SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BVP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		3 / 3 ASP A 148
ARG A 143
ILE A  65
 None
None
BVP  A 500 ( 4.2A)
 0.90A 1a4gB-1osnA:
undetectable		 1a4gB-1osnA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.03A 1axwA-4xscA:
36.4		 1axwA-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.69A 1axwA-4xscA:
36.4		 1axwA-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.79A 1axwB-4xscA:
36.5		 1axwB-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
TRP A  97
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.93A 1axwB-4xscA:
36.5		 1axwB-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.83A 1b02A-4xscA:
31.4		 1b02A-4xscA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.95A 1b02A-4xscA:
31.4		 1b02A-4xscA:
34.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 12 PHE A  68
GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.63A 1hvyA-4xscA:
40.7		 1hvyA-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 PHE A  68
GLU A  75
ILE A  96
TRP A  97
PHE A 213
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.75A 1hvyA-4xscA:
40.7		 1hvyA-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.57A 1hvyB-4xscA:
40.8		 1hvyB-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.68A 1hvyB-4xscA:
40.8		 1hvyB-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 11 PHE A  68
GLU A  75
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.49A 1hvyC-4xscA:
40.7		 1hvyC-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 11 PHE A  68
GLU A  75
ILE A  96
TRP A  97
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.71A 1hvyC-4xscA:
40.7		 1hvyC-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 11 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.60A 1hvyC-4xscA:
40.7		 1hvyC-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.53A 1hvyD-4xscA:
40.7		 1hvyD-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  75
ILE A  96
LEU A 180
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.74A 1hvyD-4xscA:
40.7		 1hvyD-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 180
PHE A 213
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
1PE  A1002 (-3.8A)
 0.74A 1hvyD-4xscA:
40.7		 1hvyD-4xscA:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 9 PHE A  68
GLU A  75
ILE A  96
TRP A  97
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.54A 1i00A-4xscA:
40.6		 1i00A-4xscA:
64.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 9 PHE A  68
TRP A  97
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 None
1PE  A1002 (-4.7A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.78A 1i00A-4xscA:
40.6		 1i00A-4xscA:
64.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 9 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.43A 1i00B-4xscA:
24.2		 1i00B-4xscA:
64.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 9 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.67A 1i00B-4xscA:
24.2		 1i00B-4xscA:
64.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.91A 1ju6A-4xscA:
40.0		 1ju6A-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.53A 1ju6A-4xscA:
40.0		 1ju6A-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 PHE A  68
ILE A  96
TRP A  97
GLY A 210
PHE A 213
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
 1.10A 1ju6A-4xscA:
40.0		 1ju6A-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 9 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.55A 1ju6B-4xscA:
40.0		 1ju6B-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.89A 1ju6C-4xscA:
40.0		 1ju6C-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.54A 1ju6C-4xscA:
40.0		 1ju6C-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.54A 1ju6D-4xscA:
40.0		 1ju6D-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 PHE A  68
ILE A  96
TRP A  97
GLY A 210
TYR A 246
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.89A 1ju6D-4xscA:
40.0		 1ju6D-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.97A 1jujA-4xscA:
39.0		 1jujA-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.49A 1jujA-4xscA:
39.0		 1jujA-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.97A 1jujB-4xscA:
39.0		 1jujB-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.50A 1jujB-4xscA:
39.0		 1jujB-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.97A 1jujC-4xscA:
39.0		 1jujC-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.49A 1jujC-4xscA:
39.0		 1jujC-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.97A 1jujD-4xscA:
39.0		 1jujD-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.49A 1jujD-4xscA:
39.0		 1jujD-4xscA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI2_A_GA2A1_1
(THYMIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		6 / 11 GLU A  48
ILE A  65
TYR A  66
GLN A  90
ARG A 130
ARG A 143
 BVP  A 500 (-2.5A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
None
 0.88A 1ki2A-1osnA:
34.7		 1ki2A-1osnA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI2_B_GA2B2_1
(THYMIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  48
TRP A  53
ILE A  65
TYR A  66
GLN A  90
ARG A 130
ARG A 143
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
None
 0.81A 1ki2B-1osnA:
34.9		 1ki2B-1osnA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  48
TRP A  53
ILE A  62
ILE A  65
TYR A  66
GLN A  90
ARG A 143
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.5A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
None
 0.96A 1ki3A-1osnA:
34.4		 1ki3A-1osnA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI3_B_PE2B2_1
(THYMIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  48
TRP A  53
ILE A  62
ILE A  65
TYR A  66
GLN A  90
ARG A 143
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.5A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
None
 0.84A 1ki3B-1osnA:
35.1		 1ki3B-1osnA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  48
TRP A  53
ILE A  62
ILE A  65
TYR A  66
GLN A  90
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.5A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
 0.64A 1ki7A-1osnA:
34.3		 1ki7A-1osnA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
ILE A  62
ILE A  65
ARG A 130
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.5A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-2.8A)
 0.79A 1ki7B-1osnA:
35.1		 1ki7B-1osnA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
ILE A  65
GLN A  90
ARG A 130
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
 0.61A 1ki7B-1osnA:
35.1		 1ki7B-1osnA:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		4 / 7 THR A 239
ASN A 214
TYR A 218
LEU A 236
 None
BVP  A1001 (-2.8A)
None
None
 1.09A 1qzrA-4xscA:
undetectable		 1qzrA-4xscA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		4 / 7 THR A 239
ASN A 214
TYR A 218
LEU A 236
 None
BVP  A1001 (-2.8A)
None
None
 1.03A 1qzrB-4xscA:
undetectable		 1qzrB-4xscA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		4 / 8 ASP A 206
LEU A 209
GLY A 210
TYR A 246
 None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.71A 1rtsA-4xscA:
40.9		 1rtsA-4xscA:
65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 8 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.48A 1rtsA-4xscA:
40.9		 1rtsA-4xscA:
65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 7 ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.51A 1rtsB-4xscA:
40.7		 1rtsB-4xscA:
65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.12A 1tlsA-4xscA:
36.3		 1tlsA-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.81A 1tlsA-4xscA:
36.3		 1tlsA-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.08A 1tlsB-4xscA:
36.5		 1tlsB-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.72A 1tlsB-4xscA:
36.5		 1tlsB-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
TRP A  97
LEU A 180
GLY A 210
PHE A 213
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
 1.05A 1tlsB-4xscA:
36.5		 1tlsB-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.07A 1tsnA-4xscA:
36.4		 1tsnA-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.74A 1tsnA-4xscA:
36.4		 1tsnA-4xscA:
40.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
ALA A 134
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.9A)
BVP  A 500 (-3.7A)
 1.38A 2jj8B-1osnA:
13.4		 2jj8B-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
ARG A 130
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-2.8A)
BVP  A 500 (-3.7A)
 1.10A 2jj8B-1osnA:
13.4		 2jj8B-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 TRP A  53
TYR A  66
GLN A  90
ARG A 130
PHE A 139
 BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
BVP  A 500 (-3.7A)
 0.98A 2jj8B-1osnA:
13.4		 2jj8B-1osnA:
23.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
TRP A  97
LEU A 180
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.94A 2kceA-4xscA:
36.5		 2kceA-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 TRP A  97
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.30A 2kceA-4xscA:
36.5		 2kceA-4xscA:
40.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 LEU A 180
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.81A 2kceB-4xscA:
36.5		 2kceB-4xscA:
40.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
ILE A  65
TYR A  66
ARG A 143
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
None
 0.96A 2ki5A-1osnA:
34.4		 2ki5A-1osnA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_A_AC2A1_1
(PROTEIN (THYMIDINE
KINASE))		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		6 / 12 TRP A  53
ILE A  62
ILE A  65
TYR A  66
GLN A  90
ARG A 143
 BVP  A 500 (-4.6A)
BVP  A 500 (-4.5A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
None
 0.71A 2ki5A-1osnA:
34.4		 2ki5A-1osnA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_B_AC2B2_1
(PROTEIN (THYMIDINE
KINASE))		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  48
TRP A  53
ILE A  65
TYR A  66
GLN A  90
ARG A 130
ARG A 143
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
None
 0.98A 2ki5B-1osnA:
35.1		 2ki5B-1osnA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KI5_B_AC2B2_1
(PROTEIN (THYMIDINE
KINASE))		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		7 / 12 TRP A  53
ILE A  62
ILE A  65
TYR A  66
GLN A  90
ARG A 130
ARG A 143
 BVP  A 500 (-4.6A)
BVP  A 500 (-4.5A)
BVP  A 500 ( 4.2A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
None
 0.60A 2ki5B-1osnA:
35.1		 2ki5B-1osnA:
29.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 7 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.28A 2tsrA-4xscA:
40.8		 2tsrA-4xscA:
65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 10 PHE A  68
GLU A  75
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.39A 2tsrC-4xscA:
40.5		 2tsrC-4xscA:
65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 10 PHE A  68
GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.60A 2tsrC-4xscA:
40.5		 2tsrC-4xscA:
65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 10 PHE A  68
GLU A  75
ILE A  96
TRP A  97
PHE A 213
TYR A 246
 None
1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.77A 2tsrC-4xscA:
40.5		 2tsrC-4xscA:
65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 9 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.56A 2tsrD-4xscA:
24.4		 2tsrD-4xscA:
65.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 9 PHE A  68
ILE A  96
TRP A  97
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.85A 2tsrD-4xscA:
24.4		 2tsrD-4xscA:
65.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
ALA A 134
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.9A)
BVP  A 500 (-3.7A)
 1.23A 2vppA-1osnA:
13.8		 2vppA-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
ARG A 130
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-2.8A)
BVP  A 500 (-3.7A)
 1.01A 2vppA-1osnA:
13.8		 2vppA-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 TRP A  53
TYR A  66
GLN A  90
ARG A 130
PHE A 139
 BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
BVP  A 500 (-3.7A)
 0.93A 2vppA-1osnA:
13.8		 2vppA-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
ALA A 134
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.9A)
BVP  A 500 (-3.7A)
 1.19A 2vppB-1osnA:
13.6		 2vppB-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
ARG A 130
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-2.8A)
BVP  A 500 (-3.7A)
 0.92A 2vppB-1osnA:
13.6		 2vppB-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 TRP A  53
TYR A  66
GLN A  90
ARG A 130
PHE A 139
 BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
BVP  A 500 (-3.7A)
 0.87A 2vppB-1osnA:
13.6		 2vppB-1osnA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
GLN A  90
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-3.7A)
 1.02A 2zi9B-1osnA:
15.7		 2zi9B-1osnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
GLN A  90
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-3.7A)
 0.94A 2ziaA-1osnA:
16.2		 2ziaA-1osnA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TYR A  66
GLN A  90
ARG A 130
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-2.8A)
BVP  A 500 (-3.7A)
 0.98A 2ziaA-1osnA:
16.2		 2ziaA-1osnA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
GLN A  90
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-3.7A)
 0.99A 2ziaB-1osnA:
15.8		 2ziaB-1osnA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2w0s THYMIDYLATE KINASE
(Vaccinia
virus) 		5 / 12 LEU A  53
GLU A 142
ARG A  41
SER A  97
TYR A 101
 BVP  A1207 ( 4.6A)
MG  A1206 (-4.3A)
BVP  A1207 (-3.7A)
BVP  A1207 ( 4.2A)
BVP  A1207 (-3.7A)
 1.40A 3apvB-2w0sA:
undetectable		 3apvB-2w0sA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		3 / 3 SER A  91
GLN A  90
PHE A  93
 None
BVP  A 500 (-3.0A)
BVP  A 500 (-3.5A)
 0.83A 3g4lC-1osnA:
0.0		 3g4lC-1osnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HP1_A_LLTA401_1
(DEOXYCYTIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  48
TRP A  53
TYR A  66
ALA A 134
PHE A 139
 BVP  A 500 (-2.5A)
BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.9A)
BVP  A 500 (-3.7A)
 1.33A 3hp1A-1osnA:
16.0		 3hp1A-1osnA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HP1_A_LLTA401_1
(DEOXYCYTIDINE KINASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 TRP A  53
TYR A  66
GLN A  90
ALA A 134
PHE A 139
 BVP  A 500 (-4.6A)
BVP  A 500 (-4.9A)
BVP  A 500 (-3.0A)
BVP  A 500 (-3.9A)
BVP  A 500 (-3.7A)
 1.31A 3hp1A-1osnA:
16.0		 3hp1A-1osnA:
23.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.82A 3k2hA-4xscA:
9.1		 3k2hA-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.94A 3k2hA-4xscA:
9.1		 3k2hA-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 180
GLY A 210
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
 0.87A 3k2hA-4xscA:
9.1		 3k2hA-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.84A 3k2hB-4xscA:
8.6		 3k2hB-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.95A 3k2hB-4xscA:
8.6		 3k2hB-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
 0.95A 3k2hB-4xscA:
8.6		 3k2hB-4xscA:
33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		4 / 5 ILE A 215
HIS A 238
VAL A 200
HIS A 184
 None
None
None
BVP  A1001 (-4.7A)
 1.44A 3nneA-4xscA:
undetectable		 3nneA-4xscA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_B_ACTB601_0
(CHOLINE OXIDASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		4 / 5 ILE A 215
HIS A 238
VAL A 200
HIS A 184
 None
None
None
BVP  A1001 (-4.7A)
 1.42A 3nneB-4xscA:
undetectable		 3nneB-4xscA:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ALA A  71
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.04A 3nrrA-4xscA:
11.5		 3nrrA-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.64A 3nrrA-4xscA:
11.5		 3nrrA-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.10A 3nrrA-4xscA:
11.5		 3nrrA-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.68A 3nrrA-4xscA:
11.5		 3nrrA-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ALA A  71
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.06A 3nrrB-4xscA:
11.4		 3nrrB-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.64A 3nrrB-4xscA:
11.4		 3nrrB-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.11A 3nrrB-4xscA:
11.4		 3nrrB-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.70A 3nrrB-4xscA:
11.4		 3nrrB-4xscA:
33.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 1.26A 3uwlB-4xscA:
36.6		 3uwlB-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 ILE A  96
LEU A 180
HIS A 184
LEU A 209
GLY A 210
ASN A 214
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-4.7A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 1.23A 3uwlB-4xscA:
36.6		 3uwlB-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.78A 3uwlB-4xscA:
36.6		 3uwlB-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
TYR A 246
 1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.76A 3uwlD-4xscA:
34.5		 3uwlD-4xscA:
41.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 PHE A 139
VAL A 260
TYR A  21
HIS A 180
LEU A 239
 BVP  A 500 (-3.7A)
None
BVP  A 500 ( 4.5A)
None
None
 1.47A 3wfhA-1osnA:
undetectable
3wfhB-1osnA:
undetectable		 3wfhA-1osnA:
20.18
3wfhB-1osnA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		5 / 12 PHE A 139
VAL A 260
TYR A  21
HIS A 180
LEU A 239
 BVP  A 500 (-3.7A)
None
BVP  A 500 ( 4.5A)
None
None
 1.47A 3whxA-1osnA:
undetectable
3whxB-1osnA:
undetectable		 3whxA-1osnA:
20.47
3whxB-1osnA:
19.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 12 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.65A 4eb4A-4xscA:
40.1		 4eb4A-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 PHE A  68
ILE A  96
TRP A  97
PHE A 213
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
 0.70A 4eb4A-4xscA:
40.1		 4eb4A-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 12 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.68A 4eb4B-4xscA:
40.1		 4eb4B-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 PHE A  68
ILE A  96
TRP A  97
PHE A 213
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
 0.72A 4eb4B-4xscA:
40.1		 4eb4B-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 9 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.63A 4eb4C-4xscA:
40.6		 4eb4C-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 10 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.62A 4eb4D-4xscA:
40.5		 4eb4D-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 10 PHE A  68
ILE A  96
TRP A  97
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.74A 4eb4D-4xscA:
40.5		 4eb4D-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.03A 4fogA-4xscA:
36.3		 4fogA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
TRP A  97
LEU A 180
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.74A 4fogA-4xscA:
36.3		 4fogA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 ILE A  96
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.12A 4fogC-4xscA:
36.4		 4fogC-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
TRP A  97
LEU A 180
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.78A 4fogC-4xscA:
36.4		 4fogC-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.12A 4fogD-4xscA:
36.4		 4fogD-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.73A 4fogD-4xscA:
36.4		 4fogD-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.71A 4fogD-4xscA:
36.4		 4fogD-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
LEU A 180
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.75A 4foxA-4xscA:
36.4		 4foxA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 180
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.83A 4foxA-4xscA:
36.4		 4foxA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.14A 4foxA-4xscA:
36.4		 4foxA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.77A 4foxA-4xscA:
36.4		 4foxA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.20A 4foxA-4xscA:
36.4		 4foxA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
LEU A 180
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.72A 4foxB-4xscA:
36.4		 4foxB-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 180
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.77A 4foxB-4xscA:
36.4		 4foxB-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.20A 4foxB-4xscA:
36.4		 4foxB-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.80A 4foxB-4xscA:
36.4		 4foxB-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 GLU A  75
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.82A 4foxC-4xscA:
36.3		 4foxC-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 GLU A  75
TRP A  97
LEU A 180
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.85A 4foxC-4xscA:
36.3		 4foxC-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.22A 4foxC-4xscA:
36.3		 4foxC-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 TRP A  97
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.23A 4foxC-4xscA:
36.3		 4foxC-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.62A 4foxD-4xscA:
36.3		 4foxD-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.99A 4foxD-4xscA:
36.3		 4foxD-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.64A 4foxE-4xscA:
36.5		 4foxE-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
TRP A  97
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.73A 4foxE-4xscA:
36.5		 4foxE-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.08A 4foxE-4xscA:
36.5		 4foxE-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
TRP A  97
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.22A 4foxE-4xscA:
36.5		 4foxE-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 GLU A  75
ILE A  96
LEU A 180
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.85A 4foxF-4xscA:
36.4		 4foxF-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 GLU A  75
ILE A  96
TRP A  97
LEU A 180
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.89A 4foxF-4xscA:
36.4		 4foxF-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.21A 4foxF-4xscA:
36.4		 4foxF-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 ILE A  96
TRP A  97
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.22A 4foxF-4xscA:
36.4		 4foxF-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  75
ILE A  96
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.74A 4foxG-4xscA:
36.5		 4foxG-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 180
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.79A 4foxG-4xscA:
36.5		 4foxG-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.17A 4foxG-4xscA:
36.5		 4foxG-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.20A 4foxG-4xscA:
36.5		 4foxG-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 GLU A  75
ILE A  96
ASP A 206
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.72A 4foxH-4xscA:
36.2		 4foxH-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 GLU A  75
ILE A  96
TRP A  97
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.83A 4foxH-4xscA:
36.2		 4foxH-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.97A 4foxH-4xscA:
36.2		 4foxH-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 ILE A  96
TRP A  97
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 1.18A 4foxH-4xscA:
36.2		 4foxH-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.68A 4fqsA-4xscA:
36.3		 4fqsA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 209
GLY A 210
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
None
BVP  A1001 (-3.4A)
 0.71A 4fqsA-4xscA:
36.3		 4fqsA-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.69A 4fqsB-4xscA:
36.3		 4fqsB-4xscA:
41.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 209
GLY A 210
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
None
BVP  A1001 (-3.4A)
 0.70A 4fqsB-4xscA:
36.3		 4fqsB-4xscA:
41.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		4 / 6 TRP A  53
ILE A  65
THR A  86
ASP A  18
 BVP  A 500 (-4.6A)
BVP  A 500 ( 4.2A)
None
None
 1.11A 4iaqA-1osnA:
1.0		 4iaqA-1osnA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		4 / 7 ASP A 206
LEU A 209
GLY A 210
TYR A 246
 None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.73A 4iqqB-4xscA:
38.6		 4iqqB-4xscA:
56.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 7 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.42A 4iqqB-4xscA:
38.6		 4iqqB-4xscA:
56.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 7 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.37A 4iqqC-4xscA:
38.8		 4iqqC-4xscA:
56.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		4 / 5 LEU A  73
ALA A  82
THR A  86
ILE A  65
 None
None
None
BVP  A 500 ( 4.2A)
 0.86A 4xe3A-1osnA:
undetectable		 4xe3A-1osnA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		4 / 5 LEU A  73
ALA A  82
THR A  86
ILE A  65
 None
None
None
BVP  A 500 ( 4.2A)
 0.92A 4xe3B-1osnA:
undetectable		 4xe3B-1osnA:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.65A 5fctA-4xscA:
40.5		 5fctA-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 PHE A  68
ILE A  96
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 None
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.85A 5fctA-4xscA:
40.5		 5fctA-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 PHE A  68
ILE A  96
TRP A  97
LEU A 180
GLY A 210
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
 0.85A 5fctA-4xscA:
40.5		 5fctA-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 VAL A  67
PHE A  68
ILE A  96
CYH A 183
LEU A 209
TYR A 246
 None
None
1PE  A1002 (-4.6A)
BVP  A1001 (-3.4A)
None
BVP  A1001 (-4.5A)
 0.75A 5fctB-4xscA:
40.6		 5fctB-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 VAL A  67
PHE A  68
ILE A  96
LEU A 180
LEU A 209
TYR A 246
 None
None
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-4.5A)
 0.80A 5fctB-4xscA:
40.6		 5fctB-4xscA:
65.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 VAL A  67
PHE A  68
ILE A  96
TRP A  97
LEU A 180
LEU A 209
 None
None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
 0.81A 5fctB-4xscA:
40.6		 5fctB-4xscA:
65.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2w0s THYMIDYLATE KINASE
(Vaccinia
virus) 		3 / 3 ASP A  13
SER A  97
TYR A 101
 MG  A1206 ( 3.4A)
BVP  A1207 ( 4.2A)
BVP  A1207 (-3.7A)
 0.84A 5glmA-2w0sA:
undetectable		 5glmA-2w0sA:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_A_D16A401_1
(ORF70)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 7 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.40A 5h3aA-4xscA:
39.9		 5h3aA-4xscA:
57.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H3A_B_D16B401_1
(ORF70)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 7 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.44A 5h3aB-4xscA:
39.9		 5h3aB-4xscA:
57.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 GLU A  75
ILE A  96
LEU A 180
LEU A 209
GLY A 210
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
 0.60A 5j7wC-4xscA:
36.5		 5j7wC-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  75
ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.79A 5j7wD-4xscA:
36.5		 5j7wD-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
ASP A 206
LEU A 209
GLY A 210
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.88A 5j7wD-4xscA:
36.5		 5j7wD-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		4 / 7 ASP A 206
LEU A 209
GLY A 210
TYR A 246
 None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.74A 5nooA-4xscA:
39.4		 5nooA-4xscA:
56.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 7 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.31A 5nooA-4xscA:
39.4		 5nooA-4xscA:
56.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		4 / 7 ASP A 206
LEU A 209
GLY A 210
TYR A 246
 None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-4.5A)
 0.74A 5nooB-4xscA:
39.2		 5nooB-4xscA:
56.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 7 ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.37A 5nooB-4xscA:
39.2		 5nooB-4xscA:
56.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 6 ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.69A 5nooC-4xscA:
38.9		 5nooC-4xscA:
56.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		3 / 3 HIS A 244
SER A  45
LYS A  35
 BVP  A1001 (-3.8A)
None
None
 1.46A 5os7A-4xscA:
undetectable		 5os7A-4xscA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 1osn THYMIDINE KINASE
(Human
alphaherpesvirus
3) 		4 / 6 ASP A  18
ARG A 130
LEU A  17
ASP A 129
 None
BVP  A 500 (-2.8A)
None
BVP  A 500 ( 4.9A)
 1.05A 5tdzA-1osnA:
undetectable		 5tdzA-1osnA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 GLU A  75
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.62A 5x5qB-4xscA:
40.6		 5x5qB-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 GLU A  75
ILE A  96
TRP A  97
GLY A 210
PHE A 213
TYR A 246
 1PE  A1002 ( 4.4A)
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.78A 5x5qB-4xscA:
40.6		 5x5qB-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 7 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.47A 5x5qC-4xscA:
41.0		 5x5qC-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 8 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.47A 5x5qD-4xscA:
41.0		 5x5qD-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 8 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.49A 5x5qF-4xscA:
41.5		 5x5qF-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 12 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.50A 5x66A-4xscA:
40.9
5x66B-4xscA:
9.9		 5x66A-4xscA:
69.66
5x66B-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 9 ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.39A 5x66C-4xscA:
40.9		 5x66C-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 10 PHE A  68
ILE A  96
ASP A 206
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.47A 5x66D-4xscA:
41.2		 5x66D-4xscA:
69.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 12 PHE A  68
ILE A  96
ASP A 206
LEU A 209
GLY A 210
PHE A 213
TYR A 246
 None
1PE  A1002 (-4.6A)
None
None
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-4.5A)
 0.48A 5x66F-4xscA:
41.2		 5x66F-4xscA:
69.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		3 / 3 HIS A 244
SER A  45
LYS A  35
 BVP  A1001 (-3.8A)
None
None
 1.46A 6gmdB-4xscA:
undetectable		 6gmdB-4xscA:
23.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 1.29A 6qxsB-4xscA:
34.5		 6qxsB-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
LEU A 180
LEU A 209
GLY A 210
ASN A 214
TYR A 246
 1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.82A 6qxsB-4xscA:
34.5		 6qxsB-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.66A 6qxsB-4xscA:
34.5		 6qxsB-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.55A 6qxsD-4xscA:
34.5		 6qxsD-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
 0.55A 6qyaB-4xscA:
34.1		 6qyaB-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 ILE A  96
LEU A 209
GLY A 210
ASN A 214
TYR A 246
 1PE  A1002 (-4.6A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.51A 6qyaD-4xscA:
34.1		 6qyaD-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.59A 6qyaD-4xscA:
34.1		 6qyaD-4xscA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 PHE A  68
ASP A 206
LEU A 209
GLY A 210
ASN A 214
TYR A 246
 None
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 0.42A 6r2eA-4xscA:
40.0		 6r2eA-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 PHE A  68
ILE A  96
GLY A 210
PHE A 213
ASN A 214
TYR A 246
 None
1PE  A1002 (-4.6A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
BVP  A1001 (-4.5A)
 1.14A 6r2eA-4xscA:
40.0		 6r2eA-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 PHE A  68
ILE A  96
LEU A 180
GLY A 210
PHE A 213
ASN A 214
 None
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
 1.31A 6r2eA-4xscA:
40.0		 6r2eA-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 PHE A  68
ILE A  96
TRP A  97
LEU A 180
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.88A 6r2eA-4xscA:
40.0		 6r2eA-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 PHE A  68
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.95A 6r2eA-4xscA:
40.0		 6r2eA-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 PHE A  68
ASP A 206
LEU A 209
GLY A 210
ASN A 214
 None
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.39A 6r2eB-4xscA:
40.0		 6r2eB-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 10 PHE A  68
ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.94A 6r2eB-4xscA:
40.0		 6r2eB-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 PHE A  68
ASP A 206
LEU A 209
GLY A 210
ASN A 214
 None
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.40A 6r2eC-4xscA:
39.9		 6r2eC-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 10 PHE A  68
ILE A  96
TRP A  97
LEU A 180
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.88A 6r2eC-4xscA:
39.9		 6r2eC-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 10 PHE A  68
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.99A 6r2eC-4xscA:
39.9		 6r2eC-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 10 PHE A  68
ASP A 206
LEU A 209
GLY A 210
ASN A 214
 None
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.40A 6r2eD-4xscA:
40.2		 6r2eD-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 10 PHE A  68
ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.87A 6r2eD-4xscA:
40.2		 6r2eD-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 12 PHE A  68
ILE A  96
LEU A 180
GLY A 210
PHE A 213
ASN A 214
 None
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
 1.32A 6r2eE-4xscA:
39.7		 6r2eE-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 12 PHE A  68
ILE A  96
TRP A  97
TYR A 123
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
None
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.92A 6r2eE-4xscA:
39.7		 6r2eE-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 PHE A  68
ASP A 206
LEU A 209
GLY A 210
ASN A 214
 None
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.40A 6r2eF-4xscA:
39.9		 6r2eF-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 11 PHE A  68
ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.89A 6r2eF-4xscA:
39.9		 6r2eF-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 11 PHE A  68
ASP A 206
LEU A 209
GLY A 210
ASN A 214
 None
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.41A 6r2eG-4xscA:
39.7		 6r2eG-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		6 / 11 PHE A  68
ILE A  96
LEU A 180
GLY A 210
PHE A 213
ASN A 214
 None
1PE  A1002 (-4.6A)
BVP  A1001 ( 4.5A)
BVP  A1001 (-3.4A)
1PE  A1002 (-3.8A)
BVP  A1001 (-2.8A)
 1.32A 6r2eG-4xscA:
39.7		 6r2eG-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		7 / 11 PHE A  68
ILE A  96
TRP A  97
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.94A 6r2eG-4xscA:
39.7		 6r2eG-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		5 / 12 PHE A  68
ASP A 206
LEU A 209
GLY A 210
ASN A 214
 None
None
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.41A 6r2eH-4xscA:
39.9		 6r2eH-4xscA:
65.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 4xsc THYMIDYLATE SYNTHASE
(Human
alphaherpesvirus
3) 		8 / 12 PHE A  68
ILE A  96
TRP A  97
TYR A 123
LEU A 180
LEU A 209
GLY A 210
ASN A 214
 None
1PE  A1002 (-4.6A)
1PE  A1002 (-4.7A)
None
BVP  A1001 ( 4.5A)
None
BVP  A1001 (-3.4A)
BVP  A1001 (-2.8A)
 0.95A 6r2eH-4xscA:
39.9		 6r2eH-4xscA:
65.94