ( 4.8A)
None
 1.37A 1rj6A-3osqA:
undetectable		 1rj6A-3osqA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		5 / 10 HIS A 348
LEU A 465
LEU A 476
THR A 474
THR A 475
 None
None
C12  A 478 ( 4.2A)
C12  A 478 ( 4.7A)
None
 1.40A 1rj6A-3osrA:
undetectable		 1rj6A-3osrA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		5 / 10 HIS A 210
LEU A 327
LEU A 338
THR A 336
THR A 337
 None
None
C12  A 340 ( 4.3A)
C12  A 340 ( 4.8A)
None
 1.33A 1rj6B-3osqA:
undetectable		 1rj6B-3osqA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		5 / 10 HIS A 348
LEU A 465
LEU A 476
THR A 474
THR A 475
 None
None
C12  A 478 ( 4.2A)
C12  A 478 ( 4.7A)
None
 1.37A 1rj6B-3osrA:
undetectable		 1rj6B-3osrA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 4y7m TYPE VI SECRETION
PROTEIN ICMF
(Escherichia
coli) 		3 / 3 ALA C 882
VAL C 884
TRP C 887
 SO4  C1201 ( 4.0A)
None
None
 0.71A 1tkqB-4y7mC:
undetectable		 1tkqB-4y7mC:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 6 VAL C  37
LEU C  48
PHE C  63
MET C  82
 None
None
GOL  C1217 (-4.0A)
None
 1.10A 1x8vA-3zkmC:
undetectable		 1x8vA-3zkmC:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA
F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis;
Methanothermobac
ter
marburgensis) 		3 / 3 TRP B 264
ARG B 261
PHE C 281
 None
SF4  C1282 ( 4.4A)
None
 1.22A 1zeaH-4ci0B:
undetectable
1zeaL-4ci0B:
undetectable		 1zeaH-4ci0B:
20.79
1zeaL-4ci0B:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		3 / 3 ARG C  99
VAL C  89
GLY C  38
 None
None
HEM  C1255 ( 4.2A)
 0.60A 2avvE-2bs4C:
undetectable		 2avvE-2bs4C:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 10 THR C 207
LEU C  33
VAL C  29
GLY C  31
VAL C 219
 FAD  C1283 (-4.6A)
None
FAD  C1283 (-4.0A)
None
None
 1.32A 2cp4A-4ci0C:
undetectable		 2cp4A-4ci0C:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Thermus
thermophilus) 		5 / 12 TYR C 130
VAL C  25
ASP C  60
ASN C  18
ILE C  89
 MQ7  C1252 (-4.4A)
None
None
MQ7  C1252 (-3.1A)
MQ7  C1252 (-3.8A)
 1.43A 2dcfA-2vpwC:
undetectable		 2dcfA-2vpwC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5fuc INTERLEUKIN-6
RECEPTOR SUBUNIT
ALPHA, INTERLEUKIN-6
RECEPTOR
VHH6
(Camelus
dromedarius;
Homo
sapiens) 		3 / 3 ASN C 226
TYR E  59
SER C 228
 NAG  C1299 (-1.8A)
None
None
 0.86A 2gvcB-5fucC:
undetectable		 2gvcB-5fucC:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 5fuc INTERLEUKIN-6
RECEPTOR SUBUNIT
ALPHA, INTERLEUKIN-6
RECEPTOR
VHH6
(Camelus
dromedarius;
Homo
sapiens) 		3 / 3 ASN C 226
TYR E  59
SER C 228
 NAG  C1299 (-1.8A)
None
None
 0.84A 2gvcE-5fucC:
undetectable		 2gvcE-5fucC:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		5 / 12 PHE C  85
GLY C  43
GLY C 186
LEU C 187
LEU C 190
 None
None
HEM  C1255 (-3.4A)
HEM  C1255 (-4.8A)
HEM  C1255 (-4.2A)
 1.07A 2hw2A-2bs4C:
undetectable		 2hw2A-2bs4C:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 2ivf ETHYLBENZENE
DEHYDROGENASE
GAMMA-SUBUNIT
(Aromatoleum
aromaticum) 		3 / 3 TYR C 203
GLY C  53
PHE C  32
 HEM  C1217 (-3.7A)
None
None
 0.69A 2m2pB-2ivfC:
undetectable		 2m2pB-2ivfC:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		5 / 12 LEU A 456
LEU A 454
ILE A 426
ALA A 449
PHE A 483
 C12  A 478 ( 4.6A)
C12  A 478 ( 4.8A)
None
None
None
 1.13A 2qb4A-3osrA:
undetectable		 2qb4A-3osrA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 6 PRO C 139
SER C 142
GLU C 136
CYH C 192
 None
None
None
SF4  C1282 (-1.9A)
 1.09A 2x7hA-4ci0C:
undetectable		 2x7hA-4ci0C:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY C 103
GLY C  97
GLY C  99
LEU C  61
LEU C  64
 None
None
None
None
MQ7  C1252 (-3.5A)
 0.98A 2zbpA-2vpwC:
undetectable		 2zbpA-2vpwC:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Thermus
thermophilus) 		5 / 12 TYR C 130
VAL C  25
ASP C  60
ASN C  18
ILE C  89
 MQ7  C1252 (-4.4A)
None
None
MQ7  C1252 (-3.1A)
MQ7  C1252 (-3.8A)
 1.40A 3a65A-2vpwC:
undetectable		 3a65A-2vpwC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA
(Methanothermobac
ter
marburgensis) 		5 / 11 ALA C 101
ASN C 137
VAL C  82
ILE B 221
THR C  99
 None
SF4  C1282 ( 3.7A)
None
SF4  C1282 ( 3.6A)
None
 1.34A 3fl9C-4ci0C:
undetectable		 3fl9C-4ci0C:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE
(Escherichia
coli;
Homo
sapiens) 		12 / 12 ASP C  14
LYS C  15
LYS C  42
GLU C  44
GLU C  45
ALA C  63
ASP C  65
ARG C  66
GLU C 111
PRO C 154
TRP C 230
TYR C 341
 MTT  C1203 (-3.2A)
MTT  C1203 (-2.8A)
MTT  C1203 (-3.5A)
MTT  C1203 (-3.1A)
MTT  C1203 (-3.4A)
MTT  C1203 (-3.3A)
MTT  C1203 (-3.0A)
MTT  C1203 (-4.3A)
MTT  C1203 (-3.0A)
MTT  C1203 (-3.6A)
MTT  C1203 (-4.5A)
MTT  C1203 (-4.5A)
 0.55A 3jyrA-5jj4C:
61.4		 3jyrA-5jj4C:
72.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE
(Escherichia
coli;
Homo
sapiens) 		7 / 7 ASN C  12
TRP C  62
GLU C 153
TYR C 155
MET C 330
TRP C 340
ARG C 344
 MTT  C1203 ( 4.8A)
MTT  C1203 (-4.1A)
MTT  C1203 (-3.5A)
MTT  C1203 (-3.9A)
MTT  C1203 (-4.2A)
MTT  C1203 (-4.0A)
MTT  C1203 (-4.1A)
 0.34A 3jyrA-5jj4C:
61.4		 3jyrA-5jj4C:
72.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
(Thermus
thermophilus) 		4 / 6 ALA C 134
ILE C  89
VAL C  25
HIS C  21
 None
MQ7  C1252 (-3.8A)
None
MQ7  C1252 (-4.1A)
 1.15A 3nneG-2vpwC:
undetectable		 3nneG-2vpwC:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 1o94 ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT
(Methylophilus
methylotrophus) 		5 / 10 ALA C   6
VAL C 116
GLY C 101
ILE C 103
LEU C   4
 AMP  C1236 (-3.6A)
None
None
None
None
 1.00A 3ogqA-1o94C:
undetectable		 3ogqA-1o94C:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 LEU C 253
TYR C 133
GLY C 208
THR C 207
SER C 206
 None
None
FAD  C1283 (-3.6A)
FAD  C1283 (-4.6A)
None
 1.26A 3okxA-4ci0C:
undetectable		 3okxA-4ci0C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 LEU C 253
TYR C 133
THR C 207
SER C 206
LEU C 257
 None
None
FAD  C1283 (-4.6A)
None
None
 1.38A 3okxA-4ci0C:
undetectable		 3okxA-4ci0C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 LEU C 253
TYR C 133
GLY C 208
THR C 207
LEU C 257
 None
None
FAD  C1283 (-3.6A)
FAD  C1283 (-4.6A)
None
 1.19A 3okxB-4ci0C:
undetectable		 3okxB-4ci0C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 LEU C 253
TYR C 133
GLY C 208
THR C 207
SER C 206
 None
None
FAD  C1283 (-3.6A)
FAD  C1283 (-4.6A)
None
 1.26A 3okxB-4ci0C:
undetectable		 3okxB-4ci0C:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3aeb SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa) 		6 / 8 PRO B 169
HIS B 216
ILE B 218
MET C  39
ILE C  43
ARG C  46
 F7A  C1201 (-4.6A)
F7A  C1201 ( 4.1A)
F3S  B 304 (-4.2A)
F7A  C1201 (-3.2A)
None
F7A  C1201 ( 3.2A)
 0.65A 3sfeB-3aebB:
36.7
3sfeC-3aebB:
undetectable		 3sfeB-3aebB:
99.60
3sfeC-3aebB:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3aeb SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
(Sus
scrofa) 		6 / 8 PRO B 169
ILE B 218
MET C  39
SER C  42
ILE C  43
ARG C  46
 F7A  C1201 (-4.6A)
F3S  B 304 (-4.2A)
F7A  C1201 (-3.2A)
F7A  C1201 (-3.1A)
None
F7A  C1201 ( 3.2A)
 0.92A 3sfeB-3aebB:
36.7
3sfeC-3aebB:
undetectable		 3sfeB-3aebB:
99.60
3sfeC-3aebB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		5 / 9 PHE A 345
VAL A 386
ASN A 395
ILE A 288
PHE A 282
 None
C12  A 340 ( 4.8A)
C12  A 340 ( 3.6A)
None
None
 1.17A 3t3rB-3osqA:
undetectable		 3t3rB-3osqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		5 / 9 PHE A 483
VAL A 524
ASN A 533
ILE A 426
PHE A 420
 None
C12  A 478 ( 4.9A)
C12  A 478 ( 3.5A)
None
None
 1.18A 3t3rB-3osrA:
undetectable		 3t3rB-3osrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		5 / 9 PHE A 345
VAL A 386
ASN A 395
ILE A 288
PHE A 282
 None
C12  A 340 ( 4.8A)
C12  A 340 ( 3.6A)
None
None
 1.21A 3t3rC-3osqA:
undetectable		 3t3rC-3osqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		5 / 9 PHE A 483
VAL A 524
ASN A 533
ILE A 426
PHE A 420
 None
C12  A 478 ( 4.9A)
C12  A 478 ( 3.5A)
None
None
 1.22A 3t3rC-3osrA:
undetectable		 3t3rC-3osrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		5 / 10 PHE A 345
VAL A 386
ASN A 395
ILE A 288
PHE A 282
 None
C12  A 340 ( 4.8A)
C12  A 340 ( 3.6A)
None
None
 1.15A 3t3rD-3osqA:
undetectable		 3t3rD-3osqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		5 / 10 PHE A 483
VAL A 524
ASN A 533
ILE A 426
PHE A 420
 None
C12  A 478 ( 4.9A)
C12  A 478 ( 3.5A)
None
None
 1.16A 3t3rD-3osrA:
undetectable		 3t3rD-3osrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE C 156
GLY C 300
LEU C 299
GLU C 111
ALA C 231
 None
None
None
MTT  C1203 (-3.0A)
None
 0.80A 3tbgB-5jj4C:
undetectable		 3tbgB-5jj4C:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE C 156
GLY C 300
LEU C 299
GLU C 111
ALA C 231
 None
None
None
MTT  C1203 (-3.0A)
None
 0.78A 3tbgD-5jj4C:
undetectable		 3tbgD-5jj4C:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		4 / 6 THR C 227
GLY C 229
ARG C 162
LEU C 225
 HEM  C1256 ( 4.4A)
None
HEM  C1256 (-3.8A)
None
 1.20A 4ac9C-2bs4C:
undetectable		 4ac9C-2bs4C:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		4 / 6 THR C 227
GLY C 229
ARG C 162
LEU C 225
 HEM  C1256 ( 4.4A)
None
HEM  C1256 (-3.8A)
None
 1.16A 4acaC-2bs4C:
undetectable		 4acaC-2bs4C:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER C 169
ARG C 166
ASN A  25
ASP C 171
 SO4  C1254 (-3.2A)
SO4  C1254 (-3.1A)
None
None
 0.91A 4d39A-5a53C:
undetectable		 4d39A-5a53C:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 SER C 169
ARG C 166
ASN A  25
ASP C 171
 SO4  C1254 (-3.2A)
SO4  C1254 (-3.1A)
None
None
 0.94A 4d39B-5a53C:
undetectable		 4d39B-5a53C:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2xb6 NEUREXIN-1-BETA
(Rattus
norvegicus) 		5 / 12 ILE C 168
ASP C 190
SER C 259
ILE C 115
LEU C 141
 None
EDO  C1292 (-3.8A)
None
None
None
 1.05A 4dfrA-2xb6C:
undetectable		 4dfrA-2xb6C:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 TYR C  93
LEU C  80
LEU C  85
ARG C  66
 None
None
None
GOL  C1217 (-3.8A)
 1.30A 4em2A-3zkmC:
undetectable		 4em2A-3zkmC:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 8 TYR C  93
ASP C  88
PHE C  63
LEU C  48
 None
GOL  C1217 ( 4.5A)
GOL  C1217 (-4.0A)
None
 0.83A 4f8hA-3zkmC:
3.3
4f8hB-3zkmC:
undetectable		 4f8hA-3zkmC:
21.94
4f8hB-3zkmC:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 8 TYR C  93
ASP C  88
PHE C  63
LEU C  48
 None
GOL  C1217 ( 4.5A)
GOL  C1217 (-4.0A)
None
 0.84A 4f8hB-3zkmC:
undetectable
4f8hC-3zkmC:
undetectable		 4f8hB-3zkmC:
21.94
4f8hC-3zkmC:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 8 TYR C  93
ASP C  88
PHE C  63
LEU C  48
 None
GOL  C1217 ( 4.5A)
GOL  C1217 (-4.0A)
None
 0.82A 4f8hC-3zkmC:
undetectable
4f8hD-3zkmC:
undetectable		 4f8hC-3zkmC:
21.94
4f8hD-3zkmC:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 8 TYR C  93
ASP C  88
PHE C  63
LEU C  48
 None
GOL  C1217 ( 4.5A)
GOL  C1217 (-4.0A)
None
 0.83A 4f8hD-3zkmC:
undetectable
4f8hE-3zkmC:
undetectable		 4f8hD-3zkmC:
21.94
4f8hE-3zkmC:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3zkm FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 8 PHE C  63
LEU C  48
TYR C  93
ASP C  88
 GOL  C1217 (-4.0A)
None
None
GOL  C1217 ( 4.5A)
 0.83A 4f8hA-3zkmC:
3.3
4f8hE-3zkmC:
undetectable		 4f8hA-3zkmC:
21.94
4f8hE-3zkmC:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 7 LEU C 128
THR C 207
THR C 221
VAL C 219
 None
FAD  C1283 (-4.6A)
None
None
 0.66A 4ik7A-4ci0C:
undetectable		 4ik7A-4ci0C:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		4 / 8 LEU C 128
THR C 207
THR C 221
VAL C 219
 None
FAD  C1283 (-4.6A)
None
None
 0.57A 4ik7B-4ci0C:
undetectable		 4ik7B-4ci0C:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE
(Escherichia
coli;
Homo
sapiens) 		4 / 5 ASN C 267
ALA C  51
GLY C  56
ASP C  14
 None
None
None
MTT  C1203 (-3.2A)
 0.99A 4n48A-5jj4C:
undetectable		 4n48A-5jj4C:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		4 / 6 VAL A 329
LEU A 327
LEU A 399
PHE A 194
 None
None
None
C12  A 340 ( 4.7A)
 0.95A 4o1zA-3osqA:
undetectable		 4o1zA-3osqA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Escherichia
coli) 		4 / 6 VAL A 467
LEU A 465
LEU A 537
PHE A 332
 None
None
None
C12  A 478 ( 4.5A)
 0.92A 4o1zA-3osrA:
undetectable		 4o1zA-3osrA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2xb6 NEUREXIN-1-BETA
(Rattus
norvegicus) 		5 / 12 GLY C 116
ILE C 245
VAL C 150
VAL C 268
ILE C 243
 EDO  C1295 ( 4.6A)
None
None
None
None
 1.01A 4q5mA-2xb6C:
undetectable		 4q5mA-2xb6C:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2xb6 NEUREXIN-1-BETA
(Rattus
norvegicus) 		5 / 12 ILE C 168
ASP C 190
SER C 259
ILE C 115
LEU C 141
 None
EDO  C1292 (-3.8A)
None
None
None
 1.04A 4qi9A-2xb6C:
undetectable		 4qi9A-2xb6C:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1o94 ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT
(Methylophilus
methylotrophus) 		3 / 3 SER C 123
ASP C  70
ASP C  39
 None
None
AMP  C1236 (-2.6A)
 0.74A 4uckA-1o94C:
undetectable		 4uckA-1o94C:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN
(Escherichia
coli;
Aequorea
victoria) 		6 / 12 ALA A 384
LEU A 338
ILE A 288
LEU A 316
TYR A 366
THR A 382
 None
C12  A 340 ( 4.3A)
None
C12  A 340 ( 4.9A)
None
None
 1.45A 4x5iA-3osqA:
undetectable		 4x5iA-3osqA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 2bs4 QUINOL-FUMARATE
REDUCTASE DIHEME
CYTOCHROME B SUBUNIT
C
(Wolinella
succinogenes) 		4 / 4 LEU C 171
ILE C 146
HIS C 143
VAL C 142
 None
None
HEM  C1256 (-3.2A)
None
 1.25A 4xyzA-2bs4C:
undetectable		 4xyzA-2bs4C:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 9 THR C 207
LEU C  33
VAL C  29
GLY C  31
VAL C 219
 FAD  C1283 (-4.6A)
None
FAD  C1283 (-4.0A)
None
None
 1.31A 5cp4A-4ci0C:
undetectable		 5cp4A-4ci0C:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 2ivf ETHYLBENZENE
DEHYDROGENASE
GAMMA-SUBUNIT
(Aromatoleum
aromaticum) 		3 / 3 ASN C 194
ALA C 195
ARG C 200
 None
None
GOL  C1216 (-4.1A)
 0.78A 5cvtB-2ivfC:
undetectable		 5cvtB-2ivfC:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN
NRFC PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL B  85
PRO B  87
ALA B  74
ILE B  91
SER C  68
 SF4  B1197 ( 4.8A)
None
SF4  B1197 ( 4.0A)
SF4  B1197 ( 4.3A)
MQ7  C1252 ( 4.9A)
 1.24A 5hgcA-2vpwB:
undetectable		 5hgcA-2vpwB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2xb6 NEUREXIN-1-BETA
(Rattus
norvegicus) 		5 / 12 ILE C 168
ASP C 190
SER C 259
ILE C 115
LEU C 141
 None
EDO  C1292 (-3.8A)
None
None
None
 0.93A 5hi6B-2xb6C:
undetectable		 5hi6B-2xb6C:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 VAL C  29
ALA C  34
VAL C 130
GLY C 131
ILE C 132
 FAD  C1283 (-4.0A)
None
None
None
FAD  C1283 (-3.6A)
 0.79A 5j2tC-4ci0C:
undetectable		 5j2tC-4ci0C:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 ILE C 220
LEU C   3
SER C 212
GLY C 208
GLY C 211
 None
None
None
FAD  C1283 (-3.6A)
None
 1.12A 5nnaA-4ci0C:
undetectable		 5nnaA-4ci0C:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 ILE C 220
LEU C   3
SER C 212
GLY C 208
GLY C 211
 None
None
None
FAD  C1283 (-3.6A)
None
 1.13A 5nnaB-4ci0C:
undetectable		 5nnaB-4ci0C:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 ILE C 220
LEU C   3
SER C 212
GLY C 208
GLY C 211
 None
None
None
FAD  C1283 (-3.6A)
None
 1.12A 5nnaC-4ci0C:
undetectable		 5nnaC-4ci0C:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA
(Methanothermobac
ter
marburgensis) 		5 / 12 ILE C 220
LEU C   3
SER C 212
GLY C 208
GLY C 211
 None
None
None
FAD  C1283 (-3.6A)
None
 1.11A 5nnaD-4ci0C:
undetectable		 5nnaD-4ci0C:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER C 169
ARG C 166
ASN A  25
ASP C 171
 SO4  C1254 (-3.2A)
SO4  C1254 (-3.1A)
None
None
 1.04A 5vunA-5a53C:
undetectable		 5vunA-5a53C:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER C 169
ARG C 166
ASN A  25
ASP C 171
 SO4  C1254 (-3.2A)
SO4  C1254 (-3.1A)
None
None
 1.01A 5vuoB-5a53C:
undetectable		 5vuoB-5a53C:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER C 169
ARG C 166
ASN A  25
ASP C 171
 SO4  C1254 (-3.2A)
SO4  C1254 (-3.1A)
None
None
 0.96A 6auuB-5a53C:
undetectable		 6auuB-5a53C:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TYR C 155
ASN C 227
LEU C 113
 MTT  C1203 (-3.9A)
None
None
 0.77A 6b58A-5jj4C:
undetectable		 6b58A-5jj4C:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 2xb6 NEUREXIN-1-BETA
(Rattus
norvegicus) 		4 / 6 PHE C 237
ARG C 180
ASN C 264
ASP C 111
 None
None
EDO  C1293 ( 4.5A)
None
 1.28A 6dhbA-2xb6C:
undetectable		 6dhbA-2xb6C:
21.74