SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BYR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 12 TYR A 110
GLY A 210
VAL A 160
TRP A 205
GLY A  11
 None
None
BYR  A 163 ( 4.8A)
None
None
 1.22A 1kiaB-4wr4A:
undetectable		 1kiaB-4wr4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 11 ILE A  71
ILE A  74
GLY A  11
LEU A   4
TYR A  27
 None
BYR  A  73 ( 4.3A)
None
BYR  A  57 ( 4.4A)
None
 1.09A 2azyA-4wr4A:
undetectable		 2azyA-4wr4A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 9 LEU A   4
GLY A   5
ILE A  74
VAL A  13
THR A  16
 BYR  A  57 ( 4.4A)
BYR  A  32 ( 4.5A)
BYR  A  73 ( 4.3A)
None
None
 1.16A 4x3mA-4wr4A:
undetectable		 4x3mA-4wr4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 9 LEU A   4
GLY A   5
ILE A  74
VAL A  13
THR A  16
 BYR  A  57 ( 4.4A)
BYR  A  32 ( 4.5A)
BYR  A  73 ( 4.3A)
None
None
 1.15A 4x3mB-4wr4A:
undetectable		 4x3mB-4wr4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 8 THR A  16
PRO A  15
ILE A  70
PRO A  55
 None
None
BYR  A  57 ( 3.8A)
GSH  A 301 (-4.5A)
 1.02A 6a4iA-4wr4A:
2.1		 6a4iA-4wr4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 12 LEU A 169
ALA A 157
LEU A 142
LEU A 129
LEU A 175
 None
None
BYR  A 141 ( 4.3A)
None
None
 0.97A 6f6iA-4wr4A:
undetectable
6f6iB-4wr4A:
undetectable		 6f6iA-4wr4A:
14.96
6f6iB-4wr4A:
14.71