SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BX7'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
VAL A  68
ASN A 140
THR A 156
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
None
IOD  A 402 ( 3.4A)
 0.57A 1fmoE-4eutA:
21.7		 1fmoE-4eutA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
VAL A  68
ASN A 140
THR A 156
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
None
IOD  A 402 ( 3.4A)
BX7  A 401 ( 3.7A)
 0.74A 1fmoE-4eutA:
21.7		 1fmoE-4eutA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
VAL A  68
THR A 156
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
IOD  A 402 ( 3.5A)
BX7  A 401 (-3.6A)
 0.65A 1fmoE-4euuA:
26.3		 1fmoE-4euuA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
VAL A  68
ASN A 140
THR A 156
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
None
IOD  A 402 ( 3.5A)
BX7  A 401 (-3.6A)
 0.74A 1fmoE-4euuA:
26.3		 1fmoE-4euuA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.64A 1iepA-4eutA:
11.2		 1iepA-4eutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.60A 1iepA-4euuA:
15.8		 1iepA-4euuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 6 LYS A  38
VAL A  58
VAL A  68
ARG A 134
 BX7  A 401 ( 4.0A)
None
None
None
 1.12A 1iepA-4eutA:
11.2		 1iepA-4eutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.59A 1iepB-4eutA:
11.6		 1iepB-4eutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.55A 1iepB-4euuA:
21.3		 1iepB-4euuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 VAL A  23
ALA A  36
GLU A  55
VAL A  68
PHE A  88
GLY A  92
 BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.72A 1opjB-4eutA:
11.8		 1opjB-4eutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 VAL A  23
ALA A  36
GLU A  55
VAL A  68
PHE A  88
GLY A  92
 BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.71A 1opjB-4euuA:
15.4		 1opjB-4euuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 6 LEU A  15
LYS A  38
VAL A  58
ARG A 134
 BX7  A 401 (-3.7A)
BX7  A 401 ( 4.0A)
None
None
 0.97A 1opjB-4eutA:
11.8		 1opjB-4eutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 (-3.5A)
 0.48A 1t46A-4eutA:
19.6		 1t46A-4eutA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
VAL A  68
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
None
BX7  A 401 (-3.3A)
 0.65A 1t46A-4euuA:
16.2		 1t46A-4euuA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 ALA A  36
GLU A  55
LEU A  59
CYH A  89
LEU A 126
HIS A 133
 BX7  A 401 (-3.4A)
None
None
BX7  A 401 (-4.1A)
None
None
 0.67A 1uwhA-4eutA:
20.5		 1uwhA-4eutA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 ALA A  36
GLU A  55
LEU A  59
CYH A  89
LEU A 126
HIS A 133
 BX7  A 401 (-3.4A)
None
None
BX7  A 401 (-4.1A)
None
None
 0.64A 1uwhA-4euuA:
13.8		 1uwhA-4euuA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 ALA A  36
LYS A  38
GLU A  55
LEU A  59
CYH A  89
LEU A 126
HIS A 133
 BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 (-4.1A)
None
None
 0.70A 1uwhB-4eutA:
20.5		 1uwhB-4eutA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 ALA A  36
LYS A  38
GLU A  55
LEU A  59
CYH A  89
LEU A 126
HIS A 133
 BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 (-4.1A)
None
None
 0.66A 1uwhB-4euuA:
13.8		 1uwhB-4euuA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		5 / 9 LEU A  15
VAL A  23
LYS A  38
LEU A  70
LEU A  84
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 ( 4.0A)
None
None
 0.73A 1xkkA-4eutA:
11.1		 1xkkA-4eutA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
ASN A 140
MET A 142
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 (-3.9A)
BX7  A 401 ( 3.7A)
 0.74A 2fumA-4eutA:
13.9		 2fumA-4eutA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
ASN A 140
MET A 142
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 (-3.9A)
BX7  A 401 ( 3.7A)
 0.76A 2fumB-4eutA:
13.9		 2fumB-4eutA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
MET A  86
ASN A 140
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 (-4.5A)
None
BX7  A 401 ( 3.7A)
 0.61A 2fumB-4eutA:
13.9		 2fumB-4eutA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
MET A  86
LYS A 137
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.7A)
None
BX7  A 401 (-3.6A)
 0.84A 2fumB-4euuA:
25.8		 2fumB-4euuA:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
MET A  86
ASN A 140
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.7A)
None
 0.79A 2fumC-4euuA:
24.4		 2fumC-4euuA:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
GLY A  16
GLY A  18
VAL A  23
ALA A  36
ASN A 140
MET A 142
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-3.5A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 (-3.9A)
BX7  A 401 ( 3.7A)
 1.12A 2fumD-4eutA:
13.0		 2fumD-4eutA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
GLY A  16
GLY A  18
VAL A  23
ALA A  36
LYS A 137
ASN A 140
MET A 142
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-3.5A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
None
BX7  A 401 (-3.9A)
 1.02A 2fumD-4eutA:
13.0		 2fumD-4eutA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
MET A  86
LYS A 137
ASN A 140
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 (-4.5A)
None
None
 0.69A 2fumD-4eutA:
13.0		 2fumD-4eutA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
GLY A  18
VAL A  23
ALA A  36
LYS A 137
MET A 142
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 (-3.7A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
BX7  A 401 (-4.0A)
 0.94A 2fumD-4euuA:
24.3		 2fumD-4euuA:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
GLY A  18
VAL A  23
ALA A  36
MET A  86
LYS A 137
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 (-3.7A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.7A)
None
 0.76A 2fumD-4euuA:
24.3		 2fumD-4euuA:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		5 / 6 LEU A  15
LYS A  38
VAL A  58
VAL A  68
ARG A 134
 BX7  A 401 (-3.7A)
BX7  A 401 ( 4.0A)
None
None
None
 1.06A 2hyyA-4eutA:
12.2		 2hyyA-4eutA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 6 LEU A  15
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.5A)
None
None
 0.72A 2hyyA-4euuA:
15.8		 2hyyA-4euuA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 6 LEU A  15
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 (-3.7A)
BX7  A 401 ( 4.0A)
None
None
 0.73A 2hyyB-4eutA:
11.4		 2hyyB-4eutA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 6 LEU A  15
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.5A)
None
None
 0.70A 2hyyB-4euuA:
21.6		 2hyyB-4euuA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
LYS A  38
GLU A  55
LEU A  59
LEU A  84
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
None
None
 0.66A 2ivuA-4euuA:
18.3		 2ivuA-4euuA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
GLY A  16
ALA A  36
LYS A  38
VAL A  68
PHE A  88
CYH A  89
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
 0.69A 3c7qA-4eutA:
18.9		 3c7qA-4eutA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
ALA A  36
LYS A  38
PHE A  88
CYH A  89
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
 0.72A 3c7qA-4euuA:
17.2		 3c7qA-4euuA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
ALA A  36
VAL A  68
PHE A  88
CYH A  89
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
 0.41A 3c7qA-4euuA:
17.2		 3c7qA-4euuA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		5 / 10 LEU A  15
VAL A  23
LYS A  38
VAL A  68
PHE A  88
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 ( 4.6A)
 0.64A 3cs9A-4eutA:
11.0		 3cs9A-4eutA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		5 / 10 LEU A  15
VAL A  23
LYS A  38
VAL A  68
PHE A  88
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
BX7  A 401 ( 4.6A)
 0.64A 3cs9A-4euuA:
21.4		 3cs9A-4euuA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		5 / 12 ALA A  36
GLU A  55
VAL A  58
PHE A  88
GLY A  92
 BX7  A 401 (-3.4A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.65A 3cs9D-4eutA:
12.1		 3cs9D-4eutA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		5 / 12 ALA A  36
GLU A  55
VAL A  58
PHE A  88
GLY A  92
 BX7  A 401 (-3.4A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.46A 3cs9D-4euuA:
4.0		 3cs9D-4euuA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		9 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
MET A  86
SER A  93
ASN A 140
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
BX7  A 401 (-3.7A)
BX7  A 401 ( 4.7A)
None
BX7  A 401 (-3.6A)
 0.83A 3eygA-4euuA:
16.7		 3eygA-4euuA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
MET A  86
SER A  93
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
BX7  A 401 (-3.7A)
BX7  A 401 ( 4.7A)
BX7  A 401 (-3.6A)
 0.74A 3fupA-4euuA:
14.4		 3fupA-4euuA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
GLY A  16
GLY A  18
VAL A  23
ALA A  36
LYS A  38
VAL A  68
MET A  86
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 (-3.7A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-3.7A)
 0.60A 3fupB-4euuA:
16.8		 3fupB-4euuA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 11 LEU A  15
VAL A  23
ALA A  36
VAL A  68
CYH A  89
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
 0.28A 3g0eA-4eutA:
18.6		 3g0eA-4eutA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 11 LEU A  15
VAL A  23
ALA A  36
VAL A  68
CYH A  89
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
 0.29A 3g0eA-4euuA:
2.8		 3g0eA-4euuA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 6 LEU A  15
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 (-3.7A)
BX7  A 401 ( 4.0A)
None
None
 0.71A 3k5vA-4eutA:
19.0		 3k5vA-4eutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 6 LEU A  15
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.5A)
None
None
 0.70A 3k5vA-4euuA:
15.5		 3k5vA-4euuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 6 LEU A  15
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 (-3.7A)
BX7  A 401 ( 4.0A)
None
None
 0.67A 3k5vB-4eutA:
18.6		 3k5vB-4eutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 6 LEU A  15
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.5A)
None
None
 0.66A 3k5vB-4euuA:
20.9		 3k5vB-4euuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 8 ALA A  36
LYS A  38
GLU A  55
LEU A  84
 BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
 0.34A 3lfaA-4euuA:
16.5		 3lfaA-4euuA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
VAL A  68
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 ( 3.7A)
 0.66A 3lxkA-4eutA:
22.3		 3lxkA-4eutA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
VAL A  68
MET A  86
 BX7  A 401 (-3.7A)
BX7  A 401 ( 3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.5A)
 0.66A 3lxkA-4eutA:
22.3		 3lxkA-4eutA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
VAL A  68
MET A  86
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-3.7A)
BX7  A 401 (-3.6A)
 0.68A 3lxkA-4euuA:
25.4		 3lxkA-4euuA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.58A 3ms9B-4eutA:
11.5		 3ms9B-4eutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.52A 3ms9B-4euuA:
21.3		 3ms9B-4euuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.62A 3mssB-4eutA:
12.5		 3mssB-4eutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.57A 3mssB-4euuA:
16.0		 3mssB-4euuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 6 VAL A  23
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 (-4.4A)
BX7  A 401 ( 4.0A)
None
None
 0.65A 3mssD-4eutA:
10.4		 3mssD-4eutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 6 VAL A  23
LYS A  38
VAL A  58
VAL A  68
 BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
None
 0.62A 3mssD-4euuA:
21.3		 3mssD-4euuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		5 / 12 VAL A  23
ALA A  36
LYS A  38
LEU A  59
CYH A  89
 BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-4.1A)
 0.77A 3og7A-4euuA:
17.2		 3og7A-4euuA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 GLY A  16
VAL A  23
ALA A  36
LYS A  38
LEU A  59
GLY A  92
 BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-3.3A)
 0.84A 3ohtB-4euuA:
2.5		 3ohtB-4euuA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.78A 3pyyA-4eutA:
12.3		 3pyyA-4eutA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.77A 3pyyA-4euuA:
21.2		 3pyyA-4euuA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  84
MET A  86
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.5A)
BX7  A 401 (-3.5A)
 0.75A 3ug2A-4eutA:
15.0		 3ug2A-4eutA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 8 VAL A  23
LYS A  38
MET A 142
ASP A 157
 BX7  A 401 (-4.4A)
BX7  A 401 ( 4.0A)
BX7  A 401 (-3.9A)
BX7  A 401 ( 3.7A)
 0.72A 3warA-4eutA:
11.1		 3warA-4eutA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 8 VAL A  23
LYS A  38
MET A 142
ASP A 157
 BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
BX7  A 401 (-4.0A)
BX7  A 401 (-3.6A)
 0.61A 3warA-4euuA:
16.2		 3warA-4euuA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
LEU A  59
CYH A  89
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
None
BX7  A 401 (-4.1A)
 0.59A 3wzdA-4eutA:
12.8		 3wzdA-4eutA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
LEU A  59
CYH A  89
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
 0.49A 3wzdA-4eutA:
12.8		 3wzdA-4eutA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
GLU A  55
LEU A  59
CYH A  89
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
 0.57A 3wzdA-4euuA:
17.3		 3wzdA-4euuA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		9 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
PHE A  88
LEU A 126
HIS A 133
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 ( 4.6A)
None
None
 0.59A 3wzeA-4eutA:
19.7		 3wzeA-4eutA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		9 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  59
PHE A  88
GLY A  92
LEU A 126
HIS A 133
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
None
 0.64A 3wzeA-4eutA:
19.7		 3wzeA-4eutA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		9 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
PHE A  88
GLY A  92
LEU A 126
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
None
 0.49A 3wzeA-4euuA:
22.0		 3wzeA-4euuA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		9 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  59
PHE A  88
GLY A  92
LEU A 126
HIS A 133
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
None
None
 0.56A 3wzeA-4euuA:
22.0		 3wzeA-4euuA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
ALA A  36
LYS A  38
GLU A  55
LEU A 126
HIS A 133
ARG A 134
 BX7  A 401 (-3.7A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
None
None
 0.70A 3zosA-4eutA:
10.8		 3zosA-4eutA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
ALA A  36
LYS A  38
GLU A  55
LEU A 126
HIS A 133
ARG A 134
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
None
SEP  A 172 ( 2.7A)
 0.71A 3zosA-4euuA:
14.0		 3zosA-4euuA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
VAL A  68
PHE A  88
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.60A 4ag8A-4eutA:
19.7		 4ag8A-4eutA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
VAL A  68
PHE A  88
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.53A 4ag8A-4euuA:
22.1		 4ag8A-4euuA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 (-3.5A)
 0.51A 4agcA-4eutA:
19.3		 4agcA-4eutA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 (-3.3A)
 0.43A 4agcA-4euuA:
21.6		 4agcA-4euuA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 11 LEU A  15
ALA A  36
VAL A  68
PHE A  88
CYH A  89
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
 0.40A 4agdA-4eutA:
12.0		 4agdA-4eutA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 11 LEU A  15
ALA A  36
VAL A  68
PHE A  88
CYH A  89
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
 0.41A 4agdA-4euuA:
21.2		 4agdA-4euuA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		10 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
PHE A  88
GLY A  92
LEU A 126
HIS A 133
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
None
 0.68A 4asdA-4eutA:
19.4		 4asdA-4eutA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		10 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  59
PHE A  88
GLY A  92
LEU A 126
HIS A 133
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
None
None
 0.61A 4asdA-4euuA:
21.8		 4asdA-4euuA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  84
MET A  86
GLY A  92
THR A 156
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.5A)
BX7  A 401 (-3.5A)
IOD  A 402 ( 3.4A)
 0.79A 4i22A-4eutA:
19.1		 4i22A-4eutA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  84
MET A  86
GLY A  92
THR A 156
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-3.7A)
BX7  A 401 (-3.3A)
IOD  A 402 ( 3.5A)
 0.79A 4i22A-4euuA:
16.2		 4i22A-4euuA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		5 / 7 GLY A  16
ALA A  36
CYH A  89
ASN A 140
ASP A 157
 BX7  A 401 ( 3.7A)
BX7  A 401 (-3.4A)
BX7  A 401 (-4.1A)
None
BX7  A 401 ( 3.7A)
 0.53A 4ogrE-4eutA:
14.6		 4ogrE-4eutA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		5 / 7 GLY A  16
ALA A  36
CYH A  89
ASN A 140
ASP A 157
 BX7  A 401 ( 3.8A)
BX7  A 401 (-3.4A)
BX7  A 401 (-4.1A)
None
BX7  A 401 (-3.6A)
 0.83A 4ogrE-4euuA:
19.5		 4ogrE-4euuA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		5 / 12 VAL A  23
ALA A  36
LYS A  38
CYH A  89
PHE A 158
 BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
BX7  A 401 (-4.1A)
None
 0.85A 4rzvB-4eutA:
20.0		 4rzvB-4eutA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 VAL A  23
ALA A  36
LYS A  38
CYH A  89
SER A  93
PHE A 158
 BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
BX7  A 401 (-4.1A)
BX7  A 401 ( 4.7A)
None
 1.11A 4rzvB-4euuA:
18.8		 4rzvB-4euuA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
PHE A  88
GLY A  92
ASN A 140
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
BX7  A 401 ( 3.7A)
 0.68A 4twpA-4eutA:
21.1		 4twpA-4eutA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
PHE A  88
GLY A  92
ASN A 140
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
BX7  A 401 ( 3.7A)
 0.79A 4twpB-4eutA:
14.1		 4twpB-4eutA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 10 LEU A  15
VAL A  23
LEU A  62
ILE A  67
VAL A  68
ARG A 134
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
None
None
None
None
 0.88A 4u0iA-4eutA:
19.2		 4u0iA-4eutA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 ALA A  36
LYS A  38
LEU A  59
CYH A  89
GLY A  92
HIS A 133
 BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
None
 0.64A 4u0iA-4eutA:
19.3		 4u0iA-4eutA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 ALA A  36
LYS A  38
LEU A  59
CYH A  89
GLY A  92
HIS A 133
 BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
None
 0.60A 4u0iA-4euuA:
21.6		 4u0iA-4euuA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 VAL A  23
ALA A  36
LYS A  38
CYH A  89
ASP A 157
PHE A 158
 BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
BX7  A 401 (-4.1A)
BX7  A 401 ( 3.7A)
None
 0.56A 4xv2A-4eutA:
13.8		 4xv2A-4eutA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 VAL A  23
ALA A  36
LYS A  38
CYH A  89
ASP A 157
PHE A 158
 BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.6A)
None
 0.69A 4xv2A-4euuA:
17.2		 4xv2A-4euuA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 ALA A  36
LYS A  38
LEU A  59
CYH A  89
ASP A 157
PHE A 158
 BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.1A)
BX7  A 401 ( 3.7A)
None
 0.66A 4xv2B-4eutA:
21.1		 4xv2B-4eutA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 ALA A  36
LYS A  38
LEU A  59
CYH A  89
ASP A 157
PHE A 158
 BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.6A)
None
 0.77A 4xv2B-4euuA:
23.4		 4xv2B-4euuA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
ALA A  36
LYS A  38
PHE A  88
CYH A  89
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
 0.83A 5ajqA-4eutA:
20.3		 5ajqA-4eutA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
ALA A  36
PHE A  88
CYH A  89
GLY A  92
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
BX7  A 401 (-3.6A)
 0.75A 5ajqA-4euuA:
17.1		 5ajqA-4euuA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 VAL A  23
ALA A  36
LYS A  38
LEU A  59
CYH A  89
PHE A 158
 BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.1A)
None
 0.68A 5cswA-4eutA:
20.7		 5cswA-4eutA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 VAL A  23
ALA A  36
LYS A  38
LEU A  59
CYH A  89
PHE A 158
 BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-4.1A)
None
 0.73A 5cswA-4euuA:
22.9		 5cswA-4euuA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 VAL A  23
ALA A  36
LYS A  38
LEU A  59
CYH A  89
PHE A 158
 BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.1A)
None
 0.80A 5cswB-4eutA:
13.9		 5cswB-4eutA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 VAL A  23
ALA A  36
LYS A  38
LEU A  59
CYH A  89
PHE A 158
 BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-4.1A)
None
 0.84A 5cswB-4euuA:
17.4		 5cswB-4euuA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 ALA A  36
GLU A  55
LEU A  59
CYH A  89
LEU A 126
HIS A 133
 BX7  A 401 (-3.4A)
None
None
BX7  A 401 (-4.1A)
None
None
 0.73A 5hi2A-4eutA:
20.8		 5hi2A-4eutA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 ALA A  36
LYS A  38
GLU A  55
LEU A  59
CYH A  89
LEU A 126
 BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 (-4.1A)
None
 0.66A 5hi2A-4eutA:
20.8		 5hi2A-4eutA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 ALA A  36
GLU A  55
LEU A  59
CYH A  89
LEU A 126
HIS A 133
 BX7  A 401 (-3.4A)
None
None
BX7  A 401 (-4.1A)
None
None
 0.71A 5hi2A-4euuA:
14.5		 5hi2A-4euuA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 ALA A  36
LYS A  38
GLU A  55
LEU A  59
CYH A  89
LEU A 126
 BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 (-4.1A)
None
 0.59A 5hi2A-4euuA:
14.5		 5hi2A-4euuA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 7 GLY A  16
GLY A  18
VAL A  23
LYS A  38
 BX7  A 401 ( 3.7A)
BX7  A 401 (-3.5A)
BX7  A 401 (-4.4A)
BX7  A 401 ( 4.0A)
 0.38A 5izjA-4eutA:
12.7		 5izjA-4eutA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 7 GLY A  16
GLY A  18
VAL A  23
LYS A  38
 BX7  A 401 ( 3.8A)
BX7  A 401 (-3.7A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.32A 5izjA-4euuA:
18.7		 5izjA-4euuA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 7 GLY A  16
GLY A  18
VAL A  23
LYS A  38
 BX7  A 401 ( 3.8A)
BX7  A 401 (-3.7A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.42A 5j5xA-4euuA:
19.9		 5j5xA-4euuA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 GLY A  16
VAL A  23
ALA A  36
VAL A  68
THR A  96
ASP A 157
 BX7  A 401 ( 3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 ( 4.7A)
BX7  A 401 ( 3.7A)
 0.74A 5l2iA-4eutA:
20.4		 5l2iA-4eutA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 10 LEU A  15
VAL A  23
LYS A  38
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.63A 5mo4A-4eutA:
16.3		 5mo4A-4eutA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 10 LEU A  15
VAL A  23
LYS A  38
GLU A  55
PHE A  88
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.52A 5mo4A-4euuA:
15.7		 5mo4A-4euuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 10 LEU A  15
VAL A  23
ALA A  36
VAL A  68
MET A  86
THR A 156
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 (-4.5A)
IOD  A 402 ( 3.4A)
 0.73A 5n3hA-4eutA:
14.2		 5n3hA-4eutA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 10 LEU A  15
VAL A  23
ALA A  36
VAL A  68
MET A  86
THR A 156
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
BX7  A 401 (-3.7A)
IOD  A 402 ( 3.5A)
 0.70A 5n3hA-4euuA:
26.1		 5n3hA-4euuA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 8 ALA A  36
GLU A  55
CYH A  89
ASP A 157
 BX7  A 401 (-3.4A)
None
BX7  A 401 (-4.1A)
BX7  A 401 ( 3.7A)
 0.47A 5owrA-4eutA:
16.2		 5owrA-4eutA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 8 ALA A  36
GLU A  55
CYH A  89
ASP A 157
 BX7  A 401 (-3.4A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.6A)
 0.38A 5owrA-4euuA:
20.1		 5owrA-4euuA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 5 LEU A  15
VAL A  23
MET A  86
CYH A  89
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-4.5A)
BX7  A 401 (-4.1A)
 0.83A 5te0A-4eutA:
21.6		 5te0A-4eutA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 5 LEU A  15
VAL A  23
MET A  86
CYH A  89
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.7A)
BX7  A 401 (-4.1A)
 0.64A 5te0A-4euuA:
24.7		 5te0A-4euuA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
ALA A  36
LYS A  38
GLU A  55
VAL A  68
LEU A  84
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
None
BX7  A 401 (-3.5A)
 0.94A 5vcvA-4eutA:
20.9		 5vcvA-4eutA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
ALA A  36
LYS A  38
GLU A  55
VAL A  68
LEU A  84
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
None
BX7  A 401 (-3.3A)
 0.92A 5vcvA-4euuA:
23.3		 5vcvA-4euuA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  84
CYH A  89
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
 1.12A 5vcyA-4eutA:
20.7		 5vcyA-4eutA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
LEU A  84
CYH A  89
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
 1.07A 5vcyA-4euuA:
23.3		 5vcyA-4euuA:
25.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		9 / 9 LEU A  15
ALA A  36
VAL A  68
MET A  86
CYH A  89
GLY A  92
THR A  96
MET A 142
THR A 156
 BX7  A 401 (-3.7A)
BX7  A 401 (-3.4A)
None
BX7  A 401 (-4.5A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
BX7  A 401 ( 4.7A)
BX7  A 401 (-3.9A)
IOD  A 402 ( 3.4A)
 0.58A 5w5vA-4eutA:
27.5		 5w5vA-4eutA:
70.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		9 / 9 LEU A  15
ALA A  36
VAL A  68
MET A  86
CYH A  89
GLY A  92
THR A  96
MET A 142
THR A 156
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.4A)
None
BX7  A 401 (-3.7A)
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
BX7  A 401 ( 4.5A)
BX7  A 401 (-4.0A)
IOD  A 402 ( 3.5A)
 0.59A 5w5vA-4euuA:
24.0		 5w5vA-4euuA:
56.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
CYH A  89
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
 0.72A 5y7zA-4eutA:
20.5		 5y7zA-4eutA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
CYH A  89
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
 0.72A 5y7zA-4eutA:
20.5		 5y7zA-4eutA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
CYH A  89
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
 0.63A 5y7zA-4euuA:
16.5		 5y7zA-4euuA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
CYH A  89
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
 0.63A 5y7zA-4euuA:
16.5		 5y7zA-4euuA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
ALA A  36
LYS A  38
GLU A  55
LEU A  84
CYH A  89
GLY A  92
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
BX7  A 401 ( 3.7A)
 0.85A 5y7zB-4eutA:
20.6		 5y7zB-4eutA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
ALA A  36
LYS A  38
GLU A  55
LEU A  84
CYH A  89
GLY A  92
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
BX7  A 401 (-3.6A)
 0.72A 5y7zB-4euuA:
10.7		 5y7zB-4euuA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
CYH A  89
GLY A  92
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
BX7  A 401 ( 3.7A)
 0.72A 5y80A-4eutA:
20.6		 5y80A-4eutA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
CYH A  89
GLY A  92
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
BX7  A 401 (-3.6A)
 0.60A 5y80A-4euuA:
22.6		 5y80A-4euuA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-3.5A)
 0.34A 5zv2B-4eutA:
19.1		 5zv2B-4eutA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-3.3A)
 0.29A 5zv2B-4euuA:
21.1		 5zv2B-4euuA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 6 LEU A  15
VAL A  58
PHE A  88
GLY A  92
 BX7  A 401 (-3.7A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.57A 6hd4B-4eutA:
18.6		 6hd4B-4eutA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		4 / 6 LEU A  15
VAL A  58
PHE A  88
GLY A  92
 BX7  A 401 (-3.9A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.53A 6hd4B-4euuA:
15.0		 6hd4B-4euuA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
VAL A  68
PHE A  88
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 ( 4.6A)
 0.78A 6hd6B-4eutA:
18.3		 6hd6B-4eutA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
VAL A  68
PHE A  88
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 ( 4.6A)
 0.71A 6hd6B-4euuA:
20.8		 6hd6B-4euuA:
16.79