SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BZC'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
5 / 7 HIS A 862
GLY A 863
TYR A 896
TYR A 907
GLU A 988
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
0.51A 1dmaA-1efyA:
5.8
1dmaA-1efyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
6 / 6 HIS A 862
GLY A 863
TYR A 896
ALA A 898
TYR A 907
GLU A 988
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
0.44A 1dmaB-1efyA:
5.6
1dmaB-1efyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
7 / 8 HIS A 862
GLY A 863
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
1.25A 3u9hA-1efyA:
19.0
3u9hA-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
7 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
0.92A 3u9hA-1efyA:
19.0
3u9hA-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
7 / 8 HIS A 862
GLY A 863
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
1.24A 3u9hB-1efyA:
19.0
3u9hB-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
7 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
0.96A 3u9hB-1efyA:
19.0
3u9hB-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
5 / 6 HIS A 862
GLY A 863
TYR A 896
TYR A 907
GLU A 988
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
0.43A 4ae1A-1efyA:
6.4
4ae1A-1efyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
5 / 5 HIS A 862
GLY A 863
TYR A 896
TYR A 907
GLU A 988
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
0.46A 4ae1B-1efyA:
0.1
4ae1B-1efyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
6 / 8 HIS A 862
GLY A 863
ALA A 898
LYS A 903
SER A 904
GLU A 988
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-4.0A)
1.30A 4bjcA-1efyA:
18.7
4bjcA-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
6 / 8 HIS A 862
GLY A 863
ALA A 898
SER A 904
TYR A 907
GLU A 988
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 ( 3.9A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
0.78A 4bjcA-1efyA:
18.7
4bjcA-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
6 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
0.91A 4bjcA-1efyA:
18.7
4bjcA-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
6 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
SER A 904
TYR A 907
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
0.27A 4bjcA-1efyA:
18.7
4bjcA-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
7 / 7 HIS A 862
GLY A 863
TYR A 896
ALA A 898
SER A 904
TYR A 907
GLU A 988
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
0.58A 4hyfA-1efyA:
19.9
4hyfA-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
8 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
0.86A 4hyfB-1efyA:
20.0
4hyfB-1efyA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
8 / 8 HIS A 862
GLY A 863
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
0.53A 4hyfC-1efyA:
20.0
4hyfC-1efyA:
23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
5 / 11 GLN A 763
TYR A 896
ALA A 898
LYS A 903
GLU A 988
BZC  A 201 (-3.8A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-4.0A)
0.92A 4rv6A-1efyA:
52.2
4rv6A-1efyA:
86.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
9 / 11 HIS A 862
GLY A 863
TYR A 889
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
None
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
0.50A 4rv6A-1efyA:
52.2
4rv6A-1efyA:
86.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
5 / 11 GLN A 763
TYR A 896
ALA A 898
LYS A 903
GLU A 988
BZC  A 201 (-3.8A)
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-4.0A)
0.93A 4rv6B-1efyA:
52.4
4rv6B-1efyA:
86.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
9 / 11 HIS A 862
GLY A 863
TYR A 889
TYR A 896
ALA A 898
LYS A 903
SER A 904
TYR A 907
GLU A 988
BZC  A 201 (-4.0A)
BZC  A 201 (-3.9A)
None
BZC  A 201 (-4.0A)
BZC  A 201 ( 3.9A)
BZC  A 201 ( 4.8A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
BZC  A 201 (-4.0A)
0.49A 4rv6B-1efyA:
52.4
4rv6B-1efyA:
86.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus
gallus)
8 / 9 ASP A 770
HIS A 862
SER A 864
ASN A 868
ILE A 872
TYR A 896
SER A 904
TYR A 907
None
BZC  A 201 (-4.0A)
None
None
None
BZC  A 201 (-4.0A)
BZC  A 201 (-3.3A)
BZC  A 201 (-3.6A)
0.55A 5ha9B-1efyA:
50.7
5ha9B-1efyA:
86.86