SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BUP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		3 / 3 LYS A 172
ASP A 233
ASP A 359
 BUP  A 464 ( 4.9A)
None
None
 1.17A 2br4A-3n6nA:
undetectable		 2br4A-3n6nA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		3 / 3 THR A 373
ASP A 329
SER A 299
 None
BUP  A 464 ( 4.1A)
None
 0.82A 2nxeA-3n6nA:
undetectable		 2nxeA-3n6nA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		3 / 3 THR A 373
ASP A 329
SER A 299
 None
BUP  A 464 ( 4.1A)
None
 0.84A 2nxeB-3n6nA:
undetectable		 2nxeB-3n6nA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		7 / 9 ASP A 238
SER A 289
ASN A 298
TYR A 327
GLY A 328
ASP A 329
ASP A 330
 BUP  A 464 (-3.2A)
BUP  A 464 (-3.0A)
None
None
None
BUP  A 464 ( 4.1A)
None
 1.00A 3sfuA-3n6nA:
30.4		 3sfuA-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		5 / 9 THR A 294
TYR A 327
GLY A 328
ASP A 329
ASP A 330
 None
None
None
BUP  A 464 ( 4.1A)
None
 0.58A 3sfuA-3n6nA:
30.4		 3sfuA-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		7 / 9 ASP A 238
ASN A 298
TYR A 327
GLY A 328
ASP A 329
ASP A 330
LEU A 375
 BUP  A 464 (-3.2A)
None
None
None
BUP  A 464 ( 4.1A)
None
None
 0.53A 3sfuB-3n6nA:
30.5		 3sfuB-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		5 / 11 ASP A 238
SER A 289
ASN A 298
GLY A 328
ASP A 329
 BUP  A 464 (-3.2A)
BUP  A 464 (-3.0A)
None
None
BUP  A 464 ( 4.1A)
 1.04A 3sfuC-3n6nA:
30.6		 3sfuC-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		6 / 11 LYS A 159
ARG A 174
ASP A 238
ASN A 298
GLY A 328
ASP A 329
 BUP  A 464 (-3.8A)
BUP  A 464 (-3.8A)
BUP  A 464 (-3.2A)
None
None
BUP  A 464 ( 4.1A)
 0.63A 3sfuC-3n6nA:
30.6		 3sfuC-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		6 / 11 LYS A 159
ARG A 174
ASP A 238
THR A 294
GLY A 328
ASP A 329
 BUP  A 464 (-3.8A)
BUP  A 464 (-3.8A)
BUP  A 464 (-3.2A)
None
None
BUP  A 464 ( 4.1A)
 0.64A 3sfuC-3n6nA:
30.6		 3sfuC-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		4 / 7 LYS A 346
LEU A 342
THR A 354
SER A 235
 None
None
None
BUP  A 464 (-2.9A)
 1.09A 4iklA-3n6nA:
undetectable
4iklB-3n6nA:
undetectable		 4iklA-3n6nA:
14.35
4iklB-3n6nA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3n6n RNA-DEPENDENT RNA
POLYMERASE
(Enterovirus
A) 		3 / 3 THR A  21
PRO A  40
ARG A 163
 None
None
BUP  A 464 (-2.6A)
 0.76A 5nd7B-3n6nA:
undetectable		 5nd7B-3n6nA:
20.84