SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BTX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 118
GLY A 186
ASP A 176
 BTX  A 501 (-3.1A)
BTX  A 501 (-3.3A)
BTX  A 501 (-3.5A)
 0.54A 1kf6A-2ewnA:
undetectable
1kf6B-2ewnA:
undetectable		 1kf6A-2ewnA:
20.00
1kf6B-2ewnA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.86A 1rl8A-2ewnA:
undetectable		 1rl8A-2ewnA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		6 / 12 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 None
BTX  A 501 (-3.3A)
None
None
None
None
 1.02A 1rl8B-2ewnA:
undetectable		 1rl8B-2ewnA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.82A 1sdtB-2ewnA:
undetectable		 1sdtB-2ewnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 11 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.81A 1sdvB-2ewnA:
undetectable		 1sdvB-2ewnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 10 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
 None
BTX  A 501 (-3.3A)
None
None
None
 0.91A 1t3rA-2ewnA:
undetectable		 1t3rA-2ewnA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 10 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.91A 2aquA-2ewnA:
undetectable		 2aquA-2ewnA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 11 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.88A 2aquB-2ewnA:
undetectable		 2aquB-2ewnA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 ARG A 121
GLY A 206
VAL A 189
ILE A 153
GLY A 154
 BTX  A 501 (-4.1A)
BTX  A 501 (-3.5A)
None
None
None
 0.88A 2avsA-2ewnA:
undetectable		 2avsA-2ewnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		4 / 7 ARG A 121
TRP A 123
LYS A 183
ASN A 208
 BTX  A 501 (-4.1A)
BTX  A 501 (-3.6A)
BTX  A 501 ( 3.7A)
BTX  A 501 (-2.9A)
 0.98A 2ejgA-2ewnA:
26.7		 2ejgA-2ewnA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.74A 2f81B-2ewnA:
undetectable		 2f81B-2ewnA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		6 / 9 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 None
BTX  A 501 (-3.3A)
None
None
None
None
 1.08A 2idwB-2ewnA:
undetectable		 2idwB-2ewnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.76A 2ienB-2ewnA:
undetectable		 2ienB-2ewnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.73A 2nmzA-2ewnA:
undetectable		 2nmzA-2ewnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.73A 2nmzB-2ewnA:
undetectable		 2nmzB-2ewnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.90A 2q64A-2ewnA:
undetectable		 2q64A-2ewnA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.97A 2qakB-2ewnA:
undetectable		 2qakB-2ewnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.83A 2r5pD-2ewnA:
undetectable		 2r5pD-2ewnA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 11 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.87A 2r5qB-2ewnA:
undetectable		 2r5qB-2ewnA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 10 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.87A 2r5qD-2ewnA:
undetectable		 2r5qD-2ewnA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		6 / 12 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 None
BTX  A 501 (-3.3A)
None
None
None
None
 1.13A 2rkgA-2ewnA:
undetectable		 2rkgA-2ewnA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		6 / 12 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 None
BTX  A 501 (-3.3A)
None
None
None
None
 1.11A 3bvbB-2ewnA:
undetectable		 3bvbB-2ewnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		6 / 8 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 None
BTX  A 501 (-3.3A)
None
None
None
None
 1.03A 3ekpA-2ewnA:
undetectable		 3ekpA-2ewnA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		6 / 10 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 None
BTX  A 501 (-3.3A)
None
None
None
None
 1.03A 3ekpD-2ewnA:
undetectable		 3ekpD-2ewnA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.80A 3ekqA-2ewnA:
undetectable		 3ekqA-2ewnA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 9 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
 None
BTX  A 501 (-3.3A)
None
None
None
 0.92A 3ektA-2ewnA:
undetectable		 3ektA-2ewnA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 11 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.80A 3ektC-2ewnA:
undetectable		 3ektC-2ewnA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 10 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.78A 3ekvA-2ewnA:
undetectable		 3ekvA-2ewnA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 10 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.88A 3ekyA-2ewnA:
undetectable		 3ekyA-2ewnA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		6 / 12 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 None
BTX  A 501 (-3.3A)
None
None
None
None
 1.13A 3jw2B-2ewnA:
undetectable		 3jw2B-2ewnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 10 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
 None
BTX  A 501 (-3.3A)
None
None
None
 0.92A 3lzvA-2ewnA:
undetectable		 3lzvA-2ewnA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 11 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.83A 3nu3B-2ewnA:
undetectable		 3nu3B-2ewnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 9 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.79A 3nu4B-2ewnA:
undetectable		 3nu4B-2ewnA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		6 / 9 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 None
BTX  A 501 (-3.3A)
None
None
None
None
 1.10A 3nujB-2ewnA:
undetectable		 3nujB-2ewnA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 9 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.81A 3nuoB-2ewnA:
undetectable		 3nuoB-2ewnA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 10 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
 None
BTX  A 501 (-3.3A)
None
None
None
 0.90A 3oy4B-2ewnA:
undetectable		 3oy4B-2ewnA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.78A 3pwmB-2ewnA:
undetectable		 3pwmB-2ewnA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 11 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.78A 3s45B-2ewnA:
undetectable		 3s45B-2ewnA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.80A 3s54B-2ewnA:
undetectable		 3s54B-2ewnA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 10 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.78A 3ttpA-2ewnA:
undetectable		 3ttpA-2ewnA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 10 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.75A 3ttpB-2ewnA:
undetectable		 3ttpB-2ewnA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 9 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
 None
BTX  A 501 (-3.3A)
None
None
None
 0.88A 3u7sA-2ewnA:
undetectable		 3u7sA-2ewnA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 10 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
 None
BTX  A 501 (-3.3A)
None
None
None
 0.91A 4dqbB-2ewnA:
undetectable		 4dqbB-2ewnA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 9 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
 None
BTX  A 501 (-3.3A)
None
None
None
 0.91A 4dqcB-2ewnA:
undetectable		 4dqcB-2ewnA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 10 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
 None
BTX  A 501 (-3.3A)
None
None
None
 0.91A 4dqeB-2ewnA:
undetectable		 4dqeB-2ewnA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 10 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.82A 4dqfB-2ewnA:
undetectable		 4dqfB-2ewnA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 10 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
 None
BTX  A 501 (-3.3A)
None
None
None
 0.91A 4dqhB-2ewnA:
undetectable		 4dqhB-2ewnA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 11 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.82A 4hlaB-2ewnA:
undetectable		 4hlaB-2ewnA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.81A 4jecA-2ewnA:
undetectable		 4jecA-2ewnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 10 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.77A 4ll3B-2ewnA:
undetectable		 4ll3B-2ewnA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 10 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.76A 4ll3A-2ewnA:
undetectable		 4ll3A-2ewnA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 9 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
 None
BTX  A 501 (-3.3A)
None
None
None
 0.90A 4q1wA-2ewnA:
undetectable		 4q1wA-2ewnA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 9 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.81A 4rvjB-2ewnA:
undetectable		 4rvjB-2ewnA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 9 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.81A 4rvjD-2ewnA:
undetectable		 4rvjD-2ewnA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		6 / 12 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 None
BTX  A 501 (-3.3A)
None
None
None
None
 1.10A 5e5kA-2ewnA:
undetectable		 5e5kA-2ewnA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		4 / 7 GLY A 186
ALA A 185
GLY A 154
ILE A 153
 BTX  A 501 (-3.3A)
None
None
None
 0.68A 5kqyB-2ewnA:
undetectable		 5kqyB-2ewnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 9 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
 None
BTX  A 501 (-3.3A)
None
None
None
 0.93A 5kr0B-2ewnA:
undetectable		 5kr0B-2ewnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 8 GLY A 186
ALA A 185
VAL A 169
GLY A 154
ILE A 153
 BTX  A 501 (-3.3A)
None
None
None
None
 1.46A 5kr1B-2ewnA:
undetectable		 5kr1B-2ewnA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.78A 5t2zB-2ewnA:
undetectable		 5t2zB-2ewnA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.78A 5t8hA-2ewnA:
undetectable		 5t8hA-2ewnA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		5 / 12 GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 BTX  A 501 (-3.3A)
None
None
None
None
 0.83A 6dgxA-2ewnA:
undetectable		 6dgxA-2ewnA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 2ewn BIRA BIFUNCTIONAL
PROTEIN
(Escherichia
coli) 		6 / 12 LEU A 131
GLY A 186
ALA A 185
GLY A 154
ILE A 153
ILE A 207
 None
BTX  A 501 (-3.3A)
None
None
None
None
 1.12A 6dilB-2ewnA:
undetectable		 6dilB-2ewnA:
13.50