SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BU2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 6 ARG A  25
ILE A  17
PHE A  55
GLU A  53
 None
None
None
BU2  A 196 (-3.2A)
 0.94A 1nsiA-2rfmA:
undetectable
1nsiB-2rfmA:
undetectable		 1nsiA-2rfmA:
18.94
1nsiB-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 6 ARG A  25
ILE A  17
PHE A  55
GLU A  53
 None
None
None
BU2  A 196 (-3.2A)
 0.95A 1nsiC-2rfmA:
undetectable
1nsiD-2rfmA:
undetectable		 1nsiC-2rfmA:
18.94
1nsiD-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 6 PHE A  55
GLU A  53
ARG A  25
ILE A  17
 None
BU2  A 196 (-3.2A)
None
None
 0.95A 1nsiC-2rfmA:
undetectable
1nsiD-2rfmA:
undetectable		 1nsiC-2rfmA:
18.94
1nsiD-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 7 ARG A  25
ILE A  17
PHE A  55
GLU A  53
 None
None
None
BU2  A 196 (-3.2A)
 0.92A 2nsiA-2rfmA:
undetectable
2nsiB-2rfmA:
undetectable		 2nsiA-2rfmA:
18.94
2nsiB-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 7 PHE A  55
GLU A  53
ARG A  25
ILE A  17
 None
BU2  A 196 (-3.2A)
None
None
 0.90A 2nsiA-2rfmA:
undetectable
2nsiB-2rfmA:
undetectable		 2nsiA-2rfmA:
18.94
2nsiB-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 7 ARG A  25
ILE A  17
PHE A  55
GLU A  53
 None
None
None
BU2  A 196 (-3.2A)
 0.91A 2nsiC-2rfmA:
undetectable
2nsiD-2rfmA:
undetectable		 2nsiC-2rfmA:
18.94
2nsiD-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 7 PHE A  55
GLU A  53
ARG A  25
ILE A  17
 None
BU2  A 196 (-3.2A)
None
None
 0.91A 2nsiC-2rfmA:
undetectable
2nsiD-2rfmA:
undetectable		 2nsiC-2rfmA:
18.94
2nsiD-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 7 ARG A  25
ILE A  17
PHE A  55
GLU A  53
 None
None
None
BU2  A 196 (-3.2A)
 0.94A 3e7gA-2rfmA:
undetectable
3e7gB-2rfmA:
undetectable		 3e7gA-2rfmA:
18.94
3e7gB-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 7 PHE A  55
GLU A  53
ARG A  25
ILE A  17
 None
BU2  A 196 (-3.2A)
None
None
 0.97A 3e7gA-2rfmA:
undetectable
3e7gB-2rfmA:
undetectable		 3e7gA-2rfmA:
18.94
3e7gB-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 7 ARG A  25
ILE A  17
PHE A  55
GLU A  53
 None
None
None
BU2  A 196 (-3.2A)
 0.91A 3e7gC-2rfmA:
undetectable
3e7gD-2rfmA:
undetectable		 3e7gC-2rfmA:
18.94
3e7gD-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 8 PHE A  55
GLU A  53
ARG A  25
ILE A  17
 None
BU2  A 196 (-3.2A)
None
None
 0.95A 3e7gC-2rfmA:
undetectable
3e7gD-2rfmA:
undetectable		 3e7gC-2rfmA:
18.94
3e7gD-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 8 ARG A  25
ILE A  17
PHE A  55
GLU A  53
 None
None
None
BU2  A 196 (-3.2A)
 0.88A 4cx7A-2rfmA:
undetectable
4cx7B-2rfmA:
undetectable		 4cx7A-2rfmA:
18.94
4cx7B-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 8 PHE A  55
GLU A  53
ARG A  25
ILE A  17
 None
BU2  A 196 (-3.2A)
None
None
 0.89A 4cx7A-2rfmA:
undetectable
4cx7B-2rfmA:
undetectable		 4cx7A-2rfmA:
18.94
4cx7B-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 8 ARG A  25
ILE A  17
PHE A  55
GLU A  53
 None
None
None
BU2  A 196 (-3.2A)
 0.96A 4cx7C-2rfmA:
undetectable
4cx7D-2rfmA:
undetectable		 4cx7C-2rfmA:
18.94
4cx7D-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 7 PHE A  55
GLU A  53
ARG A  25
ILE A  17
 None
BU2  A 196 (-3.2A)
None
None
 0.91A 4cx7C-2rfmA:
undetectable
4cx7D-2rfmA:
undetectable		 4cx7C-2rfmA:
18.94
4cx7D-2rfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 7 PHE A  55
GLU A  53
ARG A  25
ILE A  17
 None
BU2  A 196 (-3.2A)
None
None
 0.98A 4nosA-2rfmA:
undetectable
4nosB-2rfmA:
undetectable		 4nosA-2rfmA:
19.19
4nosB-2rfmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 7 ARG A  25
ILE A  17
PHE A  55
GLU A  53
 None
None
None
BU2  A 196 (-3.2A)
 1.01A 4nosC-2rfmA:
undetectable
4nosD-2rfmA:
undetectable		 4nosC-2rfmA:
19.19
4nosD-2rfmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425
(Thermoplasma
volcanium) 		4 / 6 PHE A  55
GLU A  53
ARG A  25
ILE A  17
 None
BU2  A 196 (-3.2A)
None
None
 1.06A 4nosC-2rfmA:
undetectable
4nosD-2rfmA:
undetectable		 4nosC-2rfmA:
19.19
4nosD-2rfmA:
19.19