SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'C11'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 7 HIS C 862
GLY C 863
TYR C 896
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.52A 1dmaA-4oqaC:
5.4		 1dmaA-4oqaC:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 6 HIS C 862
GLY C 863
TYR C 896
ALA C 898
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.40A 1dmaB-4oqaC:
5.9		 1dmaB-4oqaC:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 4hb4 EXPORTIN-1
(Saccharomyces
cerevisiae) 		5 / 6 ALA C 880
LYS C 883
ASP C 887
ALA C 888
LEU C 863
 None
None
GOL  C1102 ( 4.8A)
None
None
 1.36A 1iwhA-4hb4C:
undetectable		 1iwhA-4hb4C:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 2wu5 SUCCINATE
DEHYDROGENASE
CYTOCHROME B556
SUBUNIT
(Escherichia
coli) 		5 / 12 SER C  33
ILE C  36
ILE C  28
TYR C  83
HIS C  91
 None
None
CBE  C1130 (-4.0A)
None
HEM  C 305 (-3.2A)
 1.49A 1ot7A-2wu5C:
1.8		 1ot7A-2wu5C:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4hb4 EXPORTIN-1
(Saccharomyces
cerevisiae) 		4 / 6 LEU C  55
LYS C  64
LEU C 114
VAL C 107
 None
None
CL  C1106 ( 4.4A)
None
 1.12A 2dqyC-4hb4C:
undetectable		 2dqyC-4hb4C:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2cjs UNC-13 HOMOLOG A
REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2
(Rattus
norvegicus;
Rattus
norvegicus) 		5 / 11 ALA C 117
SER A   2
GLU A  52
GLY C 105
VAL C 130
 None
EDO  A1155 (-3.3A)
EDO  A1155 (-3.6A)
EDO  A1155 (-3.5A)
GOL  C1145 (-4.7A)
 1.14A 2uxpB-2cjsC:
undetectable		 2uxpB-2cjsC:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		3 / 3 GLY C 863
TYR C 907
SER C 904
 2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
 0.66A 2xatA-4oqaC:
undetectable		 2xatA-4oqaC:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 12 GLY C 871
ILE C 895
HIS C 862
LEU C 920
LEU C 999
 None
None
2US  C1101 (-3.7A)
None
None
 1.05A 3cs8A-4oqaC:
undetectable		 3cs8A-4oqaC:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 8 ASN A 352
LEU A 326
ALA A 180
SER A 153
 None
C11  A2001 (-4.4A)
None
C11  A2001 (-1.5A)
 0.98A 3kp6A-1k8qA:
undetectable		 3kp6A-1k8qA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
ALA C 898
LYS C 903
SER C 904
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.2A)
 1.38A 3u9hA-4oqaC:
18.6		 3u9hA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
ALA C 898
SER C 904
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.88A 3u9hA-4oqaC:
18.6		 3u9hA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
LYS C 903
SER C 904
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
 0.94A 3u9hA-4oqaC:
18.6		 3u9hA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
SER C 904
TYR C 907
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
 0.52A 3u9hA-4oqaC:
18.6		 3u9hA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
ALA C 898
SER C 904
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.84A 3u9hB-4oqaC:
18.6		 3u9hB-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 8 HIS C 862
GLY C 863
LYS C 903
SER C 904
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.2A)
 1.44A 3u9hB-4oqaC:
18.6		 3u9hB-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
SER C 904
TYR C 907
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
 0.55A 3u9hB-4oqaC:
18.6		 3u9hB-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 8 HIS C 862
GLY C 863
TYR C 896
LYS C 903
SER C 904
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
 1.01A 3u9hB-4oqaC:
18.6		 3u9hB-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		4 / 5 HIS C 826
SER C 902
SER C 904
VAL C 901
 None
None
2US  C1101 (-3.4A)
None
 1.47A 4a99D-4oqaC:
undetectable		 4a99D-4oqaC:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 6 HIS C 862
GLY C 863
TYR C 896
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.53A 4ae1A-4oqaC:
6.3		 4ae1A-4oqaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		5 / 5 HIS C 862
GLY C 863
TYR C 896
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.50A 4ae1B-4oqaC:
4.8		 4ae1B-4oqaC:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
ALA C 898
LYS C 903
SER C 904
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.2A)
 1.36A 4bjcA-4oqaC:
18.2		 4bjcA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
ALA C 898
SER C 904
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.81A 4bjcA-4oqaC:
18.2		 4bjcA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
LYS C 903
SER C 904
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
 0.93A 4bjcA-4oqaC:
18.2		 4bjcA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
SER C 904
TYR C 907
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
 0.44A 4bjcA-4oqaC:
18.2		 4bjcA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 1uzd RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN 1, RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN 2
(Chlamydomonas
reinhardtii;
Spinacia
oleracea) 		4 / 7 ARG C  78
GLY C  76
ILE C  39
ASN C 106
 None
EDO  C1136 (-3.4A)
EDO  C1136 (-4.3A)
None
 1.10A 4g0vA-1uzdC:
undetectable		 4g0vA-1uzdC:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		7 / 7 HIS C 862
GLY C 863
TYR C 896
ALA C 898
SER C 904
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.66A 4hyfA-4oqaC:
19.7		 4hyfA-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		7 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
LYS C 903
SER C 904
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.2A)
 0.89A 4hyfB-4oqaC:
19.8		 4hyfB-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		7 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
SER C 904
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.66A 4hyfB-4oqaC:
19.8		 4hyfB-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		8 / 8 HIS C 862
GLY C 863
TYR C 896
ALA C 898
LYS C 903
SER C 904
TYR C 907
GLU C 988
 2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.62A 4hyfC-4oqaC:
19.8		 4hyfC-4oqaC:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4hb4 EXPORTIN-1
(Saccharomyces
cerevisiae) 		5 / 10 ALA C 956
LEU C 959
PHE C 940
VAL C 936
THR C1019
 None
None
None
None
EDO  C1103 ( 4.0A)
 0.96A 4j14A-4hb4C:
undetectable		 4j14A-4hb4C:
18.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		10 / 11 GLN C 759
HIS C 862
GLY C 863
TYR C 889
TYR C 896
ALA C 898
LYS C 903
SER C 904
TYR C 907
GLU C 988
 None
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.57A 4rv6A-4oqaC:
47.9		 4rv6A-4oqaC:
79.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 11 GLU C 763
HIS C 862
GLY C 863
ALA C 898
SER C 904
TYR C 907
 None
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
 0.86A 4rv6A-4oqaC:
47.9		 4rv6A-4oqaC:
79.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		10 / 11 GLN C 759
HIS C 862
GLY C 863
TYR C 889
TYR C 896
ALA C 898
LYS C 903
SER C 904
TYR C 907
GLU C 988
 None
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.3A)
2US  C1101 (-4.2A)
2US  C1101 (-3.5A)
2US  C1101 ( 4.8A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
2US  C1101 (-3.2A)
 0.57A 4rv6B-4oqaC:
48.1		 4rv6B-4oqaC:
79.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 11 GLU C 763
HIS C 862
GLY C 863
ALA C 898
SER C 904
TYR C 907
 None
2US  C1101 (-3.7A)
2US  C1101 (-3.3A)
2US  C1101 (-3.5A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
 0.87A 4rv6B-4oqaC:
48.1		 4rv6B-4oqaC:
79.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		6 / 9 ASP C 770
SER C 864
ASN C 868
ILE C 872
SER C 904
TYR C 907
 None
None
None
None
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
 0.86A 5ha9B-4oqaC:
46.1		 5ha9B-4oqaC:
86.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens) 		7 / 9 HIS C 862
SER C 864
ASN C 868
ILE C 872
TYR C 896
SER C 904
TYR C 907
 2US  C1101 (-3.7A)
None
None
None
2US  C1101 (-4.2A)
2US  C1101 (-3.4A)
2US  C1101 (-3.5A)
 0.47A 5ha9B-4oqaC:
46.1		 5ha9B-4oqaC:
86.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 8 TRP A 275
GLN A 154
ALA A 278
GLN A 285
 C11  A2001 ( 3.7A)
None
None
None
 1.14A 5km8A-1k8qA:
undetectable
5km8B-1k8qA:
undetectable		 5km8A-1k8qA:
18.40
5km8B-1k8qA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4hb4 EXPORTIN-1
(Saccharomyces
cerevisiae) 		4 / 6 LYS C 567
VAL C 603
LYS C 605
ILE C 651
 CL  C1105 ( 3.9A)
None
None
None
 1.42A 5q1sA-4hb4C:
undetectable		 5q1sA-4hb4C:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 9 VAL A 185
LEU A  68
VAL A 269
SER A 268
 C11  A2001 ( 4.9A)
C11  A2001 ( 4.8A)
None
None
 0.99A 6c2mD-1k8qA:
undetectable		 6c2mD-1k8qA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC
(Canis
lupus) 		4 / 6 TRP A 319
GLY A  66
ALA A 180
LEU A 179
 None
C11  A2001 (-3.4A)
None
None
 1.01A 6fosA-1k8qA:
undetectable		 6fosA-1k8qA:
13.56